{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:18:09Z","timestamp":1783113489682,"version":"3.54.6"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["KG16301601"],"award-info":[{"award-number":["KG16301601"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11902020"],"award-info":[{"award-number":["11902020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L248062"],"award-info":[{"award-number":["L248062"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computers in Biology and Medicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.compbiomed.2026.111717","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:33:16Z","timestamp":1777937596000},"page":"111717","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Computational and experimental elucidation of ginsenoside Rh2 as a FAK-targeted inhibitor of tumor cell invasion and migration"],"prefix":"10.1016","volume":"210","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjie","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5113-9067","authenticated-orcid":false,"given":"Shen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehou","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6242-017X","authenticated-orcid":false,"given":"Xinbin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiomed.2026.111717_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41568-024-00763-x","article-title":"The present and future of the Cancer Dependency Map","volume":"25","author":"Arafeh","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.compbiomed.2026.111717_bib2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41392-024-01885-2","article-title":"Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives","volume":"9","author":"Shi","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.compbiomed.2026.111717_bib3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41392-024-01955-5","article-title":"Multi-stage mechanisms of tumor metastasis and therapeutic strategies","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.compbiomed.2026.111717_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.medntd.2024.100327","article-title":"Hepatocellular carcinoma imaging: exploring traditional techniques and emerging innovations for early intervention","volume":"24","author":"Vengateswaran","year":"2024","journal-title":"Medicine in Novel Technology and Devices"},{"key":"10.1016\/j.compbiomed.2026.111717_bib5","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1158\/0008-5472.CAN-19-0458","article-title":"Defining the hallmarks of metastasis","volume":"79","author":"Welch","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.compbiomed.2026.111717_bib6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrc.2017.118","article-title":"EMT in cancer","volume":"18","author":"Brabletz","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.compbiomed.2026.111717_bib7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s41568-021-00332-6","article-title":"Linking EMT programmes to normal and neoplastic epithelial stem cells","volume":"21","author":"Lambert","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.compbiomed.2026.111717_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/cac2.12629","article-title":"Advances in cervical cancer: current insights and future directions","volume":"45","author":"Xu","year":"2025","journal-title":"Cancer Commun."},{"key":"10.1016\/j.compbiomed.2026.111717_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000512218","article-title":"Epithelial-Mesenchymal transition (EMT) as a therapeutic target","volume":"211","author":"Jonckheere","year":"2021","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.compbiomed.2026.111717_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24193491","article-title":"Analysis of ginsenoside content (Panax ginseng) from different regions","volume":"24","author":"Chen","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.compbiomed.2026.111717_bib11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1749-8546-5-20","article-title":"Pharmacology of ginsenosides: a literature review","volume":"5","author":"Leung","year":"2010","journal-title":"Chin. Med."},{"key":"10.1016\/j.compbiomed.2026.111717_bib12","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/S1876-3553(13)60018-6","article-title":"Advances in ginsenoside Rh2 and its derivatives","volume":"14","author":"Cao","year":"2012","journal-title":"World Science and Technology"},{"key":"10.1016\/j.compbiomed.2026.111717_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3892\/or.2021.7984","article-title":"Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types","volume":"45","author":"Zhang","year":"2021","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.compbiomed.2026.111717_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112627","article-title":"Anticancer property of ginsenoside Rh2 from ginseng","volume":"203","author":"Li","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.compbiomed.2026.111717_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10585-019-09966-1","article-title":"The extracellular matrix in tumor progression and metastasis","volume":"36","author":"Eble","year":"2019","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.compbiomed.2026.111717_bib16","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1242\/jcs.052704","article-title":"Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions","volume":"122","author":"Albiges-Rizo","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.compbiomed.2026.111717_bib17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41580-022-00530-6","article-title":"Mechanisms and roles of podosomes and