{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:23:36Z","timestamp":1778617416672,"version":"3.51.4"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["408502\/2023"],"award-info":[{"award-number":["408502\/2023"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.compbiolchem.2025.108801","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T16:25:20Z","timestamp":1764001520000},"page":"108801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Functional profiling of the chaperone systems interactome in breast cancer using experimental and machine-learning data"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8934-7630","authenticated-orcid":false,"given":"Alexandre Luiz Korte de","family":"Azevedo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateus Vinicius Oliveira","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enilze Maria de Souza Fonseca","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talita Helen Bombardelli","family":"Gomig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiolchem.2025.108801_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.829520","article-title":"HSP70 and HSP90 in cancer: cytosolic, endoplasmic reticulum and mitochondrial chaperones of tumorigenesis","volume":"12","author":"Albakova","year":"2022","journal-title":"Front Oncol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23147792","article-title":"The chaperone system in breast cancer: roles and therapeutic prospects of the molecular chaperones Hsp27, Hsp60, Hsp70, and Hsp90","volume":"23","author":"Alberti","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells9081844","article-title":"Glucose-regulated protein 94 (GRP94): A novel regulator of insulin-like growth factor production","volume":"9","author":"Argon","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/08977190400020229","article-title":"The IGF-1 receptor and its contributions to metastatic tumor growth - novel approaches to the inhibition of IGF-1R function","volume":"23","author":"B\u00e4hr","year":"2005","journal-title":"Growth Factors"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12113271","article-title":"Breast cancer heterogeneity and response to novel therapeutics","volume":"12","author":"Baliu-Piqu\u00e9","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2021.103246","article-title":"The facilitates chromatin transcription (FACT) complex: its roles in DNA repair and implications for cancer therapy","volume":"109","author":"Bhakat","year":"2022","journal-title":"DNA Repair (Amst. )"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/1873-3468.14682","article-title":"The roles of molecular chaperones in regulating cell metabolism","volume":"597","author":"Binder","year":"2023","journal-title":"FEBS Lett."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib8","first-page":"2729","article-title":"Role of hsp90 in cancer","volume":"431","author":"Birbo","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib9","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib10","article-title":"The Src-family kinase lyn in immunoreceptor signaling","volume":"162","author":"Brian","year":"2021","journal-title":"Endocrinol. (U. S. )"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib11","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbac059","article-title":"ProteinPrompt: a webserver for predicting protein-protein interactions","volume":"2","author":"Canzler","year":"2022","journal-title":"Bioinforma. Adv."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1321654","article-title":"Editorial: Heterogeneity in breast cancer: clinical and therapeutic implications","volume":"14","author":"Carlino","year":"2024","journal-title":"Front Oncol."},{"issue":"43","key":"10.1016\/j.compbiolchem.2025.108801_bib13","doi-asserted-by":"crossref","first-page":"73947","DOI":"10.18632\/oncotarget.18166","article-title":"Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth","volume":"8","author":"Carpenter","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108801_bib14","first-page":"196","article-title":"Upregulation of RPA2 promotes NF-\u03baB activation in breast cancer by relieving the antagonistic function of menin on NF-\u03baB-regulated transcription","volume":"38","author":"Chen","year":"2016","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib15","article-title":"Chaperone-mediated autophagy promotes breast cancer angiogenesis via regulation of aerobic glycolysis","volume":"18","author":"Chen","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib16","article-title":"Protein homeostasis in aging and cancer","volume":"11","author":"Chen","year":"2023","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib17","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.860320","article-title":"Heat shock proteins and HSF1 in cancer","volume":"12","author":"Cyran","year":"2022","journal-title":"Front Oncol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib19","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-024-02976-2","article-title":"The synergism of SMC1A cohesin gene silencing and bevacizumab against colorectal cancer","volume":"43","author":"Di Nardo","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib20","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1016\/j.jmb.2019.05.026","article-title":"Intermolecular Interactions between Hsp90 and Hsp70","volume":"431","author":"Doyle","year":"2019","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41408-023-00790-1","article-title":"Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome","volume":"13","author":"Eckardt","year":"2023","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib22","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11427-016-5029-2","article-title":"Emerging roles of NudC family: from molecular regulation to clinical implications","volume":"59","author":"Fu","year":"2016","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.540134","article-title":"Quantitative proteomic profiling identifies a potential novel chaperone marker in resistant breast cancer","volume":"11","author":"Gallegos","year":"2021","journal-title":"Front Oncol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-51406-y","article-title":"Regulation of mitochondrial metabolism by autophagy supports leptin-induced cell migration","volume":"14","author":"Garc\u00eda-Miranda","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2020.00172","article-title":"The molecular chaperone CCT\/TRiC: an essential component of proteostasis and a potential modulator of