{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:02:43Z","timestamp":1778673763234,"version":"3.51.4"},"reference-count":88,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1993,11,1]],"date-time":"1993-11-01T00:00:00Z","timestamp":752112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1993,11]]},"DOI":"10.1016\/0092-8674(93)90380-9","type":"journal-article","created":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T10:14:26Z","timestamp":1083665666000},"page":"451-462","source":"Crossref","is-referenced-by-count":1188,"title":["Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease"],"prefix":"10.1016","volume":"75","author":[{"given":"J.J.M.","family":"Smit","sequence":"first","affiliation":[]},{"given":"A.H.","family":"Schinkel","sequence":"additional","affiliation":[]},{"given":"R.P.J.Oude","family":"Elferink","sequence":"additional","affiliation":[]},{"given":"A.K.","family":"Groen","sequence":"additional","affiliation":[]},{"given":"E.","family":"Wagenaar","sequence":"additional","affiliation":[]},{"given":"L.","family":"van Deemter","sequence":"additional","affiliation":[]},{"given":"C.A.A.M.","family":"Mol","sequence":"additional","affiliation":[]},{"given":"R.","family":"Ottenhoff","sequence":"additional","affiliation":[]},{"given":"N.M.T.","family":"van der Lugt","sequence":"additional","affiliation":[]},{"given":"M.A.","family":"van Roon","sequence":"additional","affiliation":[]},{"given":"M.A.","family":"van der Valk","sequence":"additional","affiliation":[]},{"given":"G.J.A.","family":"Offerhaus","sequence":"additional","affiliation":[]},{"given":"A.J.M.","family":"Berns","sequence":"additional","affiliation":[]},{"given":"P.","family":"Borst","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/0092-8674(93)90380-9_BIB1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0378-1119(87)90214-9","article-title":"Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter","volume":"60","author":"Adra","year":"1987","journal-title":"Gene"},{"key":"10.1016\/0092-8674(93)90380-9_BIB2","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/clinchem\/20.4.470","article-title":"Enzymatic determination of total serum cholesterol","volume":"20","author":"Allain","year":"1974","journal-title":"J. Clin. Chem."},{"key":"10.1016\/0092-8674(93)90380-9_BIB3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1172\/JCI113355","article-title":"Biliary physiology in rats with bile ductular cell hyperplasia: evidence for a secretory function of proliferated bile ductules","volume":"81","author":"Alpini","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1016\/0092-8674(93)90380-9_BIB4","first-page":"5392","article-title":"Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line","volume":"50","author":"Baas","year":"1990","journal-title":"Cancer Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB5","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1126\/science.1373905","article-title":"Genetic diseases: novel function discovered for the cystic fibrosis gene?","volume":"256","author":"Barinaga","year":"1992","journal-title":"Science"},{"key":"10.1016\/0092-8674(93)90380-9_BIB6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9258(18)53566-3","article-title":"Evidence for the presence of a phosphatidylcholine translocator in isolated rat liver canalicular plasma membrane vesicles","volume":"268","author":"Berr","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(93)90380-9_BIB7","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1126\/science.1373908","article-title":"Regulation of plasma membrane recycling by CFTR","volume":"256","author":"Bradbury","year":"1992","journal-title":"Science"},{"key":"10.1016\/0092-8674(93)90380-9_BIB8","series-title":"Teratocarcinomas and Embryonic Stem Cell: A Practical Approach","first-page":"113","article-title":"Production and analysis of chimeric mice","author":"Bradley","year":"1987"},{"key":"10.1016\/0092-8674(93)90380-9_BIB9","first-page":"5154","article-title":"P-glycoprotein expression during tumor progression in the rat liver","volume":"52","author":"Bradley","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1128\/MCB.11.2.595","article-title":"Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes","volume":"11","author":"Buschman","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB11","doi-asserted-by":"crossref","first-page":"18093","DOI":"10.1016\/S0021-9258(19)37157-1","article-title":"mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies","volume":"267","author":"Buschman","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(93)90380-9_BIB12","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1128\/MCB.9.9.3808","article-title":"Structure and expression of the human MDR (P-glycoprotein) gene family","volume":"9","author":"Chin","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/0092-8674(93)90380-9_BIB14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0022-2275(20)42760-9","article-title":"Structural alterations in lecithin-cholesterol vesicles following interactions with monomeric and micellar bile salts: physical-chemical basis for subselection of biliary lecithin species and aggregative states of biliary lipids during bile formation","volume":"31","author":"Cohen","year":"1990","journal-title":"J. Lipid Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2440249","article-title":"Biochemistry of bile secretion","volume":"244","author":"Coleman","year":"1987","journal-title":"Biochem. J."