{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:39:01Z","timestamp":1773290341471,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1986,11,1]],"date-time":"1986-11-01T00:00:00Z","timestamp":531187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1986,11]]},"DOI":"10.1016\/0092-8674(86)90619-7","type":"journal-article","created":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T10:14:38Z","timestamp":1083665678000},"page":"545-554","source":"Crossref","is-referenced-by-count":736,"title":["Expression and structure of the human NGF receptor"],"prefix":"10.1016","volume":"47","author":[{"given":"Dan","family":"Johnson","sequence":"first","affiliation":[]},{"given":"Anthony","family":"Lanahan","sequence":"additional","affiliation":[]},{"given":"C.Randy","family":"Buck","sequence":"additional","affiliation":[]},{"given":"Amita","family":"Sehgal","sequence":"additional","affiliation":[]},{"given":"Claudia","family":"Morgan","sequence":"additional","affiliation":[]},{"given":"Eric","family":"Mercer","sequence":"additional","affiliation":[]},{"given":"Mark","family":"Bothwell","sequence":"additional","affiliation":[]},{"given":"Moses","family":"Chao","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/0092-8674(86)90619-7_BIB1","first-page":"2417","article-title":"Nerve growth factor from mouse submaxillary gland: amino acid sequence","volume":"68","author":"Angeletti","year":"1971"},{"key":"10.1016\/0092-8674(86)90619-7_BIB2","doi-asserted-by":"crossref","first-page":"7270","DOI":"10.1016\/S0021-9258(19)42101-7","article-title":"Structure of the carbohydrate units of IgA1 Immunoglobulin","volume":"249","author":"Baenziger","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB3","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0006-291X(72)80067-6","article-title":"Human chorionic gonadotropin: amino acid sequence of the \u03b1 and \u03b2 subunits","volume":"48","author":"Bahl","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/0092-8674(86)90619-7_BIB4","first-page":"2519","article-title":"Binding of nerve growth factor in superior cervical ganglia","volume":"70","author":"Banerjee","year":"1973"},{"key":"10.1016\/0092-8674(86)90619-7_BIB5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/319226a0","article-title":"The neu oncogene encodes an epidermal growth factor receptor-related protein","volume":"319","author":"Bargmann","year":"1986","journal-title":"Nature"},{"key":"10.1016\/0092-8674(86)90619-7_BIB6","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(85)90280-6","article-title":"Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation","volume":"42","author":"Bar-Sagi","year":"1985","journal-title":"Cell"},{"key":"10.1016\/0092-8674(86)90619-7_BIB7","first-page":"206","article-title":"The structure and function of nerve growth factor","volume":"2","author":"Bradshaw","year":"1977"},{"key":"10.1016\/0092-8674(86)90619-7_BIB8","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/S0021-9258(18)89680-6","article-title":"Properties of the nerve growth factor receptor","volume":"260","author":"Buxser","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB9","first-page":"4516","article-title":"Local control of neurite development by nerve growth factor","volume":"74","author":"Campenot","year":"1978"},{"key":"10.1016\/0092-8674(86)90619-7_BIB10","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1126\/science.3008331","article-title":"Gene transfer and molecular cloning of the human NGF receptor","volume":"232","author":"Chao","year":"1986","journal-title":"Science"},{"key":"10.1016\/0092-8674(86)90619-7_BIB11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.bi.47.070178.001343","article-title":"Empirical predictions of protein conformation","volume":"47","author":"Chou","year":"1978","journal-title":"Ann. Rev. Biochem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB12","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1083\/jcb.75.3.694","article-title":"Role of nerve growth factor in the development of rat sympathetic neurons in vitro. I. Survival, growth, and differentiation of catecholamine production","volume":"75","author":"Chun","year":"1977","journal-title":"J. Cell Biol."