{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:59:04Z","timestamp":1762271944347,"version":"build-2065373602"},"reference-count":123,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computers in Biology and Medicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.compbiomed.2025.111170","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T02:55:50Z","timestamp":1759460150000},"page":"111170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["A rationally designed multi-epitope vaccine candidate targeting conserved FiuA for broad Pseudomonas aeruginosa protection"],"prefix":"10.1016","volume":"198","author":[{"given":"Anahita","family":"Hessami","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2816-6295","authenticated-orcid":false,"given":"Mona","family":"Moosavi","sequence":"additional","affiliation":[]},{"given":"Fatemeh","family":"Rahim","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4928-7335","authenticated-orcid":false,"given":"Zahra","family":"Mogharari","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4534-4139","authenticated-orcid":false,"given":"Mahdieh","family":"Heidari","sequence":"additional","affiliation":[]},{"given":"Farnoosh","family":"Farzam","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6358-3301","authenticated-orcid":false,"given":"Mohammad Reza","family":"Rahbar","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.compbiomed.2025.111170_bib1","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1021\/acscentsci.4c00387","article-title":"A semisynthetic Oligomannuronic acid-based Glycoconjugate vaccine against Pseudomonas aeruginosa","volume":"10","author":"Zhang","year":"2024","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.compbiomed.2025.111170_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.861222","article-title":"Whole genome multi-locus sequence typing and genomic single nucleotide polymorphism analysis for epidemiological typing of Pseudomonas aeruginosa from Indonesian intensive care units","volume":"13","author":"Goyal","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib3","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/mbo3.391","article-title":"Pseudomonas aeruginosa in premise plumbing of large buildings","volume":"5","author":"B\u00e9dard","year":"2016","journal-title":"MicrobiologyOpen"},{"key":"10.1016\/j.compbiomed.2025.111170_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14122619","article-title":"Airway epithelial cell junctions as targets for pathogens and antimicrobial therapy","volume":"14","author":"Gao","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.compbiomed.2025.111170_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1374466","article-title":"Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies","volume":"15","author":"Elfadadny","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00355-19","article-title":"The microbiology of bloodstream infection: 20-year trends from the SENTRY antimicrobial surveillance program","volume":"63","author":"Diekema","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.compbiomed.2025.111170_bib7","doi-asserted-by":"crossref","first-page":"S349","DOI":"10.1093\/ofid\/ofy210.995","article-title":"1162. Epidemiology of carbapenem-resistant Pseudomonas aeruginosa identified through the emerging infections program (EIP), United States, 2016\u20132017","volume":"5","author":"Grass","year":"2018","journal-title":"Open Forum Infect. Dis."},{"key":"10.1016\/j.compbiomed.2025.111170_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics11060707","article-title":"Pseudomonas aeruginosa community-onset bloodstream infections: characterization, diagnostic predictors, and predictive score development\u2014results from the PRO-BAC cohort","volume":"11","author":"Mart\u00ednez P\u00e9rez-Crespo","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.compbiomed.2025.111170_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11195574","article-title":"Gram negatives and antimicrobial resistance: two faces of the same coin","volume":"11","author":"Petrosillo","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.compbiomed.2025.111170_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11040916","article-title":"Anti-Pseudomonas aeruginosa vaccines and therapies: an assessment of clinical trials","volume":"11","author":"Elmassry","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.compbiomed.2025.111170_bib11","doi-asserted-by":"crossref","DOI":"10.5812\/jjm118107","article-title":"Five-year surveillance of antimicrobial resistance changes and epidemiological characteristics in Pseudomonas aeruginosa: a retrospective study in a Chinese city hospital","author":"Wang","year":"2021","journal-title":"Jundishapur J. Microbiol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib12","doi-asserted-by":"crossref","DOI":"10.1186\/2047-2994-3-32","article-title":"Clinical and economic consequences of hospital-acquired resistant and multidrug-resistant Pseudomonas aeruginosa infections: a systematic review and meta-analysis","volume":"3","author":"Nathwani","year":"2014","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"10.1016\/j.compbiomed.2025.111170_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/emi.2016.22","article-title":"Mortality attributable to carbapenem-resistant Pseudomonas aeruginosa bacteremia: a meta-analysis of cohort studies","volume":"5","author":"Zhang","year":"2016","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.compbiomed.2025.111170_bib14","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s40121-022-00591-2","article-title":"Therapeutic strategies for emerging multidrug-resistant Pseudomonas aeruginosa","volume":"11","author":"Kunz Coyne","year":"2022","journal-title":"Infect. Dis. Ther."