{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:56:27Z","timestamp":1770900987377,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1993,5,1]],"date-time":"1993-05-01T00:00:00Z","timestamp":736214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1993,5]]},"DOI":"10.1016\/0092-8674(93)90133-b","type":"journal-article","created":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T10:14:26Z","timestamp":1083665666000},"page":"447-456","source":"Crossref","is-referenced-by-count":204,"title":["Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor"],"prefix":"10.1016","volume":"73","author":[{"given":"Raymond G.","family":"Goodwin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark R.","family":"Alderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Armitage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"VandenBos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Jerzy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa W.","family":"Tough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Schoenborn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terri","family":"Davis-Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Hennen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Falk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cosman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant R.","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth H.","family":"Grabstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Farrah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith G.","family":"Giri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.Patricia","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0092-8674(93)90133-B_BIB1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1084\/jem.172.2.577","article-title":"Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood","volume":"172","author":"Alderson","year":"1990","journal-title":"J. Exp. Med."},{"key":"10.1016\/0092-8674(93)90133-B_BIB2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/357080a0","article-title":"Molecular and biological characterization of a murine ligand for CD40","volume":"357","author":"Armitage","year":"1992","journal-title":"Nature"},{"key":"10.1016\/0092-8674(93)90133-B_BIB3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1146\/annurev.iy.07.040189.003205","article-title":"The biology of cachectin\/TNF: a primary mediator of the host response","volume":"7","author":"Beutler","year":"1989","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/0092-8674(93)90133-B_BIB4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.141.1.21","article-title":"S152 (CD27): a modulating disulfide-linked T cell activation antigen","volume":"141","author":"Bigler","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/0092-8674(93)90133-B_BIB5","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.4049\/jimmunol.147.4.1230","article-title":"Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma","volume":"147","author":"Browning","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/0092-8674(93)90133-B_BIB6","first-page":"219","article-title":"Reassessment of two apparent deletions of chromosome 16p to an ins(11;16) and a t(1;16) by chromosome painting","volume":"33","author":"Callen","year":"1990","journal-title":"Ann. Genet."},{"key":"10.1016\/0092-8674(93)90133-B_BIB7","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.4049\/jimmunol.147.9.3165","article-title":"The T cell activation antigen CD27 is a member of the NGFTNF receptor gene family","volume":"147","author":"Camerini","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/0092-8674(93)90133-B_BIB8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0378-1119(92)90513-O","article-title":"Cloning and mapping of 5\u2032 exons from the gene encoding chicken beta nerve growth factor","volume":"116","author":"Carrier","year":"1992","journal-title":"Gene"},{"key":"10.1016\/0092-8674(93)90133-B_BIB9","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.4049\/jimmunol.146.8.2488","article-title":"Regulation of expression of CD27, a T cell-specific member of a novel family of membrane receptors","volume":"146","author":"de Jong","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/0092-8674(93)90133-B_BIB10","doi-asserted-by":"crossref","first-page":"751","DOI":"10.4049\/jimmunol.132.2.751","article-title":"The interaction of monoclonal antibodies with MHC class I antigens on mouse spleen cells. I. Analysis of the mechanism of binding","volume":"132","author":"Dower","year":"1984","journal-title":"J. Immunol."},{"key":"10.1016\/0092-8674(93)90133-B_BIB11","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0092-8674(92)90180-K","article-title":"Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease","volume":"68","author":"D\u00fcrkop","year":"1992","journal-title":"Cell"},{"key":"10.1016\/0092-8674(93)90133-B_BIB12","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4049\/jimmunol.149.2.655","article-title":"Soluble forms of CD40 inhibit biological responses of human B cells","volume":"149","author":"Fanslow","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/0092-8674(93)90133-B_BIB13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/358026b0","article-title":"Emerging cytokine family","volume":"358","author":"Farrah","year":"1992","journal-title":"Nature"},{"key":"10.1016\/0092-8674(93)90133-B_BIB14","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1002\/j.1460-2075.1989.tb08541.x","article-title":"Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor","volume":"8","author":"Gearing","year":"1989","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(93)90133-B_BIB15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0378-1119(83)90230-5","article-title":"A simple and very efficient method for generating cDNA libraries","volume":"25","author":"Gubler","year":"1983","journal-title":"Gene"},{"key":"10.1016\/0092-8674(93)90133-B_BIB16","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1002\/j.1460-2075.1992.tb05530.x","article-title":"The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity","volume":"11","author":"Hollenbaugh","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(93)90133-B_BIB17","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/194495a0","article-title":"Preparation of iodine-131 labeled human growth hormone of high specific