{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:24:22Z","timestamp":1759616662313},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,17]],"date-time":"2001-12-17T00:00:00Z","timestamp":1008547200000},"content-version":"vor","delay-in-days":3374,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1992,9,21]]},"abstract":"<jats:p>Several lines of evidence suggest that L\u2010type Cu<jats:sup>2+<\/jats:sup> channels (1,4\u2010dihydropyridine receptors) are modulated by GTP\u2010binding, proteins. We have further examined this interaction by measuring the effect of 1,4\u2010dihydropyridines on GTPase activity in brain membranes. Dihydropyridine agonists significantly increased OTPase, reflected by an increase in the maximal rate of GTP hydrolysis, without affecting the affinity for GTP or the binding of a non\u2010hydrolysable analogue of GTP. The stimulating effect on GTPase was abolished by antisera raised against G<jats:sub>o<\/jats:sub>\u03b1 but not G<jats:sub>i<\/jats:sub>\u03b1. L\u2010type Ca<jats:sup>2+<\/jats:sup> channels may act as endogenous GTPase activating proteins (GAPS) to stimulate GTP hydrolysis by G<jats:sub>o<\/jats:sub>.<\/jats:p>","DOI":"10.1016\/0014-5793(92)81148-f","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T09:09:11Z","timestamp":1027588151000},"page":"66-70","source":"Crossref","is-referenced-by-count":28,"title":["1,4\u2010Dihydropyridines modulate GTP hydrolysis by G<sub>o<\/sub> in neuronal membranes"],"prefix":"10.1002","volume":"310","author":[{"given":"M.I.","family":"Sweeney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.C.","family":"Dolphin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.52.030190.001331"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.52.030190.001423"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90194-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/325445a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90206-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.10.3633"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00370874"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90030-5"},{"key":"e_1_2_1_10_1","first-page":"177P","volume":"452","author":"Menon-Johansson A.S.","year":"1992","journal-title":"J. Physiol."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/353043a0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017653"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(88)80771-X"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00237a012"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/348125a0"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.7.4185"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/331440a0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(89)90051-5"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/y86-044"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)80574-5"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/328313a0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/340233a0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)38478-9"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90191-8"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-5-7-995"},{"key":"e_1_2_1_26_1","unstructured":"1989 Raven Press New York N.G. Bowery D.R. Hill R. Moratalla E.A. Barnard E. Costa Allosteric Modulation of Amlao Acid Receptors: Therapeutic Implications 159 172"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/340639a0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.88.3.369"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/352159a0"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb11804.x"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.91.4.469"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)75850-5"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.21.9813"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/357416a0"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90187-J"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2F0014-5793%2892%2981148-F","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2F0014-5793(92)81148-F","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/0014-5793%2892%2981148-F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T03:33:22Z","timestamp":1694921602000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/0014-5793%2892%2981148-F"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9,21]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,9,21]]}},"alternative-id":["10.1016\/0014-5793(92)81148-F"],"URL":"https:\/\/doi.org\/10.1016\/0014-5793(92)81148-f","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9,21]]}}}