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The results indicated that PDI is a real catalyst of protein folding in the cell. The secretion of h\u2010LZM increased even when both active sites of PDI were disrupted, suggesting that the effect of PDI resulted from a function other than the formation of disulfide bonds. This is the first finding that PDI without isomerase activity accelerates protein folding in vivo.<\/jats:p>","DOI":"10.1016\/0014-5793(95)01410-1","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T13:47:06Z","timestamp":1027604826000},"page":"505-511","source":"Crossref","is-referenced-by-count":77,"title":["Protein disulfide isomerase mutant lacking its isomerase activity accelerates protein folding in the cell"],"prefix":"10.1002","volume":"377","member":"311","published-online":{"date-parts":[[2000,3,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)81309-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0120929"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42505-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80993-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90469-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)37352-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31426-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1995.0312e.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)37456-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.25.14958"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/122.1.19"},{"key":"e_1_2_1_13_2","unstructured":"F. 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