{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:52:37Z","timestamp":1780419157194,"version":"3.54.1"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018214","name":"Belgian Federal Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018214","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computers in Biology and Medicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.compbiomed.2026.111737","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:21:57Z","timestamp":1778613717000},"page":"111737","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A multiscale modeling approach to study the role of mechanics and inflammation in the pathophysiology of articular cartilage"],"prefix":"10.1016","volume":"211","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1225-1179","authenticated-orcid":false,"given":"Satanik","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaelle","family":"Lesage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbet","family":"Geris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.compbiomed.2026.111737_bib0005","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00003677-200510000-00008","article-title":"The role of mechanical loading in the onset and progression of osteoarthritis","volume":"33","author":"Griffin","year":"2005","journal-title":"Exerc Sport Sci Rev"},{"issue":"9","key":"10.1016\/j.compbiomed.2026.111737_bib0010","doi-asserted-by":"crossref","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","article-title":"Global, regional, and national burden of osteoarthritis, 1990\u20132020 and projections to 2050: a systematic analysis for the global burden of disease study 2021","volume":"5","author":"Steinmetz","year":"2023","journal-title":"Lancet Rheumatol."},{"issue":"12","key":"10.1016\/j.compbiomed.2026.111737_bib0015","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.joca.2019.07.018","article-title":"Chondrocyte viability is lost during high-rate impact loading by transfer of amplified strain, but not stress, to pericellular and cellular regions","volume":"27","author":"Argote","year":"2019","journal-title":"Osteoarthr. Cartil."},{"issue":"12","key":"10.1016\/j.compbiomed.2026.111737_bib0020","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/j.jbiomech.2015.05.035","article-title":"Measuring microscale strain fields in articular cartilage during rapid impact reveals thresholds for chondrocyte death and a protective role for the superficial layer","volume":"48","author":"Bartell","year":"2015","journal-title":"J. Biomech."},{"key":"10.1016\/j.compbiomed.2026.111737_bib0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.matbio.2014.08.007","article-title":"Integrins and chondrocyte\u2013matrix interactions in articular cartilage","volume":"39","author":"Loeser","year":"2014","journal-title":"Matrix Biol."},{"issue":"4","key":"10.1016\/j.compbiomed.2026.111737_bib0030","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1073\/pnas.1319569111","article-title":"Trpv4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading","volume":"111","author":"O\u2019Conor","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"47","key":"10.1016\/j.compbiomed.2026.111737_bib0035","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1414298111","article-title":"Synergy between piezo1 and piezo2 channels confers high-strain mechanosensitivity to articular cartilage","volume":"111","author":"Lee","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6","key":"10.1016\/j.compbiomed.2026.111737_bib0040","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1172\/JCI118357","article-title":"Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration","volume":"96","author":"Hollander","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.compbiomed.2026.111737_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2020.105648","article-title":"Effect of collagen fibril distributions on the crack profile in articular cartilage","volume":"195","author":"Komeili","year":"2020","journal-title":"Comput. Methods Programs Biomed."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111737_bib0050","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s10237-025-02027-5","article-title":"An in silico mechanoregulatory model of depth-dependent adaptations to mechanical loading in intact and damaged cartilage: a proof of concept study","volume":"25","author":"Elahi","year":"2025","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.compbiomed.2026.111737_bib0055","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.680257","article-title":"An in silico framework of cartilage degeneration that integrates fibril reorientation and degradation along with altered hydration and fixed charge density loss","volume":"9","author":"Elahi","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1\u20132","key":"10.1016\/j.compbiomed.2026.111737_bib0060","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11010-017-3047-4","article-title":"Damage associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets","volume":"434","author":"Rosenberg","year":"2017","journal-title":"Mol Cell Biochem"},{"issue":"3","key":"10.1016\/j.compbiomed.2026.111737_bib0065","doi-asserted-by":"crossref","first-page":"938","DOI":"10.2353\/ajpath.2007.061083","article-title":"Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage","volume":"171","author":"Fan","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111737_bib0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-51627-6","article-title":"Multi-tissue network analysis for drug prioritization in knee