{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T11:13:27Z","timestamp":1720610007781},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Deanship of Scientific Research and The Jordanian Scientific Research Fund for their generous funds"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.compbiolchem.2017.10.003","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T03:02:11Z","timestamp":1507863731000},"page":"170-179","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Ligand-based computational modelling of platelet-derived growth factor beta receptor leading to new angiogenesis inhibitory leads"],"prefix":"10.1016","volume":"71","author":[{"given":"Rua\u2019a A.","family":"Al-Aqtash","sequence":"first","affiliation":[]},{"given":"Malek A.","family":"Zihlif","sequence":"additional","affiliation":[]},{"given":"Hana","family":"Hammad","sequence":"additional","affiliation":[]},{"given":"Zeyad D.","family":"Nassar","sequence":"additional","affiliation":[]},{"given":"Jehad Al","family":"Meliti","sequence":"additional","affiliation":[]},{"given":"Mutasem O.","family":"Taha","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.compbiolchem.2017.10.003_bib0005","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s10822-013-9699-6","article-title":"Elaborate ligand-based modeling coupled with QSAR analysis and in silico screening reveal new potent acetylcholinesterase inhibitors","volume":"27","author":"Abuhamdah","year":"2013","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"5","key":"10.1016\/j.compbiolchem.2017.10.003_bib0010","first-page":"509","article-title":"Innovative computer-aided methods for the discovery of new kinase ligands","volume":"8","author":"Abuhammad","year":"2016","journal-title":"Future"},{"key":"10.1016\/j.compbiolchem.2017.10.003_bib0015","doi-asserted-by":"crossref","DOI":"10.1002\/jmr.2644","article-title":"Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus","author":"Abuhammad","year":"2017","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.compbiolchem.2017.10.003_bib0020","first-page":"1","article-title":"Angiogenesis","volume":"Vol. 2","author":"Adair","year":"2010"},{"issue":"4","key":"10.1016\/j.compbiolchem.2017.10.003_bib0025","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/s00044-012-0204-x","article-title":"Ligand-based pharmacophore exploration and QSAR analysis of transition state analogues followed by in silico screening guide the discovery of new sub-micromolar \u03b2-secreatase inhibitors","volume":"22","author":"Al-Nadaf","year":"2013","journal-title":"Med. Chem. Res."},{"issue":"9","key":"10.1016\/j.compbiolchem.2017.10.003_bib0030","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1016\/j.bmc.2010.03.043","article-title":"Elaborate ligand-based pharmacophore exploration and QSAR analysis guide the synthesis of novel pyridinium-based potent \u03b2-secretase inhibitory leads","volume":"18","author":"Al-Nadaf","year":"2010","journal-title":"Bioorg. Med. Chem."},{"issue":"6","key":"10.1016\/j.compbiolchem.2017.10.003_bib0035","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1016\/j.ejmech.2011.03.040","article-title":"Discovery of new nanomolar peroxisome proliferator-activated receptor \u03b3 activators via elaborate ligand-based modeling","volume":"46","author":"Al-Najjar","year":"2011","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.compbiolchem.2017.10.003_bib0040","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1021\/ci100222k","article-title":"Elaborate ligand-based modeling reveals new nanomolar heat shock protein 90\u03b1 inhibitors","volume":"50","author":"Al-Sha\u2019er","year":"2010","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"10.1016\/j.compbiolchem.2017.10.003_bib0045","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1007\/s00894-014-2080-4","article-title":"Discovery of novel urokinase plasminogen activator (uPA) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis","volume":"20","author":"Al-Sha\u2019er","year":"2014","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.compbiolchem.2017.10.003_bib0050","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ejmech.2016.01.034","article-title":"Ligand-based modeling of diverse aryalkylamines yields new potent P-glycoprotein inhibitors","volume":"110","author":"AlQudah","year":"2016","journal-title":"Eur. J. Med. Chem."},{"issue":"15","key":"10.1016\/j.compbiolchem.2017.10.003_bib0055","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.4155\/fmc-2016-0056","article-title":"Computer-aided discovery of new FGFR-1 inhibitors followed by in vitro validation","volume":"8","author":"Alabed","year":"2016","journal-title":"Future Med. Chem."},{"issue":"10","key":"10.1016\/j.compbiolchem.2017.10.003_bib0060","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1101\/gad.1653708","article-title":"Role of platelet-derived growth factors in physiology and medicine","volume":"22","author":"Andrae","year":"2008","journal-title":"Genes. Dev."},{"issue":"6835","key":"10.1016\/j.compbiolchem.2017.10.003_bib0065","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/35077225","article-title":"Oncogenic kinase signalling","volume":"411","author":"Blume-Jensen","year":"2001","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.compbiolchem.2017.10.003_bib0070","first-page":"539","article-title":"A novel in vitro assay for human angiogenesis","volume":"75","author":"Brown","year":"1996","journal-title":"Lab. Invest."