{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:09:16Z","timestamp":1773655756129,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier","isbn-type":[{"value":"9780128114322","type":"print"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/b978-0-12-809633-8.20372-5","type":"book-chapter","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T01:31:41Z","timestamp":1509499901000},"page":"230-235","source":"Crossref","is-referenced-by-count":2,"title":["Infrastructure for High-Performance Computing: Grids and Grid Computing"],"prefix":"10.1016","author":[{"given":"Ivan","family":"Merelli","sequence":"first","affiliation":[]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/B978-0-12-809633-8.20372-5_bib1","first-page":"D641","article-title":"The cell cycle DB: A systems biology approach to cell cycle analysis","volume":"36","author":"Alfieri","year":"2008","journal-title":"Nucleic Acids Research"},{"issue":"17","key":"10.1016\/B978-0-12-809633-8.20372-5_bib2","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: A new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib3","doi-asserted-by":"crossref","unstructured":"Anderson, D.P., 2004. Boinc: A system for public-resource computing and storage. In: Proceedings of the Fifth IEEE\/ACM International Workshop on Grid Computing, 2004, IEEE,pp. 4\u201310.","DOI":"10.1109\/GRID.2004.14"},{"issue":"11","key":"10.1016\/B978-0-12-809633-8.20372-5_bib4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1145\/581571.581573","article-title":"SETI home: An experiment in public-resource computing","volume":"45","author":"Anderson","year":"2002","journal-title":"Communications of the ACM"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib5","unstructured":"Burke, S., Campana, S., Lorenzo, M.P., et al., 2008. Glite 3.1 User Guide (2008)."},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10723-010-9163-y","volume":"8","author":"Calabria","year":"2010","journal-title":"Journal of Grid Computing"},{"issue":"4","key":"10.1016\/B978-0-12-809633-8.20372-5_bib7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12859-016-0909-9","article-title":"A novel molecular dynamics approach to evaluate the effect of phosphorylation on multimeric protein interface: The B-crystallin case study","volume":"17","author":"Chiappori","year":"2016","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib8","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ejmech.2013.02.021","article-title":"Static and dynamic interactions between GALK enzyme and known inhibitors: Guidelines to design new drugs for galactosemic patients","volume":"63","author":"Chiappori","year":"2013","journal-title":"European Journal of Medicinal Chemistry"},{"issue":"4","key":"10.1016\/B978-0-12-809633-8.20372-5_bib9","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/prot.24016","article-title":"Structural thermal adaptation of tubulins from the Antarctic psychrophilic protozoan Euplotes focardii","volume":"80","author":"Chiappori","year":"2012","journal-title":"Proteins: Structure, Function, and Bioinformatics"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib10","unstructured":"Ciuffo, L.N., Mayo, R., 2009. Biomedical applications in the EELA-2 project. In: Proceedings of the Ninth Annual Workshop Network Tools and Applications in Biology, pp. 35\u201338."},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/138012","article-title":"Cloud infrastructures for in silico drug discovery: Economic and practical aspects","volume":"2013","author":"D\u2019Agostino","year":"2013","journal-title":"BioMed Research International"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib12","unstructured":"Darling, A., Carey, L., Feng, W.C., 2003. The design, implementation, and evaluation of mpiBLAST. In: Proceedings of ClusterWorld, 2003, pp. 13\u201315."},{"issue":"S8","key":"10.1016\/B978-0-12-809633-8.20372-5_bib13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/prot.21636","article-title":"Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home","volume":"69","author":"Das","year":"2007","journal-title":"Proteins: Structure, Function, and Bioinformatics"},{"issue":"1","key":"10.1016\/B978-0-12-809633-8.20372-5_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1471-2105-6-93","article-title":"Windows .NET network distributed basic local alignment search toolkit (W.ND-BLAST)","volume":"6","author":"Dowd","year":"2005","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib15","series-title":"Desktop Grid Computing","year":"2012"},{"issue":"6","key":"10.1016\/B978-0-12-809633-8.20372-5_bib16","first-page":"062009","article-title":"Integration of cloud, grid and local cluster resources with