},{"key":"10.1016\/j.compbiomed.2025.111170_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15122705","article-title":"Stability studies of antipseudomonal beta lactam agents for outpatient therapy","volume":"15","author":"Fern\u00e1ndez-Rubio","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.compbiomed.2025.111170_bib16","first-page":"11","article-title":"Antibiotic therapy for prosthetic joint infections: an overview","author":"Le Vavasseur","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.compbiomed.2025.111170_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics11101432","article-title":"Antimicrobial treatment of Pseudomonas aeruginosa severe sepsis","volume":"11","author":"Zakhour","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.compbiomed.2025.111170_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10123162","article-title":"Overcoming barriers to preventing and treating P. aeruginosa infections using AAV vectored immunoprophylaxis","volume":"10","author":"Lopes","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.compbiomed.2025.111170_bib19","article-title":"How to manage Pseudomonas aeruginosa infections","volume":"7","author":"Bassetti","year":"2018","journal-title":"Drugs Context (US)"},{"key":"10.1016\/j.compbiomed.2025.111170_bib20","article-title":"Comparative activity of newer \u03b2-Lactam\/\u03b2-Lactamase inhibitor combinations against Pseudomonas aeruginosa isolates from United States medical centers (2020-2021)","author":"Sader","year":"2022","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.compbiomed.2025.111170_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens13100896","article-title":"Phage-based therapy in combination with antibiotics: a promising alternative against multidrug-resistant gram-negative pathogens","volume":"13","author":"Anastassopoulou","year":"2024","journal-title":"Pathogens"},{"key":"10.1016\/j.compbiomed.2025.111170_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms13040913","article-title":"Antibiotic-resistant Pseudomonas aeruginosa: current challenges and emerging alternative therapies","volume":"13","author":"Hu","year":"2025","journal-title":"Microorganisms"},{"key":"10.1016\/j.compbiomed.2025.111170_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics12030484","article-title":"Current and emerging inhaled antibiotics for chronic pulmonary Pseudomonas aeruginosa and Staphylococcus aureus infections in cystic fibrosis","volume":"12","author":"Li","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.compbiomed.2025.111170_bib24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.imj.2023.05.003","article-title":"Pseudomonas aeruginosa: infections and novel approaches to treatment \u201cKnowing the enemy\u201d the threat of Pseudomonas aeruginosa and exploring novel approaches to treatment","volume":"2","author":"Sathe","year":"2023","journal-title":"Infectious Med."},{"key":"10.1016\/j.compbiomed.2025.111170_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/toxics13040303","article-title":"Deciphering multidrug-resistant Pseudomonas aeruginosa: mechanistic insights and environmental risks","volume":"13","author":"Pei","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.compbiomed.2025.111170_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-50859-x","article-title":"Polyclonal anti-whole cell IgY passive immunotherapy shields against P. aeruginosa-induced acute pneumonia and burn wound infections in murine models","volume":"14","author":"Ahmadi","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiomed.2025.111170_bib27","doi-asserted-by":"crossref","first-page":"999","DOI":"10.4161\/hv.7.10.16369","article-title":"Recent developments for Pseudomonas vaccines","volume":"7","author":"Sharma","year":"2011","journal-title":"Hum. Vaccines"},{"key":"10.1016\/j.compbiomed.2025.111170_bib28","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.3390\/vaccines10071100","article-title":"Pseudomonas aeruginosa: recent advances in vaccine development","volume":"10","author":"Killough","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.compbiomed.2025.111170_bib29","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1128\/IAI.00806-09","article-title":"Evaluation of flagella and flagellin of Pseudomonas aeruginosa as vaccines","volume":"78","author":"Campod\u00f3nico","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.compbiomed.2025.111170_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203143","article-title":"Development of a broad spectrum glycoconjugate vaccine to prevent wound and disseminated infections with Klebsiella pneumoniae and Pseudomonas aeruginosa","volume":"13","author":"Hegerle","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiomed.2025.111170_bib31","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3390\/vaccines9070803","article-title":"A Pseudomonas aeruginosa-derived particulate vaccine protects against P. aeruginosa infection","volume":"9","author":"Gonzaga","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.compbiomed.2025.111170_bib32","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/ppul.10457","article-title":"Antibody response to Pseudomonas aeruginosa in cystic fibrosis patients: a marker of therapeutic success?