},{"issue":"11","key":"10.1016\/j.compbiolchem.2017.10.003_bib0075","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1200\/JCO.2007.14.5375","article-title":"Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane","volume":"26","author":"Burstein","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.compbiolchem.2017.10.003_bib0080","article-title":"Arteriogenesis versus angiogenesis","volume":"Vol.105","author":"Carmeliet","year":"2017"},{"issue":"10","key":"10.1016\/j.compbiolchem.2017.10.003_bib0085","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1016\/j.bbapap.2012.10.015","article-title":"Platelet-derived growth factors and their receptors: structural and functional perspectives","volume":"1834","author":"Chen","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.compbiolchem.2017.10.003_bib0090","series-title":"Molecular Descriptors Guide. Version 1.0","author":"China Computational Biology Drug Design Group","year":"2012"},{"key":"10.1016\/j.compbiolchem.2017.10.003_bib0095","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-cellbio-092910-154002","article-title":"Developmental and pathological angiogenesis","volume":"27","author":"Chung","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"7","key":"10.1016\/j.compbiolchem.2017.10.003_bib0100","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1517\/13543776.2010.493559","article-title":"Platelet-derived growth factor receptor tyrosine kinase inhibitors: a review of the recent patent literature","volume":"20","author":"Dai","year":"2010","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.compbiolchem.2017.10.003_bib0105","series-title":"Endothelial Signaling in Development and Disease","first-page":"65","article-title":"Pericytes in vascular development and function","author":"Daneman","year":"2015"},{"key":"10.1016\/j.compbiolchem.2017.10.003_bib0110","series-title":"Discovery Studio User Guide","author":"Discovery Studio User Guide","year":"2005"},{"issue":"5","key":"10.1016\/j.compbiolchem.2017.10.003_bib0115","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1161\/ATVBAHA.107.161521","article-title":"Endothelial-mural cell signaling in vascular development and angiogenesis","volume":"29","author":"Gaengel","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"23","key":"10.1016\/j.compbiolchem.2017.10.003_bib0120","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1016\/j.bmc.2003.08.034","article-title":"Antiangiogenic and antitumor agents: design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo [2,3-d] pyrimidines as inhibitors of receptor tyrosine kinases","volume":"11","author":"Gangjee","year":"2003","journal-title":"Bioorg. Med. Chem."},{"issue":"5","key":"10.1016\/j.compbiolchem.2017.10.003_bib0125","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.bmc.2012.12.045","volume":"21","author":"Gangjee","year":"2013","journal-title":"Bioorg. Med. Chem."},{"issue":"11","key":"10.1016\/j.compbiolchem.2017.10.003_bib0130","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1021\/jm950727b","article-title":"Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins","volume":"39","author":"Gazit","year":"1996","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.compbiolchem.2017.10.003_bib0135","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/S0968-0896(03)00048-8","article-title":"Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit","volume":"11","author":"Gazit","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.compbiolchem.2017.10.003_bib0140","series-title":"Pharmacophore Perception, Development, and Use in Drug Design","first-page":"29","author":"Guner","year":"2000"},{"issue":"8","key":"10.1016\/j.compbiolchem.2017.10.003_bib0145","doi-asserted-by":"crossref","first-page":"a009100","DOI":"10.1101\/cshperspect.a009100","article-title":"Structural and functional properties of platelet-derived growth factor and stem cell factor receptors","volume":"5","author":"Heldin","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"3","key":"10.1016\/j.compbiolchem.2017.10.003_bib0150","doi-asserted-by":"crossref","first-page":"e9430","DOI":"10.1371\/journal.pone.0009430","article-title":"Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model","volume":"5","author":"Humbert","year":"2010","journal-title":"PLoS One"},{"issue":"17","key":"10.1016\/j.compbiolchem.2017.10.003_bib0155","first-page":"6534","article-title":"Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model","volume":"9","author":"Hwang","year":"2003","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.compbiolchem.2017.10.003_bib0160","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00894-010-0737-1","article-title":"Discovery of new \u03b2-D-glucosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening","volume":"17","author":"Khalaf","year":"2011","journal-title":"J. Mol. Model."