{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:42:51Z","timestamp":1777578171872,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[1999,3,2]],"date-time":"1999-03-02T00:00:00Z","timestamp":920332800000},"content-version":"vor","delay-in-days":1037,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1996,4,29]]},"abstract":"<jats:p>The widely used histamine receptor antagonists terfenadine and astemizole were shown to prolong the QT interval in electrocardiographic recordings in cases of overdose or inappropriate co\u2010medications, indicating a possible interaction with cardiac K<jats:sup>+<\/jats:sup> channels. Here, terfenadine and astemizole both inhibited the <jats:italic>h<\/jats:italic>uman <jats:italic>e<\/jats:italic>ther\u2010a\u2010go\u2010go <jats:italic>r<\/jats:italic>elated gene (HERG) encoded channels expressed in <jats:italic>Xenopus<\/jats:italic> oocytes at nanomolar concentrations in a use\u2010 and voltage\u2010dependent fashion. In contrast, inhibition of other delayed rectifier (Kvl.1 and I<jats:sub>sK<\/jats:sub>) or inward rectifier K<jats:sup>+<\/jats:sup> channels (IRK1) was much weaker and occurred only at high micromolar concentrations. These results suggest that blockade of HERG channels by terfenadine and astemizole might contribute to the cardiac side effects of these compounds.<\/jats:p>","DOI":"10.1016\/0014-5793(96)00355-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T17:55:22Z","timestamp":1027619722000},"page":"77-80","source":"Crossref","is-referenced-by-count":193,"title":["Blockade of HERG channels expressed in <i>Xenopus<\/i> oocytes by the histamine receptor antagonists terfenadine and astemizole"],"prefix":"10.1002","volume":"385","author":[{"given":"H.","family":"Suessbrich","sequence":"first","affiliation":[]},{"given":"S.","family":"Waldegger","sequence":"additional","affiliation":[]},{"given":"F.","family":"Lang","sequence":"additional","affiliation":[]},{"given":"A.E.","family":"Busch","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1999,3,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450210088038"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90656-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1742-1241.1988.tb08578.x","volume":"42","author":"Snook J.","year":"1988","journal-title":"Br. 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