{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:07:49Z","timestamp":1783955269028,"version":"3.55.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["BioSystems"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.biosystems.2026.105850","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:10:02Z","timestamp":1780985402000},"page":"105850","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The central homeorhetic principle: Lipid-organized boundary systems as constraints on cellular state realization"],"prefix":"10.1016","volume":"266","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3873-7350","authenticated-orcid":false,"given":"Cheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.biosystems.2026.105850_bib1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrg.2016.59","article-title":"The molecular hallmarks of epigenetic control","volume":"17","author":"Allis","year":"2016","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev-biochem-052809-155121","article-title":"Mechanisms of membrane curvature sensing","volume":"80","author":"Antonny","year":"2011","journal-title":"Annu. Rev. Biochem."},{"issue":"5","key":"10.1016\/j.biosystems.2026.105850_bib3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrm.2017.7","article-title":"Biomolecular condensates: organizers of cellular biochemistry","volume":"18","author":"Banani","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.biosystems.2026.105850_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrg1272","article-title":"Network biology: understanding the cell's functional organization","volume":"5","author":"Barabasi","year":"2004","journal-title":"Nat. Rev. Genet."},{"issue":"5935","key":"10.1016\/j.biosystems.2026.105850_bib5","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1126\/science.1172046","article-title":"Germline P granules are liquid droplets that localize by controlled dissolution\/condensation","volume":"324","author":"Brangwynne","year":"2009","journal-title":"Science"},{"issue":"13","key":"10.1016\/j.biosystems.2026.105850_bib6","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1073\/pnas.1100498108","article-title":"Physical effects underlying the transition from primitive to modern cell membranes","volume":"108","author":"Budin","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"26","key":"10.1016\/j.biosystems.2026.105850_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ads6132","article-title":"External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics","volume":"11","author":"Chen","year":"2025","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.biosystems.2026.105850_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.molcel.2014.03.030","article-title":"Stress, inflammation, and defense of homeostasis","volume":"54","author":"Chovatiya","year":"2014","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.biosystems.2026.105850_bib9","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium signaling","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"issue":"6000","key":"10.1016\/j.biosystems.2026.105850_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","volume":"330","author":"Coste","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.biosystems.2026.105850_bib12","first-page":"138","article-title":"On Protein Synthesis","volume":"12","author":"Crick","year":"1958","journal-title":"Symp. Soc. Exp. Biol."},{"issue":"5258","key":"10.1016\/j.biosystems.2026.105850_bib11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/227561a0","article-title":"Central dogma of molecular biology","volume":"227","author":"Crick","year":"1970","journal-title":"Nature"},{"issue":"5560","key":"10.1016\/j.biosystems.2026.105850_bib13","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1126\/science.1069981","article-title":"Reverse engineering of biological complexity","volume":"295","author":"Csete","year":"2002","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.biosystems.2026.105850_bib14","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.cell.2018.05.042","article-title":"mTORC1 controls phase separation and the biophysical properties of the cytoplasm by tuning crowding","volume":"174","author":"Delarue","year":"2018","journal-title":"Cell"},{"issue":"7112","key":"10.1016\/j.biosystems.2026.105850_bib15","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature05185","article-title":"Phosphoinositides in cell regulation and membrane dynamics","volume":"443","author":"Di Paolo","year":"2006","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.biosystems.2026.105850_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tcb.2012.09.006","article-title":"Use the force: membrane tension as an organizer of cell shape and motility","volume":"23","author":"Diz-Mu\u00f1oz","year":"2013","journal-title":"Trends Cell Biol."},{"issue":"4","key":"10.1016\/j.biosystems.2026.105850_bib17","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.biosystems.2026.105850_bib18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.plipres.2015.04.003","article-title":"Membrane lipid therapy: modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment","volume":"59","author":"Escrib\u00e1","year":"2015","journal-title":"Prog. Lipid Res."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-biophys-121219-081656","article-title":"Nonequilibrium thermodynamics in cell biology: extending equilibrium formalism to cover living systems","volume":"49","author":"Fang","year":"2020","journal-title":"Annu. Rev. Biophys."},{"issue":"11","key":"10.1016\/j.biosystems.2026.105850_bib20","doi-asserted-by":"crossref","first-page":"R458","DOI":"10.1016\/j.cub.2012.03.045","article-title":"Bistability, bifurcations, and Waddington's epigenetic landscape","volume":"22","author":"Ferrell","year":"2012","journal-title":"Curr. Biol."