},{"key":"10.1016\/0092-8674(86)90619-7_BIB13","first-page":"302","article-title":"Purification of a nerve growth promoting protein from mouse salivary gland and its neurocytotoxic antiserum","volume":"46","author":"Cohen","year":"1960"},{"key":"10.1016\/0092-8674(86)90619-7_BIB14","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1126\/science.4035354","article-title":"Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazapines","volume":"229","author":"Curran","year":"1985","journal-title":"Science"},{"key":"10.1016\/0092-8674(86)90619-7_BIB15","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/307558a0","article-title":"Computer-based characterization of epidermal growth factor precursor","volume":"307","author":"Doolittle","year":"1984","journal-title":"Nature"},{"key":"10.1016\/0092-8674(86)90619-7_BIB16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/295419a0","article-title":"Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor","volume":"295","author":"Ek","year":"1982","journal-title":"Nature"},{"key":"10.1016\/0092-8674(86)90619-7_BIB17","first-page":"565","article-title":"Nerve growth factor receptors on human melanoma cells in culture","volume":"74","author":"Fabricant","year":"1977"},{"key":"10.1016\/0092-8674(86)90619-7_BIB18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1126\/science.176.4034.482","article-title":"Nerve growth factor and insulin","volume":"176","author":"Frazier","year":"1972","journal-title":"Science"},{"key":"10.1016\/0092-8674(86)90619-7_BIB19","doi-asserted-by":"crossref","first-page":"5513","DOI":"10.1016\/S0021-9258(20)79758-9","article-title":"Properties of the specific binding of 125I nerve growth factor to responsive peripheral neurons","volume":"249","author":"Frazier","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0165-3806(83)90107-4","article-title":"NGF-mediated increase of choline acteyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain?","volume":"9","author":"Gnahn","year":"1983","journal-title":"Dev. Brain Res."},{"key":"10.1016\/0092-8674(86)90619-7_BIB21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0022-1759(76)90007-7","article-title":"The chromic chloride method of coupling antigens to erythrocytes: definition of some important parameters","volume":"10","author":"Goding","year":"1976","journal-title":"J. Immunol. Meth."},{"key":"10.1016\/0092-8674(86)90619-7_BIB22","doi-asserted-by":"crossref","first-page":"14101","DOI":"10.1016\/S0021-9258(17)38689-1","article-title":"Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells","volume":"260","author":"Greenberg","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/268349a0","article-title":"Synthesis, storage, and release of acetylcholine by a nerve-growth factor responsive line of rat pheochromocytoma cells","volume":"268","author":"Greene","year":"1977","journal-title":"Nature"},{"key":"10.1016\/0092-8674(86)90619-7_BIB24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev.ne.03.030180.002033","article-title":"The nerve growth factor: biochemistry, synthesis, and mechanism of action","volume":"3","author":"Greene","year":"1980","journal-title":"Ann. Rev. Neurosci."},{"key":"10.1016\/0092-8674(86)90619-7_BIB25","first-page":"6819","article-title":"Affinity labeling and partial purification of nerve growth factor receptors from rat phenochromocytoma and human melanoma cells","volume":"80","author":"Grob","year":"1983"},{"key":"10.1016\/0092-8674(86)90619-7_BIB26","doi-asserted-by":"crossref","first-page":"8044","DOI":"10.1016\/S0021-9258(17)39561-3","article-title":"Characterization of the human melanoma nerve growth factor receptor","volume":"260","author":"Grob","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB27","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.493992","article-title":"Neuronal chemotaxis: chick dorsal-root axons turn toward high concentrations of nerve growth factor","volume":"206","author":"Gundersen","year":"1979","journal-title":"Science"},{"key":"10.1016\/0092-8674(86)90619-7_BIB28","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/319680a0","article-title":"Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21","volume":"319","author":"Hagag","year":"1986","journal-title":"Nature"},{"key":"10.1016\/0092-8674(86)90619-7_BIB29","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0092-8674(80)90367-0","article-title":"Nerve growth factor mediates phosphorylation of specific proteins","volume":"22","author":"Halegoua","year":"1980","journal-title":"Cell"},{"key":"10.1016\/0092-8674(86)90619-7_BIB30","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0378-1119(84)90153-7","article-title":"Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing","volume":"28","author":"Henikoff","year":"1984","journal-title":"Gene"},{"key":"10.1016\/0092-8674(86)90619-7_BIB31","first-page":"3884","article-title":"Properties of the \u03b2-nerve growth factor receptor of avian dorsal root ganglia","volume":"70","author":"Herrup","year":"1973"},{"key":"10.1016\/0092-8674(86)90619-7_BIB32","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0021-9258(18)89782-4","article-title":"Molecular characteristics of nerve growth factor receptors on PC12 cells","volume":"260","author":"Hosang","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB33","doi-asserted-by":"crossref","first-page":"9568","DOI":"10.1016\/S0021-9258(18)67548-9","article-title":"Association of bovine brain-derived growth factor receptor with protein kinase activity","volume":"261","author":"Huang","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB34","series-title":"DNA Cloning