\u2014a 30\u2010year cohort study of survival in Danish CF patients after onset of chronic P. aeruginosa lung infection","volume":"37","author":"Johansen","year":"2004","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib33","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1183\/09031936.03.00004503","article-title":"Inflammatory markers in cystic fibrosis patients with transmissible Pseudomonas aeruginosa","volume":"22","author":"Jones","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.compbiomed.2025.111170_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.625597","article-title":"Immune responses to Pseudomonas aeruginosa biofilm infections","volume":"12","author":"Moser","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41541-023-00672-4","article-title":"Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa","volume":"8","author":"Wang","year":"2023","journal-title":"npj Vaccines"},{"key":"10.1016\/j.compbiomed.2025.111170_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-020-2792-z","article-title":"Efficacy, immunogenicity, and safety of IC43 recombinant Pseudomonas aeruginosa vaccine in mechanically ventilated intensive care patients\u2014a randomized clinical trial","volume":"24","author":"Adlbrecht","year":"2020","journal-title":"Crit. Care"},{"key":"10.1016\/j.compbiomed.2025.111170_bib37","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1128\/JB.188.5.1882-1891.2006","article-title":"The heterologous siderophores ferrioxamine B and ferrichrome activate signaling pathways in Pseudomonas aeruginosa","volume":"188","author":"Llamas","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib38","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1128\/JB.01539-09","article-title":"The ferrichrome uptake pathway in Pseudomonas aeruginosa involves an iron release mechanism with acylation of the siderophore and recycling of the modified desferrichrome","volume":"192","author":"Hannauer","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib39","doi-asserted-by":"crossref","first-page":"fnw104","DOI":"10.1093\/femsle\/fnw104","article-title":"The ferrichrome receptor A as a new target for Pseudomonas aeruginosa virulence attenuation","volume":"363","author":"Lee","year":"2016","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.compbiomed.2025.111170_bib40","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3390\/vaccines11010028","article-title":"Iron acquisition proteins of Pseudomonas aeruginosa as potential vaccine targets: in silico analysis and in vivo evaluation of protective efficacy of the hemophore HasAp","volume":"11","author":"Hamad","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.compbiomed.2025.111170_bib41","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.imlet.2023.08.004","article-title":"Enhanced immunoprotection against Acinetobacter baumannii infection: synergistic effects of Bap and BauA in a murine model","volume":"262","author":"Mansouri","year":"2023","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.compbiomed.2025.111170_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105874","article-title":"Combination of BauA and OmpA elicit immunoprotection against Acinetobacter baumannii in a murine sepsis model","author":"Tamehri","year":"2022","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.compbiomed.2025.111170_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106262","article-title":"A two-protein cocktail elicits a protective immune response against Acinetobacter baumannii in a murine infection model","volume":"182","author":"Mirali","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.compbiomed.2025.111170_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.933445","article-title":"Hybrid antigens expressing surface loops of BauA from Acinetobacter baumannii are capable of inducing protection against infection","volume":"13","author":"Chaudhuri","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108731","article-title":"BauA and Omp34 surface loops trigger protective antibodies against Acinetobacter baumannii in a murine sepsis model","volume":"108","author":"Akbari","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-8-361","article-title":"Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines","volume":"8","author":"Bui","year":"2007","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.compbiomed.2025.111170_bib47","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3389\/fimmu.2020.00442","article-title":"Better epitope discovery, precision immune engineering, and accelerated vaccine design using immunoinformatics tools","volume":"11","author":"De Groot","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103764","article-title":"BepiTBR: TB reciprocity enhances B cell epitope prediction","volume":"25","author":"Zhu","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.compbiomed.2025.111170_bib49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10989-021-10356-z","article-title":"Molecular characterization and designing of a novel multiepitope vaccine construct against Pseudomonas aeruginosa","volume":"28","author":"Dey","year":"2022","journal-title":"Int. J. Pept. Res. Therapeut."