invadopodia","volume":"24","author":"Linder","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.compbiomed.2026.111717_bib18","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1186\/s12967-025-06526-y","article-title":"Invadopodia in cancer metastasis: dynamics, regulation, and targeted therapies","volume":"23","author":"Hao","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.compbiomed.2026.111717_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/biom13030450","article-title":"Actin bundles dynamics and Architecture","volume":"13","author":"Rajan","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.compbiomed.2026.111717_bib20","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1038\/s41556-024-01541-5","article-title":"Spatiotemporal coordination of actin regulators generates invasive protrusions in cell\u2013cell fusion","volume":"26","author":"Lu","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.compbiomed.2026.111717_bib21","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.261898","article-title":"Matrix metalloproteinases at a glance","volume":"137","author":"Hey","year":"2024","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.compbiomed.2026.111717_bib22","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1124\/pharmrev.121.000349","article-title":"Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology","volume":"74","author":"de Almeida","year":"2022","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.compbiomed.2026.111717_bib23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.compbiomed.2026.111717_bib24","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-021-03828-1","article-title":"Highly accurate protein structure prediction for the human proteome","volume":"596","author":"Tunyasuvunakool","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.compbiomed.2026.111717_bib25","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.biopha.2017.09.033","article-title":"Ginsenoside Rh2 induces apoptosis and inhibits epithelial-mesenchymal transition in HEC1A and Ishikawa endometrial cancer cells","volume":"96","author":"Kim","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.compbiomed.2026.111717_bib26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.canlet.2021.11.026","article-title":"PKC\u03b8-mediated serine\/threonine phosphorylations of FAK govern adhesion and protrusion dynamics within the lamellipodia of migrating breast cancer cells","volume":"526","author":"Chadelle","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.compbiomed.2026.111717_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/mc.23273","article-title":"Focal adhesion kinase (FAK) inhibitor-defactinib suppresses the malignant progression of human esophageal squamous cell carcinoma (ESCC) cells via effective blockade of PI3K\/AKT axis and downstream molecular network","volume":"60","author":"Zhang","year":"2021","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.compbiomed.2026.111717_bib28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s12032-023-02092-9","article-title":"FAK inhibitor PF-562271 inhibits the migration and proliferation of high-grade serous ovarian cancer cells through FAK and FAK mediated cell cycle arrest","volume":"40","author":"Pan","year":"2023","journal-title":"Med. Oncol."},{"key":"10.1016\/j.compbiomed.2026.111717_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbamcr.2004.04.007","article-title":"Focal adhesion regulation of cell behavior","volume":"1692","author":"Wozniak","year":"2004","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.compbiomed.2026.111717_bib30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1083\/jcb.200809110","article-title":"FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion","volume":"185","author":"Chan","year":"2009","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.compbiomed.2026.111717_bib31","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jgr.2016.06.005","article-title":"The interaction of serum albumin with ginsenoside Rh2 resulted in the downregulation of ginsenoside Rh2 cytotoxicity","volume":"41","author":"Lin","year":"2017","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.compbiomed.2026.111717_bib32","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s00044-025-03462-w","article-title":"Advances in preclinical studies of ginsenoside Rh2 in antitumor therapy","volume":"34","author":"Xu","year":"2025","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.compbiomed.2026.111717_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13765-024-00881-y","article-title":"Ginsenosides as dietary supplements with immunomodulatory effects: a review","volume":"67","author":"Tang","year":"2024","journal-title":"Applied Biological Chemistry"},{"key":"10.1016\/j.compbiomed.2026.111717_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.compbiomed.2026.111717_bib35","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."}],"container-title":["Computers in Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482526002817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482526002817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:32:24Z","timestamp":1783110744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010482526002817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":35,"alternative-id":["S0010482526002817"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiomed.2026.111717","relation":{},"ISSN":["0010-4825"],"issn-type":[{"value":"0010-4825","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Computational and experimental elucidation of ginsenoside Rh2 as a FAK-targeted inhibitor of tumor cell invasion and migration","name":"articletitle","label":"Article Title"},{"value":"Computers in Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiomed.2026.111717","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111717"}}