Techniques, A Practical Approach","first-page":"49","article-title":"Construction and screening cDNA libraries in \u03bbgt10 and \u03bbgt11","author":"Huynh","year":"1985"},{"key":"10.1016\/0092-8674(86)90619-7_BIB35","doi-asserted-by":"crossref","first-page":"9581","DOI":"10.1016\/S0021-9258(17)44530-3","article-title":"Somatemedin C stimulates the phosphorylation of the beta subunit of its own receptor","volume":"258","author":"Jacobs","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB36","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/321706a0","article-title":"Idealization of the hydrophobic segment of the alkaline phosphatase signal peptide","volume":"321","author":"Kendall","year":"1986","journal-title":"Nature"},{"key":"10.1016\/0092-8674(86)90619-7_BIB37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","article-title":"A simple method for displaying the hydropathic character of a protein","volume":"157","author":"Kyte","year":"1982","journal-title":"J. Mol. Biol."},{"key":"10.1016\/0092-8674(86)90619-7_BIB38","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/0092-8674(86)90619-7_BIB39","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.100.3.677","article-title":"Nerve growth factor- and epidermal growth factor-stimulated phosphorylation of a PC12 cytoskeletally associated protein in situ","volume":"100","author":"Landreth","year":"1985","journal-title":"J. Cell Biol."},{"key":"10.1016\/0092-8674(86)90619-7_BIB40","first-page":"4751","article-title":"Nerve growth factor receptors on PC12 cells: ligand-induced conversion from low- to high-affinity states","volume":"77","author":"Landreth","year":"1980"},{"key":"10.1016\/0092-8674(86)90619-7_BIB41","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0012-1606(78)90283-X","article-title":"Chemotactic response of nerve fiber elongation to nerve growth factor","volume":"66","author":"Letourneau","year":"1978","journal-title":"Dev. Biol."},{"key":"10.1016\/0092-8674(86)90619-7_BIB42","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0012-1606(63)90149-0","article-title":"Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic nerve cells in vitro","volume":"7","author":"Levi-Montalcini","year":"1963","journal-title":"Dev. Biol."},{"key":"10.1016\/0092-8674(86)90619-7_BIB43","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1152\/physrev.1968.48.3.534","article-title":"Nerve growth factor","volume":"48","author":"Levi-Montalcini","year":"1968","journal-title":"Physiol. Rev."},{"key":"10.1016\/0092-8674(86)90619-7_BIB44","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0006-8993(77)90748-X","article-title":"Stimulation and maintenance by nerve growth factor of phenylethanolamine-N-methyltransferase in superior cervical ganglia of adult rats","volume":"138","author":"Liuzzi","year":"1977","journal-title":"Brain Res."},{"key":"10.1016\/0092-8674(86)90619-7_BIB45","first-page":"4681","article-title":"Nerve growth factor increases activity of ornithine decarboxylase in superior cervical ganglion of young rats","volume":"74","author":"MacDonnell","year":"1977"},{"key":"10.1016\/0092-8674(86)90619-7_BIB46","author":"Maniatis","year":"1982"},{"key":"10.1016\/0092-8674(86)90619-7_BIB47","article-title":"Purification and amine terminal sequencing of human melanoma nerve growth factor receptor","author":"Marano","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB48","doi-asserted-by":"crossref","first-page":"9419","DOI":"10.1016\/S0021-9258(19)68777-6","article-title":"Identification of a nerve growth factor receptor protein in sympathetic ganglia membranes by affinity labeling","volume":"256","author":"Massague","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB49","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1016\/S0021-9258(18)32870-9","article-title":"Purification of the receptor for nerve growth factor from A875 cells by affinity chromatography","volume":"258","author":"Puma","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB50","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0012-1606(80)90376-0","article-title":"The effects of nerve growth factor on acetylcholinesterase and its multiple forms in cultures of rat PC12 pheochromocytoma cells: increased total specific activity and appearance of the 16S molecular form","volume":"76","author":"Rieger","year":"1980","journal-title":"Dev. Biol."},{"key":"10.1016\/0092-8674(86)90619-7_BIB51","first-page":"6681","article-title":"Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies","volume":"81","author":"Ross","year":"1984"},{"key":"10.1016\/0092-8674(86)90619-7_BIB52","first-page":"5463","article-title":"DNA sequencing with chain termination inhibitors","volume":"74","author":"Sanger","year":"1977"},{"key":"10.1016\/0092-8674(86)90619-7_BIB53","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0092-8674(85)80047-7","article-title":"The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1","volume":"41","author":"Sherr","year":"1985","journal-title":"Cell"},{"key":"10.1016\/0092-8674(86)90619-7_BIB54","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0022-2836(75)80083-0","article-title":"Detection of specific sequences among DNA fragments separated by gel electrophoresis","volume":"98","author":"Southern","year":"1975","journal-title":"J. Mol. Biol."