{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:24:47Z","timestamp":1778617487994,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["GMUCR2025\\u201302028"],"award-info":[{"award-number":["GMUCR2025\\u201302028"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["B2025391"],"award-info":[{"award-number":["B2025391"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["B2025292"],"award-info":[{"award-number":["B2025292"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2026A1515010567"],"award-info":[{"award-number":["2026A1515010567"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["02\\u2013408\\u20132501\\u20132191"],"award-info":[{"award-number":["02\\u2013408\\u20132501\\u20132191"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.compbiolchem.2026.109031","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T17:24:55Z","timestamp":1774373095000},"page":"109031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Unveiling Colorectal Cancer Cell Heterogeneity: Identification of Biomarkers and Disease\u2010driving Cell Subpopulations through Scissor and CIBERSORTx on Integrated Transcriptomic Profiling"],"prefix":"10.1016","volume":"123","author":[{"given":"Shuzhen","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runkai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyi","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangce","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaishu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiolchem.2026.109031_bib1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1172\/JCI11476","article-title":"Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice","volume":"107","author":"Bertolotti","year":"2001","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib2","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/mi.2015.32","article-title":"New developments in goblet cell mucus secretion and function","volume":"8","author":"Birchenough","year":"2015","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1080\/10408444.2018.1439449","article-title":"Exposure to permethrin and cancer risk: a systematic review","volume":"48","author":"Boffetta","year":"2018","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41571-020-0350-x","article-title":"Roles and mechanisms of alternative splicing in cancer - implications for care","volume":"17","author":"Bonnal","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib5","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib6","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.addr.2010.07.003","article-title":"Retinoid pathway and cancer therapeutics","volume":"62","author":"Bushue","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib7","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/nbt.2038","article-title":"Single-cell dissection of transcriptional heterogeneity in human colon tumors","volume":"29","author":"Dalerba","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib8","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1186\/1471-2407-14-995","article-title":"Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer","volume":"14","author":"Davis","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib9","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib10","article-title":"IRE1\u03b1 and IRE1\u03b2 protect intestinal epithelium and suppress colorectal tumorigenesis through distinct mechanisms","author":"Deng","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1470-2045(04)01431-7","article-title":"Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters","volume":"5","author":"Entschladen","year":"2004","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jim.2012.01.013","article-title":"Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models","volume":"378","author":"Gray","year":"2012","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib13","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib14","doi-asserted-by":"crossref","first-page":"929","DOI":"10.62347\/KELA7583","article-title":"Salidroside inhibits the invasion and migration of colorectal cancer cells by regulating MMP-12 and WNT signaling pathway","volume":"15","author":"Hong","year":"2025","journal-title":"Am. J. Cancer Res"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/gcc.22512","article-title":"Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery","volume":"57","author":"Hu","year":"2018","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib16","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib17","doi-asserted-by":"crossref","DOI":"10.1172\/JCI162030","article-title":"Goblet cells need some stress","volume":"132","author":"Johansson","year":"2022","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.694","article-title":"Single-cell RNA sequencing technologies and applications: a brief overview","volume":"12","author":"Jovic","year":"2022","journal-title":"Clin. Transl. Med"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib19","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1097\/PAS.0b013e318212ae22","article-title":"The anterior gradient homolog 3 (AGR3) gene is associated with differentiation and survival in ovarian cancer","volume":"35","author":"King","year":"2011","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib21","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1038\/s41467-020-16904-3","article-title":"An entropy-based metric for assessing the purity of single cell populations","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib22","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1053\/j.gastro.2021.02.020","article-title":"Microbial community heterogeneity within colorectal neoplasia and its correlation with colorectal carcinogenesis","volume":"160","author":"Liu","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbae371","article-title":"scLEGA: an attention-based deep clustering method with a tendency for low expression of genes on single-cell RNA-seq data","volume":"25","author":"Liu","year":"2024","journal-title":"Brief. Bioinform"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: doublet detection in single-Cell RNA sequencing data using artificial nearest neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0271090","article-title":"Reduced CREB3L1 expression in triple negative and luminal a breast cancer cells contributes to enhanced cell migration, anchorage-independent growth and metastasis","volume":"17","author":"Mellor","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib26","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20235986","article-title":"Treatment of metastatic or high-risk solid cancer patients by targeting the immune system and\/or tumor burden: six cases reports","volume":"20","author":"Nicolini","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41419-020-03304-0","article-title":"STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells","volume":"12","author":"Pan","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib29","doi-asserted-by":"crossref","first-page":"6950","DOI":"10.1073\/pnas.0808722106","article-title":"The protein disulfide isomerase AGR2 is essential for production of intestinal mucus","volume":"106","author":"Park","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-19621-7","article-title":"Homoharringtonine