{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:16:31Z","timestamp":1791281791303,"version":"4.1.0"},"reference-count":126,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1991,5,1]],"date-time":"1991-05-01T00:00:00Z","timestamp":673056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Problems in Cardiology"],"published-print":{"date-parts":[[1991,5]]},"DOI":"10.1016\/0146-2806(91)90022-3","type":"journal-article","created":{"date-parts":[[2004,4,17]],"date-time":"2004-04-17T21:45:43Z","timestamp":1082238343000},"page":"313-375","source":"Crossref","is-referenced-by-count":37,"title":["Mitral valve prolapse and the mitral valve prolapse syndrome"],"prefix":"10.1016","volume":"16","author":[{"given":"Mary E.","family":"Fontana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Wooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Sparks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harisios","family":"Boudoulas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/0146-2806(91)90022-3_BIB1","series-title":"Mitral valve prolapse and the mitral valve prolapse syndrome","year":"1988"},{"key":"10.1016\/0146-2806(91)90022-3_BIB2","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/0002-8703(89)90594-2","article-title":"Mitral valve prolapse and the mitral valve prolapse syndrome: A diagnostic classification and pathogenesis of symptoms","volume":"118","author":"Boudoulas","year":"1989","journal-title":"Am Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB3","series-title":"Leonardo DaVinci Anatomical Drawings from the Royal Library","first-page":"810","article-title":"Leonardo DaVinci The Anatomist","author":"Keele","year":"1983"},{"issue":"3","key":"10.1016\/0146-2806(91)90022-3_BIB4","first-page":"191","article-title":"The application of the physics of sound to 19th century cardiology: with particular reference to the part played by CJB Williams and James Hope","volume":"8","author":"Keele","year":"1973","journal-title":"Clin Medica"},{"key":"10.1016\/0146-2806(91)90022-3_BIB5","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0002-9149(88)90366-9","article-title":"From irritable heart to mitral valve prolapse: World War I\u2014the U.S. experience and the prevalence of apical systolic murmurs and mitral regurgitation in drafted men compared with present day mitral valve prolapse studies","volume":"61","author":"Wooley","year":"1988","journal-title":"Am J Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0002-8703(44)90411-4","article-title":"Rupture of mitral chordae tendineae","volume":"28","author":"Bailey","year":"1944","journal-title":"Amer Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/hrt.15.1.55","article-title":"Mitral incompetence","volume":"15","author":"Brigden","year":"1953","journal-title":"Brit Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB8","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1161\/01.CIR.32.6.897","article-title":"Symptomatic valvular myxomatous transformation (the floppy valve syndrome)","volume":"32","author":"Read","year":"1965","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0002-8703(87)90295-X","article-title":"From irritable heart to mitral valve prolapse: systolic clicks, apical murmurs, and the auscultatory connection in the 19th century","volume":"113","author":"Wooley","year":"1987","journal-title":"Am Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB10","series-title":"Perspectives on the Mitral Valve","first-page":"45","article-title":"Mitral leaflet billowing and prolapse","author":"Barlow","year":"1987"},{"key":"10.1016\/0146-2806(91)90022-3_BIB11","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/hrt.28.4.488","article-title":"Prolapse of the mitral valve: clinical and cine-angiocardiographic findings","volume":"28","author":"Criley","year":"1966","journal-title":"Br Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB12","first-page":"694","article-title":"La d\u00e9g\u00e9rescence mucoide des valvules mitrales. Ses r\u00e9percussions fonctionnelles","volume":"25","author":"Fernex","year":"1958","journal-title":"Helvetica Medica Acta"},{"key":"10.1016\/0146-2806(91)90022-3_BIB13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/hrt.31.3.343","article-title":"Ballooning deformity (mucoid degeneration) of atrioventricular valves","volume":"31","author":"Pomerance","year":"1969","journal-title":"Br Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB14","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/hrt.40.5.468","article-title":"The floppy mitral valve: study of incidence, pathology, and complications in surgical, necropsy and forensic material","volume":"40","author":"Davies","year":"1978","journal-title":"Br Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB15","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1161\/01.CIR.66.2.288","article-title":"\u201cMyxomatous\u201d mitral valves: collagen dissolution as the primary defect","volume":"66","author":"King","year":"1982","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1001\/jama.1989.03430040095032","article-title":"Association of mitral valve prolapse and systemic abnormalities of connective