{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:52:46Z","timestamp":1758405166628,"version":"3.41.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1993,2,1]],"date-time":"1993-02-01T00:00:00Z","timestamp":728524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[1993,2]]},"DOI":"10.1016\/0016-5085(93)90427-e","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T03:46:45Z","timestamp":1486007205000},"page":"563-568","source":"Crossref","is-referenced-by-count":42,"title":["Inositol trisphosphate restores impaired human gallbladder motility associated with cholesterol stones"],"prefix":"10.1016","volume":"104","author":[{"given":"Jose","family":"Behar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Y.","family":"Rhim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Biancani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0016-5085(93)90427-E_BIB1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1172\/JCI105794","article-title":"The physicochemical basis of cholesterol gallstone formation in man","volume":"47","author":"Admirand","year":"1968","journal-title":"J Clin Invest"},{"key":"10.1016\/0016-5085(93)90427-E_BIB2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0016-5085(79)90209-9","article-title":"Nucleation time: a key factor in the pathogenesis of cholesterol gallstone disease","volume":"77","author":"Holan","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1016\/0016-5085(93)90427-E_BIB3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/0016-5085(79)90027-1","article-title":"The role of the gallbladder in the pathogenesis of cholesterol stones","volume":"77","author":"LaMorte","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1016\/0016-5085(93)90427-E_BIB4","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/BF01391749","article-title":"Abnormal gallbladder emptying in patients with gallstones","volume":"27","author":"Fisher","year":"1982","journal-title":"Dig Dis Sci"},{"key":"10.1016\/0016-5085(93)90427-E_BIB5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0002-9610(81)90011-8","article-title":"Sludge is calcium bilirubinate associated with bile stasis","volume":"141","author":"Allen","year":"1981","journal-title":"Am J Surg"},{"key":"10.1016\/0016-5085(93)90427-E_BIB6","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/0016-5085(83)90204-4","article-title":"Does total parenteral nutrition induce gallbladder sludge formation and lithiasis?","volume":"84","author":"Messing","year":"1983","journal-title":"Gastroenterology"},{"key":"10.1016\/0016-5085(93)90427-E_BIB7","first-page":"445","article-title":"Increased in prostaglandin synthesis before the formation of cholesterol gallstones","volume":"98","author":"La Morte","year":"1985","journal-title":"Surgery"},{"key":"10.1016\/0016-5085(93)90427-E_BIB8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000137535","article-title":"Effects of indomethacin on prostaglandin synthesis and on a contractile response of the guinea pig gallbladder","volume":"23","author":"Nakata","year":"1981","journal-title":"Pharmacology"},{"key":"10.1016\/0016-5085(93)90427-E_BIB9","first-page":"599","article-title":"Effects of cholesterol gallstone induction on gallbladder function and bile salt pool size in the prairie dog model","volume":"83","author":"Meyer","year":"1978","journal-title":"Surgery"},{"key":"10.1016\/0016-5085(93)90427-E_BIB10","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/0016-5085(83)90432-8","article-title":"Defective gallbladder contractility in the ground squirrel and prairie dog during the early stages of cholesterol gallstone formation","volume":"85","author":"Fridhandler","year":"1983","journal-title":"Gastroenterology"},{"key":"10.1016\/0016-5085(93)90427-E_BIB11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0016-5085(83)80245-5","article-title":"Impaired gallbladder emptying before gallstone formation in the prairie dog","volume":"85","author":"Doty","year":"1983","journal-title":"Gastroenterology"},{"key":"10.1016\/0016-5085(93)90427-E_BIB12","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/0016-5085(89)90392-2","article-title":"Gallbladder contraction in patients with pigment and cholesterol stones","volume":"97","author":"Behar","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/0016-5085(93)90427-E_BIB13","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/0016-5085(88)90370-8","article-title":"Sensitivity and specificity of microscopic examination of gallbladder bile for gallstone recognition and identification","volume":"95","author":"Ramond","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/0016-5085(93)90427-E_BIB14","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.3704641","article-title":"Cytosolic calcium during contraction of isolated mammalian gastric muscle cells","volume":"232","author":"Bitar","year":"1986","journal-title":"Science"},{"key":"10.1016\/0016-5085(93)90427-E_BIB15","first-page":"G760","article-title":"Contraction mediated by Ca2+ influx in esophageal muscle and by Ca2+ release in the LES","volume":"253","author":"Biancani","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1016\/0016-5085(93)90427-E_BIB16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/hep.1840050106","article-title":"Pigment gallstone formation in the cholesterol-fed guinea pig","volume":"5","author":"LaMorte","year":"1985","journal-title":"Hepatology"},{"key":"10.1016\/0016-5085(93)90427-E_BIB17","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/S0016-5085(83)80086-9","article-title":"Pigment sludge and stone formation in the acutely ligated dog