demonstrates a cytotoxic effect against triple-negative breast cancer cell lines and acts synergistically with paclitaxel","volume":"12","author":"Plett","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib32","doi-asserted-by":"crossref","first-page":"26109","DOI":"10.18632\/oncotarget.25450","article-title":"Conception, synthesis, and characterization of a rofecoxib-combretastatin hybrid drug with potent cyclooxygenase-2 (COX-2) inhibiting and microtubule disrupting activities in colon cancer cell culture and xenograft models","volume":"9","author":"Punganuru","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib33","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib34","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1038\/ncomms4175","article-title":"A paracrine network regulates the cross-talk between human lung stem cells and the stroma","volume":"5","author":"Ruiz","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib35","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2174\/1389450119666181022153016","article-title":"Molecular docking: challenges, advances and its use in drug discovery perspective","volume":"20","author":"Saikia","year":"2019","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib36","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1515\/bc.2010.036","article-title":"Kallikrein-related peptidases: bridges between immune functions and extracellular matrix degradation","volume":"391","author":"Sotiropoulou","year":"2010","journal-title":"Biol. Chem."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib37","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nature21713","article-title":"A distinct role for Lgr5(+) stem cells in primary and metastatic colon cancer","volume":"543","author":"de Sousa e Melo","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910260","article-title":"Growth Factors, PI3K\/AKT\/mTOR and MAPK signaling pathways in colorectal cancer pathogenesis: where are we now?","volume":"22","author":"Stefani","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib39","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41587-021-01091-3","article-title":"Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data","volume":"40","author":"Sun","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib40","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12964-021-00712-3","article-title":"Signaling pathways in intestinal homeostasis and colorectal cancer: KRAS at centre stage","volume":"19","author":"Ternet","year":"2021","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib41","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib42","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114123","article-title":"Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer","volume":"13","author":"Uhlitz","year":"2021","journal-title":"EMBO Mol. Med"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib43","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1136\/annrheumdis-2018-214865","article-title":"Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease","volume":"78","author":"Valenzi","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.dmd.2024.100026","article-title":"Exploring cytochrome P450 under hypoxia: potential pharmacological significance in drug metabolism and protection against high-altitude diseases","volume":"53","author":"Wang","year":"2025","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib45","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1158\/0008-5472.CAN-22-4017","article-title":"SENP1 decreases RNF168 phase separation to promote DNA damage repair and drug resistance in colon cancer","volume":"83","author":"Wei","year":"2023","journal-title":"Cancer Res"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib46","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1042\/BST20150090","article-title":"The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease","volume":"43","author":"Worthington","year":"2015","journal-title":"Biochem Soc. Trans."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib47","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.86032","article-title":"Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis","volume":"12","author":"Wu","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib48","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010029","article-title":"CREB3L1 facilitates pancreatic tumor progression and reprograms intratumoral tumor-associated macrophages to shape an immunotherapy-resistance microenvironment","volume":"13","author":"Xu","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-79284-0","article-title":"Molecular determinant of substrate binding and specificity of cytochrome P450 2J2","volume":"10","author":"Xu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110319","article-title":"Liquidambaric acid inhibits Wnt\/\u03b2-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2","volume":"38","author":"Yan","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262412118","article-title":"Integrative analysis of miR-21, PTEN, and immune signatures in colorectal cancer","volume":"26","author":"Yen","year":"2025","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib52","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib53","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12943-022-01616-7","article-title":"Wnt signaling in colorectal cancer: pathogenic role and therapeutic target","volume":"21","author":"Zhao","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib54","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/1534735416645408","article-title":"Vitro and in vivo efficacy studies of lavender angustifolia essential oil and its active constituents on the proliferation of human prostate cancer","volume":"16","author":"Zhao","year":"2017","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.compbiolchem.2026.109031_bib55","article-title":"KLK1 as an epithelial-specific brake inhibits colorectal tumorigenesis by suppressing B1R-mediated fibroblast phenotypic transition","author":"Zhou","year":"2025","journal-title":"Adv. Sci. (Weinh. )"},{"key":"10.1016\/j.compbiolchem.2026.109031_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1388257","article-title":"Machine learning approaches to identify the link between heavy metal exposure and ischemic stroke using the US NHANES data from 2003 to 2018","volume":"12","author":"Zibibula","year":"2024","journal-title":"Front Public Health"}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126001568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126001568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:01:56Z","timestamp":1778616116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927126001568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":56,"alternative-id":["S1476927126001568"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109031","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling Colorectal Cancer Cell Heterogeneity: Identification of Biomarkers and Disease\u2010driving Cell Subpopulations through Scissor and CIBERSORTx on Integrated Transcriptomic Profiling","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109031"}}