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Two populations of RNA (coding for tau proteins containing three or four tubulin\u2010binding motifs) are present in a similar proportion in undifferentiated neuroblastoma cells while in differentiated cells the proportion is changed in favour of that population coding for tau protein containing four tubulin\u2010binding motifs. An increase in a high molecular weight tau isoforms correlates with the increase in the RNA population coding for four tubulin\u2010binding motifs. 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