},{"issue":"10","key":"10.1016\/j.compbiolchem.2017.10.003_bib0165","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1021\/ci4003798","article-title":"Elaborate ligand-based modeling coupled with multiple linear regression and k nearest neighbor QSAR analyses unveiled new nanomolar mTOR inhibitors","volume":"53","author":"Khanfar","year":"2013","journal-title":"J. Chem. Inf. Model."},{"issue":"9","key":"10.1016\/j.compbiolchem.2017.10.003_bib0170","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2174\/0929867013372481","article-title":"Pharmacophore modeling and three-dimensional database searching for drug design using catalyst","volume":"8","author":"Kurogi","year":"2001","journal-title":"Curr. Med. Chem."},{"issue":"2","key":"10.1016\/j.compbiolchem.2017.10.003_bib0175","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11912-007-0003-6","article-title":"The platelet-derived growth factor receptor as a therapeutic target","volume":"9","author":"Lewis","year":"2007","journal-title":"Curr. Oncol. Rep."},{"issue":"10","key":"10.1016\/j.compbiolchem.2017.10.003_bib0180","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1002\/cncr.20634","article-title":"Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors","volume":"101","author":"Li","year":"2004","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.compbiolchem.2017.10.003_bib0185","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1021\/jm010988n","article-title":"Bis (1 H-2-indolyl) methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase","volume":"45","author":"Mahboobi","year":"2002","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.compbiolchem.2017.10.003_bib0190","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/j.bmc.2006.12.011","article-title":"Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis (benzo [b] furan-2-yl) methanones","volume":"15","author":"Mahboobi","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.compbiolchem.2017.10.003_bib0195","first-page":"17","article-title":"Pharmacophore model generation software tools","volume":"32","author":"Poptodorov","year":"2006","journal-title":"Methods Princ. Med. Chem."},{"issue":"3","key":"10.1016\/j.compbiolchem.2017.10.003_bib0200","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3390\/ph3030572","article-title":"Platelet-derived growth factor (PDGF)\/PDGF receptors (PDGFR) axis as target for antitumor and antiangiogenic therapy","volume":"3","author":"Raica","year":"2010","journal-title":"Pharmaceuticals"},{"issue":"2","key":"10.1016\/j.compbiolchem.2017.10.003_bib0205","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.yexcr.2014.11.014","article-title":"Tryptase, a novel angiogenic factor stored in mast cell granules","volume":"332","author":"Ribatti","year":"2015","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.compbiolchem.2017.10.003_bib0210","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1387\/ijdb.103167dr","article-title":"The role of pericytes in angiogenesis","volume":"55","author":"Ribatti","year":"2011","journal-title":"Int. J. Dev. Biol."},{"issue":"22","key":"10.1016\/j.compbiolchem.2017.10.003_bib0215","doi-asserted-by":"crossref","first-page":"11608","DOI":"10.1074\/jbc.M115.705814","article-title":"The ubiquitin ligases c-cbl and cbl-b negatively regulate platelet-derived growth factor (pdgf) bb-induced chemotaxis by affecting pdgf receptor pdgfr internalization and signaling","volume":"291","author":"Rorsman","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.compbiolchem.2017.10.003_bib0220","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbrc.2007.02.156","article-title":"Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor","volume":"356","author":"Roskoski","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.compbiolchem.2017.10.003_bib0225","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10822-011-9509-y","article-title":"Elaborate ligand-based modeling reveal new submicromolar Rho kinase inhibitors","volume":"26","author":"Shahin","year":"2012","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"25","key":"10.1016\/j.compbiolchem.2017.10.003_bib0230","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1021\/jm061103g","article-title":"Interpreting steep dose-response curves in early inhibitor discovery","volume":"49","author":"Shoichet","year":"2006","journal-title":"J. Med. Chem."},{"issue":"11","key":"10.1016\/j.compbiolchem.2017.10.003_bib0235","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1158\/1535-7163.MCT-11-0312","article-title":"Targeting FGFR\/PDGFR\/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer","volume":"10","author":"Taeger","year":"2011","journal-title":"Mol. Cancer Ther."