tissue","volume":"262","author":"Glesby","year":"1989","journal-title":"JAMA"},{"key":"10.1016\/0146-2806(91)90022-3_BIB17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0002-9343(87)90448-7","article-title":"Cardiovascular disease of connective tissue origin","volume":"82","author":"Bowen","year":"1987","journal-title":"Am J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB18","series-title":"Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome","first-page":"161","article-title":"Mitral value prolapse: prevalence","author":"Boudoulas","year":"1988"},{"key":"10.1016\/0146-2806(91)90022-3_BIB19","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/hrt.38.7.718","article-title":"Non-ejection systolic clicks and mitral systolic murmurs in black school children of Soweto, Johannesburg","volume":"38","author":"McLaren","year":"1976","journal-title":"Br Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB20","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1056\/NEJM197605132942004","article-title":"Prevalence of clinical mitral valve prolapse in 1169 young women","volume":"294","author":"Procacci","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB21","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1161\/01.CIR.53.3.464","article-title":"Mitral valve prolapse in 100 presumably healthy young females","volume":"53","author":"Markiewicz","year":"1976","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB22","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0002-8703(78)90498-2","article-title":"Four year follow-up of black school children with nonejection systolic clicks and mitral systolic murmurs","volume":"95","author":"Cohen","year":"1978","journal-title":"Am Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5694\/j.1326-5377.1981.tb135284.x","article-title":"Mitral valve prolapse: prevalence in an Australian population","volume":"1","author":"Hickey","year":"1981","journal-title":"Med J Austr"},{"key":"10.1016\/0146-2806(91)90022-3_BIB24","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1136\/hrt.49.4.334","article-title":"Prevalence of mitral valve prolapse by two-dimensional echocardiography in healthy young women","volume":"49","author":"Wanns","year":"1983","journal-title":"Br Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB25","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0002-8703(83)90704-4","article-title":"Mitral valve prolapse in the general population. I: Epidemiologic features: the Framingham study","volume":"106","author":"Savage","year":"1983","journal-title":"Am Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.0954-6820.1984.tb04986.x","article-title":"The prevalence of mitral valve prolapse in healthy men and women in Sweden: an echocardiographic study","volume":"215","author":"Bryhn","year":"1984","journal-title":"Acta Med Scand"},{"key":"10.1016\/0146-2806(91)90022-3_BIB27","series-title":"Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome","first-page":"567","article-title":"Mitral valve prolapse: cardiac arrhythmias and electrophysiologic correlates","author":"Schaal","year":"1988"},{"key":"10.1016\/0146-2806(91)90022-3_BIB28","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/archneur.1976.00500110045008","article-title":"Cerebral ischemic events associated with prolapsing mitral valve","volume":"33","author":"Barnett","year":"1976","journal-title":"Arch Neurol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1161\/01.STR.16.2.175","article-title":"The enigma of the risk of stroke in mitral valve prolapse","volume":"16","author":"Boughner","year":"1985","journal-title":"Stroke"},{"key":"10.1016\/0146-2806(91)90022-3_BIB30","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/01.STR.16.2.219","article-title":"Cerebral ischemic attacks as a complication of aortic and mitral valve prolapse","volume":"16","author":"Barletta","year":"1985","journal-title":"Stroke"},{"key":"10.1016\/0146-2806(91)90022-3_BIB31","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1161\/01.STR.13.4.451","article-title":"MVP and cerebral ischemic events","volume":"13","author":"Jones","year":"1982","journal-title":"Stroke"},{"key":"10.1016\/0146-2806(91)90022-3_BIB32","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1161\/01.CIR.67.3.632","article-title":"The myxomatous mitral valve and sudden death","volume":"67","author":"Chesler","year":"1983","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB33","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0002-9343(79)90452-2","article-title":"Calcification of the mitral annulus\u2014etiology, clinical associations, complications and therapy","volume":"66","author":"Fulkerson","year":"1979","journal-title":"Am J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/01.CIR.60.1.43","article-title":"Platelet survival time and thromboembolism in patients with mitral valve prolapse","volume":"60","author":"Steele","year":"1979","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB35","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/clc.4960091004","article-title":"Platelet function and coagulation studies in patients with mitral valve