{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:32:36Z","timestamp":1759602756768,"version":"3.44.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[1992,9]]},"DOI":"10.1016\/0145-2126(92)90040-e","type":"journal-article","created":{"date-parts":[[2004,4,19]],"date-time":"2004-04-19T09:46:32Z","timestamp":1082367992000},"page":"941-946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Molecular analysis of a HTLV-I pX defective human adult T-cell leukemia"],"prefix":"10.1016","volume":"16","author":[{"given":"Hiroharu","family":"Sakurai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhisa","family":"Ishiguro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikara","family":"Mikuni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akemi","family":"Wakisaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yoshiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0145-2126(92)90040-E_BIB1","first-page":"6476","article-title":"Adult T cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera","volume":"78","author":"Hinuma","year":"1981"},{"key":"10.1016\/0145-2126(92)90040-E_BIB2","first-page":"2534","article-title":"Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in disease","volume":"81","author":"Yoshida","year":"1984"},{"key":"10.1016\/0145-2126(92)90040-E_BIB3","first-page":"3618","article-title":"Human adult T-cell leukemia virus: Complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA","volume":"80","author":"Seiki","year":"1983"},{"key":"10.1016\/0145-2126(92)90040-E_BIB4","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/309640a0","article-title":"Nonspecific integration of the HTLV provirus genome into adult T-cell leukemia cells","volume":"309","author":"Seiki","year":"1984","journal-title":"Nature (London)"},{"key":"10.1016\/0145-2126(92)90040-E_BIB5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/j.1460-2075.1986.tb04247.x","article-title":"Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator","volume":"5","author":"Seiki","year":"1986","journal-title":"EMBO J."},{"key":"10.1016\/0145-2126(92)90040-E_BIB6","first-page":"3653","article-title":"Transcriptional (p40x) and post-transcriptional (p27x\u2212III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes","volume":"84","author":"Inoue","year":"1987"},{"key":"10.1016\/0145-2126(92)90040-E_BIB7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0092-8674(87)90754-9","article-title":"Regulation of the human interleukin-2 receptor \u03b1 chain promoter: Activation of a nonfunctional promoter by the trans-activator gene of HTLV-I","volume":"49","author":"Cross","year":"1987","journal-title":"Cell"},{"key":"10.1016\/0145-2126(92)90040-E_BIB8","first-page":"8526","article-title":"c-fos promoter transactivator by the tax 1 protein of human T-cell leukemia virus type I","volume":"85","author":"Fujii","year":"1988"},{"key":"10.1016\/0145-2126(92)90040-E_BIB9","first-page":"5389","article-title":"Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I","volume":"84","author":"Siekevitz","year":"1987"},{"key":"10.1016\/0145-2126(92)90040-E_BIB10","first-page":"273","article-title":"Defective human T-cell leukemia virus in adult T-cell leukemia patients","volume":"2","author":"Konishi","year":"1984","journal-title":"Mol. Biol. Med."},{"year":"1982","author":"Maniatis","key":"10.1016\/0145-2126(92)90040-E_BIB11"},{"key":"10.1016\/0145-2126(92)90040-E_BIB12","first-page":"8359","article-title":"p27x\u2212III and p21x\u2212III, proteins encoded by the pX sequence of human T-cell leukemia virus type I","volume":"82","author":"Kiyokawa","year":"1985"},{"key":"10.1016\/0145-2126(92)90040-E_BIB13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0092-8674(88)90043-8","article-title":"Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing","volume":"55","author":"Shiomi","year":"1988","journal-title":"Cell"},{"key":"10.1016\/0145-2126(92)90040-E_BIB14","first-page":"5620","article-title":"Detection of mRNA for the tax1\/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction","volume":"86","author":"Kinoshita","year":"1989"},{"key":"10.1016\/0145-2126(92)90040-E_BIB15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1128\/jvi.60.2.394-399.1986","article-title":"A single species of mRNA of human T-cell leukemia virus type I encodes trans-activator p40x and two other phosphoproteins","volume":"60","author":"Nagashima","year":"1986","journal-title":"J. Virology"},{"key":"10.1016\/0145-2126(92)90040-E_BIB16","first-page":"1071","article-title":"Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro","volume":"87","author":"Tanaka","year":"1984"},{"key":"10.1016\/0145-2126(92)90040-E_BIB17","first-page":"4524","article-title":"Adult T-cell leukemia\/lymphoma not associated with human T-cell leukemia virus type I","volume":"83","author":"Shimoyama","year":"1986"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:014521269290040E?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:014521269290040E?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T19:37:28Z","timestamp":1757446648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/014521269290040E"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["014521269290040E"],"URL":"https:\/\/doi.org\/10.1016\/0145-2126(92)90040-e","relation":{},"ISSN":["0145-2126"],"issn-type":[{"type":"print","value":"0145-2126"}],"subject":[],"published":{"date-parts":[[1992,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular analysis of a HTLV-I pX defective human adult T-cell leukemia","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/0145-2126(92)90040-E","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1992 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}