{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:24:44Z","timestamp":1783085084228,"version":"3.54.6"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,5,12]],"date-time":"2027-05-12T00:00:00Z","timestamp":1810080000000},"content-version":"am","delay-in-days":315,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25K10953"],"award-info":[{"award-number":["JP25K10953"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computers in Biology and Medicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.compbiomed.2026.111743","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:12:50Z","timestamp":1778602370000},"page":"111743","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Prediction of tumor control probability in prostate cancer radiotherapy using a biophysical model incorporating cancer stem cell and hypoxia"],"prefix":"10.1016","volume":"211","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7962-1867","authenticated-orcid":false,"given":"Ryo","family":"Saga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Iwamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4556-6150","authenticated-orcid":false,"given":"Yusuke","family":"Matsuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiomed.2026.111743_bib1","series-title":"Basic Clinical Radiobiology","first-page":"188","article-title":"The oxygen effect and therapeutic approaches to tumor hypoxia","year":"2019"},{"key":"10.1016\/j.compbiomed.2026.111743_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-1-4614-5915-6_9","article-title":"Intratumoral hypoxia as the genesis of genetic instability and clinical prognosis in prostate cancer","volume":"772","author":"Taiakina","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.compbiomed.2026.111743_bib3","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.ijrobp.2011.08.011","article-title":"Characterizing tumor heterogeneity with functional imaging and quantifying high-risk tumor volume for early prediction of treatment outcome: cervical cancer as a model","volume":"83","author":"Mayr","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"3","key":"10.1016\/j.compbiomed.2026.111743_bib4","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00259-015-3247-7","article-title":"Quantitative and qualitative analysis of [(18)F]FDG and [(18)F]FAZA positron emission tomography of head and neck cancers and associations with HPV status and treatment outcome","volume":"43","author":"Graves","year":"2016","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"issue":"8","key":"10.1016\/j.compbiomed.2026.111743_bib5","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00259-017-3677-5","article-title":"[18F]-FMISO PET study of hypoxia in gliomas before surgery: correlation with molecular markers of hypoxia and angiogenesis","volume":"44","author":"Bekaert","year":"2017","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111743_bib6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.21873\/anticanres.16170","article-title":"Exploring hypoxia in prostate cancer with T2-weighted magnetic resonance imaging radiomics and pimonidazole scoring","volume":"43","author":"Leech","year":"2023","journal-title":"Anticancer Res."},{"issue":"3","key":"10.1016\/j.compbiomed.2026.111743_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s13139-021-00693-8","article-title":"Quantification of hypoxia in human glioblastoma using PET with 18F-FMISO","volume":"55","author":"Abdo","year":"2021","journal-title":"Nucl. Med. Mol. Imag."},{"issue":"16","key":"10.1016\/j.compbiomed.2026.111743_bib8","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.3390\/cancers13164101","article-title":"First comparison between [18f]-FMISO and [18f]-Faza for preoperative pet imaging of hypoxia in lung cancer","volume":"13","author":"Thureau","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1016\/j.compbiomed.2026.111743_bib9","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.3109\/0284186X.2012.759273","article-title":"Hypoxia-targeted radiotherapy dose painting for head and neck cancer using (18)F-FMISO PET: a biological modeling study","volume":"52","author":"Chang","year":"2013","journal-title":"Acta Oncol."},{"issue":"3","key":"10.1016\/j.compbiomed.2026.111743_bib10","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.semradonc.2023.03.009","article-title":"Hypoxia-targeted dose painting in radiotherapy","volume":"33","author":"Salem","year":"2023","journal-title":"Semin. Radiat. Oncol."},{"issue":"5","key":"10.1016\/j.compbiomed.2026.111743_bib11","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/ajco.13953","article-title":"18F-FMISO PET-guided dose escalation with multifield optimization intensity-modulated proton therapy in nasopharyngeal carcinoma","volume":"20","author":"Sommat","year":"2024","journal-title":"Asia Pac. J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111743_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41392-020-0110-5","article-title":"Targeting cancer stem cell pathways for cancer therapy","volume":"5","author":"Yang","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"3","key":"10.1016\/j.compbiomed.2026.111743_bib13","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0167-8140(91)90022-9","article-title":"Application of the LQ model to the interpretation of absorbed dose distribution in the daily practice of radiotherapy","volume":"22","author":"Scalliet","year":"1991","journal-title":"Radiother. Oncol."},{"issue":"2","key":"10.1016\/j.compbiomed.2026.111743_bib14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0360-3016(03)00534-0","article-title":"Incorporating clinical measurements of hypoxia into tumor local control modeling of prostate cancer: implications for the \u03b1\/\u03b2 ratio","volume":"57","author":"Nahum","year":"2003","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"947","key":"10.1016\/j.compbiomed.2026.111743_bib15","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1259\/bjr\/18700614","article-title":"Dose escalation to combat hypoxia in prostate cancer: a radiobiological study on clinical data","volume":"79","author":"Wang","year":"2006","journal-title":"Br. J. Radiol."