{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:16:21Z","timestamp":1783170981552,"version":"3.54.6"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Liaoning Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024-BS-111"],"award-info":[{"award-number":["2024-BS-111"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computers & Chemical Engineering"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.compchemeng.2026.109708","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:18:41Z","timestamp":1778811521000},"page":"109708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Process intensification of pressure-swing distillation and extractive distillation with reactive distillation for separating ethyl acetate\/ethanol\/water system"],"prefix":"10.1016","volume":"212","author":[{"given":"Xueke","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-9534","authenticated-orcid":false,"given":"Jian","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbo","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.compchemeng.2026.109708_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.engfailanal.2021.105511","article-title":"Corrosion challenges and prevention in Ethyl Acetate (EA) production and related processes \u2013 an overview","volume":"127","author":"Adesina","year":"2021","journal-title":"Eng. Fail. Anal."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.energy.2023.129262","article-title":"Economic, environmental, exergy (3E) analysis and multi-objective genetic algorithm optimization of efficient and energy-saving separation of diethoxymethane\/toluene\/ethanol by extractive distillation with mixed extractants","volume":"284","author":"Cheng","year":"2023","journal-title":"Energy"},{"key":"10.1016\/j.compchemeng.2026.109708_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2023.138565","article-title":"Design and multiple performance evaluation of green energy saving process for ethyl acetate\/ethanol\/water azeotrope separation by extractive distillation based on mixed solvent","volume":"421","author":"Cheng","year":"2023","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2024.127626","article-title":"Ionic liquid-assisted extractive distillation for separating of ethyl acetate\/isopropanol from chemical wastewater: molecular insights and process intensification","volume":"347","author":"Cheng","year":"2024","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0005","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1109\/4235.996017","article-title":"A fast and elitist multiobjective genetic algorithm: NSGA-II","volume":"6","author":"Deb","year":"2002","journal-title":"IEEE Trans. Evol. Comput."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0006","series-title":"Conceptual Design of Chemical Processes","author":"Douglas","year":"1988"},{"key":"10.1016\/j.compchemeng.2026.109708_bib0007","doi-asserted-by":"crossref","first-page":"7284","DOI":"10.1021\/ie800306b","article-title":"Multiobjective design of reactive distillation with feasible regions","volume":"47","author":"Filipe","year":"2008","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0008","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1016\/j.energy.2005.10.029","article-title":"Reducing CO2 emissions of internally heat-integrated distillation columns for separation of close boiling mixtures","volume":"31","author":"Gadalla","year":"2006","journal-title":"Energy"},{"key":"10.1016\/j.compchemeng.2026.109708_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.cep.2021.108746","article-title":"Novel heat pump reactive distillation and dividing-wall column reactive distillation processes for synthesizing isopropyl acetate to save TAC and reduce CO2 emissions","volume":"171","author":"Gao","year":"2022","journal-title":"Chem. Eng. Process. - Process Intensif."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0010","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.renene.2023.01.107","article-title":"Process synthesis and 4E evaluation of hybrid reactive distillation processes for the ethanol and tert-butanol recovery from wastewater","volume":"205","author":"Geng","year":"2023","journal-title":"Renew. Energy"},{"key":"10.1016\/j.compchemeng.2026.109708_bib0011","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1016\/j.cherd.2014.07.010","article-title":"Vapor\u2013liquid equilibria for ethyl acetate+methanol and ethyl acetate+ethanol mixtures: experimental verification and prediction","volume":"92","author":"Gomes","year":"2014","journal-title":"Chem. Eng. Res. Des."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.compchemeng.2022.107865","article-title":"Process evaluation for the separation of acetonitrile-water using extractive distillation with deep eutectic solvents as entrainers","volume":"164","author":"Han","year":"2022","journal-title":"Comput. Chem. Eng."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0013","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.applthermaleng.2015.03.056","article-title":"A novel energy-efficient batch stripper: thermodynamic feasibility, cost analysis and CO2 emissions","volume":"84","author":"Jana","year":"2015","journal-title":"Appl. Therm. Eng."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0014","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1021\/ie50392a008","article-title":"Vapor-liquid equilibrium data on ethyl alcohol\u2013Water and on isopropyl alcohol\u2013Water","volume":"34","author":"Langdon","year":"1942","journal-title":"Ind. Eng. Chem."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1081\/SPM-120026627","article-title":"Extractive Distillation: a review","volume":"32","author":"Lei","year":"2003","journal-title":"Sep. Purif. Rev."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2024.129694","article-title":"Sustainable and efficient separation of ternary multi-azeotropic mixture butanone\/ethanol\/water based on the intensified reactive extractive distillation: process design, multi-objective optimization, and multi-criteria decision-making","volume":"355","author":"Li","year":"2025","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.compchemeng.2024.108590","article-title":"Design strategy research for synthesis of ethyl propionate and n-propyl propionate by reactive distillation","volume":"183","author":"Liu","year":"2024","journal-title":"Comput. Chem. Eng."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0018","doi-asserted-by":"crossref","first-page":"15217","DOI":"10.1007\/s10462-023-10526-z","article-title":"A comprehensive survey on NSGA-II for multi-objective optimization and applications","volume":"56","author":"Ma","year":"2023","journal-title":"Artif. Intell. Rev."