{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:51:40Z","timestamp":1779349900485,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1989,8,1]],"date-time":"1989-08-01T00:00:00Z","timestamp":617932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1989,8,1]],"date-time":"1989-08-01T00:00:00Z","timestamp":617932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012102","name":"Nissan Global Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[1989,8]]},"DOI":"10.1016\/0092-8674(89)90107-4","type":"journal-article","created":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T06:14:38Z","timestamp":1083651278000},"page":"729-739","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":756,"title":["Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes"],"prefix":"10.1016","volume":"58","author":[{"given":"Hisashi","family":"Harada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Furia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadatsugu","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0092-8674(89)90107-4_BIB1","first-page":"8573","article-title":"Molecular cloning of a cDNA by a high-efficiency COS cell expression system","volume":"84","author":"Aruffo","year":"1987"},{"key":"10.1016\/0092-8674(89)90107-4_BIB2","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/j.1460-2075.1989.tb03484.x","article-title":"A gamma-interferon-induced factor that binds the interferon response sequence of the MHC class I gene, H-2Kb","volume":"8","author":"Blanar","year":"1989","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(89)90107-4_BIB3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/nar\/17.2.499","article-title":"Sequence requirement for specific interaction of an enhancer binding protein (EBP1) with DNA","volume":"17","author":"Clark","year":"1989","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/0092-8674(89)90107-4_BIB4","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1002\/j.1460-2075.1988.tb02958.x","article-title":"Enhancer-like interferon responsive sequences of the human and murine (2\u2032-5\u2032) oligoadenylate synthetase gene promoters","volume":"7","author":"Cohen","year":"1988","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(89)90107-4_BIB5","series-title":"Atlas of Protein Sequence and Structure","first-page":"345","article-title":"A model of evolutionary change in proteins","author":"Dayhoff","year":"1978"},{"key":"10.1016\/0092-8674(89)90107-4_BIB6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0092-8674(85)80022-2","article-title":"Delimitation and properties of DNA sequences required for the regulated expression of human interferon-\u03b2 gene","volume":"41","author":"Fujita","year":"1985","journal-title":"Cell"},{"key":"10.1016\/0092-8674(89)90107-4_BIB7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0092-8674(87)90288-1","article-title":"Interferon-\u03b2 gene regulation: tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer","volume":"49","author":"Fujita","year":"1987","journal-title":"Cell"},{"key":"10.1016\/0092-8674(89)90107-4_BIB8","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1002\/j.1460-2075.1988.tb03213.x","article-title":"Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-\u03b2 gene regulatory elements","volume":"7","author":"Fujita","year":"1988","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(89)90107-4_BIB9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/337270a0","article-title":"Induction of endogenous IFN-\u03b1 and IFN-\u03b2 genes by a regulatory transcription factor, IRF-1","volume":"337","author":"Fujita","year":"1989","journal-title":"Nature"},{"key":"10.1016\/0092-8674(89)90107-4_BIB10","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/17.9.3335","article-title":"Involvement of a cis-element that binds an H2TF-1\/NF\u03baB like factor(s) in the virus-induced interferon-\u03b2 gene expression","author":"Fujita","year":"1989","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/0092-8674(89)90107-4_BIB11","first-page":"3065","article-title":"Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter","volume":"8","author":"Hug","year":"1988","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(89)90107-4_BIB12","first-page":"49","article-title":"Constructing and screening cDNA libraries in \u03bbgt10 and 11","volume":"Volume 1","author":"Huynh","year":"1985"},{"key":"10.1016\/0092-8674(89)90107-4_BIB13","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/322743a0","article-title":"Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H-2 gene","volume":"322","author":"Israel","year":"1986","journal-title":"Nature"},{"key":"10.1016\/0092-8674(89)90107-4_BIB14","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1126\/science.3125612","article-title":"Regulation of gene expression by interferons: control of H-2 promoter responses","volume":"239","author":"Korber","year":"1988","journal-title":"Science"},{"key":"10.1016\/0092-8674(89)90107-4_BIB15","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/0092-8674(87)90172-3","article-title":"Reversible silencing of enhancers by sequences derived from the human IFN-\u03b1 promoter","volume":"50","author":"Kuhl","year":"1987","journal-title":"Cell"},{"key":"10.1016\/0092-8674(89)90107-4_BIB16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0092-8674(89)90966-5","article-title":"The involvement of NK-\u03baB in \u03b2-interferon gene regulation reveals its role as a widely inducible mediator of signal transduction","volume":"57","author":"Lenardo","year":"1989","journal-title":"Cell"},{"key":"10.1016\/0092-8674(89)90107-4_BIB17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.bi.51.070182.001343","article-title":"Biochemistry of interferons and their actions","volume":"51","author":"Lengyel","year":"1982","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/0092-8674(89)90107-4_BIB18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1101\/gad.2.4.383","article-title":"Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control","volume":"2","author":"Levy","year":"1988","journal-title":"Genes Dev."