{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:18:17Z","timestamp":1778609897513,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1990,10,1]],"date-time":"1990-10-01T00:00:00Z","timestamp":654739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1990,10,1]],"date-time":"1990-10-01T00:00:00Z","timestamp":654739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[1990,10]]},"DOI":"10.1016\/0960-0760(90)90331-e","type":"journal-article","created":{"date-parts":[[2003,2,12]],"date-time":"2003-02-12T12:35:20Z","timestamp":1045053320000},"page":"231-236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Inhibitory effect of synthetic progestins, 4-MA and cyanoketone on human placental 3\u03b2-hydroxysteroid dehydrogenase\/5\u21924-ene-isomerase activity"],"prefix":"10.1016","volume":"37","author":[{"given":"Masakazu","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van","family":"Luu-The","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernand","family":"Labrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0960-0760(90)90331-E_BIB1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.113.2939.490","article-title":"An enzyme in endocrine tissues which oxidizes \u03945\u22123 hydroxyde steroids to \u03b1, \u03b2 unsaturated ketones","volume":"113","author":"Samuels","year":"1951","journal-title":"Science"},{"key":"10.1016\/0960-0760(90)90331-E_BIB2","first-page":"159","article-title":"The \u201csea-saw\u201d theory of parturition","volume":"Vol. 47","author":"Csapo","year":"1977"},{"key":"10.1016\/0960-0760(90)90331-E_BIB3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0021-9258(18)70286-X","article-title":"Biological aromatization of steroids","volume":"234","author":"Ryan","year":"1959","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0960-0760(90)90331-E_BIB4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0140-6736(74)92337-X","article-title":"Significant fall in progesterone and rise in oestradiol levels in human peripheral plasma before onset of labour","volume":"1","author":"Turnbull","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/0960-0760(90)90331-E_BIB5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1095\/biolreprod14.3.306","article-title":"Control of placental 3 beta-hydroxy-delta5-steroid dehydrogenase: comparison of enzyme characteristics in man, cow, goat, rat and Rhesus monkey","volume":"14","author":"Wiener","year":"1976","journal-title":"Biol. Reprod."},{"key":"10.1016\/0960-0760(90)90331-E_BIB6","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1210\/jcem-63-2-360","article-title":"A new inherited variant of the 3\u03b2-hydroxysteroid dehydrogenase-isomerase deficiency syndrome: evidence for the existence of two isoenzymes","volume":"62","author":"Cravioto","year":"1986","journal-title":"J. Clin. Endocr. Metab."},{"key":"10.1016\/0960-0760(90)90331-E_BIB7","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0039-128X(64)90131-X","article-title":"Partial separation of beef adrenal \u03945\u22123 ketosteroid isomerase: androst-5-ene-3,17-dione isomerase and pregn-5-ene-3,20-dione isomerase","volume":"4","author":"Edwald","year":"1964","journal-title":"Steroids"},{"key":"10.1016\/0960-0760(90)90331-E_BIB8","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature (Lond.)"},{"key":"10.1016\/0960-0760(90)90331-E_BIB9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Analyt. Biochem."},{"key":"10.1016\/0960-0760(90)90331-E_BIB10","first-page":"C200","article-title":"Purification and characterization of human placental 3\u03b2-hydroxysteroid dehydrogenase\/\u03945-\u03944 isomerase","volume":"11","author":"Luu-The","year":"1988","journal-title":"Clin. Invest. Med."},{"key":"10.1016\/0960-0760(90)90331-E_BIB11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0039-128X(78)90010-7","article-title":"Trilostane, an orally active inhibitor of steroid biosynthesis","volume":"32","author":"Potts","year":"1978","journal-title":"Steroids"},{"key":"10.1016\/0960-0760(90)90331-E_BIB12","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1210\/jcem-47-5-1042","article-title":"Treatment of cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis","volume":"47","author":"Komanicky","year":"1978","journal-title":"J. Clin. Endocr. Metab."