DIRAC","volume":"331","author":"Fifield","year":"2011","journal-title":"Journal of Physics: Conference Series"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkr367","article-title":"HMMER web server: Interactive sequence similarity searching","author":"Finn","year":"2011","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib18","first-page":"2","article-title":"Globus toolkit version 4: Software for service-oriented systems","volume":"3779","author":"Foster","year":"2006","journal-title":"LNCS"},{"issue":"21","key":"10.1016\/B978-0-12-809633-8.20372-5_bib19","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","article-title":"Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein\u2013ligand complexes","volume":"49","author":"Friesner","year":"2006","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib20","series-title":"The Grid: Blueprint for a New Computing Infrastructure","first-page":"121","article-title":"Knowledge Integration: In silico experiments in Bioinformatics","author":"Goble","year":"2003"},{"issue":"5","key":"10.1016\/B978-0-12-809633-8.20372-5_bib21","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/bioinformatics\/18.5.765","article-title":"BeoBLAST: Distributed BLAST and PSI-BLAST on a Beowulf cluster","volume":"18","author":"Grant","year":"2002","journal-title":"Bioinformatics"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib22","first-page":"15.3.1","article-title":"Genotyping in the cloud with crossbow","author":"Gurtowski","year":"2012","journal-title":"Current Protocols in Bioinformatics"},{"issue":"4","key":"10.1016\/B978-0-12-809633-8.20372-5_bib23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.parco.2007.02.010","article-title":"Virtual screening on large scale grids","volume":"33","author":"Jacq","year":"2007","journal-title":"Parallel Computing"},{"issue":"3","key":"10.1016\/B978-0-12-809633-8.20372-5_bib24","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.cpc.2013.12.014","article-title":"Generalized scalable multiple copy algorithms for molecular dynamics simulations in NAMD","volume":"185","author":"Jiang","year":"2014","journal-title":"Computer Physics Communications"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib25","doi-asserted-by":"crossref","unstructured":"Kee, Y.S., Kesselman, C., 2008. Grid resource abstraction, virtualization, and provisioning for time-targeted applications. In: Proceedings of the 8th IEEE International Symposium on Cluster Computing and the Grid, 2008. CCGRID\u201908, IEEE, pp. 324\u2013331.","DOI":"10.1109\/CCGRID.2008.115"},{"issue":"13","key":"10.1016\/B978-0-12-809633-8.20372-5_bib26","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/cpe.906","article-title":"GridBLAST: A globus-based high-throughput implementation of BLAST in a Grid computing framework","volume":"17","author":"Krishnan","year":"2005","journal-title":"Concurrency and Computation: Practice and Experience"},{"issue":"4","key":"10.1016\/B978-0-12-809633-8.20372-5_bib27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nature Methods"},{"issue":"4","key":"10.1016\/B978-0-12-809633-8.20372-5_bib28","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1109\/TNB.2006.887943","article-title":"Grid-enabled high-throughput in silico screening against influenza A neuraminidase","volume":"5","author":"Lee","year":"2006","journal-title":"IEEE Transactions on Nanobioscience"},{"issue":"4","key":"10.1016\/B978-0-12-809633-8.20372-5_bib29","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/prot.21804","article-title":"Docking and scoring protein complexes: CAPRI 3rd Edition","volume":"69","author":"Lensink","year":"2007","journal-title":"Proteins: Structure, Function, and Bioinformatics"},{"issue":"1","key":"10.1016\/B978-0-12-809633-8.20372-5_bib30","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1186\/1471-2105-11-598","article-title":"Initial steps towards a production platform for DNA sequence analysis on the grid","volume":"11","author":"Luyf","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib31","doi-asserted-by":"crossref","unstructured":"Mancini, E.P., Rak, M., Villano, U., 2009. Perfcloud: Grid services for performance-oriented development of cloud computing applications. In: Proceedings of the 18th IEEE International Workshops on Enabling Technologies: Infrastructures for Collaborative Enterprises, WETICE\u201909, IEEE,pp. 201\u2013206.","DOI":"10.1109\/WETICE.2009.47"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib32","doi-asserted-by":"crossref","unstructured":"Marco, C., Fabio, C., Alvise, D., et al., 2009. The glite workload management system. In: International Conference on Grid and Pervasive Computing. Berlin; Heidelberg: Springer, pp. 