},{"issue":"7280","key":"10.1016\/j.biosystems.2026.105850_bib21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nature08908","article-title":"Cell mechanics and the cytoskeleton","volume":"463","author":"Fletcher","year":"2010","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0303-2647(75)90038-6","article-title":"Organization of chemical reactions into dividing and metabolizing units: the chemotons","volume":"7","author":"G\u00e1nti","year":"1975","journal-title":"Biosystems"},{"issue":"2124","key":"10.1016\/j.biosystems.2026.105850_bib23","article-title":"Dissipative structures in biological systems: bistability, oscillations, spatial patterns and waves","volume":"376","author":"Goldbeter","year":"2018","journal-title":"Philos. Trans. R. Soc. A Math. Phys. Eng. Sci."},{"issue":"6858","key":"10.1016\/j.biosystems.2026.105850_bib24","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/35101500","article-title":"Morphogen gradient interpretation","volume":"413","author":"Gurdon","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biosystems.2026.105850_bib25","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jconrel.2023.12.020","article-title":"Selective homing of brain-derived reconstituted lipid nanoparticles to cerebral ischemic area enables improved ischemic stroke treatment","volume":"365","author":"Han","year":"2024","journal-title":"J. Contr. Release"},{"issue":"7679","key":"10.1016\/j.biosystems.2026.105850_bib26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature24297","article-title":"Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition","volume":"551","author":"Hangauer","year":"2017","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.biosystems.2026.105850_bib27","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1073\/pnas.1015623108","article-title":"Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair","volume":"108","author":"Harel-Adar","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"7356","key":"10.1016\/j.biosystems.2026.105850_bib28","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nature10317","article-title":"Molecular chaperones in protein folding and proteostasis","volume":"475","author":"Hartl","year":"2011","journal-title":"Nature"},{"issue":"Suppl. 6761","key":"10.1016\/j.biosystems.2026.105850_bib29","doi-asserted-by":"crossref","first-page":"C47","DOI":"10.1038\/35011540","article-title":"From molecular to modular cell biology","volume":"402","author":"Hartwell","year":"1999","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.biosystems.2026.105850_bib30","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.94.128701","article-title":"Cell fates as high-dimensional attractor states of a complex gene regulatory network","volume":"94","author":"Huang","year":"2005","journal-title":"Phys. Rev. Lett."},{"issue":"7","key":"10.1016\/j.biosystems.2026.105850_bib31","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.semcdb.2009.07.003","article-title":"Cancer attractors: a systems view of tumors from a gene network dynamics and developmental perspective","volume":"20","author":"Huang","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"issue":"8089","key":"10.1016\/j.biosystems.2026.105850_bib32","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41586-025-09445-6","article-title":"Mechanical confinement governs phenotypic plasticity in melanoma","volume":"647","author":"Hunter","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.biosystems.2026.105850_bib33","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1039\/f29767201525","article-title":"Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers","volume":"72","author":"Israelachvili","year":"1976","journal-title":"J. Chem. Soc., Faraday Trans. 2: Molecular and Chemical Physics"},{"issue":"3","key":"10.1016\/j.biosystems.2026.105850_bib34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrm1838","article-title":"Cell-signalling dynamics in time and space","volume":"7","author":"Kholodenko","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.biosystems.2026.105850_bib35","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nrg1471","article-title":"Biological robustness","volume":"5","author":"Kitano","year":"2004","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/PL00006283","article-title":"Did archaeal and bacterial cells arise independently from noncellular precursors? A hypothesis stating that the advent of membrane phospholipid with enantiomeric glycerophosphate backbones caused the separation of the two lines of descent","volume":"46","author":"Koga","year":"1998","journal-title":"J. Mol. Evol."},{"issue":"1813","key":"10.1016\/j.biosystems.2026.105850_bib37","article-title":"The extended evolutionary synthesis: its structure, assumptions and predictions","volume":"282","author":"Laland","year":"2015","journal-title":"Proc. Biol. Sci."},{"issue":"15","key":"10.1016\/j.biosystems.2026.105850_bib38","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.devcel.2023.06.001","article-title":"The membrane surface as a platform that organizes cellular and biochemical processes","volume":"58","author":"Leonard","year":"2023","journal-title":"Dev. Cell"},{"issue":"24","key":"10.1016\/j.biosystems.2026.105850_bib39","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1091\/mbc.e13-12-0708","article-title":"Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo","volume":"25","author":"Levin","year":"2014","journal-title":"Mol. Biol. Cell"},{"issue":"3","key":"10.1016\/j.biosystems.2026.105850_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202400196","article-title":"The multiscale wisdom of the body: collective intelligence as a tractable interface for next\u2010generation biomedicine","volume":"47","author":"Levin","year":"2025","journal-title":"Bioessays"},{"issue":"7","key":"10.1016\/j.biosystems.2026.105850_bib41","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrmicro2815","article-title":"The early evolution of lipid membranes and the three domains of life","volume":"10","author":"Lombard","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib42","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0018-506X(02)00024-7","article-title":"The concept of allostasis in biology and biomedicine","volume":"43","author":"McEwen","year":"2003","journal-title":"Horm. Behav."