{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:54:12Z","timestamp":1775483652633,"version":"3.50.1"},"reference-count":137,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020026","name":"Department of Higher Education, Government of West Bengal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computers in Biology and Medicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.compbiomed.2026.111563","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T02:10:47Z","timestamp":1771899047000},"page":"111563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Impact of coding and non-coding SNPs in the FZD8 gene on structural and functional alterations associated with tumorigenesis: A multi-faceted computational approach"],"prefix":"10.1016","volume":"205","author":[{"given":"Amalesh","family":"Mondal","sequence":"first","affiliation":[]},{"given":"Debarati","family":"Paul","sequence":"additional","affiliation":[]},{"given":"Tithi","family":"Mondal","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1448-2517","authenticated-orcid":false,"given":"Achintya Mohan","family":"Goswami","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.compbiomed.2026.111563_bib1","first-page":"13","article-title":"FZD8 indicates a poor prognosis and promotes gastric cancer invasion and metastasis via B-Catenin signaling pathway","volume":"50","author":"Chen","year":"2020","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib2","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41467-019-14149-3","article-title":"Structural insight into small molecule action on Frizzleds","volume":"11","author":"Kozielewicz","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiomed.2026.111563_bib3","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1074\/jbc.REV118.005205","article-title":"Fatty acid recognition in the Frizzled receptor family","volume":"294","author":"Nile","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.compbiomed.2026.111563_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12672-021-00429-2","article-title":"Cancer chemoprevention through Frizzled receptors and EMT","volume":"12","author":"Sompel","year":"2021","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib5","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.1002\/jcp.29563","article-title":"Frizzled-4 is required for normal bone acquisition despite compensation by Frizzled-8","volume":"235","author":"Kushwaha","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib6","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.compbiomed.2026.111563_bib7","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1038\/s41467-018-04042-w","article-title":"Frizzled-8 integrates Wnt-11 and transforming growth factor-\u03b2 signaling in prostate cancer","volume":"9","author":"Murillo-Garz\u00f3n","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiomed.2026.111563_bib8","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1096\/fj.201700144R","article-title":"Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families","volume":"31","author":"Voloshanenko","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.compbiomed.2026.111563_bib9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1136\/thoraxjnl-2015-206958","article-title":"A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis","volume":"71","author":"Spanjer","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/j.compbiomed.2026.111563_bib10","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/bph.12364","article-title":"WNT\/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR review 3","volume":"171","author":"Dijksterhuis","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib11","first-page":"1","article-title":"Role of Frizzled receptor expression on patients' survival with gastrointestinal cancers: a systematic review with meta-analysis","volume":"13","author":"Hafezi","year":"2022","journal-title":"Casp J. Intern. Med."},{"key":"10.1016\/j.compbiomed.2026.111563_bib12","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3727\/096504020X16014648664459","article-title":"Frizzled receptors in tumors, focusing on signaling, roles, modulation mechanisms, and targeted therapies","volume":"28","author":"Sun","year":"2021","journal-title":"Oncol. Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051543","article-title":"Frizzled receptors as potential therapeutic targets in human cancers","volume":"19","author":"Zeng","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib14","doi-asserted-by":"crossref","first-page":"78989","DOI":"10.18632\/oncotarget.20742","article-title":"Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.compbiomed.2026.111563_bib15","doi-asserted-by":"crossref","first-page":"ii4","DOI":"10.1093\/annonc\/mdw199.14","article-title":"P-014 are RHOA, CSNK1A1, DVL2, FZD8 and LRP5 genes novel biomarkers in the conversion from intestinal metaplasia to gastric cancer?","volume":"27","author":"Demirci","year":"2016","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib16","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/1471-2407-13-316","article-title":"Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer","volume":"13","author":"Bravo","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.compbiomed.2026.111563_bib17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.canlet.2017.05.029","article-title":"FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt\/\u03b2-catenin signaling","volume":"402","author":"Li","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.compbiomed.2026.111563_bib18","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1007\/s13277-015-4342-x","article-title":"MicroRNA-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt\/\u03b2-catenin signaling pathway","volume":"37","author":"Jiang","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib19","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.3727\/096504017X14873430389189","article-title":"MicroRNA-520b suppresses proliferation, migration, and invasion of spinal osteosarcoma cells via downregulation of Frizzled-8","volume":"25","author":"Wang","year":"2017","journal-title":"Oncol. Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib20","doi-asserted-by":"crossref","first-page":"40644","DOI":"10.18632\/oncotarget.9811","article-title":"MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8","volume":"7","author":"Xu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.compbiomed.2026.111563_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0092-8674(82)90409-3","article-title":"Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome","volume":"31","author":"Nusse","year":"1982","journal-title":"Cell"},{"key":"10.1016\/j.compbiomed.2026.111563_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-19299-x","article-title":"In silico analyses of Wnt1 nsSNPs reveal structurally destabilizing variants, altered interactions with Frizzled receptors and its deregulation in tumorigenesis","volume":"12","author":"Mondal","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiomed.2026.111563_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107286","article-title":"Progress in the development of modulators targeting Frizzleds","volume":"206","author":"Chuan","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127846","article-title":"Identification and functional validation of FZD8-specific antibodies","volume":"254","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib25","article-title":"In silico prediction of the functional consequences of nsSNPs in human beta-catenin gene","volume":"23","author":"Mondal","year":"2021","journal-title":"Gene Rep."},{"key":"10.1016\/j.compbiomed.2026.111563_bib26","doi-asserted-by":"crossref","first-page":"6525","DOI":"10.1038\/s41598-017-06575-4","article-title":"Predicting the functional consequences of non-synonymous single nucleotide polymorphisms in IL8 gene","volume":"7","author":"Dakal","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiomed.2026.111563_bib27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/bs.apcsb.2018.10.009","article-title":"Computational and modeling approaches to understand the impact of the Fabry's disease causing mutation (D92Y) on the interaction with pharmacological chaperone 1-deoxygalactonojirimycin (DGJ)","volume":"114","author":"Thirumal Kumar","year":"2019","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib28","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nprot.2009.86","article-title":"Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm","volume":"4","author":"Kumar","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.compbiomed.2026.111563_bib29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.compbiomed.2026.111563_bib30","doi-asserted-by":"crossref","first-page":"D886","DOI":"10.1093\/nar\/gky1016","article-title":"CADD: predicting the deleteriousness of variants throughout the human genome","volume":"47","author":"Rentzsch","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib31","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.ajhg.2016.08.016","article-title":"REVEL: an ensemble method for predicting the pathogenicity of rare missense variants","volume":"99","author":"Ioannidis","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.compbiomed.2026.111563_bib32","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1093\/hmg\/ddu733","article-title":"Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies","volume":"24","author":"Dong","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.compbiomed.2026.111563_bib33","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2007-8-11-r232","article-title":"Determinants of protein function revealed by combinatorial entropy optimization","volume":"8","author":"Reva","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib34","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1471-2164-14-S3-S6","article-title":"WS-SNPs& GO: a web server for predicting the deleterious effect of human protein variants using functional annotation","volume":"14","author":"Capriotti","year":"2013","journal-title":"BMC Genom."},{"key":"10.1016\/j.compbiomed.2026.111563_bib35","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1093\/bioinformatics\/btl423","article-title":"Predicting the insurgence of human genetic diseases associated to single point protein mutations with support vector machines and evolutionary information","volume":"22","author":"Capriotti","year":"2006","journal-title":"Bioinformatics"},{"issue":"Suppl 2","key":"10.1016\/j.compbiomed.2026.111563_bib36","doi-asserted-by":"crossref","first-page":"ii54","DOI":"10.1093\/bioinformatics\/bti1109","article-title":"Predicting protein stability changes from sequences using support vector machines","volume":"21","author":"Capriotti","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiomed.2026.111563_bib37","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/prot.20810","article-title":"Prediction of protein stability changes for single-site mutations using support vector machines","volume":"62","author":"Cheng","year":"2006","journal-title":"Proteins"},{"key":"10.1016\/j.compbiomed.2026.111563_bib38","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1038\/s41467-020-19669-x","article-title":"Inferring the molecular and phenotypic impact of amino acid variants with MutPred2","volume":"11","author":"Pejaver","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiomed.2026.111563_bib39","doi-asserted-by":"crossref","first-page":"W287","DOI":"10.1093\/nar\/gkae328","article-title":"Deep learning for the PSIPRED protein analysis workbench","volume":"52","author":"Buchan","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ijch.201200096","article-title":"ConSurf: using evolutionary data to raise testable hypotheses about protein function","volume":"53","author":"Celniker","year":"2013","journal-title":"Isr. J. Chem."