},{"key":"10.1016\/j.compbiomed.2025.111170_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-33087-6","article-title":"IgG-mediated immune suppression in mice is epitope specific except during high epitope density conditions","volume":"8","author":"Xu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiomed.2025.111170_bib51","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.molimm.2019.03.010","article-title":"Impact of epitope density on CD8+ T cell development and function","volume":"113","author":"Cosma","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib52","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.vaccine.2004.05.028","article-title":"High epitope density in a single recombinant protein molecule of the extracellular domain of influenza A virus M2 protein significantly enhances protective immunity","volume":"23","author":"Liu","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.compbiomed.2025.111170_bib53","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/sj.clpt.6100415","article-title":"Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics","volume":"82","author":"Poland","year":"2007","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.compbiomed.2025.111170_bib54","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1128\/JB.01539-09","article-title":"The ferrichrome uptake pathway in Pseudomonas aeruginosa involves an iron release mechanism with acylation of the siderophore and recycling of the modified desferrichrome","volume":"192","author":"Hannauer","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib55","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/2049-632X.12132","article-title":"The complex interplay of iron, biofilm formation, and mucoidy affecting antimicrobial resistance of Pseudomonas aeruginosa","volume":"70","author":"Oglesby-Sherrouse","year":"2014","journal-title":"Pathogens and disease"},{"key":"10.1016\/j.compbiomed.2025.111170_bib56","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: a worldwide hub of protein knowledge","volume":"47","author":"Consortium","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2025.111170_bib57","doi-asserted-by":"crossref","DOI":"10.1126\/science.adg7492","article-title":"Accurate proteome-wide missense variant effect prediction with AlphaMissense","volume":"381","author":"Cheng","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.compbiomed.2025.111170_bib58","doi-asserted-by":"crossref","first-page":"D423","DOI":"10.1093\/nar\/gkv1316","article-title":"PDBFlex: exploring flexibility in protein structures","volume":"44","author":"Hrabe","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2025.111170_bib59","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.compbiomed.2025.111170_bib60","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1745-7580-2-2","article-title":"Improved method for predicting linear B-cell epitopes","volume":"2","author":"Larsen","year":"2006","journal-title":"Immunome Res."},{"key":"10.1016\/j.compbiomed.2025.111170_bib61","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1472-6807-7-64","article-title":"Antibody-protein interactions: benchmark datasets and prediction tools evaluation","volume":"7","author":"Ponomarenko","year":"2007","journal-title":"BMC Struct. Biol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib62","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1110\/ps.062405906","article-title":"Prediction of residues in discontinuous B-cell epitopes using protein 3D structures","volume":"15","author":"Haste Andersen","year":"2006","journal-title":"Protein Sci."},{"key":"10.1016\/j.compbiomed.2025.111170_bib63","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkx346","article-title":"BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes","author":"Jespersen","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2025.111170_bib64","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4497","article-title":"BepiPred\u20103.0: improved B\u2010cell epitope prediction using protein language models","volume":"31","author":"Clifford","year":"2022","journal-title":"Protein Sci."},{"key":"10.1016\/j.compbiomed.2025.111170_bib65","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1186\/1471-2105-9-514","article-title":"ElliPro: a new structure-based tool for the prediction of antibody epitopes","volume":"9","author":"Ponomarenko","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.compbiomed.2025.111170_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1322712","article-title":"DiscoTope-3.0: improved B-cell epitope prediction using inverse folding latent representations","volume":"15","author":"H\u00f8ie","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib67","first-page":"5272","article-title":"SEMA: antigen B-cell conformational epitope prediction using deep transfer learning","author":"Shashkova","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib68","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/pro.4219","article-title":"Spatial arrangement of proteins in planar and curved membranes by PPM 3.0","volume":"31","author":"Lomize","year":"2022","journal-title":"Protein Sci."