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To test the possibility that these 2 regions in 18 S rRNA may be involved in mRNA binding and translational initiation, we have tested, using an in vitro translation system, the effects of DNA oligonucleotides complementary to these 18 S rRNA sequences on protein synthesis. Results show that an oligonucleotide complementary to one 18 S rRNA region does inhibit translation at the step of initiation. We propose a Competitive\u2010Displacement Model for the initiation of translation involving the intermolecular base\u2010pairing of 5 S rRNA 18 S rRNA and mRNA.<\/jats:p>","DOI":"10.1016\/0014-5793(91)81437-d","type":"journal-article","created":{"date-parts":[[2003,11,6]],"date-time":"2003-11-06T12:02:06Z","timestamp":1068120126000},"page":"234-238","source":"Crossref","is-referenced-by-count":11,"title":["Evidence for a Competitive\u2010Displacement Model for the initiation of protein synthesis involving the intermolecular hybridization of 5 S rRNA, 18 S rRNA and mRNA"],"prefix":"10.1002","volume":"294","author":[{"given":"Kevin D.","family":"Sarge","sequence":"first","affiliation":[]},{"given":"E.Stuart","family":"Maxwell","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2003,11,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90762-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(87)90418-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(91)90153-D"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(69)90084-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/4.12.4165"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(79)90382-6"},{"key":"e_1_2_1_8_1","unstructured":"1969 Academic Press New York K. 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