{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:25:10Z","timestamp":1762673110738},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1999,11,30]],"date-time":"1999-11-30T00:00:00Z","timestamp":943920000000},"content-version":"vor","delay-in-days":1380,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1996,2,19]]},"abstract":"<jats:p>The enzyme component of the actin ADP\u2010ribosylating <jats:italic>Clostridium perfringens<\/jats:italic> iota toxin was affinity labelled by UV irradiation in the presence of [carbonyl\u2010<jats:sup>14<\/jats:sup>C]NAD. A peptide containing the radiolabel was generated by CNBr cleavage and subsequent proteolysis with trypsin. Its amino acid sequence is Gly\u2010Ser\u2010Pro\u2010Gly\u2010Ala\u2010Tyr\u2010Leu\u2010Ser\u2010Ala\u2010Ile\u2010Pro\u2010Gly\u2010Tyr\u2010Ala\u2010Gly\u2010X\u2010Tyr\u2010Glu\u2010Val\u2010Leu\u2010Leu\u2010Asn\u2010His\u2010Gly\u2010Ser\u2010Lys corresponding with the region Gly\u2010363 through Lys\u2010388 in the <jats:italic>C. perfringens<\/jats:italic> iota toxin. Mass spectrometric data as well as the results of the PTH\u2010amino acid analysis are in line with a modification of a glutamic acid side chain located at position 378. Therefore, in addition to Glu\u2010380, as could be concluded by analogy with other ADP\u2010ribosyltransferases, Glu\u2010378 may play a pivotal role in the active site of <jats:italic>C. perfringens<\/jats:italic> iota toxin.<\/jats:p>","DOI":"10.1016\/0014-5793(96)00052-x","type":"journal-article","created":{"date-parts":[[2003,4,30]],"date-time":"2003-04-30T22:24:07Z","timestamp":1051741447000},"page":"291-295","source":"Crossref","is-referenced-by-count":29,"title":["Analysis of the catalytic site of the actin ADP\u2010ribosylating <i>Clostridium perfringens<\/i> iota toxin"],"prefix":"10.1002","volume":"380","author":[{"given":"Josef","family":"van Damme","sequence":"first","affiliation":[]},{"given":"Martin","family":"Jung","sequence":"additional","affiliation":[]},{"given":"Fred","family":"Hofmann","sequence":"additional","affiliation":[]},{"given":"Ingo","family":"Just","sequence":"additional","affiliation":[]},{"given":"Joel","family":"Vandekerckhove","sequence":"additional","affiliation":[]},{"given":"Klaus","family":"Aktories","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1999,11,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb13780.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/322390a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(88)80435-2"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.57.8.2462-2469.1989"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.4.1385"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-76966-5_5"},{"key":"e_1_2_1_8_1","first-page":"1223","volume":"251","author":"Simpson L.L.","year":"1989","journal-title":"J. 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