},{"key":"10.1016\/0092-8674(86)90619-7_BIB55","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/jnr.490080226","article-title":"Nerve growth factor effects and receptors in cultured human neuroblastoma cell lines","volume":"8","author":"Sonnenfeld","year":"1982","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/0092-8674(86)90619-7_BIB56","first-page":"1950","article-title":"Nerve growth factor receptor molecules in rat brain","volume":"83","author":"Taniuchi","year":"1986"},{"key":"10.1016\/0092-8674(86)90619-7_BIB57","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1152\/physrev.1980.60.4.1284","article-title":"Physiology of nerve growth factor","volume":"60","author":"Thoenen","year":"1980","journal-title":"Physiol. Rev."},{"key":"10.1016\/0092-8674(86)90619-7_BIB58","first-page":"1598","article-title":"Selective induction of tyrosine hydroxylase and dopamine hydroxylase in rat superior cervical ganglia by nerve growth factor","volume":"68","author":"Thoenen","year":"1971"},{"key":"10.1016\/0092-8674(86)90619-7_BIB59","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0022-2836(81)90515-5","article-title":"Disulphide bridges in globular proteins","volume":"151","author":"Thornton","year":"1981","journal-title":"J. Mol. Biol."},{"key":"10.1016\/0092-8674(86)90619-7_BIB60","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/309418a0","article-title":"Human epidermal growth factor receptor cDNA sequences and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells","volume":"309","author":"Ullrich","year":"1984","journal-title":"Nature"},{"key":"10.1016\/0092-8674(86)90619-7_BIB61","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/313756a0","article-title":"Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes","volume":"313","author":"Ullrich","year":"1985","journal-title":"Nature"},{"key":"10.1016\/0092-8674(86)90619-7_BIB62","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1016\/S0021-9258(18)43497-7","article-title":"Tyrosine kinase activity of the epidermal growth factor receptor","volume":"255","author":"Ushiro","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(86)90619-7_BIB63","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0092-8674(85)90229-6","article-title":"Nucleotide sequence from neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats","volume":"43","author":"Wharton","year":"1985","journal-title":"Cell"},{"key":"10.1016\/0092-8674(86)90619-7_BIB64","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0092-8674(79)90093-X","article-title":"Transformation of mammalian cells with genes from procaryotes and eucaryotes","volume":"16","author":"Wigler","year":"1979","journal-title":"Cell"},{"key":"10.1016\/0092-8674(86)90619-7_BIB65","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1126\/science.6208611","article-title":"Role of the conserved AAUAAA sequence: four AAUAAA point mutants prevent mRNA 3\u2032 end formation","volume":"226","author":"Wilkins","year":"1984","journal-title":"Science"},{"key":"10.1016\/0092-8674(86)90619-7_BIB66","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/0014-4827(86)90361-7","article-title":"Dexamethazone rapidly reduces the expression of the \u03b2-NGF gene in mouse L-929 cells","volume":"127","author":"Wion","year":"1986","journal-title":"Exp. Cell Res."},{"key":"10.1016\/0092-8674(86)90619-7_BIB67","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0092-8674(84)90188-0","article-title":"The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA","volume":"39","author":"Yamamoto","year":"1984","journal-title":"Cell"},{"key":"10.1016\/0092-8674(86)90619-7_BIB68","doi-asserted-by":"crossref","first-page":"10481","DOI":"10.1016\/S0021-9258(19)70489-X","article-title":"Increased phosphorylation of specific nuclear proteins in superior cervical ganglia and PC12 cells in response to nerve growth factor","volume":"255","author":"Yu","year":"1980","journal-title":"J. Biol. Chem."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0092867486906197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0092867486906197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T08:27:07Z","timestamp":1623918427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0092867486906197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,11]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,11]]}},"alternative-id":["0092867486906197"],"URL":"https:\/\/doi.org\/10.1016\/0092-8674(86)90619-7","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1986,11]]}}}