osteoarthritis","volume":"9","author":"Neidlin","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111737_bib0075","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"10.1016\/j.compbiomed.2026.111737_bib0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005262","article-title":"Biomechanical thresholds regulate inflammation through the NF-KB pathway: experiments and modeling","volume":"4","author":"Nam","year":"2009","journal-title":"PLOS ONE"},{"issue":"12","key":"10.1016\/j.compbiomed.2026.111737_bib0085","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.joca.2013.08.021","article-title":"Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-a and interleukin-6, but accentuates degradation above a strain threshold","volume":"21","author":"Li","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.compbiomed.2026.111737_bib0090","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cobme.2020.01.002","article-title":"Computational systems mechanobiology of growth and remodeling: integration of tissue mechanics and cell regulatory network dynamics","volume":"15","author":"Sree","year":"2020","journal-title":"Curr. Opin. Biomed. Eng."},{"key":"10.1016\/j.compbiomed.2026.111737_bib0095","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.00093","article-title":"Use of computational modeling to study joint degeneration: a review","volume":"8","author":"Mukherjee","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"6","key":"10.1016\/j.compbiomed.2026.111737_bib0100","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.joca.2023.01.004","article-title":"Contribution of collagen degradation and proteoglycan depletion to cartilage degeneration in primary and secondary osteoarthritis: an in silico study","volume":"31","author":"Elahi","year":"2023","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.compbiomed.2026.111737_bib0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1007998","article-title":"Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus","volume":"16","author":"Eskelinen","year":"2020","journal-title":"PLOS Comput. Biol."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111737_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010337","article-title":"Injury-related cell death and proteoglycan loss in articular cartilage: numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines","volume":"19","author":"Kosonen","year":"2023","journal-title":"PLOS Comput. Biol."},{"issue":"4","key":"10.1016\/j.compbiomed.2026.111737_bib0115","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s10237-025-01961-8","article-title":"Mechanobiochemical finite element model to analyze impact-loading-induced cell damage, subsequent proteoglycan loss, and anti-oxidative treatment effects in articular cartilage","volume":"24","author":"Kosonen","year":"2025","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.compbiomed.2026.111737_bib0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2023.107419","article-title":"A chemo-mechano-biological modeling framework for cartilage evolving in health, disease, injury, and treatment","volume":"231","author":"Rahman","year":"2023","journal-title":"Comput. Methods Programs Biomed."},{"key":"10.1016\/j.compbiomed.2026.111737_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2025.108902","article-title":"Predicting the heterogeneous chemo-mechano-biological degeneration of cartilage using 3-d biphasic finite elements","volume":"270","author":"Rahman","year":"2025","journal-title":"Comput. Methods Programs Biomed."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111737_bib0130","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1038\/s41598-022-07776-2","article-title":"Regulatory network-based model to simulate the biochemical regulation of chondrocytes in healthy and osteoarthritic environments","volume":"12","author":"Segarra-Queralt","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiomed.2026.111737_bib0135","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1006066","article-title":"Network-based modelling of mechano-inflammatory chondrocyte regulation in early osteoarthritis","volume":"11","author":"Segarra-Queralt","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"8","key":"10.1016\/j.compbiomed.2026.111737_bib0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162052","article-title":"A qualitative model of the differentiation network in chondrocyte maturation: a holistic view of chondrocyte hypertrophy","volume":"11","author":"Kerkhofs","year":"2016","journal-title":"PLOS ONE"},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111737_bib0145","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12915-022-01451-8","article-title":"An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis","volume":"20","author":"Lesage","year":"2022","journal-title":"BMC Biol."},{"issue":"12","key":"10.1016\/j.compbiomed.2026.111737_bib0150","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0021-9290(00)00105-6","article-title":"The mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions in articular cartilage","volume":"33","author":"Guilak","year":"2000","journal-title":"J. Biomech."