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In vivo, <jats:italic>sodA\u2010lacZ<\/jats:italic> fusion activity was increased 3\u2010fold by introducing plasmid pPL341, containing the <jats:italic>hmp<\/jats:italic> gene, or by growth with paraquat. The effects were additive and SOXS\u2010dependent. Thus HMP activity causes oxidative stress in vivo. Activities of <jats:italic>sodA\u2010lacZ<\/jats:italic> and <jats:italic>hmp\u2010lacZ<\/jats:italic> fusions were stimulated in a <jats:italic>himA<\/jats:italic> mutant, demonstrating repression of both promoters by integration host factor (IHF), but the effects of pPL341 on <jats:italic>sodA\u2010lacZ<\/jats:italic> activity were not due to titration of IHF by the <jats:italic>hmp<\/jats:italic> promoter.<\/jats:p>","DOI":"10.1016\/0014-5793(96)00154-8","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T15:03:33Z","timestamp":1027609413000},"page":"141-144","source":"Crossref","is-referenced-by-count":66,"title":["The flavohaemoglobin (HMP) of <i>Escherichia coli<\/i> generates superoxide in vitro and causes oxidative stress in vivo"],"prefix":"10.1002","volume":"382","author":[{"given":"Jorge","family":"Membrillo-Hern\u00e1ndez","sequence":"first","affiliation":[]},{"given":"Nicolaos","family":"Ioannidis","sequence":"additional","affiliation":[]},{"given":"Robert K.","family":"Poole","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1999,11,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00273586"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/322481a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)80452-M"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2880649"},{"key":"e_1_2_1_6_1","first-page":"251","volume-title":"Proc. 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