},{"issue":"7068","key":"10.1016\/j.biosystems.2026.105850_bib43","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nature04396","article-title":"Membrane curvature and mechanisms of dynamic cell membrane remodelling","volume":"438","author":"McMahon","year":"2005","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib44","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s42003-024-06037-4","article-title":"Collective intelligence: a unifying concept for integrating biology across scales and substrates","volume":"7","author":"McMillen","year":"2024","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib45","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0092-8674(00)81687-6","article-title":"The road taken: past and future foundations of membrane traffic","volume":"100","author":"Mellman","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.biosystems.2026.105850_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biosystems.2025.105553","article-title":"A biogenic principle within the constructal law: the flow of information in biological systems","author":"Miller","year":"2025","journal-title":"BioSystems"},{"issue":"4","key":"10.1016\/j.biosystems.2026.105850_bib47","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cell.2007.01.028","article-title":"Beyond the sequence: cellular organization of genome function","volume":"128","author":"Misteli","year":"2007","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.biosystems.2026.105850_bib48","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1469-185X.1966.tb01501.x","article-title":"Chemiosmotic coupling in oxidative and photosynthetic phosphorylation","volume":"41","author":"Mitchell","year":"1966","journal-title":"Biol. Rev."},{"key":"10.1016\/j.biosystems.2026.105850_bib49","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jtbi.2015.02.029","article-title":"Biological organisation as closure of constraints","volume":"372","author":"Mont\u00e9vil","year":"2015","journal-title":"J. Theor. Biol."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib50","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1098\/rsfs.2011.0067","article-title":"A theory of biological relativity: no privileged level of causation","volume":"2","author":"Noble","year":"2012","journal-title":"Interface Focus"},{"issue":"7203","key":"10.1016\/j.biosystems.2026.105850_bib51","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/454424a","article-title":"Life, logic and information","volume":"454","author":"Nurse","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib52","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cell.2013.11.028","article-title":"The bacterial cytoplasm has glass-like properties and is fluidized by metabolic activity","volume":"156","author":"Parry","year":"2014","journal-title":"Cell"},{"issue":"5618","key":"10.1016\/j.biosystems.2026.105850_bib53","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1126\/science.1083653","article-title":"Assembly of cell regulatory systems through protein interaction domains","volume":"300","author":"Pawson","year":"2003","journal-title":"Science"},{"issue":"7245","key":"10.1016\/j.biosystems.2026.105850_bib54","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nature08147","article-title":"Emerging roles for lipids in shaping membrane-protein function","volume":"459","author":"Phillips","year":"2009","journal-title":"Nature"},{"issue":"4358","key":"10.1016\/j.biosystems.2026.105850_bib55","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.201.4358.777","article-title":"Time, structure, and fluctuations","volume":"201","author":"Prigogine","year":"1978","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.biosystems.2026.105850_bib56","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2008.09.050","article-title":"Nature, nurture, or chance: stochastic gene expression and its consequences","volume":"135","author":"Raj","year":"2008","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.biosystems.2026.105850_bib57","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1023\/B:ORIG.0000016440.53346.dc","article-title":"A universal definition of life: autonomy and open-ended evolution","volume":"34","author":"Ruiz-Mirazo","year":"2004","journal-title":"Orig. Life Evol. Biosph."},{"issue":"6400","key":"10.1016\/j.biosystems.2026.105850_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/science.aar3958","article-title":"Coactivator condensation at super-enhancers links phase separation and gene control","volume":"361","author":"Sabari","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.biosystems.2026.105850_bib59","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev-biochem-061516-044932","article-title":"Endoplasmic reticulum\u2013plasma membrane contact sites","volume":"86","author":"Saheki","year":"2017","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib60","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/s41467-019-09253-3","article-title":"Coming together to define membrane contact sites","volume":"10","author":"Scorrano","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib61","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1749-6632.2009.04990.x","article-title":"Revisiting the central dogma in the 21st century","volume":"1178","author":"Shapiro","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.biosystems.2026.105850_bib62","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s41589-023-01268-8","article-title":"Membrane