},{"key":"10.1016\/j.compbiomed.2025.111170_bib69","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1093\/bioinformatics\/btac680","article-title":"DREAMM: a web-based server for drugging protein-membrane interfaces as a novel workflow for targeted drug design","volume":"38","author":"Chatzigoulas","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiomed.2025.111170_bib70","doi-asserted-by":"crossref","first-page":"W449","DOI":"10.1093\/nar\/gkaa379","article-title":"NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data","volume":"48","author":"Reynisson","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2025.111170_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-018-1560-1","article-title":"Computer-aided prediction of antigen presenting cell modulators for designing peptide-based vaccine adjuvants","volume":"16","author":"Nagpal","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.compbiomed.2025.111170_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012773","article-title":"Structure of the Pseudomonas aeruginosa PAO1 type IV pilus","volume":"20","author":"Ochner","year":"2024","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.compbiomed.2025.111170_bib73","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jmb.2016.11.034","article-title":"iFrag: a protein-protein interface prediction server based on sequence fragments","volume":"429","author":"Garcia-Garcia","year":"2017","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib74","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2025.111170_bib75","first-page":"D6","article-title":"Basic local alignment search tool","volume":"43","author":"Blast","year":"2015","journal-title":"Natl. Libr. Med. Natl. Cent. Biotechnol. Inf"},{"key":"10.1016\/j.compbiomed.2025.111170_bib76","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7007-4-41","article-title":"Composition-based statistics and translated nucleotide searches: improving the TBLASTN module of BLAST","volume":"4","author":"Gertz","year":"2006","journal-title":"BMC Biol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib77","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00251-005-0781-7","article-title":"The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage","volume":"57","author":"Nielsen","year":"2005","journal-title":"Immunogenetics"},{"key":"10.1016\/j.compbiomed.2025.111170_bib78","series-title":"Immunoinformatics: Predicting Immunogenicity in Silico","first-page":"381","article-title":"TAPPred prediction of TAP-binding peptides in antigens","author":"Bhasin","year":"2007"},{"key":"10.1016\/j.compbiomed.2025.111170_bib79","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s13205-024-04022-6","article-title":"Integrating pan-genome and reverse vaccinology to design multi-epitope vaccine against Herpes simplex virus type-1","volume":"14","author":"Roy","year":"2024","journal-title":"3 Biotech"},{"key":"10.1016\/j.compbiomed.2025.111170_bib80","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.vacun.2024.04.003","article-title":"Immunoinformatics strategy for designing a multi-epitope chimeric vaccine to combat Neisseria gonorrhoeae","volume":"25","author":"Priyamvada","year":"2024","journal-title":"Vacunas"},{"key":"10.1016\/j.compbiomed.2025.111170_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.biologicals.2024.101782","article-title":"Designing multi-epitope vaccine against human cytomegalovirus integrating pan-genome and reverse vaccinology pipelines","volume":"87","author":"Biswas","year":"2024","journal-title":"Biologicals"},{"key":"10.1016\/j.compbiomed.2025.111170_bib82","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1093\/bioinformatics\/btr335","article-title":"Immune system simulation online","volume":"27","author":"Rapin","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiomed.2025.111170_bib83","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkx246","article-title":"GalaxyHomomer: a web server for protein homo-oligomer structure prediction from a monomer sequence or structure","author":"Baek","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2025.111170_bib84","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1093\/bioinformatics\/btaa646","article-title":"protein-sol pKa: prediction of electrostatic frustration, with application to coronaviruses","volume":"36","author":"Hebditch","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiomed.2025.111170_bib85","doi-asserted-by":"crossref","first-page":"W300","DOI":"10.1093\/nar\/gkz321","article-title":"Aggrescan3D (A3D) 2.0: prediction and engineering of protein solubility","volume":"47","author":"Kuriata","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2025.111170_bib86","series-title":"Insoluble Proteins: Methods and Protocols","first-page":"65","article-title":"A3D 2.0 update for the prediction and optimization of protein solubility","author":"Pujols","year":"2022"},{"key":"10.1016\/j.compbiomed.2025.111170_bib87","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nprot.2016.169","article-title":"The ClusPro web server for protein\u2013protein docking","volume":"12","author":"Kozakov","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.compbiomed.2025.111170_bib88","doi-asserted-by":"crossref","first-page":"W338","DOI":"10.1093\/nar\/gky356","article-title":"CABS-flex 2.0: a web server for fast simulations of flexibility of protein structures","volume":"46","author":"Kuriata","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2025.111170_bib89","doi-asserted-by":"crossref","first-page":"W271","DOI":"10.1093\/nar\/gku339","article-title":"iMODS: internal coordinates normal mode analysis server","volume":"42","author":"L\u00f3pez-Blanco","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2025.111170_bib90","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/s41587-021-01156-3","article-title":"SignalP 6.0 predicts all five types of signal peptides using protein language models","volume":"40","author":"Teufel","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00284-025-04275-1","article-title":"Loop 3 repeats in Omp34 is a promising immunogen