protein aggregation","volume":"11","author":"Grantham","year":"2020","journal-title":"Front Genet"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib26","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11684-015-0416-9","article-title":"Function of slit\/robo signaling in breast cancer","volume":"9","author":"Gu","year":"2015","journal-title":"Front Med"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib27","doi-asserted-by":"crossref","first-page":"12900","DOI":"10.1074\/jbc.RA120.013364","article-title":"The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients","volume":"295","author":"Guo","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib28","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm.2016.159","article-title":"Histone chaperone networks shaping chromatin function","volume":"18","author":"Hammond","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib29","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.bbamcr.2011.08.013","article-title":"Approaches for defining the Hsp90-dependent proteome","volume":"1823","author":"Hartson","year":"2012","journal-title":"Biochim Biophys. Acta Mol. Cell Res"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib30","doi-asserted-by":"crossref","first-page":"679","DOI":"10.18632\/oncotarget.28653","article-title":"Molecular chaperones: guardians of tumor suppressor stability and function","volume":"15","author":"Heritz","year":"2024","journal-title":"Oncotarget"},{"issue":"52","key":"10.1016\/j.compbiolchem.2025.108801_bib31","doi-asserted-by":"crossref","first-page":"33486","DOI":"10.1073\/pnas.2007991117","article-title":"The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis","volume":"117","author":"Hoj","year":"2020","journal-title":"PNAS"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092560","article-title":"The HSP90 family: structure, regulation, function, and implications in health and disease","volume":"19","author":"Hoter","year":"2018","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib33","article-title":"Diversity of extracellular HSP70 in cancer: advancing from a molecular biomarker to a novel therapeutic target","volume":"14","author":"Hu","year":"2024","journal-title":"Front Oncol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib34","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1093\/nar\/gkl241","article-title":"Modulation of nucleosome-binding activity of FACT by poly(ADP-ribosyl)ation","volume":"34","author":"Huang","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2025.103839","article-title":"Role of HSP40 proteins in genome maintenance, insulin signaling and cancer therapy","volume":"149","author":"Huang","year":"2025","journal-title":"DNA Repair"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib36","article-title":"DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib37","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a034025","article-title":"Mechanisms of small heat shock proteins","volume":"11","author":"Janowska","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib38","article-title":"Investigation of the effects of overexpression of jumping translocation breakpoint (JTB) protein in MCF7 cells for potential use as a biomarker in breast cancer","author":"Jayathirtha","year":"2022","journal-title":"Am. J. Cancer Res"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib39","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413527","article-title":"Regulation of p53 and cancer signaling by heat shock protein 40\/j-domain protein family members","volume":"22","author":"Kaida","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/iub.2586","article-title":"Transcriptional regulatory networks of the proteasome in mammalian systems","author":"Kapetanou","year":"2022","journal-title":"IUBMB Life"},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108801_bib42","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1073\/pnas.89.6.2195","article-title":"Molecular surface recognition: determination of geometric fit between proteins and their ligands by correlation techniques","volume":"89","author":"Katchalski-Katzirtt","year":"1992","journal-title":"Proc. Natl. Acad. Sci.15"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-06754-y","article-title":"GRP94 is an IGF-1R chaperone and regulates beta cell death in diabetes","volume":"15","author":"Kim","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-43556-1","article-title":"Heat shock proteins create a signature to predict the clinical outcome in breast cancer","volume":"9","author":"Klimczak","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib45","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s12192-008-0093-6","article-title":"Hsp70 translocates to the nuclei and nucleoli, binds to XRCC1 and PARP-1, and protects HeLa cells from single-strand DNA breaks","volume":"14","author":"Kotoglou","year":"2009","journal-title":"Cell Stress Chaperon.."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib46","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/prot.21117","article-title":"PIPER: an FFT-based protein docking program with pairwise potentials","volume":"65","author":"Kozakov","year":"2006","journal-title":"Proteins Structure Function Genetics"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib47","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nprot.2016.169","article-title":"The ClusPro web server for protein-protein docking","volume":"12","author":"Kozakov","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib48","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/s41416-022-01747-0","article-title":"CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt\/\u03b2-catenin signalling pathway","volume":"126","author":"Li","year":"2022","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib49","doi-asserted-by":"crossref","first-page":"12881","DOI":"10.1002\/cam4.5891","article-title":"Effects of SMC1A on immune microenvironment and cancer stem cells in colon adenocarcinoma","volume":"12","author":"Li","year":"2023","journal-title":"Cancer Med"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib50","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib51","doi-asserted-by":"crossref","DOI":"10.1186\/s12876-023-02850-z","article-title":"SMC1A facilitates gastric cancer cell proliferation, migration, and invasion via promoting SNAIL activated EMT","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-023-04915-x","article-title":"Pathway and mechanism of tubulin folding mediated by TRiC\/CCT along its ATPase cycle revealed using cryo-EM","volume":"6","author":"Liu","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24630","article-title":"Silencing LINC00665 inhibits cutaneous melanoma in vitro progression and induces apoptosis via the miR-339-3p\/TUBB","volume":"36","author":"Liu","year":"2022","journal-title":"J. Clin. Lab Anal."