},{"issue":"7","key":"10.1016\/j.compbiolchem.2017.10.003_bib0240","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ejmech.2004.10.014","article-title":"Ligand-based assessment of factor Xa binding site flexibility via elaborate pharmacophore exploration and genetic algorithm-based QSAR modeling","volume":"40","author":"Taha","year":"2005","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.compbiolchem.2017.10.003_bib0245","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ejmech.2004.10.014","article-title":"Ligand-based assessment of factor Xa binding site flexibility via elaborate pharmacophore exploration and genetic algorithm-based QSAR modeling","volume":"40","author":"Taha","year":"2005","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.compbiolchem.2017.10.003_bib0250","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1021\/jm7009765","article-title":"Pharmacophore modeling, quantitative structure\u2013activity relationship analysis, and in silico screening reveal potent glycogen synthase kinase-3\u03b2 inhibitory activities for cimetidine, hydroxychloroquine, and gemifloxacin","volume":"51","author":"Taha","year":"2008","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.compbiolchem.2017.10.003_bib0255","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.bmc.2007.10.076","article-title":"Discovery of new murf inhibitors via pharmacophore modeling and QSAR analysis followed by in-silico screening","volume":"16","author":"Taha","year":"2008","journal-title":"Bioorg. Med. Chem."},{"issue":"20","key":"10.1016\/j.compbiolchem.2017.10.003_bib0260","doi-asserted-by":"crossref","first-page":"6478","DOI":"10.1021\/jm800718k","article-title":"Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors","volume":"51","author":"Taha","year":"2008","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.compbiolchem.2017.10.003_bib0265","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1747-0285.2011.01160.x","article-title":"Discovery of new antifungal leads via pharmacophore modeling and qsar analysis of fungal n-myristoyl transferase inhibitors followed by in silico screening","volume":"78","author":"Taha","year":"2011","journal-title":"Chem. Biol. Drug Des."},{"issue":"3","key":"10.1016\/j.compbiolchem.2017.10.003_bib0270","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1021\/ci100368t","article-title":"Docking-based comparative intermolecular contacts analysis as new 3-D QSAR concept for validating docking studies and in silico screening: NMT and GP inhibitors as case studies","volume":"51","author":"Taha","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.compbiolchem.2017.10.003_bib0275","doi-asserted-by":"crossref","DOI":"10.5772\/2049","article-title":"Mixing pharmacophore modeling and classical QSAR analysis as powerful tool for lead discovery","author":"Taha","year":"2012","journal-title":"Virtual Screen. InTech."},{"issue":"7","key":"10.1016\/j.compbiolchem.2017.10.003_bib0280","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1021\/jm049092j","article-title":"Virtual screening workflow development guided by the receiver operating characteristic curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4","volume":"48","author":"Triballeau","year":"2005","journal-title":"J. Med. Chem."},{"issue":"18","key":"10.1016\/j.compbiolchem.2017.10.003_bib0285","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1161\/01.CIR.103.18.2242","article-title":"Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFD genes","volume":"103","author":"Uutela","year":"2001","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.compbiolchem.2017.10.003_bib0290","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/micc.12229","article-title":"Angiogenesis revisited: an overlooked role of endothelial cell metabolism in vessel sprouting","volume":"22","author":"Vandekeere","year":"2015","journal-title":"Microcirculation"},{"issue":"4","key":"10.1016\/j.compbiolchem.2017.10.003_bib0295","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrd1063","article-title":"Designing screens:how to make your hits a hit","volume":"2","author":"Walters","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.compbiolchem.2017.10.003_bib0300","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cell.2014.01.066","article-title":"Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor \u03b2 signaling","volume":"157","author":"Weissmueller","year":"2014","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.compbiolchem.2017.10.003_bib0305","first-page":"XE01","article-title":"Tumour angiogenesis and angiogenic inhibitors: a review","volume":"9","author":"Yadav","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"issue":"6","key":"10.1016\/j.compbiolchem.2017.10.003_bib0310","first-page":"XE01","article-title":"Tumour angiogenesis and angiogenic inhibitors: a review","volume":"9","author":"Yadav","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"issue":"1","key":"10.1016\/j.compbiolchem.2017.10.003_bib0315","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1021\/ci980033m","article-title":"Novel variable selection quantitative structure- property relationship approach based on the k-nearest-neighbor principle","volume":"40","author":"Zheng","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927117305558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927117305558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T14:55:39Z","timestamp":1538664939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927117305558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":63,"alternative-id":["S1476927117305558"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2017.10.003","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ligand-based computational modelling of platelet-derived growth factor beta receptor leading to new angiogenesis inhibitory leads","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2017.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}