for vaccine development against acinetobacter baumannii infections","volume":"82","author":"Bashiri","year":"2025","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib92","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.molimm.2022.06.010","article-title":"Immunoprotective characterization of egg yolk immunoglobulin raised to loop 3 of outer membrane protein 34 (Omp34) in a murine model against Acinetobacter baumannii","volume":"149","author":"Moghaddam","year":"2022","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib93","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3390\/biology13070510","article-title":"Reverse vaccinology approach to identify novel and immunogenic targets against Streptococcus gordonii","volume":"13","author":"Abid","year":"2024","journal-title":"Biology"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111170_bib94","doi-asserted-by":"crossref","DOI":"10.1007\/s13721-022-00395-x","article-title":"Immunoinformatics design of multi-epitope peptide-based vaccine against Haemophilus influenzae strain using cell division protein","volume":"12","author":"AlChalabi","year":"2022","journal-title":"Network Modeling Analysis in Health Informatics and Bioinformatics"},{"key":"10.1016\/j.compbiomed.2025.111170_bib95","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3390\/vaccines9111327","article-title":"Annotation of potential vaccine targets and design of a multi-epitope subunit vaccine against Yersinia pestis through reverse vaccinology and validation through an agent-based modeling approach","volume":"9","author":"Haq","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.compbiomed.2025.111170_bib96","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.3389\/fimmu.2020.01784","article-title":"Contriving multi-epitope subunit of vaccine for COVID-19: immunoinformatics approaches","volume":"11","author":"Dong","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib97","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines11010028","article-title":"Iron acquisition proteins of Pseudomonas aeruginosa as potential vaccine targets: in silico analysis and in vivo evaluation of protective efficacy of the hemophore HasAp","volume":"11","author":"Hamad","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.compbiomed.2025.111170_bib98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gks1039","article-title":"A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence","volume":"41","author":"Balasubramanian","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2025.111170_bib99","doi-asserted-by":"crossref","first-page":"7790","DOI":"10.3390\/molecules20057790","article-title":"Development of a novel antimicrobial screening system targeting the pyoverdine-mediated iron acquisition system and xenobiotic efflux pumps","volume":"20","author":"Sato","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.compbiomed.2025.111170_bib100","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1128\/MMBR.00012-07","article-title":"Siderophore-based iron acquisition and pathogen control","volume":"71","author":"Miethke","year":"2007","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.compbiomed.2025.111170_bib101","doi-asserted-by":"crossref","first-page":"10106","DOI":"10.1080\/07391102.2021.1942211","article-title":"New putative therapeutic targets against Serratia marcescens using reverse vaccinology and subtractive genomics","volume":"40","author":"Prado","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.compbiomed.2025.111170_bib102","doi-asserted-by":"crossref","first-page":"6179","DOI":"10.1128\/IAI.69.10.6179-6185.2001","article-title":"TonB-dependent systems of uropathogenic Escherichia coli: aerobactin and heme transport and TonB are required for virulence in the mouse","volume":"69","author":"Torres","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.compbiomed.2025.111170_bib103","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.1128\/IAI.68.11.6329-6336.2000","article-title":"TonB is required for intracellular growth and virulence of Shigella dysenteriae","volume":"68","author":"Reeves","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.compbiomed.2025.111170_bib104","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000949","article-title":"The battle for iron between bacterial pathogens and their vertebrate hosts","volume":"6","author":"Skaar","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.compbiomed.2025.111170_bib105","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1099\/mic.0.26131-0","article-title":"Antigenic diversity of meningococcal enterobactin receptor FetA, a vaccine component","volume":"149 Pt 7","author":"Thompson","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.compbiomed.2025.111170_bib106","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.immuni.2016.06.020","article-title":"Post-translational modification control of innate immunity","volume":"45","author":"Liu","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.compbiomed.2025.111170_bib107","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/MOP.0000000000000356","article-title":"Genetic and epigenetic factors in the regulation of the immune response","volume":"28","author":"Dahmer","year":"2016","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.compbiomed.2025.111170_bib108","first-page":"10","article-title":"Racial and ethnic diversity in SARS-CoV-2 vaccine clinical trials conducted in the United