activity","volume":"194","author":"Hunter","year":"1962","journal-title":"Nature"},{"key":"10.1016\/0092-8674(93)90133-B_BIB18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0092-8674(91)90614-5","article-title":"The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis","volume":"66","author":"Itoh","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0092-8674(93)90133-B_BIB19","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0092-8674(86)90619-7","article-title":"Expression and structure of the human NGF receptor","volume":"47","author":"Johnson","year":"1986","journal-title":"Cell"},{"key":"10.1016\/0092-8674(93)90133-B_BIB20","first-page":"321","article-title":"The three-dimensional structure of tumor necrosis factor","volume":"349","author":"Jones","year":"1990","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/0092-8674(93)90133-B_BIB21","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/nar\/12.2.857","article-title":"Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs","volume":"12","author":"Kozak","year":"1984","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/0092-8674(93)90133-B_BIB22","first-page":"1963","article-title":"cDNA sequences of two inducible T-cell genes","volume":"86","author":"Kwon","year":"1989"},{"key":"10.1016\/0092-8674(93)90133-B_BIB23","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/0092-8674(93)90133-B_BIB24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0092-8674(90)90815-V","article-title":"Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor","volume":"61","author":"Loetscher","year":"1990","journal-title":"Cell"},{"key":"10.1016\/0092-8674(93)90133-B_BIB25","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/j.1460-2075.1990.tb08211.x","article-title":"Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes: a molecule related to nerve growth factor receptor","volume":"9","author":"Mallet","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(93)90133-B_BIB26","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1002\/eji.1830201223","article-title":"CD27 expression by a distinct subpopulation of human B lymphocytes","volume":"20","author":"Maurer","year":"1990","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/0092-8674(93)90133-B_BIB27","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.4049\/jimmunol.148.12.3700","article-title":"IgM and IgG but not cytokine secretion is restricted to the CD27+ B lymphocyte subset","volume":"148","author":"Maurer","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/0092-8674(93)90133-B_BIB28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/354411a0","article-title":"New protein fold revealed by a 2.3-\u00c5 resolution crystal structure of nerve growth factor","volume":"354","author":"McDonald","year":"1991","journal-title":"Nature"},{"key":"10.1016\/0092-8674(93)90133-B_BIB29","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1002\/j.1460-2075.1991.tb07831.x","article-title":"A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types","volume":"10","author":"McMahan","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(93)90133-B_BIB30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0092-8674(89)90295-X","article-title":"The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms","volume":"59","author":"Mosley","year":"1989","journal-title":"Cell"},{"key":"10.1016\/0092-8674(93)90133-B_BIB31","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1749-6632.1949.tb27297.x","article-title":"The attractions of protein for small molecules and ions","volume":"51","author":"Scatchard","year":"1949","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/0092-8674(93)90133-B_BIB32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0092-8674(90)90816-W","article-title":"Molecular cloning and expression of a receptor for human tumor necrosis factor","volume":"61","author":"Schall","year":"1990","journal-title":"Cell"},{"key":"10.1016\/0092-8674(93)90133-B_BIB33","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1126\/science.2160731","article-title":"A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins","volume":"248","author":"Smith","year":"1990","journal-title":"Science"},{"key":"10.1016\/0092-8674(93)90133-B_BIB34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0006-291X(91)90929-2","article-title":"T2 open reading frame from the Shope fibroma virus encodes a soluble form of the TNF receptor","volume":"176","author":"Smith","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/0092-8674(93)90133-B_BIB35","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1084\/jem.176.6.1543","article-title":"Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion","volume":"176","author":"Spriggs","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/0092-8674(93)90133-B_BIB36","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/j.1460-2075.1989.tb03521.x","article-title":"A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas","volume":"8","author":"Stamenkovic","year":"1989","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(93)90133-B_BIB37","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.4049\/jimmunol.147.5.1477","article-title":"The 1A4 molecule (CD27) is involved in T cell activation","volume":"147","author":"Sugita","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/0092-8674(93)90133-B_BIB38","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1016\/S0021-9258(18)69149-5","article-title":"Affinity purification and chemical analysis of the interleukin-1 receptor","volume":"263","author":"Urdal","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(93)90133-B_BIB39","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.4049\/jimmunol.139.5.1589","article-title":"Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen","volume":"139","author":"van Lier","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/0092-8674(93)90133-B_BIB40","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/eji.1830180523","article-title":"Anti-CD27 monoclonal antibodies identify two functionally distinct subpopulations within the CD4+ T cell subset","volume":"18","author":"van Lier","year":"1988","journal-title":"Eur. J. Immunol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:009286749390133B?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:009286749390133B?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T11:41:54Z","timestamp":1734349314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/009286749390133B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,5]]}},"alternative-id":["009286749390133B"],"URL":"https:\/\/doi.org\/10.1016\/0092-8674(93)90133-b","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1993,5]]}}}