},{"key":"10.1016\/j.compbiomed.2026.111563_bib41","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1186\/1471-2105-11-548","article-title":"Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfaces","volume":"11","author":"Venselaar","year":"2010","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.compbiomed.2026.111563_bib42","doi-asserted-by":"crossref","first-page":"W475","DOI":"10.1093\/nar\/gkt291","article-title":"The RNAsnp web server: predicting SNP effects on local RNA secondary structure","volume":"41","author":"Sabarinathan","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib43","doi-asserted-by":"crossref","first-page":"W70","DOI":"10.1093\/nar\/gkn188","article-title":"The Vienna RNA websuite","volume":"36","author":"Gruber","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib44","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.compbiomed.2026.111563_bib45","doi-asserted-by":"crossref","first-page":"W294","DOI":"10.1093\/nar\/gks493","article-title":"GalaxyWEB server for protein structure prediction and refinement","volume":"40","author":"Ko","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib46","doi-asserted-by":"crossref","first-page":"W407","DOI":"10.1093\/nar\/gkm290","article-title":"ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins","volume":"35","author":"Wiederstein","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib47","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","article-title":"Verification of protein structures: patterns of nonbonded atomic interactions","volume":"2","author":"Colovos","year":"1993","journal-title":"Protein Sci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib48","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF00228148","article-title":"AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR","volume":"8","author":"Laskowski","year":"1996","journal-title":"J. Biomol. NMR"},{"key":"10.1016\/j.compbiomed.2026.111563_bib49","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1093\/nar\/gki524","article-title":"TM-align: a protein structure alignment algorithm based on the TM-score","volume":"33","author":"Zhang","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib50","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/bioinformatics\/btt691","article-title":"mCSM: predicting the effects of mutations in proteins using graph-based signatures","volume":"30","author":"Pires","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiomed.2026.111563_bib51","doi-asserted-by":"crossref","first-page":"W314","DOI":"10.1093\/nar\/gku411","article-title":"DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach","volume":"42","author":"Pires","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib52","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1093\/bioinformatics\/btw192","article-title":"INPS-MD: a web server to predict stability of protein variants from sequence and structure","volume":"32","author":"Savojardo","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiomed.2026.111563_bib53","doi-asserted-by":"crossref","first-page":"W229","DOI":"10.1093\/nar\/gkx439","article-title":"SDM: a server for predicting effects of mutations on protein stability","volume":"45","author":"Pandurangan","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.729513","article-title":"Structural biology in the clouds: the WeNMR-EOSC ecosystem","volume":"8","author":"Honorato","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib55","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nprot.2016.169","article-title":"The ClusPro web server for protein-protein docking","volume":"12","author":"Kozakov","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.compbiomed.2026.111563_bib56","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.compbiomed.2026.111563_bib57","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1002\/jcc.23354","article-title":"CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data","volume":"34","author":"Huang","year":"2013","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.compbiomed.2026.111563_bib58","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/jcc.20289","article-title":"Scalable molecular dynamics with NAMD","volume":"26","author":"Phillips","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.compbiomed.2026.111563_bib59","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1063\/1.464397","article-title":"Particle mesh Ewald: an N \u22c5log(N) method for Ewald sums in large systems","volume":"98","author":"Darden","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.compbiomed.2026.111563_bib60","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1063\/1.470648","article-title":"Constant pressure molecular dynamics simulation: the Langevin piston method","volume":"103","author":"Feller","year":"1995","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.compbiomed.2026.111563_bib61","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","article-title":"Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes","volume":"23","author":"Ryckaert","year":"1977","journal-title":"J. Comput. Phys."