},{"key":"10.1016\/0960-0760(90)90331-E_BIB13","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1210\/endo-109-3-830","article-title":"Response of rat ventral prostate to a new and novel 5 alpha-reductase inhibitor","volume":"107","author":"Brooks","year":"1981","journal-title":"Endocrinology"},{"key":"10.1016\/0960-0760(90)90331-E_BIB14","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1021\/jm00378a028","article-title":"Azasteroids as inhibitors of rat prostatic 5 alpha-reductase","volume":"27","author":"Rasmusson","year":"1984","journal-title":"J. Med. Chem."},{"key":"10.1016\/0960-0760(90)90331-E_BIB15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0039-128X(75)90050-1","article-title":"Human placental \u03945-3\u03b2-hydroxysteroid dehydrogenase activity (\u03945-3\u03b2 HSDH): intracellular distribution, kinetic properties, retroinhibition and influence of membrane delipidation","volume":"26","author":"Ferre","year":"1975","journal-title":"Steroids"},{"key":"10.1016\/0960-0760(90)90331-E_BIB16","series-title":"Proc. IPFP Cong. on Agents Affecting Control of Fertility in Male","first-page":"129","article-title":"New antiandrogens and their mode of action","author":"Neumann","year":"1976"},{"key":"10.1016\/0960-0760(90)90331-E_BIB17","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0303-7207(85)90059-0","article-title":"Comparison of the antiandrogenic activities of flutamide, cyproterone acetate and megestrol acetate","volume":"32","author":"Poyet","year":"1985","journal-title":"Molec. Cell. Endocr."},{"key":"10.1016\/0960-0760(90)90331-E_BIB18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0303-7207(90)90190-J","article-title":"Synthetic progestins stimulate prostatic binding protein messenger RNAs in the rat ventral prostate","volume":"68","author":"Labrie","year":"1990","journal-title":"Molec. Cell. Endocr."},{"key":"10.1016\/0960-0760(90)90331-E_BIB19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1210\/jcem-28-1-49","article-title":"Inhibition alpha and beta hydroxysteroid dehydrogenase and steroid delta isomerase by substrate analogues","volume":"28","author":"Neville","year":"1968","journal-title":"J. Clin. Endocr."},{"key":"10.1016\/0960-0760(90)90331-E_BIB20","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0015-0282(16)48259-2","article-title":"Inhibition of 3-beta-hydroxysteroid dehydrogenase (3 beta-HSD) activity in first and second trimester human pregnancy and the luteal phase using Epostane","volume":"42","author":"Pattison","year":"1984","journal-title":"Fert. Steril."},{"key":"10.1016\/0960-0760(90)90331-E_BIB21","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0006-291X(87)80490-4","article-title":"The inhibition of 3 beta HSD activity in porcine granulosa cells by 4-MA, a potent 5 alpha-reductase inhibitor","volume":"144","author":"Chan","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/0960-0760(90)90331-E_BIB22","series-title":"Steroid Formation, Degradation and Action in Peripheral, Normal and Neoplastic Tissues","first-page":"389","article-title":"Biosynthesis and degradation of androgens in human prostatic cancer cell lines","volume":"595","author":"Lacoste","year":"1990"},{"key":"10.1016\/0960-0760(90)90331-E_BIB23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1210\/jcem-32-6-737","article-title":"Androgen metabolism in human skin","volume":"32","author":"Flamigni","year":"1971","journal-title":"J. Clin. Endocr. Metab."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:096007609090331E?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:096007609090331E?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T17:51:00Z","timestamp":1757526660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/096007609090331E"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,10]]}},"alternative-id":["096007609090331E"],"URL":"https:\/\/doi.org\/10.1016\/0960-0760(90)90331-e","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[1990,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibitory effect of synthetic progestins, 4-MA and cyanoketone on human placental 3\u03b2-hydroxysteroid dehydrogenase\/5\u21924-ene-isomerase activity","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/0960-0760(90)90331-E","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1990 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}