{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:42:25Z","timestamp":1772120545925,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computer Methods and Programs in Biomedicine"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.cmpb.2022.107207","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T18:43:07Z","timestamp":1667241787000},"page":"107207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Development of a multimodal machine-learning fusion model to non-invasively assess ileal Crohn\u2019s disease endoscopic activity"],"prefix":"10.1016","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7536-8614","authenticated-orcid":false,"given":"Itai","family":"Guez","sequence":"first","affiliation":[]},{"given":"Gili","family":"Focht","sequence":"additional","affiliation":[]},{"given":"Mary-Louise C.","family":"Greer","sequence":"additional","affiliation":[]},{"given":"Ruth","family":"Cytter-Kuint","sequence":"additional","affiliation":[]},{"given":"Li-Tal","family":"Pratt","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7300-6556","authenticated-orcid":false,"given":"Denise A.","family":"Castro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5160-868X","authenticated-orcid":false,"given":"Dan","family":"Turner","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8623-4665","authenticated-orcid":false,"given":"Anne M.","family":"Griffiths","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1083-1548","authenticated-orcid":false,"given":"Moti","family":"Freiman","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"10114","key":"10.1016\/j.cmpb.2022.107207_bib0001","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"The Lancet"},{"issue":"2","key":"10.1016\/j.cmpb.2022.107207_bib0002","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.disamonth.2017.07.001","article-title":"A comprehensive review and update on crohn\u2019s disease","volume":"64","author":"Gajendran","year":"2018","journal-title":"Disease-a-month"},{"issue":"20","key":"10.1016\/j.cmpb.2022.107207_bib0003","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.3748\/wjg.v22.i20.4794","article-title":"Inflammatory bowel disease and cancer: the role of inflammation, immunosuppression, and cancer treatment","volume":"22","author":"Axelrad","year":"2016","journal-title":"World journal of gastroenterology"},{"issue":"4","key":"10.1016\/j.cmpb.2022.107207_bib0004","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0016-5107(04)01878-4","article-title":"Development and validation of a new, simplified endoscopic activity score for crohn\u2019s disease: the ses-cd","volume":"60","author":"Daperno","year":"2004","journal-title":"Gastrointestinal endoscopy"},{"issue":"9","key":"10.1016\/j.cmpb.2022.107207_bib0005","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/ecco-jcc\/jjw120","article-title":"Effect of standardised scoring conventions on inter-rater reliability in the endoscopic evaluation of crohn\u2019s disease","volume":"10","author":"Dubcenco","year":"2016","journal-title":"Journal of Crohn\u2019s and Colitis"},{"issue":"10","key":"10.1016\/j.cmpb.2022.107207_bib0006","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1097\/MIB.0000000000000131","article-title":"A systematic review of measurement of endoscopic disease activity and mucosal healing in crohn\u2019s disease: recommendations for clinical trial design","volume":"20","author":"Khanna","year":"2014","journal-title":"Inflammatory bowel diseases"},{"issue":"7","key":"10.1016\/j.cmpb.2022.107207_bib0007","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1136\/gutjnl-2014-308973","article-title":"Reliability among central readers in the evaluation of endoscopic findings from patients with crohn\u2019s disease","volume":"65","author":"Khanna","year":"2016","journal-title":"Gut"},{"issue":"23","key":"10.1016\/j.cmpb.2022.107207_bib0008","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.3748\/wjg.v19.i23.3596","article-title":"Risk factors for colonoscopic perforation: a population-based study of 80118 cases","volume":"19","author":"Hamdani","year":"2013","journal-title":"World Journal of Gastroenterology: WJG"},{"issue":"10","key":"10.1016\/j.cmpb.2022.107207_bib0009","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nrgastro.2016.128","article-title":"Current best practice for disease activity assessment in ibd","volume":"13","author":"Walsh","year":"2016","journal-title":"Nature reviews Gastroenterology & hepatology"},{"issue":"7","key":"10.1016\/j.cmpb.2022.107207_bib0010","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.cgh.2018.03.034","article-title":"Is the objective of treatment for crohn\u2019s disease mucosal or transmural healing?","volume":"16","author":"Pan\u00e9s","year":"2018","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"2","key":"10.1016\/j.cmpb.2022.107207_bib0011","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/ibd\/izx040","article-title":"Reliability of measuring ileo-colonic disease activity in crohn\u2019s disease by magnetic resonance enterography","volume":"24","author":"Jairath","year":"2018","journal-title":"Inflammatory bowel diseases"},{"issue":"5","key":"10.1016\/j.cmpb.2022.107207_bib0012","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00247-017-3790-4","article-title":"Magnetic