phase separation drives responsive assembly of receptor signaling domains","volume":"19","author":"Shelby","year":"2023","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib63","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41556-025-01820-9","article-title":"Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction","volume":"28","author":"Shen","year":"2026","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib64","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1038\/ncomms8219","article-title":"Membrane tension controls the assembly of curvature-generating proteins","volume":"6","author":"Simunovic","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib65","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1038\/s41467-024-47208-5","article-title":"Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2","volume":"15","author":"Sorum","year":"2024","journal-title":"Nat. Commun."},{"issue":"6285","key":"10.1016\/j.biosystems.2026.105850_bib66","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1126\/science.aad9964","article-title":"Phase separation of signaling molecules promotes T cell receptor signal transduction","volume":"352","author":"Su","year":"2016","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.biosystems.2026.105850_bib67","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.celrep.2016.10.033","article-title":"Piezo1 channels are inherently mechanosensitive","volume":"17","author":"Syeda","year":"2016","journal-title":"Cell Rep."},{"issue":"6818","key":"10.1016\/j.biosystems.2026.105850_bib68","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/35053176","article-title":"Synthesizing life","volume":"409","author":"Szostak","year":"2001","journal-title":"Nature"},{"issue":"4345","key":"10.1016\/j.biosystems.2026.105850_bib69","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1126\/science.653353","article-title":"The hydrophobic effect and the organization of living matter","volume":"200","author":"Tanford","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.biosystems.2026.105850_bib70","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2015.11.001","article-title":"Extracellular matrix structure","volume":"97","author":"Theocharis","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.biosystems.2026.105850_bib71","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"Van Meer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.biosystems.2026.105850_bib72","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0303-2647(74)90031-8","article-title":"Autopoiesis: the organization of living systems, its characterization and a model","volume":"5","author":"Varela","year":"1974","journal-title":"Biosystems"},{"issue":"3","key":"10.1016\/j.biosystems.2026.105850_bib73","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bbamcr.2005.06.010","article-title":"Seeing spots: complex phase behavior in simple membranes","volume":"1746","author":"Veatch","year":"2005","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"1","key":"10.1016\/j.biosystems.2026.105850_bib74","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0968-0004(01)02003-5","article-title":"Solute and macromolecule diffusion in cellular aqueous compartments","volume":"27","author":"Verkman","year":"2002","journal-title":"Trends Biochem. Sci."},{"issue":"6","key":"10.1016\/j.biosystems.2026.105850_bib75","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1021\/acs.molpharmaceut.2c01033","article-title":"Reconstituted lipid nanoparticles from cells\/tissues for drug delivery in cancer","volume":"20","author":"Wang","year":"2023","journal-title":"Mol. Pharm."},{"issue":"20","key":"10.1016\/j.biosystems.2026.105850_bib76","doi-asserted-by":"crossref","first-page":"8257","DOI":"10.1073\/pnas.1017017108","article-title":"Quantifying the waddington landscape and biological paths for development and differentiation","volume":"108","author":"Wang","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.biosystems.2026.105850_bib77","doi-asserted-by":"crossref","first-page":"6543","DOI":"10.1073\/pnas.0501844102","article-title":"Developmental plasticity and the origin of species differences","volume":"102","author":"West-Eberhard","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.biosystems.2026.105850_bib78","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nmat3889","article-title":"Mechanical memory and dosing influence stem cell fate","volume":"13","author":"Yang","year":"2014","journal-title":"Nat. Mater."},{"issue":"7846","key":"10.1016\/j.biosystems.2026.105850_bib79","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41586-021-03196-w","article-title":"Visualization of the mechanosensitive ion channel MscS under membrane tension","volume":"590","author":"Zhang","year":"2021","journal-title":"Nature"}],"container-title":["BioSystems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303264726001607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303264726001607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:29:23Z","timestamp":1783952963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303264726001607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":79,"alternative-id":["S0303264726001607"],"URL":"https:\/\/doi.org\/10.1016\/j.biosystems.2026.105850","relation":{},"ISSN":["0303-2647"],"issn-type":[{"value":"0303-2647","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The central homeorhetic principle: Lipid-organized boundary systems as constraints on cellular state realization","name":"articletitle","label":"Article Title"},{"value":"BioSystems","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biosystems.2026.105850","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105850"}}