{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:07:01Z","timestamp":1785546421208,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.compbiolchem.2026.109169","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:01:30Z","timestamp":1780963290000},"page":"109169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Structural insights into hyaluronic acid recognition by human HYAL2: A cross-species comparative study"],"prefix":"10.1016","volume":"124","author":[{"suffix":"V","family":"Rajalakshmi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarramathi","family":"Aravind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Prakasam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Syed Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiolchem.2026.109169_bib1","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","article-title":"Molecular dynamics with coupling to an external bath","volume":"81","author":"Berendsen","year":"1984","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.compbiolchem.2026.109169_bib2","series-title":"A Trickster in Disguise: Hyaluronan\u2019s Ambivalent Roles in the Matrix","author":"Boehm","year":"2017"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib3","doi-asserted-by":"crossref","unstructured":"Chao, Kinlin L., Muthukumar, L., Herzberg, O., 2007. Structure of Human Hyaluronidase-1, a Hyaluronan Hydrolyzing Enzyme Involved in Tumor Growth and Angiogenesis \u2020,\u2021 6911\u20136920.","DOI":"10.1021\/bi700382g"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib4","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.1021\/bi700382g","article-title":"Structure of Human Hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis","volume":"46","author":"Chao","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib5","doi-asserted-by":"crossref","unstructured":"Cowman, M.K., Lee, H., Schwertfeger, K.L., Mccarthy, J.B., 2015. The content and size of hyaluronan in 6, 1\u20138. https:\/\/doi.org\/10.3389\/fimmu.2015.00261.","DOI":"10.3389\/fimmu.2015.00261"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib6","doi-asserted-by":"crossref","unstructured":"Fallacara, A., 2018. Hyaluronic Acid in the Third Millennium. https:\/\/doi.org\/10.3390\/polym10070701.","DOI":"10.3390\/polym10070701"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib7","author":"Grant","year":"2025","journal-title":"Gener. 3D Models Carbohydr. GLYCAM-Web"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41596-024-01011-0","article-title":"The HADDOCK2.4 web server for integrative modeling of biomolecular complexes","author":"Honorato","year":"2024","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.compbiolchem.2026.109169_bib9","doi-asserted-by":"crossref","unstructured":"Jedrzejas, M.J., Stern, R., 2005. Structures of Vertebrate Hyaluronidases and Their Unique Enzymatic Mechanism of Hydrolysis 238, 227\u2013238. https:\/\/doi.org\/10.1002\/prot.20592.","DOI":"10.1002\/prot.20592"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib10","doi-asserted-by":"crossref","unstructured":"Jiang, D., Liang, J., Noble, P.W., 2011. Hyaluronan as an Immune Regulator in Human Diseases 221\u2013264. https:\/\/doi.org\/10.1152\/physrev.00052.2009.","DOI":"10.1152\/physrev.00052.2009"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib11","doi-asserted-by":"crossref","unstructured":"Jre, A.F., Tc, L., Ubg, L., 1997. Hyaluronan: its nature, distribution, functions and turnover 27\u201333.","DOI":"10.1046\/j.1365-2796.1997.00170.x"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib12","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib13","doi-asserted-by":"crossref","unstructured":"Kakizaki, I., Ibori, N., Kojima, K., Yamaguchi, M., Endo, M., 2010. Mechanism for the hydrolysis of hyaluronan oligosaccharides by bovine testicular hyaluronidase 277, 1776\u20131786. https:\/\/doi.org\/10.1111\/j.1742-4658.2010.07600.x.","DOI":"10.1111\/j.1742-4658.2010.07600.x"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib14","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/jcc.540130812","article-title":"THE weighted histogram analysis method for free-energy calculations on biomolecules. I. The method","volume":"13","author":"Kumar","year":"1992","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.compbiolchem.2026.109169_bib15","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/jcc.20703","article-title":"Speeding up parallel GROMACS on high-latency networks","volume":"28","author":"Kutzner","year":"2007","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.compbiolchem.2026.109169_bib16","doi-asserted-by":"crossref","unstructured":"Larkin, M.A., Blackshields, G., Brown, N.P., Chenna, R., Mcgettigan, P.A., Mcwilliam, H., Valentin, F., Wallace, I.M., Wilm, A., Lopez, R., Thompson, J.D., Gibson, T.J., Higgins, D.G., 2007. Clustal W and Clustal X version 2. 