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Our results demonstrated that the membrane\u2010proximal cytoplasmic region, encompassing the src homology region 2 (SH2)\u2010like subdomain, of the \u03b3 chain is essential for association and activation of JAK3. Furthermore, IL\u20102\u2010induced activation of JAK3 paralleled induction of the c\u2010<jats:italic>myc<\/jats:italic> gene and DNA synthesis but not induction of the c\u2010<jats:italic>fos<\/jats:italic> and c\u2010<jats:italic>jun<\/jats:italic> genes. These results support the hypothesis that JAK3 plays a pivotal role in the IL\u20102 receptor\u2010mediated signals for cell growth.<\/jats:p>","DOI":"10.1016\/0014-5793(94)00831-0","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:40:55Z","timestamp":1027582855000},"page":"201-206","source":"Crossref","is-referenced-by-count":39,"title":["Interleukin 2\u2010induced activation of JAK3: Possible involvement in signal transduction for c\u2010<i>myc<\/i> induction and cell proliferation"],"prefix":"10.1002","volume":"351","author":[{"given":"Hironobu","family":"Asao","sequence":"first","affiliation":[]},{"given":"Nobuyuki","family":"Tanaka","sequence":"additional","affiliation":[]},{"given":"Naoto","family":"Ishii","sequence":"additional","affiliation":[]},{"given":"Masaya","family":"Higuchi","sequence":"additional","affiliation":[]},{"given":"Toshikazu","family":"Takeshita","sequence":"additional","affiliation":[]},{"given":"Masataka","family":"Nakamura","sequence":"additional","affiliation":[]},{"given":"Takuji","family":"Shirasawa","sequence":"additional","affiliation":[]},{"given":"Kazuo","family":"Sugamura","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,10,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1631559"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.3.637"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)80605-G"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68588-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.5.2214"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.143.3.870"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.143.8.2530"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39806-0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39418-9"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.147.4.1253"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.5.1996"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.7.2674"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.9.4201"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2047859"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90607-7"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90152-G"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90105-L"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/366129a0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/366166a0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/366580a0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/366583a0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90414-L"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90415-M"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.18.8429"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8272872"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8272873"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.8.2985"},{"key":"e_1_2_1_29_1","author":"Tanaka N.","year":"1994","journal-title":"Proc. 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