},{"key":"10.1016\/0092-8674(93)90380-9_BIB16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0005-2760(92)90036-U","article-title":"Lipid flow in bile formation","volume":"1125","author":"Coleman","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/0092-8674(93)90380-9_BIB17","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1177\/38.9.1974900","article-title":"Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues","volume":"38","author":"Cordon-Cardo","year":"1990","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/0092-8674(93)90380-9_BIB18","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1128\/MCB.9.3.1346","article-title":"The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues","volume":"9","author":"Croop","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB19","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1128\/MCB.12.8.3365","article-title":"Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus","volume":"12","author":"Deng","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB20","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1128\/MCB.10.4.1652","article-title":"Two members of the mouse mdr family confer multidrug resistance with overlapping but distinct drug specificities","volume":"10","author":"Devault","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB21","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1021\/bi00219a001","article-title":"Static and dynamic lipid asymmetry in cell membranes","volume":"30","author":"Devaux","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/0092-8674(93)90380-9_BIB22","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.bb.21.060192.002221","article-title":"Protein involvement in transmembrane lipid asymmetry","volume":"21","author":"Devaux","year":"1992","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1016\/0092-8674(93)90380-9_BIB23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.bi.58.070189.001033","article-title":"The biochemistry of P-glycoprotein-mediated multidrug resistance","volume":"58","author":"Endicott","year":"1989","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/0092-8674(93)90380-9_BIB24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/10425179109039677","article-title":"Complete cDNA sequences encoding the Chinese hamster P-glycoprotein gene family","volume":"2","author":"Endicott","year":"1991","journal-title":"J. DNA Seq. Map."},{"key":"10.1016\/0092-8674(93)90380-9_BIB25","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1128\/MCB.6.3.801","article-title":"Activation of the human \u03b2-interferon gene requires an interferon-inducible factor","volume":"6","author":"Enoch","year":"1986","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB26","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/S0021-9258(18)45997-2","article-title":"Canalicular transport of reduced glutathione in normal and mutant eisai hyperbilirubinemic rats","volume":"267","author":"Fern\u00e1ndez-Checa","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(93)90380-9_BIB27","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1021\/bi00333a006","article-title":"Membrane bilayer balance and erythrocyte shape: a quantitative assessment","volume":"24","author":"Ferrell","year":"1985","journal-title":"Biochemistry"},{"key":"10.1016\/0092-8674(93)90380-9_BIB28","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/nar\/13.5.1431","article-title":"Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family","volume":"13","author":"Fort","year":"1985","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0016-5085(92)91138-T","article-title":"New treatment for primary sclerosing cholangitis: promising results with ursodiol","volume":"103","author":"Fromm","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/0092-8674(93)90380-9_BIB30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0092-8674(92)90263-C","article-title":"Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein","volume":"71","author":"Gill","year":"1992","journal-title":"Cell"},{"key":"10.1016\/0092-8674(93)90380-9_BIB31","first-page":"747","article-title":"How cancer cells evade chemotherapy: six-teenth Richard and Hinda Rosenthal Foundation award lecture","volume":"53","author":"Gottesman","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB32","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3109\/07357909109018954","article-title":"Multidrug resistance: a novel class of membrane-associated transport proteins is identified","volume":"9","author":"Gros","year":"1991","journal-title":"Cancer Invest."