},{"key":"10.1016\/j.compbiomed.2026.111563_bib62","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jcc.20945","article-title":"CHARMM-GUI: a web-based graphical user interface for CHARMM","volume":"29","author":"Jo","year":"2008","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.compbiomed.2026.111563_bib63","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","article-title":"The MM\/PBSA and MM\/GBSA methods to estimate ligand-binding affinities","volume":"10","author":"Genheden","year":"2015","journal-title":"Expet Opin. Drug Discov."},{"key":"10.1016\/j.compbiomed.2026.111563_bib64","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0006-3495(97)78756-3","article-title":"The statistical-thermodynamic basis for computation of binding affinities: a critical review","volume":"72","author":"Gilson","year":"1997","journal-title":"Biophys. J."},{"key":"10.1016\/j.compbiomed.2026.111563_bib65","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1002\/jcc.10321","article-title":"Generalized born model with a simple smoothing function","volume":"24","author":"Im","year":"2003","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.compbiomed.2026.111563_bib66","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gkab1079","article-title":"miRTarBase update 2022: an informative resource for experimentally validated miRNA-target interactions","volume":"50","author":"Huang","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib67","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1002\/prot.26578","article-title":"RNA tertiary structure prediction using RNAComposer in CASP15","volume":"91","author":"Sarzynska","year":"2023","journal-title":"Proteins"},{"key":"10.1016\/j.compbiomed.2026.111563_bib68","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/s41596-020-0312-x","article-title":"The HDOCK server for integrated protein\u2013protein docking","volume":"15","author":"Yan","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.compbiomed.2026.111563_bib69","doi-asserted-by":"crossref","first-page":"W530","DOI":"10.1093\/nar\/gkab294","article-title":"Plip 2021: expanding the scope of the protein-ligand interaction profiler to DNA and RNA","volume":"49","author":"Adasme","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib70","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.gpb.2019.09.006","article-title":"hTFtarget: a comprehensive database for regulations of human transcription factors and their targets","volume":"18","author":"Zhang","year":"2020","journal-title":"Genom. Proteom. Bioinform."},{"key":"10.1016\/j.compbiomed.2026.111563_bib71","doi-asserted-by":"crossref","first-page":"D337","DOI":"10.1093\/nar\/gkac1016","article-title":"UTRdb 2.0: a comprehensive, expert curated catalog of eukaryotic mRNAs untranslated regions","volume":"51","author":"Lo Giudice","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib72","doi-asserted-by":"crossref","first-page":"D139","DOI":"10.1093\/nar\/gkw1064","article-title":"SNP2TFBS - a database of regulatory SNPs affecting predicted transcription factor binding site affinity","volume":"45","author":"Kumar","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib73","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib74","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/nar\/29.1.221","article-title":"PDBsum: summaries and analyses of PDB structures","volume":"29","author":"Laskowski","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib75","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1093\/bioinformatics\/btt079","article-title":"GalaxyGemini: a web server for protein homo-oligomer structure prediction based on similarity","volume":"29","author":"Lee","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiomed.2026.111563_bib76","doi-asserted-by":"crossref","first-page":"D396","DOI":"10.1093\/nar\/gkae970","article-title":"DNAproDB: an updated database for the automated and interactive analysis of protein\u2013DNA complexes","volume":"53","author":"Mitra","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib77","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41588-023-01365-3","article-title":"Annotating and prioritizing human non-coding variants with RegulomeDB v.2","volume":"55","author":"Dong","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.compbiomed.2026.111563_bib78","doi-asserted-by":"crossref","first-page":"D127","DOI":"10.1093\/nar\/gkz757","article-title":"miRDB: an online database for prediction of functional microRNA targets","volume":"48","author":"Chen","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib79","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.cell.2006.07.031","article-title":"A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes","volume":"126","author":"Miranda","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.compbiomed.2026.111563_bib80","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.3390\/ijms22052622","article-title":"TNMplot.com: a web tool for the comparison of gene expression in normal, tumor and metastatic tissues","volume":"22","author":"Bartha","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib81","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.1038\/s41598-021-84787-5","article-title":"Pancancer survival analysis of cancer hallmark genes","volume":"11","author":"Nagy","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiomed.2026.111563_bib82","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.gpb.2022.04.006","article-title":"dbDEMC 3.0: functional exploration of differentially expressed miRNAs in cancers of human and model organisms","volume":"20","author":"Xu","year":"2022","journal-title":"Genom. Proteom. Bioinform."