},{"issue":"7","key":"10.1016\/j.compbiomed.2026.111743_bib16","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1118\/1.4730292","article-title":"A modified hypoxia-based TCP model to investigate the clinical outcome of stereotactic hypofractionated regimes for early stage non-small-cell lung cancer (NSCLC)","volume":"39","author":"Strigari","year":"2012","journal-title":"Med. Phys."},{"issue":"2","key":"10.1016\/j.compbiomed.2026.111743_bib17","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1118\/1.4939260","article-title":"A validated tumor control probability model based on a meta-analysis of low, intermediate, and high-risk prostate cancer patients treated by photon, proton, or carbon-ion radiotherapy","volume":"43","author":"Walsh","year":"2016","journal-title":"Med. Phys."},{"issue":"3","key":"10.1016\/j.compbiomed.2026.111743_bib18","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/jrr\/rrz011","article-title":"Analysis of the high-dose-range radioresistance of prostate cancer cells, including cancer stem cells, based on a stochastic model","volume":"60","author":"Saga","year":"2019","journal-title":"J. Radiat. Res."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111743_bib19","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/s41598-022-05172-4","article-title":"Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability","volume":"12","author":"Fukui","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiomed.2026.111743_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2022.109444","article-title":"Translational study for stereotactic body radiotherapy against non-small cell lung cancer, including oligometastases, considering cancer stem-like cells enable predicting clinical outcome from in vitro data","volume":"181","author":"Saga","year":"2023","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.compbiomed.2026.111743_bib21","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/acc720","article-title":"Modelling oxygen effects on the in- and out-of-field radiosensitivity of cells exposed to intensity-modulated radiation fields","volume":"68","author":"Matsuya","year":"2023","journal-title":"Phys. Med. Biol."},{"issue":"2","key":"10.1016\/j.compbiomed.2026.111743_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.stem.2011.01.007","article-title":"Critical appraisal of the side population assay in stem cell and cancer stem cell research","volume":"8","author":"Golebiewska","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.compbiomed.2026.111743_bib23","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/jrr\/rrt222","article-title":"Quantitative estimation of DNA damage by photon irradiation based on the microdosimetric-kinetic model","volume":"55","author":"Matsuya","year":"2014","journal-title":"J. Radiat. Res."},{"issue":"2","key":"10.1016\/j.compbiomed.2026.111743_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/stem.5530090206","article-title":"The density of clonogenic cells in human solid tumors","volume":"9","author":"Baker","year":"1991","journal-title":"Int. J. Cell Clon."},{"key":"10.1016\/j.compbiomed.2026.111743_bib25","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.3390\/cancers13194897","article-title":"Biologically targeted radiation therapy: incorporating patient-specific hypoxia data derived from quantitative magnetic resonance imaging","volume":"13","author":"Her","year":"2021","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.compbiomed.2026.111743_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2024.07.1300","article-title":"Hypoxia-guided dose escalated radiation therapy in prostate cancer: a dosimetric feasibility study progression free survival prediction for oligometastatic renal cell cancer patients after stereotactic ablative radiation therapy","volume":"120","author":"Gibbard","year":"2024","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"2","key":"10.1016\/j.compbiomed.2026.111743_bib27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/09553002.2022.2013572","article-title":"Track-structure modes in particle and heavy ion transport code system (PHITS): application to radiobiological research","volume":"98","author":"Matsuya","year":"2022","journal-title":"Int. J. Radiat. Biol."},{"issue":"2","key":"10.1016\/j.compbiomed.2026.111743_bib28","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.3390\/ijms24021386","article-title":"An analytical method for quantifying the yields of DNA double-strand breaks coupled with strand breaks by \u03b3-H2AX focus formation assay based on track-structure simulation","volume":"24","author":"Yachi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.compbiomed.2026.111743_bib29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41420-020-00311-0","article-title":"Inside the hypoxic tumour: reprogramming of the DDR and radioresistance","volume":"6","author":"Begg","year":"2020","journal-title":"Cell Death Discov."},{"issue":"7","key":"10.1016\/j.compbiomed.2026.111743_bib30","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to image J: 25 years of image analysis","volume":"9","author":"Shneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.compbiomed.2026.111743_bib31","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1038\/emboj.2009.276","article-title":"ATM and artemis promote homologous recombination of radiation\u2010induced DNA double\u2010strand breaks in G2","volume":"28","author":"Beucher","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.compbiomed.2026.111743_bib32","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/emboj.2011.27","article-title":"Factors determining DNA double\u2010strand break repair pathway choice in G2 phase","volume":"30","author":"Shibata","year":"2011","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111743_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-62679-8","article-title":"The impact of dose rate on responses of human lens epithelial cells to ionizing irradiation","volume":"14","author":"Matsuya","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111743_bib34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ijrobp.2020.08.014","article-title":"Tumor control probability modeling and systematic review of the literature of stereotactic body radiation therapy for prostate cancer","volume":"110","author":"Royce","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.compbiomed.2026.111743_bib35","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1002\/mp.12508","article-title":"Markov chain Monte Carlo analysis for the selection of a cell-killing model under high-dose rate irradiation","volume":"44","author":"Matsuya","year":"2017","journal-title":"Med. Phys."