},{"key":"10.1016\/0092-8674(93)90380-9_BIB33","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/323728a0","article-title":"Isolation and expression of a cDNA (mdr) that confers multidrug resistance","volume":"323","author":"Gros","year":"1986","journal-title":"Nature"},{"key":"10.1016\/0092-8674(93)90380-9_BIB34","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1128\/MCB.8.7.2770","article-title":"Cloning and characterization of a second member of the mouse mdr gene family","volume":"8","author":"Gros","year":"1988","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0022-2275(20)35380-3","article-title":"Enzymatic measurement of choline containing phospholipids in bile","volume":"22","author":"Gurantz","year":"1981","journal-title":"J. Lipid Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1258\/002367784780865324","article-title":"An ethanol-acetic acid-formol saline fixative for routine use with special application to the fixation of non-perfused rat lung","volume":"18","author":"Harrison","year":"1984","journal-title":"Lab. Anim."},{"key":"10.1016\/0092-8674(93)90380-9_BIB37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.cb.08.110192.000435","article-title":"ABC transporters: from microorganisms to man","volume":"8","author":"Higgins","year":"1992","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0968-0004(92)90419-A","article-title":"Is the multidrug transporter a flippase?","volume":"17","author":"Higgins","year":"1992","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/0092-8674(93)90380-9_BIB39","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/326292a0","article-title":"HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells","volume":"326","author":"Hooper","year":"1987","journal-title":"Nature"},{"key":"10.1016\/0092-8674(93)90380-9_BIB40","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/hep.1840070116","article-title":"Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary-conjugated hyperbilirubinemia","volume":"7","author":"Jansen","year":"1987","journal-title":"Hepatology"},{"key":"10.1016\/0092-8674(93)90380-9_BIB41","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0005-2736(76)90160-7","article-title":"A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants","volume":"455","author":"Juliano","year":"1976","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/0092-8674(93)90380-9_BIB42","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0016-5085(93)90440-N","article-title":"New strategies needed for treatment of primary biliary cirrhosis?","volume":"104","author":"Kaplan","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/0092-8674(93)90380-9_BIB43","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/0016-5085(92)91727-L","article-title":"Tauro-\u03b2-muricholate preserves choleresis and prevents taurocholate-induced cholestasis in colchicine-treated rat liver","volume":"102","author":"Katagiri","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/0092-8674(93)90380-9_BIB44","first-page":"3557","article-title":"Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR\u2212) rats with conjugated hyperbilirubinemia","volume":"87","author":"Kitamura","year":"1990"},{"key":"10.1016\/0092-8674(93)90380-9_BIB45","first-page":"531","article-title":"Activation of multidrug resistance (P-glycoprotein) mdr3mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice","volume":"3","author":"Kuo","year":"1992","journal-title":"Cell Growth Differ."},{"key":"10.1016\/0092-8674(93)90380-9_BIB46","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1093\/nar\/19.15.4293","article-title":"Simplified mammalian DNA isolation procedure","volume":"19","author":"Laird","year":"1991","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB47","first-page":"1779","article-title":"The multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 cDNA","volume":"50","author":"Lincke","year":"1990","journal-title":"Cancer Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB48","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1042\/bj2220631","article-title":"Rapid kinetic analysis of the bile-salt-dependent secretion of phospholipid, cholesterol and a plasma-membrane enzyme into bile","volume":"222","author":"Lowe","year":"1984","journal-title":"Biochem. J."