{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T20:17:21Z","timestamp":1778012241975,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3211,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.cell.2004.10.005","type":"journal-article","created":{"date-parts":[[2005,2,9]],"date-time":"2005-02-09T07:19:40Z","timestamp":1107933580000},"page":"393-405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":268,"title":["Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless"],"prefix":"10.1016","volume":"119","author":[{"given":"Holger","family":"Sondermann","sequence":"first","affiliation":[]},{"given":"Stephen M.","family":"Soisson","sequence":"additional","affiliation":[]},{"given":"Sean","family":"Boykevisch","sequence":"additional","affiliation":[]},{"given":"Shao-Song","family":"Yang","sequence":"additional","affiliation":[]},{"given":"Dafna","family":"Bar-Sagi","sequence":"additional","affiliation":[]},{"given":"John","family":"Kuriyan","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2004.10.005_BIB1","first-page":"45","article-title":"Fluorescence methods in the study of small GTP-binding proteins","volume":"189","author":"Ahmadian","year":"2002","journal-title":"Methods Mol. Biol"},{"key":"10.1016\/j.cell.2004.10.005_BIB2","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0092-8674(94)90271-2","article-title":"Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway","volume":"78","author":"Aronheim","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.cell.2004.10.005_BIB3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/28548","article-title":"The structural basis of the activation of Ras by Sos","volume":"394","author":"Boriack-Sjodin","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cell.2004.10.005_BIB4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","article-title":"Crystallography & NMR system","volume":"54","author":"Br\u00fcnger","year":"1998","journal-title":"Acta Crystallogr. D Biol. Crystallogr"},{"key":"10.1016\/j.cell.2004.10.005_BIB5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0092-8674(93)90146-H","article-title":"Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor","volume":"73","author":"Buday","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.cell.2004.10.005_BIB6","first-page":"2055","article-title":"p21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos\/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus","volume":"13","author":"Byrne","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2004.10.005_BIB7","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1093\/emboj\/16.6.1351","article-title":"The role of the PH domain in the signal-dependent membrane targeting of Sos","volume":"16","author":"Chen","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.cell.2004.10.005_BIB8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrm1365","article-title":"RAS and RHO GTPases in G1-phase cell-cycle regulation","volume":"5","author":"Coleman","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1016\/j.cell.2004.10.005_BIB9","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/MCB.18.2.880","article-title":"Regulation of Sos activity by intramolecular interactions","volume":"18","author":"Corbalan-Garcia","year":"1998","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/j.cell.2004.10.005_BIB10","doi-asserted-by":"crossref","first-page":"15074","DOI":"10.1074\/jbc.M907269199","article-title":"Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding","volume":"275","author":"Das","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.cell.2004.10.005_BIB11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/363045a0","article-title":"Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation","volume":"363","author":"Egan","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.cell.2004.10.005_BIB12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1097-2765(00)00037-X","article-title":"Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains","volume":"6","author":"Ferguson","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2004.10.005_BIB13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/363088a0","article-title":"Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras","volume":"363","author":"Gale","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.cell.2004.10.005_BIB14","doi-asserted-by":"crossref","first-page":"27629","DOI":"10.1074\/jbc.M101727200","article-title":"Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange","volume":"276","author":"Hall","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.cell.2004.10.005_BIB15","doi-asserted-by":"crossref","first-page":"d288","DOI":"10.2741\/hall","article-title":"Autoinhibition of Sos by intramolecular interactions","volume":"7","author":"Hall","year":"2002","journal-title":"Front. Biosci"},{"key":"10.1016\/j.cell.2004.10.005_BIB16","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1093\/emboj\/21.9.2095","article-title":"The complex of Arl2-GTP and PDE delta","volume":"21","author":"Hanzal-Bayer","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.cell.2004.10.005_BIB17","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1038\/sj.onc.1201822","article-title":"Activation of Ras and its downstream extracellular signal-regulated protein kinases by the CDC25 homology domain of mouse Son-of-sevenless 1 (mSos1)","volume":"16","author":"Kim","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2004.10.005_BIB18","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1107\/S0907444996001783","article-title":"Efficient rebuilding of protein structures","volume":"52","author":"Kleywegt","year":"1996","journal-title":"Acta Crystallogr. D. Biol. Crystallogr"},{"key":"10.1016\/j.cell.2004.10.005_BIB19","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0022-2836(02)01136-1","article-title":"Fluorescently labelled guanine nucleotide binding proteins to analyse elementary steps of GAP-catalysed reactions","volume":"324","author":"Kraemer","year":"2002","journal-title":"J. Mol. Biol"},{"key":"10.1016\/j.cell.2004.10.005_BIB20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/363085a0","article-title":"Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling","volume":"363","author":"Li","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.cell.2004.10.005_BIB21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00149-1","article-title":"Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS","volume":"112","author":"Margarit","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.cell.2004.10.005_BIB22","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1126\/science.2406906","article-title":"Molecular switch for signal transduction","volume":"247","author":"Milburn","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.cell.2004.10.005_BIB23","doi-asserted-by":"crossref","unstructured":"Nimnual, A., and Bar-Sagi, D. (2002). The two hats of SOS. Sci STKE 2002, PE36. 10.1126\/stke.2002.145.pe36","DOI":"10.1126\/scisignal.1452002pe36"},{"key":"10.1016\/j.cell.2004.10.005_BIB24","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1126\/science.279.5350.560","article-title":"Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos","volume":"279","author":"Nimnual","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.cell.2004.10.005_BIB25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.cell.2004.10.005_BIB26","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1002\/j.1460-2075.1990.tb07409.x","article-title":"Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 \u00c5 resolution","volume":"9","author":"Pai","year":"1990","journal-title":"EMBO J"},{"key":"10.1016\/j.cell.2004.10.005_BIB27","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1128\/MCB.18.2.771","article-title":"N terminus of Sos1 Ras exchange factor","volume":"18","author":"Qian","year":"1998","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/j.cell.2004.10.005_BIB28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/gene.20054","article-title":"New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function","volume":"39","author":"Silver","year":"2004","journal-title":"Genesis"},{"key":"10.1016\/j.cell.2004.10.005_BIB29","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/ncb1096","article-title":"Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation","volume":"6","author":"Sini","year":"2004","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.cell.2004.10.005_BIB30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0092-8674(00)81756-0","article-title":"Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein","volume":"95","author":"Soisson","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.cell.2004.10.005_BIB31","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.str.2003.10.015","article-title":"Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless","volume":"11","author":"Sondermann","year":"2003","journal-title":"Structure"},{"key":"10.1016\/j.cell.2004.10.005_BIB32","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1126\/science.1062023","article-title":"The guanine nucleotide-binding switch in three dimensions","volume":"294","author":"Vetter","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cell.2004.10.005_BIB33","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/35047014","article-title":"Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1","volume":"408","author":"Worthylake","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cell.2004.10.005_BIB34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/35052073","article-title":"Untangling the ErbB signalling network","volume":"2","author":"Yarden","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867404009511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867404009511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:51:46Z","timestamp":1758797506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867404009511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0092867404009511"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2004.10.005","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2004.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}