{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:28:42Z","timestamp":1773419322918,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[1999,11,30]],"date-time":"1999-11-30T00:00:00Z","timestamp":943920000000},"content-version":"vor","delay-in-days":1359,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1996,3,11]]},"abstract":"<jats:p>K<jats:sub>\n<jats:italic>V<\/jats:italic>\n<\/jats:sub>,<jats:sub>\n<jats:italic>Ca<\/jats:italic>\n<\/jats:sub>\n<jats:italic>\u03b2<\/jats:italic> subunit dramatically increases the apparent calcium sensitivity of the \u03b1 subunit of MaxlK channels when probed in the micromolar [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> range. Analysis in a wide range of [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> revealed that this functional coupling is exquisitely modulated by [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>. Ca<jats:sup>2+<\/jats:sup> ions switch MaxiK <jats:italic>\u03b1<\/jats:italic>+<jats:italic>\u03b2<\/jats:italic> complex into a functionally coupled state at concentrations beyond resting [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>. At [Ca<jats:sup>2+<\/jats:sup>] \u2264 100 nM, MaxiK activity becomes independent of Ca<jats:sup>2+<\/jats:sup>, is purely voltage\u2010activated, and its functional coupling with its \u03b2 subunit is released. The functional switch develops at [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> that occur during cellular excitation, providing the molecular basis of how MaxiK channels regulate smooth muscle excitability and neurotransmitter release.<\/jats:p>","DOI":"10.1016\/0014-5793(96)00151-2","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T19:16:52Z","timestamp":1027624612000},"page":"84-88","source":"Crossref","is-referenced-by-count":183,"title":["A calcium switch for the functional coupling between \u03b1 (<i>hslo<\/i>) and \u03b2 subunits (K<sub><i>V<\/i><\/sub>, <sub><i>Ca<\/i><\/sub><i>\u03b2<\/i>) of maxi K channels"],"prefix":"10.1002","volume":"382","author":[{"given":"P","family":"Meera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Wallner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Toro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,11,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90160-F"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32551-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90321-6"},{"key":"e_1_2_1_5_1","first-page":"185","volume":"3","author":"Wallner M","year":"1995","journal-title":"Receptors Channels"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/369289a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90279-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(88)57093-3"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)41720-0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5236.633"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1350109"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.124.1.5"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.82.4.511"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018861"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8211185"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2F0014-5793%2896%2900151-2","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2F0014-5793(96)00151-2","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/0014-5793%2896%2900151-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T07:59:08Z","timestamp":1694937548000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/0014-5793%2896%2900151-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3,11]]},"references-count":14,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1996,3,11]]}},"alternative-id":["10.1016\/0014-5793(96)00151-2"],"URL":"https:\/\/doi.org\/10.1016\/0014-5793(96)00151-2","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3,11]]}}}