{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:23:31Z","timestamp":1779344611428,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2001,11,14]],"date-time":"2001-11-14T00:00:00Z","timestamp":1005696000000},"content-version":"vor","delay-in-days":2942,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1993,10,25]]},"abstract":"<jats:p>The <jats:italic>mos<\/jats:italic> protooncogene encodes a serine\/threonine protein kinase that is only expressed at significant levels in germ cells. Recombinant <jats:italic>malE\u2010mos<\/jats:italic> protein (<jats:italic>Xenopus mos<\/jats:italic> protooncogene fused in frame to the maltose binding protein of <jats:italic>E. coli<\/jats:italic>) activates MAP kinase in cell\u2010free extracts prepared from <jats:italic>Xenopus<\/jats:italic> oocytes and eggs. Here we show that <jats:italic>malE\u2010mos<\/jats:italic> immunoprecipitates from <jats:italic>Xenopus<\/jats:italic> extracts phosphorylate and activate MAP kinase kinase in vitro, indicating that <jats:italic>mos<\/jats:italic> can function as a MAP kinase kinase kinase. Moreover, ectopic expression of <jats:italic>mos<\/jats:italic> in mammalian somatic cells, that lack any endogenous <jats:italic>mos<\/jats:italic> protein, triggers the activation of MAP kinase in vivo. These results identify the <jats:italic>mos<\/jats:italic> protooncogene as a direct activator of the MAP kinase pathway, with the potential to activate this kinase cascade even in cells where normally there is no expression of <jats:italic>mos<\/jats:italic>.<\/jats:p>","DOI":"10.1016\/0014-5793(93)80401-f","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:41:36Z","timestamp":1027582896000},"page":"183-187","source":"Crossref","is-referenced-by-count":56,"title":["The protein kinase <i>mos<\/i> activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo"],"prefix":"10.1002","volume":"333","author":[{"given":"Angel 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