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This is puzzling since previous reports indicated that EGF stimulates proliferation rather than differentiation in PC12 cells. In this paper, we re\u2010examined the biological effect of EGF and TGF\u2010\u03b1, and found that these factors can also induce neuronal differentiation under particular culture conditions. Not only the outgrowth of long neurites, but the induction of neurofilament proteins and the metalloprotease transin was also observed in the EGF\u2010 and TGF\u2010\u03b1\u2010stimulated cells. These data clearly indicate that in addition to NGF, EGF and TGF\u2010\u03b1 can also induce the differentiation of PC12 cells under particular conditions.<\/jats:p>","DOI":"10.1016\/0014-5793(93)81169-z","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:42:02Z","timestamp":1027582922000},"page":"227-232","source":"Crossref","is-referenced-by-count":24,"title":["Epidermal growth factor and transforming growth factor\u2010\u03b1 can induce neuronal differentiation of rat pheochromocytoma PC 12 cells under particular culture 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