{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:52:45Z","timestamp":1767855165145,"version":"3.49.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computers in Biology and Medicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.compbiomed.2025.111430","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T13:53:27Z","timestamp":1766757207000},"page":"111430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Comprehensive epigenomic and transcriptomic analysis identifies FABP7 and CLIC6 as methylation-driven prognostic biomarker for a novel breast cancer subtype"],"prefix":"10.1016","volume":"201","author":[{"given":"Kaniz","family":"Fahima","sequence":"first","affiliation":[]},{"given":"Md Raiyan","family":"Hosen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2971-5283","authenticated-orcid":false,"given":"Zimam","family":"Mahmud","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.compbiomed.2025.111430_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.compbiomed.2025.111430_bib2","author":"Organization"},{"issue":"2","key":"10.1016\/j.compbiomed.2025.111430_bib3","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1200\/JCO.2009.23.8162","article-title":"Male breast cancer: a population-based comparison with female breast cancer","volume":"28","author":"Anderson","year":"2010","journal-title":"J. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.compbiomed.2025.111430_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16081583","article-title":"Causes and risk factors of breast cancer, what do we know for sure? An evidence synthesis of systematic reviews and meta-analyses","volume":"16","author":"L\u00f8yland","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1016\/j.compbiomed.2025.111430_bib5","first-page":"1067","article-title":"EP300 and SIRT1\/6 Co-Regulate lapatinib sensitivity via modulating FOXO3-Acetylation and activity","volume":"11","author":"Mahmud","year":"2019","journal-title":"Breast Cancer"},{"key":"10.1016\/j.compbiomed.2025.111430_bib6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bcp.2019.03.009","article-title":"Oncogenic EP300 can be targeted with inhibitors of aldo-keto reductases","volume":"163","author":"Mahmud","year":"2019","journal-title":"Biochem. Pharmacol."},{"issue":"11","key":"10.1016\/j.compbiomed.2025.111430_bib7","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJMra072067","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.compbiomed.2025.111430_bib8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s11626-018-0245-7","article-title":"Culturing conditions highly affect DNA methylation and gene expression levels in MCF7 breast cancer cell line","volume":"54","author":"Hamadneh","year":"2018","journal-title":"In Vitro Anim. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.compbiomed.2025.111430_bib9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng1990","article-title":"Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome","volume":"39","author":"Weber","year":"2007","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.compbiomed.2025.111430_bib10","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/emmm.201100801","article-title":"DNA methylation profiling reveals a predominant immune component in breast cancers","volume":"3","author":"Dedeurwaerder","year":"2011","journal-title":"EMBO Mol. Med."},{"issue":"4","key":"10.1016\/j.compbiomed.2025.111430_bib11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1586\/erm.10.17","article-title":"DNA methylation as a universal biomarker","volume":"10","author":"Levenson","year":"2010","journal-title":"Expert Rev. Mol. Diagn"},{"key":"10.1016\/j.compbiomed.2025.111430_bib12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1471-2164-11-137","article-title":"Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing","volume":"11","author":"Ruike","year":"2010","journal-title":"BMC Genom."},{"issue":"15","key":"10.1016\/j.compbiomed.2025.111430_bib13","doi-asserted-by":"crossref","first-page":"7762","DOI":"10.1093\/nar\/gkad566","article-title":"Integration of gene expression and DNA methylation data across different experiments","volume":"51","author":"Itai","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.compbiomed.2025.111430_bib14","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s12015-023-10529-x","article-title":"Cancer stem cells: an insight into the development of metastatic tumors and therapy resistance","volume":"19","author":"Nairuz","year":"2023","journal-title":"Stem Cell Reviews and Reports"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.molonc.2010.11.003","article-title":"Deconstructing the molecular portraits of breast cancer","volume":"5","author":"Prat","year":"2011","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41523-019-0124-8","article-title":"Robust and interpretable PAM50 reclassification exhibits survival advantage for myoepithelial and immune phenotypes","volume":"5","author":"Mathews","year":"2019","journal-title":"npj Breast Cancer"},{"issue":"8","key":"10.1016\/j.compbiomed.2025.111430_bib17","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1200\/JCO.2008.18.1370","article-title":"Supervised risk predictor of breast cancer based on intrinsic subtypes","volume":"27","author":"Parker","year":"2009","journal-title":"J. