{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T16:44:10Z","timestamp":1763829850134},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1999,11,30]],"date-time":"1999-11-30T00:00:00Z","timestamp":943920000000},"content-version":"vor","delay-in-days":1338,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:p>At least 22 different mutations associated with early\u2010onset familial Alzheimer's disease (AD) in various kindreds have been reported to occur in a recently identified gene on chromosome 14, presenilin 1 (PS\u20101) (Sherrington et al. (1995) Nature 375, 754\u2013760 [1] and reviewed by Van Broeckhoven (1995) Nat. Genet. 11, 230\u2013231 [2]). In order to study the localization of PS\u20101 in the brain, we raised a polyclonal antiserum specific to a fragment of the predicted protein sequence of PS\u20101. PS\u20101 immunostaining was found intracellularly, in the perikaria of discrete cells, mostly neurons, appearing as thick granules, resembling large\u2010size vesicles. These granules were located in the periphery of cell bodies and extended into dendrites and neurites. PS\u20101 expression was found to be broadly distributed throughout the mouse brain, not only in structures involved in AD pathology, but also in structures unaltered by this disease.<\/jats:p>","DOI":"10.1016\/0014-5793(96)00250-5","type":"journal-article","created":{"date-parts":[[2003,4,25]],"date-time":"2003-04-25T01:18:33Z","timestamp":1051233513000},"page":"219-222","source":"Crossref","is-referenced-by-count":48,"title":["Immunohistochemical analysis of presenilin\u20101 expression in the mouse brain"],"prefix":"10.1002","volume":"383","author":[{"given":"S.","family":"Moussaoui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Czech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Pradier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bonici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gohin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Imperato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Revah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,11,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/375754a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-230"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.65041431.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7638622"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/376775a0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/377351a0"},{"key":"e_1_2_1_9_1","first-page":"1253","volume":"134","author":"Mita S.","year":"1989","journal-title":"Am. 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