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Activation of MAPKAP kinase\u20103, like MAPKAP kinase\u20102, was prevented by SB 203580, a specific inhibitor of SAPK\u20102, the upstream activator of MAPKAP kinase\u20102. MAPKAP kinase\u20103 and MAPKAP kinase\u20102 phosphorylated peptide substrates with similar kinetic constants and phosphorylated the same serine residues in HSP27 at the same relative rates. These results establish that MAPKAP kinase\u20103 lies \u2018downstream\u2019 of SAPK\u20102 and that it is likely to have overlapping or identical substrates to MAPKAP kinase\u20102 in vivo.<\/jats:p>","DOI":"10.1016\/0014-5793(96)00816-2","type":"journal-article","created":{"date-parts":[[2003,4,23]],"date-time":"2003-04-23T20:36:00Z","timestamp":1051130160000},"page":"209-214","source":"Crossref","is-referenced-by-count":105,"title":["A comparison of the substrate specificity of MAPKAP kinase\u20102 and MAPKAP kinase\u20103 and their activation by cytokines and cellular stress"],"prefix":"10.1002","volume":"392","author":[{"given":"Andrew D.","family":"Clifton","sequence":"first","affiliation":[]},{"given":"Peter R.","family":"Young","sequence":"additional","affiliation":[]},{"given":"Philip","family":"Cohen","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1999,3,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05492.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2960843"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7914033"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90278-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90277-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/372739a0"},{"key":"e_1_2_1_8_1","unstructured":"1995 A.S. 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