{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:50:47Z","timestamp":1787507447216,"version":"build-2736575974"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Free Radical Biology and Medicine"],"published-print":{"date-parts":[[1991]]},"DOI":"10.1016\/0891-5849(91)90015-u","type":"journal-article","created":{"date-parts":[[2003,2,11]],"date-time":"2003-02-11T21:03:32Z","timestamp":1044997412000},"page":"7-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Evidence for an early free radical-mediated reperfusion injury in frostbite"],"prefix":"10.1016","volume":"10","author":[{"given":"Paul N.","family":"Manson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Jesudass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Marzella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory B.","family":"Bulkley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash K.","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/0891-5849(91)90015-U_BIB1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/00005373-197810000-00006","article-title":"Doppler ultrasound and digital plethysmography to determine the need for sympathetic blockage after frostbite","volume":"18","author":"Rakower","year":"1978","journal-title":"J. Trauma"},{"key":"10.1016\/0891-5849(91)90015-U_BIB2","first-page":"557","article-title":"Treatment of experimental frostbite with intra-arterial sympathetic blocking drugs","volume":"77","author":"Snider","year":"1975","journal-title":"Surgery"},{"key":"10.1016\/0891-5849(91)90015-U_BIB3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0022-4804(86)90141-1","article-title":"Analysis of microvascular changes in frostbite injury","volume":"40","author":"Bourne","year":"1986","journal-title":"J. Surg. Res."},{"key":"10.1016\/0891-5849(91)90015-U_BIB4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1748-1716.1965.tb04048.x","article-title":"Functional qualities of small blood vessels in tissue injured by freezing and thawing","volume":"63","author":"Reite","year":"1965","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/0891-5849(91)90015-U_BIB5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0022-4804(64)80004-4","article-title":"Experimental studies in cold injury. II: The pathogenesis of frostbite","volume":"4","author":"Weatherly-White","year":"1964","journal-title":"J. Surg. Res."},{"key":"10.1016\/0891-5849(91)90015-U_BIB6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1080\/00039896.1965.10664249","article-title":"Cold injury of the skin. The pathogenetic role of microcirculatory impairment","volume":"2","author":"Kulka","year":"1965","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/0891-5849(91)90015-U_BIB7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0026-2862(82)90039-5","article-title":"Changes in macromolecular permeability by intravascular generation of oxygen-derived free radicals","volume":"24","author":"Ley","year":"1982","journal-title":"Microvasc. Res."},{"key":"10.1016\/0891-5849(91)90015-U_BIB8","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/00006534-198605000-00018","article-title":"The etiologic role of free radicals in hematoma-induced flap necrosis","volume":"77","author":"Angel","year":"1986","journal-title":"Plast. Reconstr. Surg."},{"issue":"Suppl. VIII","key":"10.1016\/0891-5849(91)90015-U_BIB9","first-page":"66","article-title":"Free radical-mediated reperfusion injury: a selective review","volume":"55","author":"Bulkley","year":"1987","journal-title":"Br. J. Cancer"},{"key":"10.1016\/0891-5849(91)90015-U_BIB10","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.210504","article-title":"The biology of oxygen radicals","volume":"201","author":"Fridovich","year":"1978","journal-title":"Science"},{"key":"10.1016\/0891-5849(91)90015-U_BIB11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0016-5085(81)90648-X","article-title":"Superoxide radicals in feline intestinal ischemia","volume":"81","author":"Granger","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1016\/0891-5849(91)90015-U_BIB12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00000658-198503000-00018","article-title":"Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps","volume":"201","author":"Im","year":"1985","journal-title":"Ann. Surg."},{"key":"10.1016\/0891-5849(91)90015-U_BIB13","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/00006534-198402000-00023","article-title":"Effect of allopurinol on the survival of hyperemic island skin flaps","volume":"73","author":"Im","year":"1984","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/0891-5849(91)90015-U_BIB14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00000658-198307000-00017","article-title":"The role of oxygen-free radicals in ischemic tissue injury in island skin flaps","volume":"198","author":"Manson","year":"1983","journal-title":"Ann. Surg."},{"key":"10.1016\/0891-5849(91)90015-U_BIB15","first-page":"412","article-title":"The superoxide free radical: its biochemistry and pathophysiology","volume":"94","author":"McCord","year":"1983","journal-title":"Surgery"},{"key":"10.1016\/0891-5849(91)90015-U_BIB16","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/00007890-198802000-00006","article-title":"Ablatin of free radical-mediated reprefusion injury for the salvage of kidneys taken from non heart beating donors","volume":"45","author":"Hoshino","year":"1988","journal-title":"Transplantation"},{"key":"10.1016\/0891-5849(91)90015-U_BIB17","first-page":"122","article-title":"The primary localization of free radial generation following anoxia\/reoxygenation in isolated endothelial cells","volume":"102","author":"Ratytch","year":"1987","journal-title":"Surgery"},{"key":"10.1016\/0891-5849(91)90015-U_BIB18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00006534-198901000-00012","article-title":"Morphological characterization of acute injury to vascular endothelium of skin after frosbite","volume":"83","author":"Marzella","year":"1989","journal-title":"Plast. Recon. Surg."},{"key":"10.1016\/0891-5849(91)90015-U_BIB19","first-page":"208","article-title":"Experimental studies in cold injury. V. Circulatory hemodynamics","volume":"66","author":"Weatherly-Thite","year":"1969","journal-title":"Surgery"},{"key":"10.1016\/0891-5849(91)90015-U_BIB20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1161\/01.RES.57.1.142","article-title":"Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in cats","volume":"57","author":"Kontos","year":"1985","journal-title":"Circ. Res."},{"key":"10.1016\/0891-5849(91)90015-U_BIB21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/00005373-198302000-00013","article-title":"Frosbite injuries: a rational approach based on the pathophysiology","volume":"23","author":"McCauley","year":"1983","journal-title":"J. Trauma"},{"key":"10.1016\/0891-5849(91)90015-U_BIB22","first-page":"557","article-title":"Antiprostaglandins and antithromboxanes for the treatment of frostbite","volume":"31","author":"Raine","year":"1980","journal-title":"Surg. Form"},{"key":"10.1016\/0891-5849(91)90015-U_BIB23","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00006534-198103000-00010","article-title":"Experimental evidence of involvement of prostaglandins in viability of acute skin flaps: effects on viability and mode of action","volume":"67","author":"Sasaki","year":"1981","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/0891-5849(91)90015-U_BIB24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-5793(87)81458-8","article-title":"Allopurinol and oxypurinol are hydroxyl Radical scavengers","volume":"213","author":"Moorhouse","year":"1987","journal-title":"Federation of European Biochemical Societies"},{"key":"10.1016\/0891-5849(91)90015-U_BIB25","first-page":"202","article-title":"Allopurinol does not enhance antioxidant properties of extracellular fluid","volume":"255","author":"Zimmerman","year":"1988","journal-title":"Am. Physiol. Soc."}],"container-title":["Free Radical Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:089158499190015U?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:089158499190015U?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T15:22:51Z","timestamp":1757517771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/089158499190015U"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991]]}},"alternative-id":["089158499190015U"],"URL":"https:\/\/doi.org\/10.1016\/0891-5849(91)90015-u","relation":{},"ISSN":["0891-5849"],"issn-type":[{"value":"0891-5849","type":"print"}],"subject":[],"published":{"date-parts":[[1991]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence for an early free radical-mediated reperfusion injury in frostbite","name":"articletitle","label":"Article Title"},{"value":"Free Radical Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/0891-5849(91)90015-U","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1991 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}