},{"key":"10.1016\/0092-8674(93)90380-9_BIB49","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/336348a0","article-title":"Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes","volume":"336","author":"Mansour","year":"1988","journal-title":"Nature"},{"key":"10.1016\/0092-8674(93)90380-9_BIB50","first-page":"134S","article-title":"Secretion of biliary lipids from the hepatocyte","volume":"12","author":"Marzolo","year":"1990","journal-title":"Hepatology"},{"key":"10.1016\/0092-8674(93)90380-9_BIB51","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1093\/nar\/19.20.5755","article-title":"The mouse Pgk-1 gene promoter contains an upstream activator sequence","volume":"19","author":"McBurney","year":"1991","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB52","first-page":"275","article-title":"The nucleotide sequence of a cDNA clone containing the entire coding region for mouse X-chromosome-linked phosphoglycerate kinase","volume":"45","author":"Mori","year":"1987","journal-title":"Gene"},{"key":"10.1016\/0092-8674(93)90380-9_BIB53","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/bjc.1991.152","article-title":"Multidrug resistance (mdr) genes in human cancer","volume":"63","author":"Nooter","year":"1991","journal-title":"Br. J. Cancer"},{"key":"10.1016\/0092-8674(93)90380-9_BIB54","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1172\/JCI114189","article-title":"Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia","volume":"84","author":"Oude Elferink","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/0092-8674(93)90380-9_BIB55","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev.me.42.020191.001425","article-title":"Multidrug resistance","volume":"42","author":"Pastan","year":"1991","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/0092-8674(93)90380-9_BIB56","first-page":"593","article-title":"Biology of disease: mechanisms of cholestasis","volume":"54","author":"Phillips","year":"1986","journal-title":"Lab. Invest."},{"key":"10.1016\/0092-8674(93)90380-9_BIB57","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1101\/gad.4.12b.2308","article-title":"Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations","volume":"4","author":"Rathjen","year":"1990","journal-title":"Genes Dev."},{"key":"10.1016\/0092-8674(93)90380-9_BIB58","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1128\/MCB.10.4.1642","article-title":"Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells","volume":"10","author":"Raymond","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB59","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0165-1110(92)90005-T","article-title":"From amplification to function: the case of the MDR1 gene","volume":"276","author":"Roninson","year":"1992","journal-title":"Mutat. Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB60","first-page":"4538","article-title":"Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells","volume":"83","author":"Roninson","year":"1986"},{"key":"10.1016\/0092-8674(93)90380-9_BIB61","author":"Sambrook","year":"1989"},{"key":"10.1016\/0092-8674(93)90380-9_BIB62","first-page":"213","article-title":"Multidrug resistance mediated by P-glycoproteins","volume":"2","author":"Schinkel","year":"1991","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB63","first-page":"2628","article-title":"Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies","volume":"51","author":"Schinkel","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB64","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1182\/blood.V79.3.782.782","article-title":"Mechanisms of amphipath-induced stomatocytosis in human erythrocytes","volume":"79","author":"Schrier","year":"1992","journal-title":"Blood"},{"key":"10.1016\/0092-8674(93)90380-9_BIB65","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1182\/blood.V79.6.1496.1496","article-title":"High expression of the mdr3 multidrug-resistance gene in advanced-stage chronic lymphocytic leukemia","volume":"79","author":"Sonneveld","year":"1992","journal-title":"Blood"},{"key":"10.1016\/0092-8674(93)90380-9_BIB66","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1042\/bj2250787","article-title":"Reverse-phase HPLC separation, quantitation and preparation of bilirubin and its conjugates from native bile","volume":"225","author":"Spivak","year":"1985","journal-title":"Biochem. J."},{"key":"10.1016\/0092-8674(93)90380-9_BIB67","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0041-008X(88)90037-3","article-title":"Species variations in biliary excretion of glutathione related thiols and methylmercury","volume":"93","author":"Stein","year":"1988","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB68","first-page":"71","article-title":"Drug induced hepatic injury","volume":"Volume 5","author":"Stricker","year":"1992"},{"key":"10.1016\/0092-8674(93)90380-9_BIB69","first-page":"G665","article-title":"Taurocholate transport and Na+-K+-ATPase activity in fetal and neonatal rat liver plasma membrane vesicles","volume":"251","author":"Suchy","year":"1986","journal-title":"Am. J. Physiol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB70","first-page":"715","article-title":"Gamma-glutamyltranspeptidase","volume":"Volume 2","author":"Szasz","year":"1982"},{"key":"10.1016\/0092-8674(93)90380-9_BIB71","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1128\/MCB.10.11.5728","article-title":"Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse-hepatocellular carcinomas","volume":"10","author":"Teeter","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB72","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/mc.2940040506","article-title":"Coordinate activation of multidrug-resistance (P-glycoprotein) genes mdr2 and mdr3 during mouse liver regeneration","volume":"4","author":"Teeter","year":"1991","journal-title":"Mol. Carcin."