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.compbiomed.2025.111430_bib18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10549-020-06068-5","article-title":"FOXA1 is a determinant of drug resistance in breast cancer cells","volume":"186","author":"Kumar","year":"2021","journal-title":"Breast Cancer Res. Treat."},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib19","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1038\/s41467-020-15574-5","article-title":"Re-definition of claudin-low as a breast cancer phenotype","volume":"11","author":"Fougner","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00231362","article-title":"Detection, tissue distribution and (sub)cellular localization of fatty acid-binding protein types","volume":"98","author":"Veerkamp","year":"1990","journal-title":"Mol. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.compbiomed.2025.111430_bib21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrd2589","article-title":"Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets","volume":"7","author":"Furuhashi","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.compbiomed.2025.111430_bib22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.prp.2009.06.010","article-title":"Overexpression of fatty acid binding protein-7 correlates with basal-like subtype of breast cancer","volume":"206","author":"Tang","year":"2010","journal-title":"Pathol. Res. Pract."},{"issue":"5","key":"10.1016\/j.compbiomed.2025.111430_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2024.103980","article-title":"The emerging role of fatty acid binding protein 7 (FABP7) in cancers","volume":"29","author":"George Warren","year":"2024","journal-title":"Drug Discov. Today"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib24","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1186\/s12935-020-01656-3","article-title":"FABP7 is a potential biomarker to predict response to neoadjuvant chemotherapy for breast cancer","volume":"20","author":"Xie","year":"2020","journal-title":"Cancer Cell Int."},{"issue":"37","key":"10.1016\/j.compbiomed.2025.111430_bib25","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.1038\/s41388-019-0893-4","article-title":"FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis","volume":"38","author":"Cordero","year":"2019","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.compbiomed.2025.111430_bib26","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3892\/ol.2022.13374","article-title":"FABP7 inhibits proliferation and invasion abilities of cutaneous squamous cell carcinoma cells via the Notch signaling pathway","volume":"24","author":"Sun","year":"2022","journal-title":"Oncol. Lett."},{"issue":"11","key":"10.1016\/j.compbiomed.2025.111430_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105349","article-title":"Biophysical characterization of chloride intracellular channel 6 (CLIC6)","volume":"299","author":"Loyo-Celis","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.compbiomed.2025.111430_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00096","article-title":"Intracellular chloride channels: novel biomarkers in diseases","volume":"11","author":"Gururaja Rao","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.compbiomed.2025.111430_bib29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.25259\/Cytojournal_183_2024","article-title":"Chloride intracellular channel 6 inhibits hepatocellular carcinoma progression by modulating immune cell balance and promoting tumor cell apoptosis","volume":"22","author":"Zhou","year":"2025","journal-title":"CytoJournal"},{"issue":"2","key":"10.1016\/j.compbiomed.2025.111430_bib30","first-page":"258","article-title":"Chloride intracellular channels in oncology as potential novel biomarkers and personalized therapy targets: a systematic review","volume":"29","author":"Wojtera","year":"2024","journal-title":"Rep. Practical Oncol. Radiother."},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib31","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1476-4598-12-106","article-title":"Expression profiling of ion channel genes predicts clinical outcome in breast cancer","volume":"12","author":"Ko","year":"2013","journal-title":"Mol. Cancer"},{"issue":"24","key":"10.1016\/j.compbiomed.2025.111430_bib32","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1093\/bioinformatics\/btx513","article-title":"ChAMP: updated methylation analysis pipeline for Illumina BeadChips","volume":"33","author":"Tian","year":"2017","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.compbiomed.2025.111430_bib33","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/bioinformatics\/btt684","article-title":"ChAMP: 450k chip analysis methylation pipeline","volume":"30","author":"Morris","year":"2013","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.compbiomed.2025.111430_bib34","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1093\/bioinformatics\/btv020","article-title":"MethylMix: an R package for identifying DNA methylation-driven genes","volume":"31","author":"Gevaert","year":"2015","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib35","doi-asserted-by":"crossref","first-page":"7220","DOI":"10.1038\/s41598-025-89274-9","article-title":"Gene expression associated with endocrine therapy resistance in estrogen receptor-positive breast cancer","volume":"15","author":"Jones","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiomed.2025.111430_bib36","doi-asserted-by":"crossref","first-page":"208","DOI":"10.58496\/MJAIH\/2025\/020","article-title":"Machine