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The cells were then stimulated by interferon\u2010\u03b3 and tumor necrosis factor\u2010\u03b1 to increase their production of NO from 1.3 to 12.2 \u03bcM in 24 h, as measured by nitrite. Lipid peroxidation of LDL, as measured by thiobarbituric acid\u2010reactive materials (TBARS), was reduced in stimulated cells in a time\u2010dependent manner. At 24 h, the decrease was about 27%. In the presence of an NO synthase inhibitor (N<jats:sup>o<\/jats:sup>\u2010aminophomoarginine), the generation of NO was diminished and the protection against LDL lipid peroxidation was reversed. The extent of LDL protein modification was also assessed by examining its electrophoretic mobility. It was found that macrophage NO reduced the change in LDL electromobility. These data indicate that the production of NO may inhibit the oxidative modification of LDL with cytokine\u2010stimulated macrophages. 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