prolapse","volume":"9","author":"Zuppiroli","year":"1986","journal-title":"Clin Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB36","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/01.CIR.63.3.552","article-title":"Platelets, thromboembolism and mitral valve prolapse","volume":"63","author":"Walsh","year":"1981","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB37","series-title":"Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome","first-page":"525","article-title":"Mitral valve prolapse syndrome: clinical presentation and diagnostic evaluation","author":"Boudoulas","year":"1988"},{"key":"10.1016\/0146-2806(91)90022-3_BIB38","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/0002-9149(83)90021-8","article-title":"Mitral valve prolapse syndrome: analysis of 62 patients aged 60 years and older","volume":"52","author":"Kolibash","year":"1983","journal-title":"Am J Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB39","series-title":"Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome","first-page":"109","article-title":"Inheritance and phenotypic features of mitral valve prolapse","author":"Devereux","year":"1988"},{"key":"10.1016\/0146-2806(91)90022-3_BIB40","doi-asserted-by":"crossref","first-page":"826","DOI":"10.7326\/0003-4819-97-6-826","article-title":"Inheritance of mitral valve prolapse: effect of age and sex on gene expression","volume":"97","author":"Devereux","year":"1982","journal-title":"Ann Int Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB41","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/hrt.55.6.582","article-title":"Age and the clinical profile of idiopathic mitral valve prolapse","volume":"55","author":"Hickey","year":"1986","journal-title":"Br Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB42","first-page":"41","article-title":"Mitral valve prolapse in childhood","author":"Greenwood","year":"1986","journal-title":"Hosp Pract"},{"key":"10.1016\/0146-2806(91)90022-3_BIB43","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1161\/01.CIR.62.2.423","article-title":"Clinical spectrum and longterm follow-up of isolated mitral valve prolapse in 119 children","volume":"62","author":"Bisset","year":"1980","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB44","series-title":"Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome","first-page":"129","article-title":"Heritable disorders of connective tissue","author":"Pyeritz","year":"1988"},{"key":"10.1016\/0146-2806(91)90022-3_BIB45","series-title":"Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome","first-page":"217","article-title":"Mitral valve prolapse: physical examination and hemodynamics","author":"Fontana","year":"1988"},{"key":"10.1016\/0146-2806(91)90022-3_BIB46","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0140-6736(82)92680-0","article-title":"Association of mitral valve prolapse with low body weight and low blood pressure","volume":"2","author":"Devereux","year":"1982","journal-title":"Lancet"},{"key":"10.1016\/0146-2806(91)90022-3_BIB47","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0002-8703(79)90429-0","article-title":"Incidence of mitral valve prolapse in subjects with thoracic skeletal abnormalities\u2014a prospective study","volume":"97","author":"Udoshi","year":"1979","journal-title":"Am Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB48","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0002-9149(80)90879-6","article-title":"Mitral valve prolapse syndrome: anthropometric, sexual and clinical features (abstract)","volume":"45","author":"King","year":"1980","journal-title":"Am J Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0002-9149(75)90864-4","article-title":"Thoracic skeletal abnormalities in idiopathic mitral valve prolapse","volume":"36","author":"Salomon","year":"1975","journal-title":"Am J Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB50","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0002-9343(81)90196-0","article-title":"Distinctive anthropometric characteristics of women with mitral valve prolapse","volume":"71","author":"Schutte","year":"1981","journal-title":"Am J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0002-9149(75)90863-2","article-title":"Radiographic appearance of the thorax in systolic click-late systolic murmur syndrome","volume":"36","author":"BonTempo","year":"1975","journal-title":"Am J Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB52","first-page":"73","article-title":"Heritable Disorders of Connective Tissue","author":"McKusick","year":"1972"},{"key":"10.1016\/0146-2806(91)90022-3_BIB53","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1056\/NEJM197904053001406","article-title":"The Marfan syndrome\u2014diagnosis and management","volume":"300","author":"Pyeritz","year":"1979","journal-title":"N Engl J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB54","doi-asserted-by":"crossref","first-page":"171","DOI":"10.7326\/0003-4819-92-2-171","article-title":"The spectrum of cardiac defects in the Ehlers-Danlos syndrome, types I & III","volume":"92","author":"Leier","year":"1980","journal-title":"Ann