States","author":"Khalil","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.compbiomed.2025.111170_bib109","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1365-2249.1998.00554.x","article-title":"Differential potentiation of anti-mycobacterial activity and reactive nitrogen intermediate-producing ability of murine peritoneal macrophages activated by interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha)","volume":"112","author":"Sato","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib110","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1046\/j.1365-2249.2001.01439.x","article-title":"Opsonizing antibodies (IgG1) up-regulate monocyte proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-6 but not anti-inflammatory cytokine IL-10 in mycobacterial antigen-stimulated monocytes-implications for pathogenesis","volume":"123","author":"Hussain","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib111","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1056\/NEJM198608213150807","article-title":"Response to oligosaccharide-protein conjugate vaccine against Hemophilus influenzae b in two patients with IgG2 deficiency unresponsive to capsular polysaccharide vaccine","volume":"315","author":"Insel","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.compbiomed.2025.111170_bib112","series-title":"Bacterial Protein Toxins","first-page":"67","article-title":"Pseudomonas aeruginosa exotoxin A: structure\/function, production, and intoxication of eukaryotic cells","author":"West","year":"2000"},{"key":"10.1016\/j.compbiomed.2025.111170_bib113","article-title":"Designing a multi-epitope vaccine against Pseudomonas aeruginosa via integrating reverse vaccinology with immunoinformatics approaches","volume":"15","author":"Zhu","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiomed.2025.111170_bib114","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0165-2478(91)90026-7","article-title":"Mechanisms involved in the evasion of the host defence by Pseudomonas aeruginosa","volume":"30","author":"Kharazmi","year":"1991","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.compbiomed.2025.111170_bib115","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00188","article-title":"Role of fused Mycobacterium tuberculosis immunogens and adjuvants in modern tuberculosis vaccines","volume":"5","author":"Junqueira-Kipnis","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib116","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/IAI.70.1.240-248.2002","article-title":"Bacterial lipoprotein-based vaccines induce tumor necrosis factor-dependent type 1 protective immunity against leishmania major","volume":"70","author":"Cote-Sierra","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.compbiomed.2025.111170_bib117","first-page":"2017","article-title":"Future directions and molecular basis of ventilator associated pneumonia","author":"Aykac","year":"2017","journal-title":"Cancer Res. J."},{"issue":"2","key":"10.1016\/j.compbiomed.2025.111170_bib118","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1574-695X.2010.00764.x","article-title":"Early production of IL-17 protects against acute pulmonary Pseudomonas aeruginosa infection in mice","volume":"61","author":"Liu","year":"2011","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib119","doi-asserted-by":"crossref","DOI":"10.1189\/jlb.0811410","article-title":"Toll\u2010like receptors in the host defense against Pseudomonas aeruginosa respiratory infection and cystic fibrosis","volume":"92","author":"McIsaac","year":"2012","journal-title":"J. Leukoc. Biol."},{"volume":"vol. 10","year":"2022","author":"Killough","key":"10.1016\/j.compbiomed.2025.111170_bib120"},{"key":"10.1016\/j.compbiomed.2025.111170_bib121","article-title":"Production and immunological characterisation of recombinant flagellin C of Pseudomonas aeruginosa, Biological Products. Prevention","author":"Zherebtsov","year":"2024","journal-title":"Diagnosis, Treatment"},{"key":"10.1016\/j.compbiomed.2025.111170_bib122","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.610651","article-title":"Mediated necroptosis in mouse tumor cells induces long-lasting systemic antitumor immunity","volume":"10","author":"Qi","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.compbiomed.2025.111170_bib123","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1128\/IAI.01384-15","article-title":"Toll-like receptor 4 agonistic antibody promotes host defense against chronic Pseudomonas aeruginosa lung infection in mice","volume":"84","author":"Nakamura","year":"2016","journal-title":"Infect. Immun."}],"container-title":["Computers in Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482525015239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482525015239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:44:28Z","timestamp":1762271068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010482525015239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":123,"alternative-id":["S0010482525015239"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiomed.2025.111170","relation":{},"ISSN":["0010-4825"],"issn-type":[{"type":"print","value":"0010-4825"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A rationally designed multi-epitope vaccine candidate targeting conserved FiuA for broad Pseudomonas aeruginosa protection","name":"articletitle","label":"Article Title"},{"value":"Computers in Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiomed.2025.111170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111170"}}