},{"key":"10.1016\/j.compbiomed.2026.111563_bib83","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/ijc.33283","article-title":"muTarget: a platform linking gene expression changes and mutation status in solid tumors","volume":"148","author":"Nagy","year":"2021","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.compbiomed.2026.111563_bib84","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41594-019-0216-z","article-title":"Crystal structure of a mammalian Wnt-frizzled complex","volume":"26","author":"Hirai","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib85","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.tibs.2012.07.001","article-title":"Allosteric post-translational modification codes","volume":"37","author":"Nussinov","year":"2012","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib86","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/pro.2494","article-title":"The structural and functional signatures of proteins that undergo multiple events of post-translational modification","volume":"23","author":"Pejaver","year":"2014","journal-title":"Protein Sci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0272625","article-title":"A comprehensive in silico analysis of the deleterious nonsynonymous SNPs of human FOXP2 protein","volume":"17","author":"Akter","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiomed.2026.111563_bib88","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101436","article-title":"In silico analysis of functional single nucleotide polymorphisms in the human TRIM22 gene","volume":"9","author":"Kelly","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiomed.2026.111563_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/biom11111733","article-title":"Comprehensive characterization of the coding and non-coding single nucleotide polymorphisms in the tumor protein p63 (TP63) gene using in silico tools","volume":"11","author":"Akter","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.compbiomed.2026.111563_bib90","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12860-020-00252-7","article-title":"In silico analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the human GJA3 gene associated with congenital cataract","volume":"21","author":"Zhang","year":"2020","journal-title":"BMC Mol. Cell. Biol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib91","doi-asserted-by":"crossref","DOI":"10.3390\/genes10010055","article-title":"Special issue: computational analysis of RNA structure and function","volume":"10","author":"Gorodkin","year":"2019","journal-title":"Genes"},{"key":"10.1016\/j.compbiomed.2026.111563_bib92","doi-asserted-by":"crossref","first-page":"i207","DOI":"10.1093\/bioinformatics\/bts226","article-title":"Towards 3D structure prediction of large RNA molecules: an integer programming framework to insert local 3D motifs in RNA secondary structure","volume":"28","author":"Reinharz","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiomed.2026.111563_bib93","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ymeth.2016.04.025","article-title":"The RNA 3D Motif Atlas: computational methods for extraction, organization and evaluation of RNA motifs","volume":"103","author":"Parlea","year":"2016","journal-title":"Methods"},{"key":"10.1016\/j.compbiomed.2026.111563_bib94","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.sbi.2006.05.009","article-title":"The building blocks and motifs of RNA architecture","volume":"16","author":"Leontis","year":"2006","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib95","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.mgene.2018.06.002","article-title":"\u03b1-Adducin nsSNPs affect mRNA secondary structure, protein modification and stability","volume":"17","author":"Goswami","year":"2018","journal-title":"Meta Gene"},{"key":"10.1016\/j.compbiomed.2026.111563_bib96","first-page":"29","article-title":"Affinity of estrogens for human progesterone receptor A and B monomers and risk of breast cancer: a comparative molecular modeling study","volume":"4","author":"Hasan","year":"2011","journal-title":"Adv. Appl. Bioinform. Chem."},{"key":"10.1016\/j.compbiomed.2026.111563_bib97","doi-asserted-by":"crossref","DOI":"10.3390\/cells13060521","article-title":"TNF-related apoptosis-inducing ligand: non-apoptotic signalling","volume":"13","author":"Guerrache","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.compbiomed.2026.111563_bib98","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1093\/nar\/gkac519","article-title":"Anatomy of four human argonaute proteins","volume":"50","author":"Nakanishi","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232213725","article-title":"SNPs in 3\u2019UTR miRNA target sequences associated with individual drug susceptibility","volume":"23","author":"Rykova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2024.1321232","article-title":"Implications of SNP-triggered miRNA dysregulation in Schizophrenia development","volume":"15","author":"Mohamed","year":"2024","journal-title":"Front. Genet."