Int Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB55","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/01.CIR.64.1.121","article-title":"Mitral valve prolapse: a consistent manifestation of type N Ehlers-Danlos syndrome","volume":"64","author":"Jaffe","year":"1981","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB56","first-page":"433","article-title":"Hereditary progressive arthro-ophthalmopathy","volume":"40","author":"Stickler","year":"1965"},{"key":"10.1016\/0146-2806(91)90022-3_BIB57","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1056\/NEJM198207223070406","article-title":"Pseudoxanthoma elasticum and mitral valve prolapse","volume":"307","author":"Lebwohl","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB58","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in osteogenesis imperfecta","volume":"16","author":"Sillence","year":"1979","journal-title":"J Med Genet"},{"key":"10.1016\/0146-2806(91)90022-3_BIB59","first-page":"1087","article-title":"Mitral valve prolapse in osteogenesis imperfecta","volume":"17","author":"Schwarz","year":"1981","journal-title":"Isr J Med Sci"},{"key":"10.1016\/0146-2806(91)90022-3_BIB60","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ajmg.1320230113","article-title":"Aortic root dilatation and mitral valve prolapse in the fragile X syndrome","volume":"23","author":"Loehr","year":"1986","journal-title":"Am J Med Genet"},{"key":"10.1016\/0146-2806(91)90022-3_BIB61","doi-asserted-by":"crossref","first-page":"683","DOI":"10.7326\/0003-4819-100-5-683","article-title":"Cardiovascular abnormalities associated with adult polycystic kidney disease","volume":"100","author":"Leier","year":"1984","journal-title":"Ann Intern Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB62","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/0002-9343(81)90353-3","article-title":"Orthostatic hypotension: a commonly unrecognized cause of symptoms in mitral valve prolapse","volume":"71","author":"Santos","year":"1981","journal-title":"Am J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB63","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1161\/01.CIR.41.5.807","article-title":"The varying clinical spectrum of the systolic click-late systolic murmur syndrome","volume":"41","author":"Fontana","year":"1970","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB64","series-title":"Physiologic Principles of Heart Sounds and Murmurs","first-page":"126","article-title":"Functional anatomy of mitral valve prolapse","author":"Fontana","year":"1975"},{"key":"10.1016\/0146-2806(91)90022-3_BIB65","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/01.CIR.51.1.165","article-title":"Postural changes in left ventricular and mitral valvular dynamics in the systolic click-late systolic murmur syndrome","volume":"51","author":"Fontana","year":"1975","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB66","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/01.CIR.53.5.872","article-title":"The determinants of mitral valve prolapse in the systolic click-late systolic murmur syndrome","volume":"53","author":"Mathey","year":"1976","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB67","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1161\/01.CIR.51.3.522","article-title":"Simultaneous echocardiographic-phonocardiographic recordings at rest and during amyl nitrite administration in patients with mitral valve prolapse","volume":"51","author":"Winkle","year":"1976","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB68","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/01.CIR.59.5.894","article-title":"Autonomic dysfunction in women with mitral valve prolapse syndrome","volume":"59","author":"Gaffney","year":"1979","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB69","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1378\/chest.80.2.197","article-title":"The effect of congesting cuffs on the echophonocardiographic findings in mitral valve prolapse","volume":"80","author":"Abinader","year":"1981","journal-title":"Chest"},{"key":"10.1016\/0146-2806(91)90022-3_BIB70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.CIR.39.1.1","article-title":"The syndrome of apical systolic click, late systolic murmur, and abnormal T waves","volume":"39","author":"Engle","year":"1969","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB71","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0033-0620(73)80026-X","article-title":"Mitral valve prolapse\u2014click syndrome","volume":"15","author":"Jeresaty","year":"1973","journal-title":"Progr Cardiovasc Dis"},{"key":"10.1016\/0146-2806(91)90022-3_BIB72","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0002-8703(76)80212-8","article-title":"Adrenergic beta blockade and ECG changes in the systolic click murmur syndrome","volume":"91","author":"Abinader","year":"1976","journal-title":"Am Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB73","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0002-8703(77)80403-1","article-title":"Propranolol for patients with mitral valve prolapse","volume":"93","author":"Winkle","year":"1977","journal-title":"Am Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB74","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM198904203201602","article-title":"Identification