},{"issue":"3","key":"10.1016\/j.compbiomed.2026.111743_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034545","article-title":"Oxygen levels do not determine radiation survival of breast cancer stem cells","volume":"7","author":"Lagadec","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.compbiomed.2026.111743_bib37","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1007\/s11626-021-00625-y","article-title":"Prolonged hypoxia switched on cancer stem cell-like plasticity in HepG2 tumourspheres cultured in serum-free media","volume":"57","author":"Ayob","year":"2012","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.compbiomed.2026.111743_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107985","article-title":"Cell plasticity, senescence, and quiescence in cancer stem cells: biological and therapeutic implications","volume":"231","author":"Paul","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.compbiomed.2026.111743_bib39","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ab7d14","article-title":"A theoretical cell-killing model to evaluate oxygen enhancement ratios at DNA damage and cell survival endpoints in radiation therapy","volume":"65","author":"Matsuya","year":"2020","journal-title":"Phys. Med. Biol."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111743_bib40","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/mutage\/gez019","article-title":"Impact of hypoxia on DNA repair and genome integrity","volume":"35","author":"Kaplan","year":"2019","journal-title":"Mutagenesis"},{"issue":"4","key":"10.1016\/j.compbiomed.2026.111743_bib41","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1515\/hsz-2012-0311","article-title":"HIF mediated and DNA damage independent histone H2AX phosphorylation in chronic hypoxia","volume":"394","author":"Wrann","year":"2013","journal-title":"Biol. Chem."},{"key":"10.1016\/j.compbiomed.2026.111743_bib42","article-title":"Impact of hypoxic versus oxic conditions on local tumor control after proton irradiation in a rat prostate carcinoma","volume":"53","author":"Schmitt","year":"2025","journal-title":"Clin. Transl. Radiat. Oncol."},{"issue":"1","key":"10.1016\/j.compbiomed.2026.111743_bib43","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/1748-717X-6-171","article-title":"Theoretical analysis of the dose dependence of the oxygen enhancement ratio and its relevance for clinical applications","volume":"6","author":"Wenzl","year":"2011","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.compbiomed.2026.111743_bib44","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.radonc.2018.12.022","article-title":"Reoxygenation during radiotherapy in intermediate-risk prostate cancer","volume":"133","author":"Supiot","year":"2016","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.compbiomed.2026.111743_bib45","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1007\/s00259-016-3431-4","article-title":"The reoxygenation of hypoxia and the reduction of glucose metabolism in head and neck cancer by fractionated radiotherapy with intensity-modulated radiation therapy","volume":"43","author":"Okamoto","year":"2016","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"issue":"2","key":"10.1016\/j.compbiomed.2026.111743_bib46","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ijrobp.2013.07.022","article-title":"The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved?","volume":"88","author":"Brown","year":"2014","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.compbiomed.2026.111743_bib47","first-page":"40","article-title":"Hypoxia in relationship to tumor volume using hypoxia PET-imaging in head & neck cancer \u2013 a scoping review","volume":"36","author":"Hildingsson","year":"2022","journal-title":"Clin. Trasl. Radiat. Oncol."},{"issue":"4","key":"10.1016\/j.compbiomed.2026.111743_bib48","article-title":"Generality assessment of a model considering heterogeneous cancer cells for predicting tumor control probability for stereotactic body radiation therapy against non-small cell lung cancer","volume":"9","author":"Saga","year":"2024","journal-title":"Adv. Radiat. Oncol."},{"issue":"6","key":"10.1016\/j.compbiomed.2026.111743_bib49","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.3390\/cancers15061918","article-title":"Quantitative MRI to characterize hypoxic tumors in comparison to FMISO PET\/CT for radiotherapy in oropharynx cancers","volume":"15","author":"Gouel","year":"2023","journal-title":"Cancers (Basel)"}],"container-title":["Computers in Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482526003070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0010482526003070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:11:42Z","timestamp":1783084302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0010482526003070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":49,"alternative-id":["S0010482526003070"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiomed.2026.111743","relation":{},"ISSN":["0010-4825"],"issn-type":[{"value":"0010-4825","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction of tumor control probability in prostate cancer radiotherapy using a biophysical model incorporating cancer stem cell and hypoxia","name":"articletitle","label":"Article Title"},{"value":"Computers in Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiomed.2026.111743","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111743"}}