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These phenomena have been documented in <jats:italic>Paramecium<\/jats:italic>, in <jats:italic>Drosophila<\/jats:italic>, in vertebrate photoreceptors and olfactory receptors, as well as in ryanodine receptor Ca<jats:sup>2+<\/jats:sup>\u2010release channels. Furthermore, studies on calmodulin mutants in <jats:italic>Paramecium<\/jats:italic> have shown a clear bipartite distribution of two groups of mutations in the calmodulin gene that lead to opposite behavioral and electrophysiological phenotypes. These results indicate that the N\u2010lobe of calmodulin specifically interacts with one class of ion\u2010channel proteins and the C\u2010lobe with another.<\/jats:p>","DOI":"10.1016\/0014-5793(94)00782-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:40:55Z","timestamp":1027582855000},"page":"155-158","source":"Crossref","is-referenced-by-count":60,"title":["Ion channel regulation by calmodulin binding"],"prefix":"10.1002","volume":"350","author":[{"given":"Yoshiro","family":"Saimi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching","family":"Kung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.54.030192.000525"},{"key":"e_1_2_1_3_1","unstructured":"1992 Sinauer MA B. 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