learning approaches for predicting breast cancer recurrence: a comparative analysis","volume":"2025","author":"Abbas","year":"2025","journal-title":"Mesopotamian J..Artificial Intelligence Healthcare"},{"issue":"7","key":"10.1016\/j.compbiomed.2025.111430_bib37","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2025.111430_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.70470\/SHIFAA\/2023\/001","article-title":"Integrative genomic and proteomic profiling for personalized oncological treatments: enhancing therapeutic efficacy and reducing adverse effects in breast cancer patients","volume":"2023","author":"Tambe-Jagtap","year":"2023","journal-title":"SHIFAA"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib39","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12859-018-2053-1","article-title":"CEMiTool: a bioconductor package for performing comprehensive modular co-expression analyses","volume":"19","author":"Russo","year":"2018","journal-title":"BMC Bioinf."},{"issue":"30","key":"10.1016\/j.compbiomed.2025.111430_bib40","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1002\/sim.5958","article-title":"Estimating and comparing time-dependent areas under receiver operating characteristic curves for censored event times with competing risks","volume":"32","author":"Blanche","year":"2013","journal-title":"Stat. Med."},{"key":"10.1016\/j.compbiomed.2025.111430_bib41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.70470\/SHIFAA\/2023\/007","article-title":"Epigenetic modifications as predictive biomarkers for cardiovascular disease: a longitudinal study on DNA methylation patterns and disease risk","volume":"2023","author":"Burhanuddin","year":"2023","journal-title":"SHIFAA"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13148-025-01922-z","article-title":"A review of the use of tumour DNA methylation for breast cancer subtyping and prediction of outcomes","volume":"17","author":"Zarean","year":"2025","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.compbiomed.2025.111430_bib43","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fgene.2020.00301","article-title":"Genome-wide analysis of methylation-driven genes and identification of an eight-gene panel for prognosis prediction in breast cancer","volume":"11","author":"Kuang","year":"2020","journal-title":"Front. Genet."},{"issue":"8","key":"10.1016\/j.compbiomed.2025.111430_bib44","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1002\/2211-5463.13211","article-title":"Prognostic biomarker identification and tumor classification in breast cancer patients by methylation and transcriptome analysis","volume":"11","author":"Zhong","year":"2021","journal-title":"FEBS Open Bio"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib45","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12967-019-2126-6","article-title":"A novel epigenetic signature for overall survival prediction in patients with breast cancer","volume":"17","author":"Bao","year":"2019","journal-title":"J. Transl. Med."},{"issue":"4","key":"10.1016\/j.compbiomed.2025.111430_bib46","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/(SICI)1097-0258(19970228)16:4<385::AID-SIM380>3.0.CO;2-3","article-title":"The lasso method for variable selection in the cox model","volume":"16","author":"Tibshirani","year":"1997","journal-title":"Stat. Med."},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/1471-2407-14-211","article-title":"Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status","volume":"14","author":"Zhao","year":"2014","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.compbiomed.2025.111430_bib48","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/path.4001","article-title":"A fatty acid-binding protein 7\/RXR\u03b2 pathway enhances survival and proliferation in triple-negative breast cancer","volume":"228","author":"Liu","year":"2012","journal-title":"J. Pathol."},{"key":"10.1016\/j.compbiomed.2025.111430_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.579692","article-title":"A novel promoter CpG-Based signature for long-term survival prediction of breast cancer patients","volume":"10","author":"Guo","year":"2020","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib50","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12672-025-01742-w","article-title":"Characterization of stem cell landscape and identification of stemness-relevant prognostic gene signature to aid immunotherapy in breast cancer","volume":"16","author":"Yang","year":"2025","journal-title":"Discov. Oncol."},{"issue":"4","key":"10.1016\/j.compbiomed.2025.111430_bib51","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1158\/1055-9965.EPI-18-0863","article-title":"PAM50 molecular intrinsic subtypes in the nurses' health study cohorts","volume":"28","author":"Kensler","year":"2019","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"16","key":"10.1016\/j.compbiomed.2025.111430_bib52","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1158\/1078-0432.CCR-12-0286","article-title":"A 50-Gene intrinsic subtype classifier for prognosis and prediction of benefit from adjuvant tamoxifen","volume":"18","author":"Chia","year":"2012","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.compbiomed.2025.111430_bib53","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1349-7006.2006.00197.x","article-title":"Signal transduction of inflammatory cytokines and tumor development","volume":"97","author":"Yoshimura","year":"2006","journal-title":"Cancer Sci."