resonance enterography has good inter-rater agreement and diagnostic accuracy for detecting inflammation in pediatric crohn disease","volume":"47","author":"Church","year":"2017","journal-title":"Pediatric radiology"},{"key":"10.1016\/j.cmpb.2022.107207_bib0013","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2022.07.048","article-title":"Development, validation and evaluation of the pediatric inflammatory crohn\u2019s magnetic resonance enterography index (picmi) from the imagekids study","author":"Focht","year":"2022","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.cmpb.2022.107207_bib0014","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1053\/j.gastro.2017.11.274","article-title":"Consensus recommendations for evaluation, interpretation, and utilization of computed tomography and magnetic resonance enterography in patients with small bowel crohn\u2019s disease","volume":"154","author":"Bruining","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cmpb.2022.107207_bib0015","doi-asserted-by":"crossref","DOI":"10.1177\/1756284818765956","article-title":"A review of magnetic resonance enterography-based indices for quantification of crohn\u2019s disease inflammation","volume":"11","author":"Rozendorn","year":"2018","journal-title":"Therapeutic advances in gastroenterology"},{"issue":"8","key":"10.1016\/j.cmpb.2022.107207_bib0016","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1002\/ibd.21551","article-title":"Magnetic resonance imaging for evaluation of crohn\u2019s disease: validation of parameters of severity and quantitative index of activity","volume":"17","author":"Rimola","year":"2011","journal-title":"Inflammatory bowel diseases"},{"key":"10.1016\/j.cmpb.2022.107207_bib0017","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1007\/s00261-020-02590-8","article-title":"Assessment of pediatric crohn\u2019s disease activity: validation of the magnetic resonance enterography global score (megs) against endoscopic activity score (ses-cd)","volume":"45","author":"Zheng","year":"2020","journal-title":"Abdominal Radiology"},{"issue":"2","key":"10.1016\/j.cmpb.2022.107207_bib0018","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00330-013-3010-z","article-title":"Evaluation of crohn\u2019s disease activity: initial validation of a magnetic resonance enterography global score (megs) against faecal calprotectin","volume":"24","author":"Makanyanga","year":"2014","journal-title":"European radiology"},{"issue":"1","key":"10.1016\/j.cmpb.2022.107207_bib0019","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/gutjnl-2018-317987","article-title":"Designing clinical trials in paediatric inflammatory bowel diseases: a pibdnet commentary","volume":"69","author":"Turner","year":"2020","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.cmpb.2022.107207_bib0020","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/MPG.0000000000002404","article-title":"Simple endoscopic score of crohn disease and magnetic resonance enterography in children: report from imagekids study","volume":"69","author":"Weiss","year":"2019","journal-title":"Journal of pediatric gastroenterology and nutrition"},{"issue":"6","key":"10.1016\/j.cmpb.2022.107207_bib0021","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3390\/diagnostics10060367","article-title":"Biochemical biomarkers of mucosal healing for inflammatory bowel disease in adults","volume":"10","author":"Krzystek-Korpacka","year":"2020","journal-title":"Diagnostics"},{"key":"10.1016\/j.cmpb.2022.107207_bib0022","doi-asserted-by":"crossref","first-page":"101602","DOI":"10.1016\/j.bpg.2019.02.004","article-title":"What is the role of c-reactive protein and fecal calprotectin in evaluating crohn\u2019s disease activity?","volume":"38","author":"Ma","year":"2019","journal-title":"Best Practice & Research Clinical Gastroenterology"},{"issue":"1","key":"10.1016\/j.cmpb.2022.107207_bib0023","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1053\/j.gastro.2019.08.058","article-title":"Application of artificial intelligence to gastroenterology and hepatology","volume":"158","author":"Le Berre","year":"2020","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.cmpb.2022.107207_bib0024","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41575-019-0102-5","article-title":"Big data in ibd: a look into the future","volume":"16","author":"Olivera","year":"2019","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"issue":"8","key":"10.1016\/j.cmpb.2022.107207_bib0025","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1136\/gutjnl-2019-320065","article-title":"Big data in ibd: big progress for clinical practice","volume":"69","author":"Seyed Tabib","year":"2020","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.cmpb.2022.107207_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41746-020-00341-z","article-title":"Fusion of medical imaging and electronic health records using deep learning: a systematic review and implementation guidelines","volume":"3","author":"Huang","year":"2020","journal-title":"NPJ digital medicine"},{"key":"10.1016\/j.cmpb.2022.107207_bib0027","unstructured":"https:\/\/www.clinicaltrials.gov\/ct2\/show\/study\/nct01881490."