},{"issue":"8","key":"10.1016\/j.compbiomed.2026.111737_bib0155","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jbiomech.2015.02.043","article-title":"A multi-scale finite element model for investigation of chondrocyte mechanics in normal and medial meniscectomy human knee joint during walking","volume":"48","author":"Tanska","year":"2015","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111737_bib0160","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1053\/joca.1998.0162","article-title":"The deformation behavior and mechanical properties of chondrocytes in articular cartilage","volume":"7","author":"Guilak","year":"1999","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.compbiomed.2026.111737_bib0165","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0021-9290(03)00267-7","article-title":"Stresses in the local collagen network of articular cartilage: a poroviscoelastic fibril-reinforced finite element study","volume":"37","author":"Wilson","year":"2004","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111737_bib0170","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10237-016-0807-0","article-title":"Relative contribution of articular cartilage\u2019s constitutive components to load support depending on strain rate","volume":"16","author":"Quiroga","year":"2017","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.compbiomed.2026.111737_bib0175","article-title":"From human joints to bioreactor setups: quantifying mechanical stimuli in cartilage physiology and regeneration","author":"Mukherjee","year":"2025","ISSN":"https:\/\/id.crossref.org\/issn\/2692-8205","issn-type":"print"},{"issue":"11","key":"10.1016\/j.compbiomed.2026.111737_bib0180","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/jor.24101","article-title":"Osteochondral resurfacing implantation angle is more important than implant material stiffness","volume":"36","author":"Heuijerjans","year":"2018","journal-title":"J. Orthop. Res."},{"issue":"12","key":"10.1016\/j.compbiomed.2026.111737_bib0185","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s11517-009-0547-8","article-title":"Composition of the pericellular matrix modulates the deformation behaviour of chondrocytes in articular cartilage under static loading","volume":"47","author":"Julkunen","year":"2009","journal-title":"Med. Biol. Eng. Comput."},{"issue":"5","key":"10.1016\/j.compbiomed.2026.111737_bib0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037538","article-title":"Chondrocyte deformations as a function of tibiofemoral joint loading predicted by a generalized high-throughput pipeline of multi-scale simulations","volume":"7","author":"Sibole","year":"2012","journal-title":"PLOS ONE"},{"issue":"10","key":"10.1016\/j.compbiomed.2026.111737_bib0195","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1080\/10255842.2013.809711","article-title":"Evaluation of a post-processing approach for multiscale analysis of biphasic mechanics of chondrocytes","volume":"16","author":"Sibole","year":"2013","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"issue":"3","key":"10.1016\/j.compbiomed.2026.111737_bib0200","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000074629","article-title":"Deformation of chondrocytes in articular cartilage under compressive load: a morphological study","volume":"175","author":"K\u00e4\u00e4b","year":"2003","journal-title":"Cells Tissues Organs"},{"issue":"Pt 1","key":"10.1016\/j.compbiomed.2026.111737_bib0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1469-7580.1997.19110001.x","article-title":"Review. Articular cartilage chondrons: form, function and failure","volume":"191","author":"POOLE","year":"1997","journal-title":"J. Anat."},{"issue":"4","key":"10.1016\/j.compbiomed.2026.111737_bib0210","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1242\/jcs.103.4.1101","article-title":"Chondrons from articular cartilage: v.* Immunohistochemical evaluation of type VI collagen organisation in isolated chondrons by light, confocal and electron microscopy","volume":"103","author":"Poole","year":"1992","journal-title":"J. Cell Sci."},{"issue":"9","key":"10.1016\/j.compbiomed.2026.111737_bib0215","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.joca.2006.02.017","article-title":"Zonal variations in the three-dimensional morphology of the chondron measured in situ using confocal microscopy","volume":"14","author":"Youn","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.compbiomed.2026.111737_bib0220","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.actbio.2015.10.035","article-title":"Shape of chondrocytes within articular cartilage affects the solid but not the fluid microenvironment under unconfined compression","volume":"29","author":"Guo","year":"2016","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.compbiomed.2026.111737_bib0225","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41580-019-0134-2","article-title":"Integrins as biomechanical sensors of the microenvironment","volume":"20","author":"Kechagia","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.compbiomed.2026.111737_bib0230","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41580-023-00583-1","article-title":"Cell-extracellular matrix mechanotransduction in 3D","volume":"24","author":"Saraswathibhatla","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.compbiomed.2026.111737_bib0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130033","article-title":"A semiquantitative framework for gene regulatory networks: increasing the time and quantitative resolution of Boolean networks","volume":"10","author":"Kerkhofs","year":"2015","journal-title":"PLOS ONE"},{"key":"10.1016\/j.compbiomed.2026.111737_bib0240","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.plrev.2024.02.003","article-title":"The interplay between biochemical mediators and mechanotransduction in chondrocytes: unravelling the differential responses in primary knee osteoarthritis","volume":"48","author":"Segarra-Queralt","year":"2024","journal-title":"Phys. Life Rev."