},{"issue":"4","key":"10.1016\/j.compbiomed.2025.111430_bib54","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.4049\/jimmunol.1103613","article-title":"IL-6 amplifier, NF-\u03baB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses","volume":"189","author":"Lee","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.compbiomed.2025.111430_bib55","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.3389\/fimmu.2019.01891","article-title":"Regulation of IgA production by intestinal dendritic cells and related cells","volume":"10","author":"Tezuka","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib56","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/imr.13369","article-title":"All roads lead to IgA: mapping the many pathways of IgA induction in the gut","volume":"326","author":"Siniscalco","year":"2024","journal-title":"Immunol. Rev."},{"issue":"12","key":"10.1016\/j.compbiomed.2025.111430_bib57","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.21037\/tcr-23-628","article-title":"A novel prognostic and therapeutic target biomarker based on complement-related gene signature in gastric cancer","volume":"12","author":"Liu","year":"2023","journal-title":"Transl. Cancer Res."},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib58","article-title":"Development and validation of a risk model for effective immune and stromal related signature predicting prognosis of patients with ovarian cancer","volume":"15","author":"Yu","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiomed.2025.111430_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1023349","article-title":"A novel risk score based on immune-related genes for hepatocellular carcinoma as a reliable prognostic biomarker and correlated with immune infiltration","volume":"13","author":"Long","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.compbiomed.2025.111430_bib60","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.21037\/tlcr-21-223","article-title":"A signature of estimate-stromal-immune score-based genes associated with the prognosis of lung adenocarcinoma","volume":"10","author":"Ma","year":"2021","journal-title":"Transl. Lung Cancer Res."},{"issue":"23","key":"10.1016\/j.compbiomed.2025.111430_bib61","doi-asserted-by":"crossref","first-page":"9052","DOI":"10.1002\/cam4.3505","article-title":"Tumor purity as a prognosis and immunotherapy relevant feature in gastric cancer","volume":"9","author":"Gong","year":"2020","journal-title":"Cancer Med."},{"key":"10.1016\/j.compbiomed.2025.111430_bib62","article-title":"Analysis of stemness and prognosis of subtypes in breast cancer using the transcriptome sequencing data","volume":"2022","author":"Chen","year":"2022","journal-title":"J. Oncol."},{"issue":"18","key":"10.1016\/j.compbiomed.2025.111430_bib63","doi-asserted-by":"crossref","first-page":"9020","DOI":"10.1073\/pnas.1818210116","article-title":"Cancer stemness, intratumoral heterogeneity, and immune response across cancers","volume":"116","author":"Miranda","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.compbiomed.2025.111430_bib64","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3186427","article-title":"Immune infiltration analysis with the CIBERSORT method in lung cancer","volume":"2022","author":"Guan","year":"2022","journal-title":"Dis. Markers"},{"key":"10.1016\/j.compbiomed.2025.111430_bib65","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fimmu.2014.00514","article-title":"From monocytes to M1\/M2 macrophages: phenotypical vs. functional differentiation","volume":"5","author":"Italiani","year":"2014","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.compbiomed.2025.111430_bib66","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1615\/CritRevImmunol.2014010373","article-title":"CD4 T-cell memory generation and maintenance","volume":"34","author":"Gasper","year":"2014","journal-title":"Crit. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.compbiomed.2025.111430_bib67","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41416-020-01048-4","article-title":"Cytotoxic CD8(+) T cells in cancer and cancer immunotherapy","volume":"124","author":"Raskov","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.compbiomed.2025.111430_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.954936","article-title":"Role of B cells as antigen presenting cells","volume":"13","author":"Rastogi","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.compbiomed.2025.111430_bib69","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"issue":"10","key":"10.1016\/j.compbiomed.2025.111430_bib70","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41571-019-0222-4","article-title":"Tumour-associated neutrophils in patients with cancer","volume":"16","author":"Shaul","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.compbiomed.2025.111430_bib71","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10555-022-10024-8","article-title":"Mechanistic insights into the interplays between neutrophils and other immune cells in cancer development and progression","volume":"41","author":"Mahmud","year":"2022","journal-title":"Cancer Metastasis Rev."