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells9112356","article-title":"The tubulin code in mitosis and cancer","volume":"9","author":"Lopes","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.683132","article-title":"Redefining molecular chaperones as chaotropes","volume":"8","author":"Maco\u0161ek","year":"2021","journal-title":"Front Mol. Biosci."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2018.00108","article-title":"VDAC1 as pharmacological target in cancer and neurodegeneration: focus on its role in apoptosis","volume":"6","author":"Magr\u00ec","year":"2018","journal-title":"Front Chem."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12030739","article-title":"The multifactorial role of PARP-1 in tumor microenvironment","volume":"12","author":"Mart\u00ed","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib58","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s00018-004-4464-6","article-title":"Hsp70 chaperones: cellular functions and molecular mechanism","volume":"62","author":"Mayer","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib59","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1128\/MCB.23.9.3141-3151.2003","article-title":"The Hsp70 and TRiC\/CCT chaperone systems cooperate in vivo to assemble the von hippel-lindau tumor suppressor complex","volume":"23","author":"Melville","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib60","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1038\/sj.onc.1207529","article-title":"Molecular chaperones and the stress of oncogenesis","volume":"9","author":"Mosser","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib61","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1177\/1947601910383418","article-title":"Upregulation of poly (ADP-Ribose) polymerase-1 (PARP1) in triple-negative breast cancer and other primary human tumor types","volume":"1","author":"Ossovskaya","year":"2010","journal-title":"Genes Cancer"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114491","article-title":"New insights about the PDGF\/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies","volume":"161","author":"Pandey","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/cells11050776","article-title":"\u03b2III- tubulin structural domains regulate mitochondrial network architecture in an isotype-specific manner","volume":"11","author":"Parker","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib64","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkae1011","article-title":"The PRIDE database at 20 years: 2025 update","volume":"53","author":"Perez-Riverol","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib65","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1172\/JCI60534","article-title":"Heterogeneity in breast cancer","volume":"121","author":"Polyak","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib66","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cels.2016.02.001","article-title":"System-wide clinical proteomics of breast cancer reveals global remodeling of tissue homeostasis","volume":"2","author":"Pozniak","year":"2016","journal-title":"Cell Syst."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib67","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12192-016-0676-6","article-title":"The human HSP70 family of chaperones: where do we stand?","volume":"21","author":"Radons","year":"2016","journal-title":"Cell Stress Chaperon.."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.gde.2022.101900","article-title":"H3\u2013H4 histone chaperones and cancer","volume":"73","author":"Ray-Gallet","year":"2022","journal-title":"Curr. Opin. Genet Dev."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib69","doi-asserted-by":"crossref","first-page":"26706","DOI":"10.3390\/ijms161125975","article-title":"Contribution of the type II chaperonin, TRiC\/CCT, to oncogenesis","volume":"16","author":"Roh","year":"2015","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib70","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41580-019-0133-3","article-title":"The Hsp70 chaperone network","volume":"20","author":"Rosenzweig","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5229","key":"10.1016\/j.compbiolchem.2025.108801_bib71","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1126\/science.7544915","article-title":"TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40","volume":"269","author":"Rothe","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib72","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1210\/er.2006-0001","article-title":"The role of the IGF system in cancer growth and metastasis: overview and recent insights","volume":"28","author":"Samani","year":"2007","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib73","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-019-1116-0","article-title":"Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development","volume":"38","author":"Sarogni","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.842418","article-title":"The chaperone protein GRP78 promotes survival and migration of head and neck cancer after direct radiation exposure and extracellular vesicle-transfer","volume":"12","author":"Schneider","year":"2022","journal-title":"Front Oncol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib75","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib76","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1229507","article-title":"Germline landscape of RPA1, RPA2 and RPA3 variants in pediatric malignancies: identification of RPA1 as a novel cancer predisposition candidate gene","volume":"13","author":"Sharma","year":"2023","journal-title":"Front Oncol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib77","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-57602-w","article-title":"Investigating chaperonin-containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis","volume":"10","author":"Showalter","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib78","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14164055","article-title":"TNF receptor associated factor 2 (TRAF2) signaling in