{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:11:51Z","timestamp":1777907511555,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011914","name":"M\u00e4lardalens universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["BioSystems"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.biosystems.2025.105640","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:45:58Z","timestamp":1762231558000},"page":"105640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Anticipation, memory, and top-down causation in living systems"],"prefix":"10.1016","volume":"259","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9881-400X","authenticated-orcid":false,"given":"Gordana","family":"Dodig-Crnkovic","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.biosystems.2025.105640_bib1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/43199","article-title":"Robustness in simple biochemical networks","volume":"387","author":"Barkai","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.biosystems.2025.105640_bib2","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2019.0757","article-title":"Adaptive behaviour and learning in slime moulds: the role of oscillations","volume":"376","author":"Boussard","year":"2021","journal-title":"Phil. Trans. Biol. Sci."},{"key":"10.1016\/j.biosystems.2025.105640_bib3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/376307a0","article-title":"Protein molecules as computational elements in living cells","volume":"376","author":"Bray","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.biosystems.2025.105640_bib4","series-title":"Teleonomy in Living Systems","article-title":"Evolution \u201cOn Purpose\u201d","author":"Corning","year":"2023"},{"key":"10.1016\/j.biosystems.2025.105640_bib5","series-title":"Incomplete Nature. How Mind Emerged from Matter","author":"Deacon","year":"2011"},{"key":"10.1016\/j.biosystems.2025.105640_bib6","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2013.0475","article-title":"Life as we know it","volume":"10","author":"Friston","year":"2013","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.biosystems.2025.105640_bib7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nrn2787","article-title":"The free-energy principle: a unified brain theory?","volume":"11","author":"Friston","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.biosystems.2025.105640_bib8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00422-010-0364-z","article-title":"Action and behavior: a free-energy formulation","volume":"102","author":"Friston","year":"2010","journal-title":"Biol. Cybern."},{"key":"10.1016\/j.biosystems.2025.105640_bib9","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1534\/genetics.112.143016","article-title":"Cellular memory of acquired stress resistance in Saccharomyces cerevisiae","volume":"192","author":"Guan","year":"2012","journal-title":"Genetics"},{"key":"10.1016\/j.biosystems.2025.105640_bib10","series-title":"Roald Hoffmann on the Philosophy, Art, and Science of Chemistry","author":"Hoffmann","year":"2012"},{"key":"10.1016\/j.biosystems.2025.105640_bib11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev.micro.53.1.389","article-title":"Circadian programs in cyanobacteria: adaptiveness and mechanism","volume":"53","author":"Johnson","year":"1999","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.biosystems.2025.105640_bib12","series-title":"Stochastic Processes in Physics and Chemistry","author":"Kampen","year":"2007"},{"key":"10.1016\/j.biosystems.2025.105640_bib13","series-title":"The Origins of Order: Self-Organization and Selection in Evolution","author":"Kauffman","year":"1993"},{"key":"10.1016\/j.biosystems.2025.105640_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12064-020-00313-7","article-title":"The information theory of individuality","volume":"139","author":"Krakauer","year":"2020","journal-title":"Theor. Biosci."},{"key":"10.1016\/j.biosystems.2025.105640_bib15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.plrev.2019.06.001","article-title":"Morphogenesis as Bayesian inference: a variational approach to pattern formation and control in complex biological systems","volume":"33","author":"Kuchling","year":"2020","journal-title":"Phys. Life Rev."},{"key":"10.1016\/j.biosystems.2025.105640_bib16","series-title":"Robert Rosen and Relational System Theory: an Overview","author":"Lennox","year":"2024"},{"key":"10.1016\/j.biosystems.2025.105640_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2022.768201","article-title":"Technological approach to mind everywhere: an experimentally-grounded framework for understanding diverse bodies and minds","volume":"16","author":"Levin","year":"2022","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.biosystems.2025.105640_bib18","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.3389\/fpsyg.2019.02688","article-title":"The computational boundary of a \u201cSelf\u201d: developmental bioelectricity drives multicellularity and scale-free cognition","volume":"10","author":"Levin","year":"2019","journal-title":"Front. Psychol."},{"key":"10.1016\/j.biosystems.2025.105640_bib19","article-title":"Shape as memory. A geometric theory of architecture, ambient intelligence for scientific discovery","volume":"3345","author":"Leyton","year":"2006","journal-title":"Lect. Notes Comput. Sci."