gallbladder","volume":"85","author":"Bernhoft","year":"1983","journal-title":"Gastroenterology"},{"key":"10.1016\/0016-5085(93)90427-E_BIB18","first-page":"203","article-title":"Effects of verapamil on the concentrations of guinea pig tracheal muscle induced by calcium, strontium and barium","volume":"84","author":"Baba","year":"1985","journal-title":"Br J Pharmacol"},{"key":"10.1016\/0016-5085(93)90427-E_BIB19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0300-9629(84)90088-4","article-title":"A possible explanation for effects of Sr2+ on contraction-relaxation cycle in canine stomach","volume":"78A","author":"Yasuda","year":"1984","journal-title":"Comp Biochem Physiol A"},{"key":"10.1016\/0016-5085(93)90427-E_BIB20","first-page":"G785","article-title":"Calcium sources utilized by cholecystokinin and acetylcholine in the cat gallbladder muscle","volume":"256","author":"Lee","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/0016-5085(93)90427-E_BIB21","first-page":"A384","article-title":"Intracellular pathways of gallbladder contraction (abstr)","volume":"98","author":"Rhim","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/0016-5085(93)90427-E_BIB22","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1748-1716.1983.tb07224.x","article-title":"The effects of Ca2+ and Sr2+ at different modes of activation in the smooth muscle of the rat portal vein","volume":"117","author":"Arner","year":"1983","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/0016-5085(93)90427-E_BIB23","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1126\/science.174.4012.955","article-title":"Strontium accumulation by sarcoplasmic reticulum and mitochondria in vascular smooth muscle","volume":"174","author":"Somlyo","year":"1971","journal-title":"Science"},{"key":"10.1016\/0016-5085(93)90427-E_BIB24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0143-4160(89)90022-5","article-title":"Calcium release induced by inositol 1,4,5-triphosphate in thymocytes microsomes. Inhibition by barium and strontium","volume":"10","author":"Baquero-Leonis","year":"1989","journal-title":"Cell Calcium"},{"key":"10.1016\/0016-5085(93)90427-E_BIB25","first-page":"G655","article-title":"Cholecystokinin-induced formation of inositol phosphates in pancreatic acini","volume":"259","author":"Rowley","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/0016-5085(93)90427-E_BIB26","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1016\/S0021-9258(17)43052-3","article-title":"Lithium-induced accumulation of inositol 1-phosphate during cholecystokinin octapeptide-and acetylcholine-stimulated phosphatidylinositol breakdown in dispersed mouse pancreas acinar cells","volume":"259","author":"Hokin-Neaverson","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1016\/0016-5085(93)90427-E_BIB27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0026-895X(25)11113-9","article-title":"Differential effects of heparin on inositol 1,4,5-triphosphate binding, metabolism and calcium release activity in the bovine adrenal cortex","volume":"35","author":"Guillemette","year":"1989","journal-title":"Mol Pharmacol"},{"key":"10.1016\/0016-5085(93)90427-E_BIB28","doi-asserted-by":"crossref","first-page":"11075","DOI":"10.1016\/S0021-9258(18)37923-7","article-title":"Competitive, reversible and potent antagonism of inositol 1,4,5-triphosphate-activated calcium release by heparin","volume":"263","author":"Ghosh","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/0016-5085(93)90427-E_BIB29","unstructured":"Rhim BY, Biancani P, DePetris G, Behar J. Mechanisms of signal transduction in the CCK-induced gallbladder contraction. Am J Physiol (submitted)."},{"key":"10.1016\/0016-5085(93)90427-E_BIB30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0022-2275(20)36995-9","article-title":"Absorption of cholesterol by the gallbladder","volume":"17","author":"Neiderhiser","year":"1976","journal-title":"J Lipid Res"},{"key":"10.1016\/0016-5085(93)90427-E_BIB31","series-title":"Physiology of membrane fluidity","first-page":"73","article-title":"Regulation of cell membrane cholesterol","author":"Cooper","year":"1984"},{"key":"10.1016\/0016-5085(93)90427-E_BIB32","series-title":"Physiology of membrane fluidity","first-page":"1","article-title":"Membrane fluidity and cellular functions","author":"Shinitzky","year":"1984"},{"key":"10.1016\/0016-5085(93)90427-E_BIB33","doi-asserted-by":"crossref","first-page":"6844","DOI":"10.1016\/S0021-9258(18)34506-X","article-title":"Effect of membrane cholesterol on phospholipid metabolism in thrombinstimulated platelet-enhanced activation of platelet phospholipase for liberation of arachidonic acid","volume":"257","author":"Kramer","year":"1982","journal-title":"J Biol Chem"},{"key":"10.1016\/0016-5085(93)90427-E_BIB34","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/0016-5085(87)90027-8","article-title":"Calcium-induced contraction and contractile protein content of gallbladder smooth muscle after high cholesterol feeding of prairie dogs","volume":"92","author":"Li","year":"1987","journal-title":"Gastroenterology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:001650859390427E?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:001650859390427E?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T22:55:30Z","timestamp":1749941730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/001650859390427E"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,2]]}},"alternative-id":["001650859390427E"],"URL":"https:\/\/doi.org\/10.1016\/0016-5085(93)90427-e","relation":{},"ISSN":["0016-5085"],"issn-type":[{"type":"print","value":"0016-5085"}],"subject":[],"published":{"date-parts":[[1993,2]]}}}