},{"key":"10.1016\/0092-8674(89)90107-4_BIB19","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0076-6879(80)65059-9","article-title":"Sequencing end-labeled DNA with base-specific chemical cleavages","volume":"65","author":"Maxam","year":"1980","journal-title":"Meth. Enzymol."},{"key":"10.1016\/0092-8674(89)90107-4_BIB20","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0092-8674(88)91307-4","article-title":"Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-\u03b2 gene regulatory elements","volume":"54","author":"Miyamoto","year":"1988","journal-title":"Cell"},{"key":"10.1016\/0092-8674(89)90107-4_BIB21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0092-8674(82)90257-4","article-title":"Specific protein-DNA interaction at four sites flanking the chicken lysozyme gene","volume":"30","author":"Nowock","year":"1982","journal-title":"Cell"},{"key":"10.1016\/0092-8674(89)90107-4_BIB22","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1146\/annurev.bi.56.070187.003455","article-title":"Interferons and their actions","volume":"56","author":"Pestka","year":"1987","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/0092-8674(89)90107-4_BIB23","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/nar\/16.4.1371","article-title":"Transcriptional stimulation by CaPO4-DNA precipitates","volume":"16","author":"Pine","year":"1988","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/0092-8674(89)90107-4_BIB24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0378-1119(87)90165-X","article-title":"Vectors for selective expression of cloned DNAs by T7 RNA polymerase","volume":"56","author":"Rosenberg","year":"1987","journal-title":"Gene"},{"key":"10.1016\/0092-8674(89)90107-4_BIB25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0092-8674(85)80023-4","article-title":"A 46-nucleotide promoter segment from an IFN-\u03b1 gene renders an unrelated promoter inducible by virus","volume":"41","author":"Ryals","year":"1985","journal-title":"Cell"},{"key":"10.1016\/0092-8674(89)90107-4_BIB26","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/329840a0","article-title":"An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2","volume":"329","author":"Seed","year":"1987","journal-title":"Nature"},{"key":"10.1016\/0092-8674(89)90107-4_BIB27","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0092-8674(86)90346-6","article-title":"Multiple nuclear factors interact with the immunoglobulin enhancer sequences","volume":"46","author":"Sen","year":"1986","journal-title":"Cell"},{"key":"10.1016\/0092-8674(89)90107-4_BIB28","series-title":"The Interferon System","author":"Stewart","year":"1979"},{"key":"10.1016\/0092-8674(89)90107-4_BIB29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0022-2836(86)90385-2","article-title":"Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes","volume":"189","author":"Studier","year":"1986","journal-title":"J. Mol. Biol."},{"key":"10.1016\/0092-8674(89)90107-4_BIB30","first-page":"2625","article-title":"Interferons increase transcription of a major histocompatibility class I gene via a 5\u2032 interferon consensus sequence","volume":"7","author":"Sugita","year":"1987","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(89)90107-4_BIB31","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev.iy.06.040188.002255","article-title":"Regulation of cytokine gene expression","volume":"6","author":"Taniguchi","year":"1988","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/0092-8674(89)90107-4_BIB32","series-title":"The Biology of the Interferon System 1988","first-page":"3","article-title":"Cytokine gene expression: regulation in the type I IFN and the IL-2 system","author":"Taniguchi","year":"1989"},{"key":"10.1016\/0092-8674(89)90107-4_BIB33","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/305827a0","article-title":"Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus","volume":"305","author":"Toh","year":"1983","journal-title":"Nature"},{"key":"10.1016\/0092-8674(89)90107-4_BIB34","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/j.1460-2075.1989.tb03483.x","article-title":"Double-stranded RNA activates binding of NF-\u03baB to an inducible element in the human \u03b2-interferon promoter","volume":"8","author":"Visvanathan","year":"1989","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(89)90107-4_BIB35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1432-1033.1988.tb14101.x","article-title":"Regulation of two interferon-inducible human genes by interferon, poly(rl):poly(rC) and viruses","volume":"174","author":"Wathelet","year":"1988","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/0092-8674(89)90107-4_BIB36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0079-6603(08)60026-4","article-title":"The interferon genes","volume":"33","author":"Weissmann","year":"1986","journal-title":"Prog. Nucl. Acid Res. Mol. Biol."},{"key":"10.1016\/0092-8674(89)90107-4_BIB37","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0092-8674(87)90130-9","article-title":"Binding of transcription factor TFIID to the major late promoter during in vitro nucleosome assembly potentiates subsequent initiation by RNA polymerase II","volume":"51","author":"Workman","year":"1987","journal-title":"Cell"},{"key":"10.1016\/0092-8674(89)90107-4_BIB38","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.3281258","article-title":"2-Aminopurine selectively inhibits the induction of \u03b2-interferon, c-fos, and c-myc gene expression","volume":"240","author":"Zinn","year":"1988","journal-title":"Science"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0092867489901074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0092867489901074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T18:51:09Z","timestamp":1757443869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0092867489901074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,8]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,8]]}},"alternative-id":["0092867489901074"],"URL":"https:\/\/doi.org\/10.1016\/0092-8674(89)90107-4","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1989,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/0092-8674(89)90107-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1989","name":"copyright","label":"Copyright"}]}}