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Further analysis by GC\u2010MS confirmed that levels of 8OHDG in SLE urine were 10<jats:sup>3<\/jats:sup>\u2010fold lower than in an age\u2010 and sex\u2010matched control group. Experiments utilising cultures of SLE and normal lymphocytes exposed to H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> confirmed the impaired ability of SLE lymphocytes to repair 8OHDG. We subsequently observed in SLE patients that 8OHDG had accumulated in low molecular weight DNA associated with circulating immune complexes. 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