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Our results demonstrate that cyclosporine (i) stimulates TGF\u2010<jats:italic>\u03b2<\/jats:italic>\n<jats:sub>1<\/jats:sub> promoter\u2010dependent transcription of chloramphenicol acetyl transferase gene in transiently transfected human A\u2010549 cells, (ii) stimulates the synthesis of TGF\u2010<jats:italic>\u03b2<\/jats:italic>\n<jats:sub>1<\/jats:sub> RNA transcripts in human T cells, and (iii) permits the expression\/emergence of DNA regulatory proteins (retinoblastoma control factor\u20101 (RCF\u20101) and RCF\u20102) that bind and regulate TGF\u2010<jats:italic>\u03b2<\/jats:italic>\n<jats:sub>1<\/jats:sub> promoter activity. Our studies demonstrate for the first time that cyclosporine stimulates TGF\u2010<jats:italic>\u03b2<\/jats:italic>\n<jats:sub>1<\/jats:sub> gene transcription and suggest a novel mechanism of action of cyclosporine.<\/jats:p>","DOI":"10.1016\/0014-5793(94)01382-b","type":"journal-article","created":{"date-parts":[[2003,4,30]],"date-time":"2003-04-30T22:24:07Z","timestamp":1051741447000},"page":"109-112","source":"Crossref","is-referenced-by-count":79,"title":["Stimulation of transforming growth factor\u2010<i>\u03b2<\/i><sub>1<\/sub> transcription by cyclosporine"],"prefix":"10.1002","volume":"358","author":[{"given":"Y.","family":"Prashar","sequence":"first","affiliation":[]},{"given":"A.","family":"Khanna","sequence":"additional","affiliation":[]},{"given":"P.","family":"Sehajpal","sequence":"additional","affiliation":[]},{"given":"V.K.","family":"Sharma","sequence":"additional","affiliation":[]},{"given":"M.","family":"Suthanthiran","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2000,2,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198912213212507"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.06.110190.003121"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/08977199309029129"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90107-5"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.4.922"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90111-J"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1259"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199402000-00018"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31272-3"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)47311-0"},{"key":"e_1_2_1_12_1","first-page":"3052","volume-title":"Proc. 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