256\u2013268.","DOI":"10.1007\/978-3-642-01671-4_24"},{"issue":"1","key":"10.1016\/B978-0-12-809633-8.20372-5_bib33","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1186\/1471-2105-14-S1-S9","article-title":"SNPranker 2.0: A gene-centric data mining tool for diseases associated SNP prioritization in GWAS","volume":"14","author":"Merelli","year":"2013","journal-title":"BMC Bioinformatics"},{"issue":"4","key":"10.1016\/B978-0-12-809633-8.20372-5_bib34","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1109\/TCBB.2010.21","article-title":"Image-based surface matching algorithm oriented to structural biology","volume":"8","author":"Merelli","year":"2011","journal-title":"IEEE\/ACM Transactions on Computational Biology and Bioinformatics (TCBB)"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib35","article-title":"Porting bioinformatics applications from grid to cloud: A macromolecular surface analysis application case study","author":"Merelli","year":"2015","journal-title":"International Journal of High Performance Computing Applications"},{"issue":"3","key":"10.1016\/B978-0-12-809633-8.20372-5_bib36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1109\/TNB.2007.903483","article-title":"Evaluation of a grid based molecular dynamics approach for polypeptide simulations","volume":"6","author":"Merelli","year":"2007","journal-title":"IEEE Transactions on NanoBioscience"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib37","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"Autodock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"16","author":"Morris","year":"2009","journal-title":"Journal of Computational Chemistry"},{"issue":"11","key":"10.1016\/B978-0-12-809633-8.20372-5_bib38","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1021\/ci1001982","article-title":"Docking validation resources: Protein family and ligand flexibility experiments","volume":"50","author":"Mukherjee","year":"2010","journal-title":"Journal of Chemical Information and Modeling"},{"issue":"3","key":"10.1016\/B978-0-12-809633-8.20372-5_bib39","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"The American Journal of Human Genetics"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib40","doi-asserted-by":"crossref","unstructured":"Ronchieri, E., D\u05f3Agostino, D., Milanesi, L., et al., 2016. MicroRNA\u2013target interaction: A parallel approach for computing pairing energy. In: Proceedings of the 24th Euromicro International Conference on Parallel, Distributed, and Network-Based Processing (PDP), IEEE, pp. 535\u2013540.","DOI":"10.1109\/PDP.2016.117"},{"issue":"5","key":"10.1016\/B978-0-12-809633-8.20372-5_bib41","first-page":"052017","article-title":"WNoDeS, a tool for integrated grid and cloud access and computing farm virtualization","volume":"331","author":"Salomoni","year":"2011","journal-title":"Journal of Physics: Conference Series"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib42","volume":"vol. 1","year":"2007"},{"issue":"15","key":"10.1016\/B978-0-12-809633-8.20372-5_bib43","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1002\/cpe.1041","article-title":"How to measure a large open source distributed system","volume":"18","author":"Thain","year":"2006","journal-title":"Concurrency and Computation: Practice and Experience"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib44","first-page":"23","article-title":"BGBlast: A blast grid implementation with database self-updating and adaptive replication","volume":"126","author":"Trombetti","year":"2007","journal-title":"Studies in Health Technology and Informatics"},{"key":"10.1016\/B978-0-12-809633-8.20372-5_bib45","doi-asserted-by":"crossref","unstructured":"Tusa, F., Paone, M., Villari, M., et al., 2010. CLEVER: A cloud-enabled virtual environment. In: IEEE Symposium on Computers and Communications (ISCC),IEEE, pp. 477\u2013482.","DOI":"10.1109\/ISCC.2010.5546555"},{"issue":"14","key":"10.1016\/B978-0-12-809633-8.20372-5_bib46","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/bioinformatics\/btg244","article-title":"Soap-HT-BLAST: High throughput BLAST based on Web services","volume":"19","author":"Wang","year":"2003","journal-title":"Bioinformatics"}],"container-title":["Encyclopedia of Bioinformatics and Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780128096338203725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780128096338203725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T18:51:44Z","timestamp":1603219904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/B9780128096338203725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9780128114322"],"references-count":46,"URL":"https:\/\/doi.org\/10.1016\/b978-0-12-809633-8.20372-5","relation":{},"subject":[],"published":{"date-parts":[[2019]]}}}