of high-risk and lowrisk subgroups of patients with mitral valve prolapse","volume":"320","author":"Marks","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB75","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0735-1097(83)80354-4","article-title":"Mitral valve prolapse\u2014comparative value of M-mode, two-dimensional and Doppler echocardiography","volume":"2","author":"Abbasi","year":"1983","journal-title":"J Am Coil Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB76","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0735-1097(86)80308-4","article-title":"Pulsed Doppler echocardiographic evaluation of valvular regurgitation in patients with mitral valve prolapse: comparison with normal subjects","volume":"8","author":"Coe","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB77","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0735-1097(86)80214-5","article-title":"Prevalence and severity of mitral regurgitation in the mitral valve prolapse syndrome; a Doppler echocardiographic study of 80 patients","volume":"7","author":"Panidis","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB78","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/0002-9149(78)90093-0","article-title":"Stress myocardial imaging in mitral leaflet prolapse syndrome","volume":"42","author":"Klein","year":"1978","journal-title":"Am J Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB79","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/01.CIR.78.5.1087","article-title":"Current concepts of mitral valve reconstruction for mitral insufficiency","volume":"78","author":"Galloway","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB80","first-page":"7","article-title":"Mitral valve repair for mitral incompetence","volume":"56","author":"Kirklin","year":"1987","journal-title":"Mod Concepts Cardiovasc Dis"},{"key":"10.1016\/0146-2806(91)90022-3_BIB81","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/0002-8703(87)90934-3","article-title":"Reparative operations for mitral valve incompetence: an emerging treatment of choice","volume":"113","author":"Bashour","year":"1987","journal-title":"Am Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB82","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0735-1097(86)80415-6","article-title":"Relation between clinical features of the mitral prolapse syndrome and echocardiographically documented mitral valve prolapse","volume":"8","author":"Devereux","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB83","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/0002-8703(83)90706-8","article-title":"Mitral valve prolapse in the general population. 3. Dysrhythmias: the Framingham study","volume":"106","author":"Savage","year":"1983","journal-title":"Am Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB84","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1161\/01.CIR.61.6.1200","article-title":"Metabolic studies in mitral valve prolapse syndrome","volume":"61","author":"Boudoulas","year":"1980","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB85","series-title":"The Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome","first-page":"455","article-title":"Stability of hyperadrenergic state, atrial natriuretic factor, and platelet abnormalities in mitral valve prolapse syndrome","author":"Pasternac","year":"1988"},{"key":"10.1016\/0146-2806(91)90022-3_BIB86","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0735-1097(83)80303-9","article-title":"Mitral valve prolapse syndrome: the effect of adrenergic stimulation","volume":"2","author":"Boudoulas","year":"1983","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB87","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/01.CIR.60.1.164","article-title":"Changes in diastolic time with various pharmacologic agents: implications for myocardial perfusion","volume":"60","author":"Boudoulas","year":"1979","journal-title":"Circulation"},{"key":"10.1016\/0146-2806(91)90022-3_BIB88","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0002-9343(87)90055-6","article-title":"Mitral valve prolapse with symptoms of beta adrenergic hypersensitivity. Beta2 adrenergic receptor supercoupling with desensitization of isoproterenol exposure","volume":"82","author":"Davies","year":"1987","journal-title":"Am J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB89","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0002-9149(83)90130-3","article-title":"Abnormal cardiovascular regulation in the mitral valve prolapse syndrome","volume":"52","author":"Gaffney","year":"1983","journal-title":"Am J Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB90","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0735-1097(88)91523-9","article-title":"Postural exercise abnormalities in symptomatic patients with mitral valve prolapse","volume":"11","author":"Bashore","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB91","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0002-9343(79)90397-8","article-title":"Dysautonomia in mitral valve prolapse","volume":"67","author":"Coghlan","year":"1979","journal-title":"Am