{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:35:56Z","timestamp":1777952156992,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["BioSystems"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.biosystems.2026.105754","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:32:44Z","timestamp":1772497964000},"page":"105754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mathematical principle underlying the law of entropy increase is vital for actively stable\n                        lowering of biosystem entropy"],"prefix":"10.1016","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-0748","authenticated-orcid":false,"given":"Yury P.","family":"Shimansky","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.biosystems.2026.105754_bib1","author":"Cortes\u00c3\u00a3o"},{"key":"10.1016\/j.biosystems.2026.105754_bib2","series-title":"Stochastic Modeling and Control","author":"Davis","year":"1985"},{"key":"10.1016\/j.biosystems.2026.105754_bib3","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1080\/00018730210155133","article-title":"The fluctuation theorem","volume":"51","author":"Evans","year":"2002","journal-title":"Adv. Phys."},{"key":"10.1016\/j.biosystems.2026.105754_bib4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1088\/0143-0807\/32\/1\/007","article-title":"Derivation of the Schr\u00c3\u00b6dinger equation from the Hamilton-Jacobi equation in\n                            Feynman's path integral formulation of quantum mechanics","volume":"32","author":"Field","year":"2011","journal-title":"Eur. J. Phys."},{"key":"10.1016\/j.biosystems.2026.105754_bib5","first-page":"13083","article-title":"Direct measurement of weakly nonequilibrium system entropy is consistent with\n                            Gibbs\u00e2\u20ac\u201cShannon form","volume":"115","author":"Gavrilov","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biosystems.2026.105754_bib6","article-title":"B\u00c3\u00a9nard\u00e2\u20ac\u201cRayleigh convection: Structures and dynamics","author":"Getling","year":"1998","journal-title":"World Scientific"},{"key":"10.1016\/j.biosystems.2026.105754_bib7","series-title":"The Structure of Evolutionary Theory","author":"Gould","year":"2002"},{"key":"10.1016\/j.biosystems.2026.105754_bib8","series-title":"Handbook of the Philosophy of Science. Philosophy of Information","first-page":"289","article-title":"Algorithmic information theory","author":"Gr\u00c3\u00bcwald","year":"2008"},{"key":"10.1016\/j.biosystems.2026.105754_bib9","series-title":"A Unified Grand Tour of Theoretical Physics","author":"Lawrie","year":"1990"},{"key":"10.1016\/j.biosystems.2026.105754_bib10","series-title":"The Emergence of Life: from Chemical Origins to Synthetic Biology","author":"Luisi","year":"2016"},{"key":"10.1016\/j.biosystems.2026.105754_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.physrep.2005.12.001","article-title":"Maximum entropy production principle in physics, chemistry and biology","volume":"426","author":"Martyushev","year":"2006","journal-title":"Phys. Rep."},{"key":"10.1016\/j.biosystems.2026.105754_bib12","series-title":"Autopoiesis and Cognition: the Realization of the Living","author":"Maturana","year":"1980"},{"key":"10.1016\/j.biosystems.2026.105754_bib13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/cplx.20191","article-title":"Energy flow and the organization of life","volume":"13","author":"Morowitz","year":"2007","journal-title":"Complexity"},{"key":"10.1016\/j.biosystems.2026.105754_bib14","series-title":"Self-Organization. Non-equilibrium System","author":"Prigogine","year":"1977"},{"key":"10.1016\/j.biosystems.2026.105754_bib15","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1351\/pac200577111905","article-title":"Stability in chemistry and biology: life as a kinetic state of matter","volume":"77","author":"Pross","year":"2005","journal-title":"Pure Appl. Chem."},{"issue":"303","key":"10.1016\/j.biosystems.2026.105754_bib16","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1093669","article-title":"Evolution. Transitions from nonliving to living matter","volume":"13","author":"Rasmussen","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.biosystems.2026.105754_bib17","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s11084-012-9297-y","article-title":"Autopoiesis 40 years later. A review and a reformulation","volume":"42","author":"Razeto-Barry","year":"2012","journal-title":"Orig. Life Evol. Biosph."},{"key":"10.1016\/j.biosystems.2026.105754_bib18","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1119\/1.4894381","article-title":"Entropic forces in Brownian motion","volume":"82","author":"Roos","year":"2014","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.biosystems.2026.105754_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084098","article-title":"Entropy perspectives of molecular and evolutionary biology","volume":"23","author":"Sabater","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biosystems.2026.105754_bib20","series-title":"What is Life?","author":"Schr\u00c3\u00b6dinger","year":"1944"},{"key":"10.1016\/j.biosystems.2026.105754_bib21","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00422-018-0757-y","article-title":"Trans-algorithmic nature of learning in biological systems","volume":"112","author":"Shimansky","year":"2018","journal-title":"Biol. Cybern."},{"key":"10.1016\/j.biosystems.2026.105754_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00422-010-0387-5","article-title":"Adaptive force produced by stress-induced regulation of random variation\n                            intensity","volume":"103","author":"Shimansky","year":"2010","journal-title":"Biol. Cybern."},{"key":"10.1016\/j.biosystems.2026.105754_bib23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00422-009-0341-6","article-title":"Biologically plausible learning in neural networks: a lesson from bacterial\n                            chemotaxis","volume":"101","author":"Shimansky","year":"2009","journal-title":"Biol. Cybern."},{"key":"10.1016\/j.biosystems.2026.105754_bib24","series-title":"Biological Cybernetics Research Trends","first-page":"95","article-title":"Role of optimization in simple and learning-based adaptation and its biologically\n                            plausible mechanisms","author":"Shimansky","year":"2007"},{"key":"10.1016\/j.biosystems.2026.105754_bib25","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1023\/B:MIND.0000045988.12140.9f","article-title":"The concept of a universal learning system as a basis for creating a general\n                            mathematical theory of learning","volume":"14","author":"Shimansky","year":"2004","journal-title":"Minds Mach."},{"key":"10.1016\/j.biosystems.2026.105754_bib26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00422-003-0452-4","article-title":"A novel model of motor learning capable of developing an optimal movement\n                            trajectory on-line from scratch","volume":"90","author":"Shimansky","year":"2004","journal-title":"Biol. Cybern."},{"key":"10.1016\/j.biosystems.2026.105754_bib27","series-title":"The Origin and Nature of Life on Earth: the Emergence of the Fourth Geosphere","author":"Smith","year":"2016"},{"key":"10.1016\/j.biosystems.2026.105754_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0303-2647(74)90031-8","article-title":"Autopoiesis: the organization of living systems, its characterization and a model","volume":"5","author":"Varela","year":"1974","journal-title":"Biosystems"},{"key":"10.1016\/j.biosystems.2026.105754_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/e24070914","article-title":"Autopoiesis, thermodynamics, and the natural drift of living beings: another way\n                            to the new evolutionary synthesis","volume":"24","author":"Villalobos","year":"2022","journal-title":"Entropy (Basel)"}],"container-title":["BioSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030326472600064X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030326472600064X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:50:24Z","timestamp":1777895424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030326472600064X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":29,"alternative-id":["S030326472600064X"],"URL":"https:\/\/doi.org\/10.1016\/j.biosystems.2026.105754","relation":{},"ISSN":["0303-2647"],"issn-type":[{"value":"0303-2647","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mathematical principle underlying the law\n                            of entropy increase is vital for actively stable lowering of biosystem entropy","name":"articletitle","label":"Article Title"},{"value":"BioSystems","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biosystems.2026.105754","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00c2\u00a9 2026 Elsevier B.V. All rights are reserved,\n                            including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105754"}}