{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:36:15Z","timestamp":1777952175257,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["BioSystems"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.biosystems.2026.105741","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:08:31Z","timestamp":1772125711000},"page":"105741","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mechanical evidence of the impossibility of directed motion of Trypanosoma cruzi towards\n                        preferred organs in the human body, a simulation 2D model within a laminar flow"],"prefix":"10.1016","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3024-3449","authenticated-orcid":false,"given":"Alberto-Mario","family":"Castillo","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4582-265X","authenticated-orcid":false,"given":"Gabriel","family":"Villalobos","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biosystems.2026.105741_b1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003967","article-title":"Simulating the complex cell design of Trypanosoma brucei and its motility","volume":"11","author":"Alizadehrad","year":"2015","journal-title":"PLoS Comput. Biol."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105741_b2","doi-asserted-by":"crossref","first-page":"15894","DOI":"10.1038\/s41598-020-72604-4","article-title":"Motility patterns of Trypanosoma cruzi trypomastigotes correlate with the\n                            efficiency of parasite invasion in vitro","volume":"10","author":"Arias-del Angel","year":"2020","journal-title":"Sci. Rep."},{"issue":"15","key":"10.1016\/j.biosystems.2026.105741_b3","doi-asserted-by":"crossref","DOI":"10.1063\/1.1883163","article-title":"Poiseuille flow to measure the viscosity of particle model fluids","volume":"122","author":"Backer","year":"2005","journal-title":"J. Chem. Phys."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105741_b4","article-title":"Flagellar motility of Trypanosoma cruzi epimastigotes","volume":"2012","author":"Ballesteros-Rodea","year":"2012","journal-title":"BioMed Res. Int."},{"issue":"2","key":"10.1016\/j.biosystems.2026.105741_b5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1005448","article-title":"Species-specific adaptations of trypanosome morphology and motility to the\n                            Mammalian Host","volume":"12","author":"Bargul","year":"2016","journal-title":"PLOS Pathog."},{"issue":"2","key":"10.1016\/j.biosystems.2026.105741_b6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.actatropica.2006.04.003","article-title":"Effect of suramin on trypomastigote forms of Trypanosoma cruzi: changes on cell\n                            motility and on the ultrastructure of the flagellum-cell body attachment region","volume":"98","author":"Bisaggio","year":"2006","journal-title":"Acta Trop."},{"issue":"3","key":"10.1016\/j.biosystems.2026.105741_b7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1039\/C3LC51022K","article-title":"Measuring single cell mass, volume, and density with dual suspended microchannel\n                            resonators","volume":"14","author":"Bryan","year":"2014","journal-title":"Lab Chip"},{"key":"10.1016\/j.biosystems.2026.105741_b8","series-title":"Dataset for the paper \u00e2\u20ac\u0153Mechanical Evidence of the imposibility of directed\n                            motion ofTrypanosoma cruzi towards preferred organs in the HumanBody, a simulation 2D model\n                            within a laminar flow\u00e2\u20ac\u009d","author":"Castillo","year":"2025"},{"issue":"6","key":"10.1016\/j.biosystems.2026.105741_b9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0012288","article-title":"In vitro characterization of Trypanosoma cruzi infection dynamics in skeletal and\n                            cardiac myotubes models suggests a potential cell-to-cell transmission in mediating cardiac\n                            pathology","volume":"18","author":"Contreras-Ortiz","year":"2024","journal-title":"PLOS Negl. Trop. Dis."},{"issue":"12","key":"10.1016\/j.biosystems.2026.105741_b10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002270","article-title":"Multiscale modeling of red blood cell mechanics and blood flow in malaria","volume":"7","author":"Fedosov","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.biosystems.2026.105741_b11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.exppara.2015.01.007","article-title":"Altering the motility of Trypanosoma cruzi with rabbit polyclonal anti-peptide\n                            antibodies reduces infection to susceptible mammalian cells","volume":"150","author":"Finkelsztein","year":"2015","journal-title":"Exp. Parasitol."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105741_b12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13071-018-2664-4","article-title":"Revisiting the Trypanosoma cruzi metacyclogenesis: morphological and\n                            ultrastructural analyses during cell differentiation","volume":"11","author":"Gon\u00c3\u00a7alves","year":"2018","journal-title":"Parasites Vectors"},{"issue":"27","key":"10.1016\/j.biosystems.2026.105741_b13","doi-asserted-by":"crossref","first-page":"10992","DOI":"10.1073\/pnas.1104651108","article-title":"Measuring single-cell density","volume":"108","author":"Grover","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.biosystems.2026.105741_b14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1209\/0295-5075\/19\/3\/001","article-title":"Simulating microscopic hydrodynamic phenomena with dissipative particle dynamics","volume":"19","author":"Hoogerbrugge","year":"1992","journal-title":"Eur. Lett. (EPL)"},{"key":"10.1016\/j.biosystems.2026.105741_b15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF01907921","article-title":"The measurement of blood density and its meaning","volume":"84","author":"Kenner","year":"1989","journal-title":"Basic Res. Cardiol."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105741_b16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.fluid.29.1.399","article-title":"Blood flow in arteries","volume":"29","author":"Ku","year":"1997","journal-title":"Annu. Rev. Fluid Mech."