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The expressed \u03bcOR1 recognizes tested opiate drugs and opioid peptides in a sodium\u2010 and GTP\u2010sensitive fashion with affinities virtually identical to those displayed by the rat \u03bc opiate receptor. Effects on cyclic AMP are similar to those noted for the rat \u03bc opiate receptor. An 18 kb genomic clone hybridizing with the h\u03bcOR1 cDNA contains 63 and 489 bp exonic sequences flanked by splice donor\/acceptor sequences. Analysis of hybridization to DNA prepared from human rodent hybrid cell lines and chromosomal in situ hybridization studies indicate localization to 6q24\u201325. 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