},{"issue":"11","key":"10.1016\/j.compbiomed.2025.111430_bib72","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol."},{"issue":"4","key":"10.1016\/j.compbiomed.2025.111430_bib73","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ijc.25429","article-title":"Regulatory T cells in tumor immunity","volume":"127","author":"Nishikawa","year":"2010","journal-title":"Int. J. Cancer"},{"issue":"7550","key":"10.1016\/j.compbiomed.2025.111430_bib74","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature14395","article-title":"Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy","volume":"521","author":"Shalapour","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.compbiomed.2025.111430_bib75","doi-asserted-by":"crossref","first-page":"118","DOI":"10.70470\/EDRAAK\/2024\/015","article-title":"Machine and deep learning techniques in cancer prediction and risk stratification using bioinformatics in big data era: a review","volume":"2024","author":"Lateef","year":"2024","journal-title":"EDRAAK"},{"key":"10.1016\/j.compbiomed.2025.111430_bib76","series-title":"Translational Research in Breast Cancer","first-page":"81","article-title":"Ras signaling in breast cancer","author":"Moon","year":"2021"},{"issue":"3","key":"10.1016\/j.compbiomed.2025.111430_bib77","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.238865","article-title":"Pumping the brakes on RAS \u2013 negative regulators and death effectors of RAS","volume":"133","author":"Harrell Stewart","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.compbiomed.2025.111430_bib78","author":"Uhl\u00e9n"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib79","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1369\/00221554211048951","article-title":"Emerging roles of DLK1 in the stem cell niche and cancer stemness","volume":"70","author":"Grassi","year":"2022","journal-title":"J. Histochem. Cytochem."},{"issue":"3","key":"10.1016\/j.compbiomed.2025.111430_bib80","article-title":"DLK1 promotes lung cancer cell invasion through upregulation of MMP9 expression depending on notch signaling","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiomed.2025.111430_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.808041","article-title":"TGF\u03b22 is a prognostic biomarker for gastric cancer and is associated with methylation and immunotherapy responses","volume":"13","author":"Han","year":"2022","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib82","article-title":"The cancer stem cells characteristics analysis of LGR5 + cells that influence lung cancer risk by using single cell RNA-seq analysis","volume":"15","author":"Wen","year":"2025","journal-title":"Sci. Rep."},{"issue":"7647","key":"10.1016\/j.compbiomed.2025.111430_bib83","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nature21713","article-title":"A distinct role for Lgr5(+) stem cells in primary and metastatic colon cancer","volume":"543","author":"de Sousa e Melo","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib84","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41523-022-00424-y","article-title":"Primary endocrine resistance of ER+ breast cancer with ESR1 mutations interrogated by droplet digital PCR","volume":"8","author":"Ahn","year":"2022","journal-title":"npj Breast Cancer"},{"issue":"6","key":"10.1016\/j.compbiomed.2025.111430_bib85","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.7150\/jca.37637","article-title":"Tumour-Infiltrating immune cell-based subtyping and signature gene analysis in breast cancer based on gene expression profiles","volume":"11","author":"Jiang","year":"2020","journal-title":"J. Cancer"},{"issue":"10","key":"10.1016\/j.compbiomed.2025.111430_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12103054","article-title":"A methylation-based reclassification of bladder cancer based on immune cell genes","volume":"12","author":"Luo","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib87","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12943-024-02198-2","article-title":"Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins","volume":"24","author":"Freitas-Cortez","year":"2025","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.compbiomed.2025.111430_bib88","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1186\/s12864-019-6142-y","article-title":"DNA methylation profiles capturing breast cancer heterogeneity","volume":"20","author":"Chen","year":"2019","journal-title":"BMC Genom."}],"container-title":["Computers in Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482525017846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482525017846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:19:31Z","timestamp":1767835171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010482525017846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":88,"alternative-id":["S0010482525017846"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiomed.2025.111430","relation":{},"ISSN":["0010-4825"],"issn-type":[{"value":"0010-4825","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive epigenomic and transcriptomic analysis identifies FABP7 and CLIC6 as methylation-driven prognostic biomarker for a novel breast cancer subtype","name":"articletitle","label":"Article Title"},{"value":"Computers in Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiomed.2025.111430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111430"}}