},{"key":"10.1016\/j.compbiomed.2026.111737_bib0245","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.732917","article-title":"An ECHO of cartilage: in silico prediction of combinatorial treatments to switch between transient and permanent cartilage phenotypes with ex vivo validation","volume":"9","author":"Khurana","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"2","key":"10.1016\/j.compbiomed.2026.111737_bib0250","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41584-021-00724-w","article-title":"Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis","volume":"18","author":"Hodgkinson","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.compbiomed.2026.111737_bib0255","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.csbj.2020.12.025","article-title":"Towards understanding the messengers of extracellular space: computational models of outside-in integrin reaction networks","volume":"19","author":"Karag\u00f6z","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"9","key":"10.1016\/j.compbiomed.2026.111737_bib0260","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1002\/jor.22649","article-title":"Changes in the integrins expression are related with the osteoarthritis severity in an experimental animal model in rats","volume":"32","author":"Almonte-Becerril","year":"2014","journal-title":"J. Orthop. Res."},{"issue":"13","key":"10.1016\/j.compbiomed.2026.111737_bib0265","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2001611118","article-title":"Inflammatory signaling sensitizes piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis","volume":"118","author":"Lee","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.compbiomed.2026.111737_bib0270","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.885224","article-title":"The role of mechanically-activated ION channels piezo1, piezo2, and trpv4 in chondrocyte mechanotransduction and mechano-therapeutics for osteoarthritis","volume":"10","author":"Gao","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"30","key":"10.1016\/j.compbiomed.2026.111737_bib0275","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2221958120","article-title":"Membrane stretch as the mechanism of activation of piezo1 ION channels in chondrocytes","volume":"120","author":"Savadipour","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111737_bib0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-023-00304-6","article-title":"Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications","volume":"12","author":"Fan","year":"2024","journal-title":"Bone Res"},{"issue":"7033","key":"10.1016\/j.compbiomed.2026.111737_bib0285","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature03417","article-title":"Adamts5 is the major aggrecanase in mouse cartilage in vivo and in vitro","volume":"434","author":"Stanton","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.compbiomed.2026.111737_bib0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.127917","article-title":"Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage","volume":"315","author":"Paggi","year":"2020","journal-title":"Sens. Actuators B Chem."},{"issue":"4","key":"10.1016\/j.compbiomed.2026.111737_bib0295","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41584-021-00736-6","article-title":"Joint-on-chip platforms: entering a new era of in vitro models for arthritis","volume":"18","author":"Paggi","year":"2022","journal-title":"Nat Rev Rheumatol"},{"issue":"7","key":"10.1016\/j.compbiomed.2026.111737_bib0300","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41551-019-0406-3","article-title":"Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model","volume":"3","author":"Occhetta","year":"2019","journal-title":"Nat. Biomed. Eng."},{"issue":"2","key":"10.1016\/j.compbiomed.2026.111737_bib0305","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s10439-020-02615-9","article-title":"Chondrocyte deformations under mild dynamic loading conditions","volume":"49","author":"Komeili","year":"2021","journal-title":"Ann. Biomed. Eng."},{"issue":"21005","key":"10.1016\/j.compbiomed.2026.111737_bib0310","article-title":"Dynamic deformation calculation of articular cartilage and cells using resonance-driven laser scanning microscopy","volume":"145","author":"Sibole","year":"2022","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.compbiomed.2026.111737_bib0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbiomech.2024.112179","article-title":"Chondrocyte deformation during the unloading phase of cyclic compression loading","volume":"171","author":"Otoo","year":"2024","journal-title":"J. Biomech."}],"container-title":["Computers in Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001048252600301X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001048252600301X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T01:35:36Z","timestamp":1780018536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001048252600301X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":63,"alternative-id":["S001048252600301X"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiomed.2026.111737","relation":{},"ISSN":["0010-4825"],"issn-type":[{"value":"0010-4825","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multiscale modeling approach to study the role of mechanics and inflammation in the pathophysiology of articular cartilage","name":"articletitle","label":"Article Title"},{"value":"Computers in Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiomed.2026.111737","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111737"}}