},{"key":"10.1016\/j.compbiomed.2026.111563_bib101","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032976","article-title":"The functional meaning of 5\u2019UTR in protein-coding genes","volume":"24","author":"Ryczek","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188872","article-title":"ETS transcription factors: multifaceted players from cancer progression to tumor immunity","volume":"1878","author":"Wang","year":"2023","journal-title":"Biochim. Biophys. Acta, Rev. Cancer"},{"key":"10.1016\/j.compbiomed.2026.111563_bib103","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib104","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018067","article-title":"The impact of miRNA target sites in coding sequences and in 3\u2032UTRs","volume":"6","author":"Fang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiomed.2026.111563_bib105","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3892\/ol.2023.14065","article-title":"Expression pattern, prognostic value and potential microRNA silencing of FZD8 in breast cancer","volume":"26","author":"Al-Zahrani","year":"2023","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.compbiomed.2026.111563_bib106","first-page":"1","article-title":"Comprehensive analysis of rsSNPs associated with hypertension using In-Silico bioinformatics tools","author":"Gassoum","year":"2016","journal-title":"OALib 03"},{"key":"10.1016\/j.compbiomed.2026.111563_bib107","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220711","article-title":"Computational analysis of high-risk SNPs in human CHK2 gene responsible for hereditary breast cancer: a functional and structural impact","volume":"14","author":"Badgujar","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiomed.2026.111563_bib108","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.mgene.2016.05.002","article-title":"In silico analysis of deleterious single nucleotide polymorphisms in human BUB1 mitotic checkpoint serine\/threonine kinase B gene","volume":"9","author":"Akhoundi","year":"2016","journal-title":"Meta Gene"},{"key":"10.1016\/j.compbiomed.2026.111563_bib109","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/pmic.201100540","article-title":"Protein charge and mass contribute to the spatio-temporal dynamics of protein-protein interactions in a minimal proteome","volume":"13","author":"Xu","year":"2013","journal-title":"Proteomics"},{"key":"10.1016\/j.compbiomed.2026.111563_bib110","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007880","article-title":"Frizzled and LRP5\/6 receptors for Wnt\/\u03b2-catenin signaling","volume":"4","author":"MacDonald","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib111","doi-asserted-by":"crossref","first-page":"E812","DOI":"10.1073\/pnas.1114802109","article-title":"Wnt\/\u03b2-catenin signaling requires interaction of the dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled","volume":"109","author":"Tauriello","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.compbiomed.2026.111563_bib112","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27134037","article-title":"Molecular analysis and conformational dynamics of human MC4R disease-causing mutations","volume":"27","author":"Fatima","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.compbiomed.2026.111563_bib113","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1740768","article-title":"Scrutinizing deleterious nonsynonymous SNPs and their effect on human POLD1 gene","volume":"2022","author":"Bappy","year":"2022","journal-title":"Genet. Res."},{"key":"10.1016\/j.compbiomed.2026.111563_bib114","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/mt.2015.214","article-title":"Modulation of protein-protein interactions for the development of novel therapeutics","volume":"24","author":"Petta","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.compbiomed.2026.111563_bib115","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1093\/bioinformatics\/btw514","article-title":"PRODIGY: a web server for predicting the binding affinity of protein-protein complexes","volume":"32","author":"Xue","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiomed.2026.111563_bib116","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.molliq.2014.07.007","article-title":"Role of thumb index fold in Wnt-4 protein and its dynamics through a molecular dynamics simulation study","volume":"198","author":"Azam","year":"2014","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.compbiomed.2026.111563_bib117","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1021\/jm100087s","article-title":"Intramolecular hydrogen bonding in medicinal chemistry","volume":"53","author":"Kuhn","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.compbiomed.2026.111563_bib118","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib119","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1158\/1055-9965.EPI-11-0035","article-title":"MicroRNA signatures: novel biomarker for colorectal cancer?","volume":"20","author":"Luo","year":"2011","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.compbiomed.2026.111563_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105436","article-title":"A bioinformatic approach of targeting SARS-CoV-2 replication by silencing a conserved alternative reserve of the orf8 gene using host miRNAs","volume":"145","author":"Goud","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.compbiomed.2026.111563_bib121","doi-asserted-by":"crossref","DOI":"10.7324\/JABB.2024.111009","article-title":"In silico screening and analysis of candidate microRNA-target interaction involved in progression of prediabetes to type II diabetes mellitus","author":"Mendonca","year":"2023","journal-title":"J. Appl. Biol. Biotechnol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib122","doi-asserted-by":"crossref","first-page":"112","DOI":"10.5808\/GI.2016.14.3.112","article-title":"In silico study of miRNA based gene regulation, involved in solid cancer, by the assistance of argonaute protein","volume":"14","author":"Rath","year":"2016","journal-title":"Genom. Inf."