},{"issue":"7","key":"10.1016\/j.cmpb.2022.107207_bib0028","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.cgh.2018.01.024","article-title":"Associations among mucosal and transmural healing and fecal level of calprotectin in children with crohn\u2019s disease","volume":"16","author":"Weinstein-Nakar","year":"2018","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"4","key":"10.1016\/j.cmpb.2022.107207_bib0029","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0016-5107(04)01878-4","article-title":"Development and validation of a new, simplified endoscopic activity score for crohn\u2019s disease: the ses-cd","volume":"60","author":"Daperno","year":"2004","journal-title":"Gastrointestinal endoscopy"},{"issue":"1","key":"10.1016\/j.cmpb.2022.107207_bib0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests","volume":"45","author":"Breiman","year":"2001","journal-title":"Machine learning"},{"key":"10.1016\/j.cmpb.2022.107207_bib0031","unstructured":"https:\/\/www.scikit-learn.org\/stable\/auto_examples\/ensemble\/plot_forest_importances.html."},{"key":"10.1016\/j.cmpb.2022.107207_bib0032","series-title":"Breakthroughs in statistics","first-page":"196","article-title":"Individual comparisons by ranking methods","author":"Wilcoxon","year":"1992"},{"issue":"4","key":"10.1016\/j.cmpb.2022.107207_bib0033","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/biomet\/75.4.800","article-title":"A sharper bonferroni procedure for multiple tests of significance","volume":"75","author":"Hochberg","year":"1988","journal-title":"Biometrika"},{"key":"10.1016\/j.cmpb.2022.107207_bib0034","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.cmpb.2022.107207_bib0035","first-page":"2825","article-title":"Scikit-learn: Machine learning in python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"the Journal of machine Learning research"},{"issue":"5","key":"10.1016\/j.cmpb.2022.107207_bib0036","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00535-016-1253-6","article-title":"Comparison of three magnetic resonance enterography indices for grading activity in crohn\u2019s disease","volume":"52","author":"Rimola","year":"2017","journal-title":"Journal of gastroenterology"},{"issue":"9","key":"10.1016\/j.cmpb.2022.107207_bib0037","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/ajg.2015.233","article-title":"Selecting therapeutic targets in inflammatory bowel disease (stride): determining therapeutic goals for treat-to-target","volume":"110","author":"Peyrin-Biroulet","year":"2015","journal-title":"Official journal of the American College of Gastroenterology| ACG"},{"issue":"1","key":"10.1016\/j.cmpb.2022.107207_bib0038","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ajg.2009.545","article-title":"Fecal calprotectin correlates more closely with the simple endoscopic score for crohn\u2019s disease (ses-cd) than crp, blood leukocytes, and the cdai","volume":"105","author":"Schoepfer","year":"2010","journal-title":"Official journal of the American College of Gastroenterology| ACG"},{"issue":"2","key":"10.1016\/j.cmpb.2022.107207_bib0039","doi-asserted-by":"crossref","first-page":"353","DOI":"10.5114\/aoms.2014.43672","article-title":"Is faecal calprotectin equally useful in all crohn\u2019s disease locations? a prospective, comparative study","volume":"11","author":"Stawczyk-Eder","year":"2015","journal-title":"Archives of Medical Science"},{"issue":"7","key":"10.1016\/j.cmpb.2022.107207_bib0040","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1007\/s00330-015-4036-1","article-title":"Monitoring crohn\u2019s disease during anti-tnf-\u03b1 therapy: validation of the magnetic resonance enterography global score (megs) against a combined clinical reference standard","volume":"26","author":"Prezzi","year":"2016","journal-title":"European radiology"},{"issue":"3","key":"10.1016\/j.cmpb.2022.107207_bib0041","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1148\/radiol.2513081184","article-title":"Crohn disease of the small bowel: comparison of ct enterography, mr enterography, and small-bowel follow-through as diagnostic techniques","volume":"251","author":"Lee","year":"2009","journal-title":"Radiology"}],"container-title":["Computer Methods and Programs in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260722005880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260722005880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:13:44Z","timestamp":1759205624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169260722005880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":41,"alternative-id":["S0169260722005880"],"URL":"https:\/\/doi.org\/10.1016\/j.cmpb.2022.107207","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.29.21262424","asserted-by":"object"}]},"ISSN":["0169-2607"],"issn-type":[{"value":"0169-2607","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a multimodal machine-learning fusion model to non-invasively assess ileal Crohn\u2019s disease endoscopic activity","name":"articletitle","label":"Article Title"},{"value":"Computer Methods and Programs in Biomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmpb.2022.107207","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107207"}}