},{"key":"10.1016\/0092-8674(93)90380-9_BIB73","doi-asserted-by":"crossref","DOI":"10.1016\/0166-6851(93)90014-O","article-title":"Stable transformation of Trypanosoma brucei","author":"ten Asbroek","year":"1993","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB74","first-page":"5128","article-title":"Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs","volume":"89","author":"te Riele","year":"1992"},{"key":"10.1016\/0092-8674(93)90380-9_BIB75","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0163-7258(91)90059-U","article-title":"Multidrug resistance gene family and chemical carcinogens","volume":"49","author":"Thorgeirsson","year":"1991","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/0092-8674(93)90380-9_BIB76","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","article-title":"Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues","volume":"27","author":"Tietze","year":"1969","journal-title":"Anal. Biochem."},{"key":"10.1016\/0092-8674(93)90380-9_BIB77","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-2275(20)40709-6","article-title":"Reevaluation of the 3-hydroxysteroid dehydrogenase assay for total bile acids in bile","volume":"19","author":"Turley","year":"1978","journal-title":"J. Lipid Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB78","first-page":"3004","article-title":"Expression of a full-length cDNA for the human MDR1 gene confers resistance to colchicine, doxorubicin, and vinblastine","volume":"84","author":"Ueda","year":"1987"},{"key":"10.1016\/0092-8674(93)90380-9_BIB79","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/355830a0","article-title":"Volume regulated chloride channels associated with the human multidrug-resistance P-glycoprotein","volume":"355","author":"Valverde","year":"1992","journal-title":"Nature"},{"key":"10.1016\/0092-8674(93)90380-9_BIB80","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1128\/MCB.6.5.1671","article-title":"Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line","volume":"6","author":"van der Bliek","year":"1986","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB81","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1002\/j.1460-2075.1987.tb02653.x","article-title":"The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver","volume":"6","author":"van der Bliek","year":"1987","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(93)90380-9_BIB82","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0378-1119(88)90057-1","article-title":"Sequence of mdr3 cDNA, encoding a human P-glycoprotein","volume":"71","author":"van der Bliek","year":"1988","journal-title":"Gene"},{"key":"10.1016\/0092-8674(93)90380-9_BIB83","first-page":"5927","article-title":"Genes amplified and overexpressed in human multidrug resistant cell lines","volume":"48","author":"van der Bliek","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/0092-8674(93)90380-9_BIB84","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0378-1119(91)90161-4","article-title":"A pgk::hprt fusion as a selectable marker for targeting of genes in mouse embryonic stem cells: disruption of the T-cell receptor \u03b4-chain-encoding gene","volume":"105","author":"van der Lugt","year":"1991","journal-title":"Gene"},{"key":"10.1016\/0092-8674(93)90380-9_BIB85","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/oxfordjournals.annonc.a057676","article-title":"Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues","volume":"1","author":"van der Valk","year":"1990","journal-title":"Ann. Oncol."},{"key":"10.1016\/0092-8674(93)90380-9_BIB86","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1172\/JCI106930","article-title":"Biliary excretion of lecithin and cholesterol in the dog","volume":"51","author":"Wheeler","year":"1972","journal-title":"J. Clin. Invest."},{"key":"10.1016\/0092-8674(93)90380-9_BIB87","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev.bi.60.070191.000445","article-title":"Phospholipid transfer proteins","volume":"60","author":"Wirtz","year":"1991","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/0092-8674(93)90380-9_BIB88","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/0092-8674(83)90544-5","article-title":"Identification of two distinct regulatory regions adjacent to the human \u03b2-interferon gene","volume":"34","author":"Zinn","year":"1983","journal-title":"Cell"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0092867493903809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0092867493903809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T08:14:24Z","timestamp":1623917664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0092867493903809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":88,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["0092867493903809"],"URL":"https:\/\/doi.org\/10.1016\/0092-8674(93)90380-9","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1993,11]]}}}