},{"key":"10.1016\/j.biosystems.2025.105640_bib20","series-title":"Symmetry, Causality, Mind","author":"Leyton","year":"1992"},{"key":"10.1016\/j.biosystems.2025.105640_bib21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1108\/14636681011049848","article-title":"Robert Rosen's anticipatory systems","volume":"12","author":"Louie","year":"2010","journal-title":"Foresight"},{"key":"10.1016\/j.biosystems.2025.105640_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature15386","article-title":"CRISPR-Cas immunity in prokaryotes","volume":"526","author":"Marraffini","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.biosystems.2025.105640_bib23","author":"Mayr"},{"key":"10.1016\/j.biosystems.2025.105640_bib24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s11229-023-04164-9","article-title":"Evolutionary trends and goal directedness","volume":"201","author":"McShea","year":"2023","journal-title":"Synthese"},{"key":"10.1016\/j.biosystems.2025.105640_bib25","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0893-6080(96)00035-4","article-title":"Forward models for physiological motor control","volume":"9","author":"Miall","year":"1996","journal-title":"Neural Netw."},{"key":"10.1016\/j.biosystems.2025.105640_bib26","series-title":"Biological Autonomy: a Philosophical and Theoretical Enquiry","author":"Moreno","year":"2015"},{"key":"10.1016\/j.biosystems.2025.105640_bib27","series-title":"Janeway's Immunobiology","author":"Murphy","year":"2016"},{"key":"10.1016\/j.biosystems.2025.105640_bib28","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1126\/science.1108451","article-title":"Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro","volume":"308","author":"Nakajima","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biosystems.2025.105640_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: a program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.biosystems.2025.105640_bib30","series-title":"From Dissipative Structures to Order Through Fluctuations","article-title":"Self-Organization in nonequilibrium systems","author":"Nicolis","year":"1977"},{"key":"10.1016\/j.biosystems.2025.105640_bib31","author":"Noble"},{"key":"10.1016\/j.biosystems.2025.105640_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1098\/rsfs.2011.0067","article-title":"A theory of biological relativity: no privileged level of causation","volume":"2","author":"Noble","year":"2012","journal-title":"Interface Focus"},{"key":"10.1016\/j.biosystems.2025.105640_bib33","series-title":"Understanding Living Systems","author":"Noble","year":"2023"},{"key":"10.1016\/j.biosystems.2025.105640_bib34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11023-008-9095-5","article-title":"Coordinating with the future: the anticipatory nature of representation","volume":"18","author":"Pezzulo","year":"2008","journal-title":"Minds Mach."},{"key":"10.1016\/j.biosystems.2025.105640_bib35","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2016.0555","article-title":"Top-down models in biology: explanation and control of complex living systems above the molecular level","volume":"13","author":"Pezzulo","year":"2016","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.biosystems.2025.105640_bib36","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.3390\/math10224172","article-title":"Robert Rosen's anticipatory systems theory: the science of life and mind","volume":"10","author":"Rosen","year":"2022","journal-title":"Mathematics"},{"key":"10.1016\/j.biosystems.2025.105640_bib37","series-title":"Life Itself. A Comprehensive Inquiry into the Nature, Origin, and Fabrication of Life","author":"Rosen","year":"1991"},{"key":"10.1016\/j.biosystems.2025.105640_bib38","series-title":"Anticipatory Systems","author":"Rosen","year":"1985"},{"key":"10.1016\/j.biosystems.2025.105640_bib39","series-title":"Evolution: a View from the 21st Century","author":"Shapiro","year":"2011"},{"key":"10.1016\/j.biosystems.2025.105640_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.biosystems.2025.105618","article-title":"When Maxwell's demon leaves the room","volume":"258","author":"Tello","year":"2025","journal-title":"Biosystems"},{"key":"10.1016\/j.biosystems.2025.105640_bib41","doi-asserted-by":"crossref","first-page":"14855","DOI":"10.1073\/pnas.0807569105","article-title":"Modeling the chemotactic response of Escherichia coli to time-varying stimuli","volume":"105","author":"Tu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biosystems.2025.105640_bib42","series-title":"A Third Window : Natural Life Beyond Newton and Darwin","author":"Ulanowicz","year":"2009"},{"key":"10.1016\/j.biosystems.2025.105640_bib43","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12304-011-9111-7","article-title":"Natural genome editing from a biocommunicative perspective","volume":"4","author":"Witzany","year":"2011","journal-title":"Biosemiotics"},{"key":"10.1016\/j.biosystems.2025.105640_bib44","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S1364-6613(98)01221-2","article-title":"Internal models in the cerebellum","volume":"2","author":"Wolpert","year":"1998","journal-title":"Trends Cognit. Sci."},{"key":"10.1016\/j.biosystems.2025.105640_bib45","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1091\/mbc.e10-08-0721","article-title":"Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness","volume":"22","author":"Zakrzewska","year":"2011","journal-title":"Mol. Biol. Cell"}],"container-title":["BioSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303264725002503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303264725002503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:36:42Z","timestamp":1777642602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303264725002503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":45,"alternative-id":["S0303264725002503"],"URL":"https:\/\/doi.org\/10.1016\/j.biosystems.2025.105640","relation":{},"ISSN":["0303-2647"],"issn-type":[{"value":"0303-2647","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anticipation, memory, and top-down causation in living systems","name":"articletitle","label":"Article Title"},{"value":"BioSystems","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biosystems.2025.105640","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105640"}}