cancer","volume":"14","author":"Siegmund","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib79","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.bbamcr.2018.03.008","article-title":"Regulation of the Hsp90 system","volume":"1865","author":"Sima","year":"2018","journal-title":"Biochim Biophys. Acta Mol. Cell Res"},{"issue":"29","key":"10.1016\/j.compbiolchem.2025.108801_bib80","article-title":"NFKB1 as a key player in Tumor biology: from mechanisms to therapeutic implications","volume":"41","author":"Song","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib81","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1158\/1541-7786.MCR-17-0408","article-title":"Heat shock protein 70 (Hsp70) suppresses RIP1-dependent apoptotic and necroptotic cascades","volume":"16","author":"Srinivasan","year":"2018","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib82","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-022-00555-9","article-title":"MCM2 in human cancer: functions, mechanisms, and clinical significance","volume":"28","author":"Sun","year":"2022","journal-title":"Mol. Med."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101979","article-title":"Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells","volume":"298","author":"Tang","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib84","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-020-00554-5","article-title":"PINOT: an intuitive resource for integrating protein-protein interactions","volume":"18","author":"Tomkins","year":"2020","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib85","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrc2887","article-title":"Targeting the dynamic HSP90 complex in cancer","volume":"10","author":"Trepel","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib86","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jprot.2013.02.024","article-title":"Non-enzymatic post-translational protein modifications and proteostasis network deregulation in carcinogenesis","volume":"92","author":"Trougakos","year":"2013","journal-title":"J. Proteom."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib87","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib88","doi-asserted-by":"crossref","DOI":"10.1038\/srep31842","article-title":"Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer","volume":"6","author":"Vahid","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib89","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3103\/S0096392516030123","article-title":"Histone chaperones: variety and functions","volume":"71","author":"Valieva","year":"2016","journal-title":"Mosc. Univ. Biol. Sci. Bull."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib90","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.4161\/cc.9.7.11256","article-title":"Identification of filamin A as a BRCA1-interacting protein required for efficient DNA repair","volume":"9","author":"Velkova","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib91","doi-asserted-by":"crossref","DOI":"10.12703\/r\/10-72","article-title":"Recent advances in understanding the role of proteostasis","volume":"10","author":"Verma","year":"2021","journal-title":"Fac. Rev."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib92","doi-asserted-by":"crossref","first-page":"32020","DOI":"10.1074\/jbc.M110.112110","article-title":"ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein","volume":"285","author":"Walerych","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib93","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1074\/jbc.M109.024000","article-title":"Hsp40 chaperones promote degradation of the hERG potassium channel","volume":"285","author":"Walker","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib94","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.7150\/jca.87983","article-title":"CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas","volume":"14","author":"Wu","year":"2023","journal-title":"J. Cancer"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib95","article-title":"Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response","volume":"42","author":"Xu","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib96","doi-asserted-by":"crossref","DOI":"10.3390\/cells14020128","article-title":"Association of Structural Maintenance of Chromosome-1A Phosphorylation with Progression of Breast Cancer","volume":"14","author":"Yadav","year":"2025","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108801_bib97","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064338","article-title":"Role of SMC1 in overcoming drug resistance in triple negative breast cancer","volume":"8","author":"Yadav","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib98","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.dnarep.2011.10.019","article-title":"Filamin-A as a marker and target for DNA damage-based cancer therapy","volume":"11","author":"Yue","year":"2012","journal-title":"DNA Repair (Amst. )"},{"key":"10.1016\/j.compbiolchem.2025.108801_bib99","article-title":"Heat shock proteins and breast cancer","volume":"25","author":"Zhang","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib100","first-page":"229","article-title":"Global burden of female breast cancer: new estimates in 2022, temporal trend and future projections up to 2050 based on the latest release from GLOBOCAN","volume":"74","author":"Zhang","year":"2025","journal-title":"J. Natl. Cancer Cent."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib101","article-title":"The dual-function of HSP70 in immune response and tumor immunity: from molecular regulation to therapeutic innovations","volume":"16","author":"Zhang","year":"2025","journal-title":"Front Immunol."},{"key":"10.1016\/j.compbiolchem.2025.108801_bib102","article-title":"Chaperone-mediated autophagy regulates the metastatic state of mesenchymal tumors","author":"Zhou","year":"2025","journal-title":"EMBO Mol. Med"}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927125004645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927125004645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:01:31Z","timestamp":1778616091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927125004645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":102,"alternative-id":["S1476927125004645"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108801","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional profiling of the chaperone systems interactome in breast cancer using experimental and machine-learning data","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108801"}}