},{"key":"10.1016\/j.compbiomed.2026.111563_bib123","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1471-2164-11-101","article-title":"Computational prediction and experimental validation of evolutionarily conserved microRNA target genes in bilaterian animals","volume":"11","author":"Takane","year":"2010","journal-title":"BMC Genom."},{"key":"10.1016\/j.compbiomed.2026.111563_bib124","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.866072","article-title":"Prediction of site directed miRNAs as key players of transcriptional regulators against influenza C virus infection through computational approaches","volume":"9","author":"Hassan","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib125","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1101\/gad.1184404","article-title":"Specificity of microRNA target selection in translational repression","volume":"18","author":"Doench","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.compbiomed.2026.111563_bib126","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.3390\/ijms20194899","article-title":"MicroRNA assisted gene regulation in colorectal cancer","volume":"20","author":"Fadaka","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib127","doi-asserted-by":"crossref","first-page":"18","DOI":"10.14802\/jmd.16037","article-title":"MicroRNA biomarkers in neurodegenerative diseases and emerging nano-sensors technology","volume":"10","author":"Shah","year":"2017","journal-title":"J. Mov. Disord."},{"key":"10.1016\/j.compbiomed.2026.111563_bib128","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1039\/c1md00093d","article-title":"Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space","volume":"2","author":"Alex","year":"2011","journal-title":"Medchemcomm"},{"key":"10.1016\/j.compbiomed.2026.111563_bib129","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.712546","article-title":"Non-coding RNA and frizzled receptors in cancer","volume":"8","author":"Smith","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib130","article-title":"Mechanisms of miRNA-Mediated gene regulation from common downregulation to mRNA-Specific upregulation","volume":"2014","author":"Valinezhad Orang","year":"2014","journal-title":"Int. J. Genom."},{"key":"10.1016\/j.compbiomed.2026.111563_bib131","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1689340","article-title":"SCGB1A1 rs3741240 variant downregulates CC16: a molecular insight into COPD pathogenesis in Indian population","volume":"16","author":"Sultana","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.compbiomed.2026.111563_bib132","doi-asserted-by":"crossref","first-page":"873","DOI":"10.4161\/epi.25522","article-title":"E2f6-mediated repression of the meiotic Stag3 and Smc1\u03b2 genes during early embryonic development requires Ezh2 and not the de novo methyltransferase Dnmt3b","volume":"8","author":"Leseva","year":"2013","journal-title":"Epigenetics"},{"key":"10.1016\/j.compbiomed.2026.111563_bib133","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047967","article-title":"E2F6 associates with BRG1 in transcriptional regulation","volume":"7","author":"Leung","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiomed.2026.111563_bib134","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1756-0381-2-7","article-title":"LD-spline: mapping SNPs on genotyping platforms to genomic regions using patterns of linkage disequilibrium","volume":"2","author":"Bush","year":"2009","journal-title":"BioData Min."},{"key":"10.1016\/j.compbiomed.2026.111563_bib135","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ng.2764","article-title":"The cancer genome Atlas pan-cancer analysis project","volume":"45","author":"Weinstein","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.compbiomed.2026.111563_bib136","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00018-024-05314-z","article-title":"Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements","volume":"81","author":"I\u00f1iguez-Mu\u00f1oz","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.compbiomed.2026.111563_bib137","doi-asserted-by":"crossref","DOI":"10.3389\/fgeed.2024.1481443","article-title":"Towards functional maps of non-coding variants in cancer","author":"Wang","year":"2024","journal-title":"Front Genom."}],"container-title":["Computers in Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482526001265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482526001265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:04:24Z","timestamp":1775480664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010482526001265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":137,"alternative-id":["S0010482526001265"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiomed.2026.111563","relation":{},"ISSN":["0010-4825"],"issn-type":[{"value":"0010-4825","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of coding and non-coding SNPs in the FZD8 gene on structural and functional alterations associated with tumorigenesis: A multi-faceted computational approach","name":"articletitle","label":"Article Title"},{"value":"Computers in Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiomed.2026.111563","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111563"}}