},{"issue":"4","key":"10.1016\/j.biosystems.2026.105741_b17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chom.2014.09.003","article-title":"The Trypanosoma cruzi flagellum is discarded via asymmetric cell division\n                            following invasion and provides early targets for protective CD8+ T cells","volume":"16","author":"Kurup","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"8","key":"10.1016\/j.biosystems.2026.105741_b18","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0021-9290(02)00044-1","article-title":"Numerical simulation of steady flow fields in a model of abdominal aorta with its\n                            peripheral branches","volume":"35","author":"Lee","year":"2002","journal-title":"J. Biomech."},{"issue":"15","key":"10.1016\/j.biosystems.2026.105741_b19","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.1073\/pnas.0811484106","article-title":"Flow-induced clustering and alignment of vesicles and red blood cells in\n                            microcapillaries","volume":"106","author":"McWhirter","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.biosystems.2026.105741_b20","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210006","article-title":"The plastic cell: mechanical deformation of cells and tissues","volume":"11","author":"Molnar","year":"2021","journal-title":"Open Biol."},{"key":"10.1016\/j.biosystems.2026.105741_b21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1590\/S0074-02762003000100012","article-title":"Morphological comparison of axenic amastigogenesis of trypomastigotes and\n                            metacyclic forms of Trypanosoma cruzi","volume":"98","author":"Navarro","year":"2003","journal-title":"Mem. Inst. Oswaldo Cruz"},{"issue":"3","key":"10.1016\/j.biosystems.2026.105741_b22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0010-4655(03)00202-9","article-title":"How would you integrate the equations of motion in dissipative particle dynamics\n                            simulations?","volume":"153","author":"Nikunen","year":"2003","journal-title":"Comput. Phys. Comm."},{"key":"10.1016\/j.biosystems.2026.105741_b23","unstructured":"Organization, World Health, et al., 2012. Research Priorities for Chagas\n                            Disease, Human African Trypanosomiasis and Leishmaniasis. World Health Organization\n                            Technical Report Series, (975):v."},{"issue":"5","key":"10.1016\/j.biosystems.2026.105741_b24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1013111","article-title":"Modelling motility of Trypanosoma brucei","volume":"21","author":"Overberg","year":"2025","journal-title":"PLoS Comput. Biol."},{"issue":"3","key":"10.1016\/j.biosystems.2026.105741_b25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.mvr.2008.11.006","article-title":"Accuracy of 1D microvascular flow models in the limit of low Reynolds numbers","volume":"77","author":"Pindera","year":"2009","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.biosystems.2026.105741_b26","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0010-4655(99)00341-0","article-title":"Boundary conditions in dissipative particle dynamics","volume":"121\u00e2\u20ac\u201c122","author":"Revenga","year":"1999","journal-title":"Comput. Phys. Comm."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105741_b27","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-fluid-010816-060302","article-title":"Blood flow in the microcirculation","volume":"49","author":"Secomb","year":"2017","journal-title":"Annu. Rev. Fluid Mech."},{"issue":"11","key":"10.1016\/j.biosystems.2026.105741_b28","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3390\/pathogens12111367","article-title":"Implications of flagellar attachment zone proteins TcGP72 and TcFLA-1BP in\n                            morphology, proliferation, and intracellular dynamics in Trypanosoma cruzi","volume":"12","author":"Souza-Melo","year":"2023","journal-title":"Pathogens"},{"issue":"3","key":"10.1016\/j.biosystems.2026.105741_b29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.gheart.2015.06.001","article-title":"The burden of Chagas disease: estimates and challenges","volume":"10","author":"Stanaway","year":"2015","journal-title":"Glob. Heart"},{"key":"10.1016\/j.biosystems.2026.105741_b30","series-title":"Unicellular parasite motility: a quantitative perspective","author":"Uppaluri","year":"2011"},{"issue":"6","key":"10.1016\/j.biosystems.2026.105741_b31","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00436-009-1383-3","article-title":"Perspectives on the Trypanosoma cruzi\u00e2\u20ac\u201chost cell receptor interactions","volume":"104","author":"Villalta","year":"2009","journal-title":"Parasitol. Res."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105741_b32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev.bioeng.1.1.299","article-title":"Fluid mechanics of vascular systems, diseases, and thrombosis","volume":"1","author":"Wootton","year":"1999","journal-title":"Annu. Rev. Biomed. Eng."}],"container-title":["BioSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303264726000511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303264726000511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:50:14Z","timestamp":1777895414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303264726000511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":32,"alternative-id":["S0303264726000511"],"URL":"https:\/\/doi.org\/10.1016\/j.biosystems.2026.105741","relation":{},"ISSN":["0303-2647"],"issn-type":[{"value":"0303-2647","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanical evidence of the impossibility of\n                            directed motion of Trypanosoma cruzi towards preferred organs in the human body, a\n                            simulation 2D model within a laminar flow","name":"articletitle","label":"Article Title"},{"value":"BioSystems","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biosystems.2026.105741","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00c2\u00a9 2026 Elsevier B.V. All rights are reserved,\n                            including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105741"}}