J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB92","series-title":"Mital Valve Prolapse and the Mitral Valve Prolapse Syndrome","first-page":"427","article-title":"Mitral valve prolapse and autonomic nervous system dysfunction: A pathophysiological link","author":"Gaffney","year":"1988"},{"key":"10.1016\/0146-2806(91)90022-3_BIB93","series-title":"The Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome","first-page":"389","article-title":"Autonomic dysfunction in the mitral valve prolapse syndrome: the brain-heart connection and interaction","author":"Coghlan","year":"1988"},{"key":"10.1016\/0146-2806(91)90022-3_BIB94","first-page":"986","article-title":"Acceleration tolerance of asymptomatic aircrew with mitral valve prolapse","author":"Whinnery","year":"1986","journal-title":"Aviat Space Environ Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB95","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0167-5273(90)90244-Y","article-title":"Mitral valve prolapse: cardiac arrest with long-term survival","volume":"26","author":"Boudoulas","year":"1990","journal-title":"Int J Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB96","first-page":"985","article-title":"Atrhythmias in mitral valve prolapse. Electrophysiologic definition","volume":"10","author":"Schaal","year":"1987","journal-title":"PACE"},{"key":"10.1016\/0146-2806(91)90022-3_BIB97","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/0002-8703(79)90468-X","article-title":"The nature and prevalence of the abnormal exercise electrocardiogram in mitral valve prolapse","volume":"98","author":"Engel","year":"1979","journal-title":"Am Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB98","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1136\/hrt.48.2.130","article-title":"Exercise testing in mitral valve prolapse before and after beta blockade","volume":"48","author":"Abinader","year":"1982","journal-title":"Br Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB99","first-page":"95","article-title":"The effect of beta blockade on the abnormal exercise test in patients with mitral valve prolapse","volume":"4","author":"Abinader","year":"1984","journal-title":"J Cardiac Rehab"},{"key":"10.1016\/0146-2806(91)90022-3_BIB100","first-page":"1","article-title":"The clinical diagnosis of syncope","volume":"7","author":"Boudoulas","year":"1982"},{"key":"10.1016\/0146-2806(91)90022-3_BIB101","series-title":"The Heart","first-page":"521","article-title":"Cardiac syncope\u2014diagnosis, mechanism, and management","author":"Boudoulas","year":"1986"},{"key":"10.1016\/0146-2806(91)90022-3_BIB102","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000284082","article-title":"Mitral valve prolapse: a marker for anxiety or overlapping phenomenon?","volume":"17","author":"Boudoulas","year":"1984","journal-title":"Psychopathology"},{"key":"10.1016\/0146-2806(91)90022-3_BIB103","first-page":"323","article-title":"Panic anxiety: a new biological model","volume":"45","author":"Carr","year":"1984","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/0146-2806(91)90022-3_BIB104","unstructured":"Boudoulas H, Kolibash AJ, Wooley CF: Mitral valve prolapse and the mitral valve prolapse syndrome. Primary Cardiol, In press."},{"key":"10.1016\/0146-2806(91)90022-3_BIB105","unstructured":"Boudoulas H, Kolibash AJ, Wooley CF: Mitral valve prolapse: the high risk patient. Practical Cardiol, In press."},{"key":"10.1016\/0146-2806(91)90022-3_BIB106","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/0002-9149(86)90352-8","article-title":"Evidence for progression from mild to severe mitral regurgitation in mitral valve prolapse","volume":"58","author":"Kolibash","year":"1986","journal-title":"Am J Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB107","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0735-1097(88)90164-7","article-title":"Long-term follow-up of idiopathic mitral valve prolapse in 300 patients: a prospective study","volume":"11","author":"Duren","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/0146-2806(91)90022-3_BIB108","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1056\/NEJM198511213132101","article-title":"Echocardiographically documented mitral valve prolapse: long-term follow-up of 237 patients","volume":"313","author":"Nishimura","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB109","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0002-9149(90)90300-P","article-title":"Follow-up in mitral valve prolapse by phonocardiography, M-mode and two-dimensional echocardiography and Doppler echocardiography","volume":"65","author":"You-Bing","year":"1990","journal-title":"Am J Cardiol"},{"issue":"17","key":"10.1016\/0146-2806(91)90022-3_BIB110","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1001\/jama.1983.03340170044026","article-title":"Apparent failures of endocarditis prophylaxis","volume":"250","author":"Durack","year":"1983","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/0146-2806(91)90022-3_BIB111","first-page":"963A","article-title":"Infective endocarditis in the 1980s: nature of the underlying cardiac