0 23, 2947\u20132948. https:\/\/doi.org\/10.1093\/bioinformatics\/btm404.","DOI":"10.1093\/bioinformatics\/btm404"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib17","doi-asserted-by":"crossref","first-page":"22466","DOI":"10.1074\/jbc.273.35.22466","article-title":"HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity","volume":"273","author":"Lepperdinger","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.compbiolchem.2026.109169_bib18","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1021\/ct200196m","article-title":"An Automated force field Topology Builder (ATB) and repository: Version 1.0","volume":"7","author":"Malde","year":"2011","journal-title":"J. Chem. Theory Comput."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109169_bib19","first-page":"78","article-title":"Hyaluronic acid in inflammation and tissue regeneration","volume":"28","author":"Malgorzata Litwiniuk","year":"2016","journal-title":"wounds"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib20","article-title":"Crystal structure of bee venom hyaluronidase in complex with hyaluronic acid tetramer","author":"Markovic-Housley","year":"2001","journal-title":"Worldw. Protein Data Bank."},{"key":"10.1016\/j.compbiolchem.2026.109169_bib21","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0969-2126(00)00511-6","article-title":"Crystal structure of hyaluronidase, a major allergen of bee venom","volume":"8","author":"Markovi\u0107-Housley","year":"2000","journal-title":"Structure"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib22","doi-asserted-by":"crossref","unstructured":"Niu, M., Mcgrath, M., Sammon, D., Gardner, S., Morgan, R.M., Maio, A.Di, Liu, Y., Bubeck, D., Hohenester, E., 2024. Structure of the transmembrane protein 2 ( TMEM2) ectodomain and its apparent lack of hyaluronidase activity 2, 1\u201320.","DOI":"10.12688\/wellcomeopenres.18937.2"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib23","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.3390\/biom12121764","article-title":"Boosting the full potential of PyMOL with structural biology plugins","volume":"12","author":"Rosignoli","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1078\/0171-9335-00392","article-title":"Hyaluronan catabolism: a new metabolic pathway","volume":"83","author":"Stern","year":"2004","journal-title":"Eur. J. Cell. Biol."},{"key":"10.1016\/j.compbiolchem.2026.109169_bib25","doi-asserted-by":"crossref","unstructured":"Stern, R., Asari, A.A., Sugahara, K.N., 2006. Hyaluronan fragments: An information-rich system 85, 699\u2013715. https:\/\/doi.org\/10.1016\/j.ejcb.2006.05.009.","DOI":"10.1016\/j.ejcb.2006.05.009"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib26","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1021\/cr050247k","article-title":"Hyaluronidases: their genomics, structures, and mechanisms of action","volume":"106","author":"Stern","year":"2006","journal-title":"Chem. Rev."},{"key":"10.1016\/j.compbiolchem.2026.109169_bib27","doi-asserted-by":"crossref","unstructured":"Vangone, A., Bonvin, A.M.J.J., 2015. Contacts-based prediction of binding affinity in protein \u2013 protein complexes 1\u201315. https:\/\/doi.org\/10.7554\/eLife.07454.","DOI":"10.7554\/eLife.07454.018"},{"key":"10.1016\/j.compbiolchem.2026.109169_bib28","doi-asserted-by":"crossref","first-page":"36777","DOI":"10.1074\/jbc.R700036200","article-title":"Hyaluronan synthases: a decade-plus of novel","volume":"282","author":"Weigel","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.compbiolchem.2026.109169_bib29","doi-asserted-by":"crossref","unstructured":"Yoshida, H., Nagaoka, A., Kusaka-kikushima, A., Tobiishi, M., Kawabata, K., Sayo, T., 2013. KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization 1\u20136. https:\/\/doi.org\/10.1073\/pnas.1215432110.","DOI":"10.1073\/pnas.1215432110"}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126002951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126002951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:42:10Z","timestamp":1785541330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927126002951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"alternative-id":["S1476927126002951"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109169","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural insights into hyaluronic acid recognition by human HYAL2: A cross-species comparative study","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109169"}}