lesions","volume":"34","author":"McKinsey","year":"1986","journal-title":"Clin Res"},{"issue":"4","key":"10.1016\/0146-2806(91)90022-3_BIB112","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/0002-8703(67)90209-8","article-title":"The isolated click with bacterial endocarditis","volume":"73","author":"LeBauer","year":"1967","journal-title":"Am Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB113","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1136\/hrt.37.3.326","article-title":"Infective endocarditis in the billowing mitral leaflet syndrome","volume":"37","author":"Lachman","year":"1975","journal-title":"Br Heart J"},{"key":"10.1016\/0146-2806(91)90022-3_BIB114","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1378\/chest.66.1.88","article-title":"Subacute bacterial endocarditis in a patient with isolated, nonejection systolic click but without a murmur","volume":"66","author":"Kincaid","year":"1974","journal-title":"Chest"},{"key":"10.1016\/0146-2806(91)90022-3_BIB115","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0002-8703(85)90543-5","article-title":"Mitral valve prolapse and bacterial endocarditis: when is antibiotic prophylaxis necessary?","volume":"109","author":"Hickey","year":"1985","journal-title":"Am Heart J"},{"issue":"5","key":"10.1016\/0146-2806(91)90022-3_BIB116","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0002-9343(86)90339-6","article-title":"Complications of mitral valve prolapse","volume":"81","author":"Devereux","year":"1986","journal-title":"Am J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB117","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0002-9149(87)80080-2","article-title":"Risk of infective endocarditis in mitral valve prolapse with and without precordial systolic murmurs","volume":"59","author":"MacMahon","year":"1987","journal-title":"Am J Cardiol"},{"issue":"13","key":"10.1016\/0146-2806(91)90022-3_BIB118","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1056\/NEJM198209233071302","article-title":"A controlled evaluation of the risk of bacterial endocarditis in persons with mitral valve prolapse","volume":"307","author":"Clemens","year":"1982","journal-title":"N Engl J Mea"},{"key":"10.1016\/0146-2806(91)90022-3_BIB119","doi-asserted-by":"crossref","first-page":"419","DOI":"10.7326\/0003-4819-104-3-419","article-title":"Prophylaxis for infective endocarditis: an update","volume":"104","author":"Kaye","year":"1986","journal-title":"Ann Int Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB120","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0002-9343(84)90300-0","article-title":"Endocarditis prophylaxis for patients with mitral valve prolapse","volume":"76","author":"Bor","year":"1984","journal-title":"Am J Med"},{"key":"10.1016\/0146-2806(91)90022-3_BIB121","first-page":"197","article-title":"An appreciation of mitral valve prolapse","volume":"4","author":"Devereux","year":"1990","journal-title":"Choices in Cardiology"},{"key":"10.1016\/0146-2806(91)90022-3_BIB122","series-title":"Mitral Valve Prolapse and the Mitral Valve Prolapse Syndrome","first-page":"555","article-title":"Mitral valve prolapse syndrome: therapeutic considerations","author":"Boudoulas","year":"1988"},{"key":"10.1016\/0146-2806(91)90022-3_BIB123","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1378\/chest.83.2.436","article-title":"Effects of long-term clonidine administration on the hemodynamic and neuroendocrine postural responses of patients with dysautonomia","volume":"2","author":"Gaffney","year":"1983","journal-title":"Chest"},{"key":"10.1016\/0146-2806(91)90022-3_BIB124","series-title":"16th Bethesda Conference: cardiovascular abnormalities in the athlete: recommendations regarding eligibility for competition","first-page":"1215","article-title":"Task force III: hypertrophic cardiomyopathy, other myopericardial diseases and mitral valve prolapse","volume":"6","author":"Maron","year":"1985"},{"key":"10.1016\/0146-2806(91)90022-3_BIB125","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0002-9378(81)90666-9","article-title":"Mitral valve prolapse and pregnancy","volume":"141","author":"Rayburn","year":"1981","journal-title":"Am J Obstet Gynec"},{"key":"10.1016\/0146-2806(91)90022-3_BIB126","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/0002-9343(81)90365-X","article-title":"Maternal and fetal complications of pregnancy in the Marfan syndrome","volume":"71","author":"Pyeritz","year":"1981","journal-title":"Am J Med"}],"container-title":["Current Problems in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0146280691900223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0146280691900223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T03:24:31Z","timestamp":1585711471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0146280691900223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,5]]},"references-count":126,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,5]]}},"alternative-id":["0146280691900223"],"URL":"https:\/\/doi.org\/10.1016\/0146-2806(91)90022-3","relation":{},"ISSN":["0146-2806"],"issn-type":[{"value":"0146-2806","type":"print"}],"subject":[],"published":{"date-parts":[[1991,5]]}}}