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0019","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.psep.2020.10.033","article-title":"Efficient recovery of benzene and n-propanol from wastewater via vapor recompression assisted extractive distillation based on techno-economic and environmental analysis","volume":"148","author":"Ma","year":"2021","journal-title":"Process Saf. Environ. Prot."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0020","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.psep.2020.04.039","article-title":"Energy, economic and environmental evaluations for the separation of ethyl acetate\/ethanol\/water mixture via distillation and pervaporation unit","volume":"140","author":"Meng","year":"2020","journal-title":"Process Saf. Environ. Prot."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0021","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.energy.2014.06.020","article-title":"On the definition of exergy efficiencies for petroleum systems: application to offshore oil and gas processing","volume":"73","author":"Nguyen","year":"2014","journal-title":"Energy"},{"key":"10.1016\/j.compchemeng.2026.109708_bib0022","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0378-3812(91)85005-F","article-title":"Salt effect in phase equilibria and heat of mixing: effect of dissolved inorganic salts on the liquid-liquid equilibria of ethyl acetate-2-propanol-water system and the vapor-liquid equilibria and heat of mixing of its constituent binaries","volume":"70","author":"Rajendran","year":"1991","journal-title":"Fluid Ph. Equilib."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.cep.2025.110388","article-title":"Process intensification control: advancing efficiency and sustainability, a review","volume":"216","author":"Ram\u00edrez-M\u00e1rquez","year":"2025","journal-title":"Chem. Eng. Process. - Process Intensif."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0024","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0009-2509(59)80029-4","article-title":"Equilibres liquide\u2014vapeur de m\u00e9langes binaires donnant une r\u00e9action chimique: syst\u00e8mes m\u00e9thanol\u2014acide ac\u00e9tique ; \u00e9thanol\u2014acide ac\u00e9tique ; n-propanol\u2014acide ac\u00e9tique ; n-butanol\u2014acide ac\u00e9tique","volume":"10","author":"Rius","year":"1959","journal-title":"Chem. Eng. Sci."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0025","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0377-2217(01)00190-4","article-title":"A new multiobjective evolutionary algorithm","volume":"140","author":"Sarker","year":"2002","journal-title":"Eur. J. Oper. Res."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0026","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cep.2015.09.004","article-title":"Reactive distillation: a review of optimal design using deterministic and stochastic techniques","volume":"97","author":"Segovia-Hern\u00e1ndez","year":"2015","journal-title":"Chem. Eng. Process.: Process Intensif."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2024.126335","article-title":"Design and multi-objective optimization of hybrid extractive distillation process for separating the toluene-methanol-water ternary azeotrope","volume":"336","author":"Shan","year":"2024","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnucene.2021.103830","article-title":"A survey of multi-objective optimization methods and their applications for nuclear scientists and engineers","volume":"138","author":"Stewart","year":"2021","journal-title":"Prog. Nucl. Energy"},{"key":"10.1016\/j.compchemeng.2026.109708_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2020.123145","article-title":"Investigation on ternary system tetrahydrofuran\/ethanol\/water with three azeotropes separation via the combination of reactive and extractive distillation","volume":"273","author":"Su","year":"2020","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2024.128280","article-title":"A different strategy to reduce energy consumption for designing heterogeneous decanter-assisted advanced pressure-swing distillation process","volume":"352","author":"Sun","year":"2025","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0031","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.seppur.2013.07.036","article-title":"A novel integrated process to break the ethanol\/water azeotrope using reactive distillation \u2013 Part I: parametric study","volume":"118","author":"Tavan","year":"2013","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0032","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0378-3812(96)03207-4","article-title":"Effect of 1,2-propanediol on the vapor-liquid equilibria of the ethyl acetate + ethanol system at 101.3 kPa","volume":"130","author":"Tu","year":"1997","journal-title":"Fluid Ph. Equilib."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0033","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.fluid.2011.06.009","article-title":"Measurements and thermodynamic modeling of the ethanol\u2013water system with emphasis to the azeotropic region","volume":"308","author":"Voutsas","year":"2011","journal-title":"Fluid Ph. Equilib."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0034","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1002\/jctb.5988","article-title":"Separation of a ternary mixture with multiple azeotropes via pressure-swing distillation","volume":"94","author":"Wang","year":"2019","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0035","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.psep.2022.09.010","article-title":"Evaluation on the separation effect and extractant recovery efficiency of extractive distillation for separating ethyl acetate\/methanol with ionic liquids as extractants","volume":"167","author":"Yan","year":"2022","journal-title":"Process Saf. Environ. Prot."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2020.117210","article-title":"Investigation of energy-efficient and sustainable reactive\/pressure-swing distillation processes to recover tetrahydrofuran and ethanol from the industrial effluent","volume":"250","author":"Yang","year":"2020","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.compchemeng.2024.108618","article-title":"Energy-efficient heterogeneous triple-column azeotropic distillation process for recovery of ethyl acetate and methanol from wastewater","volume":"183","author":"Yang","year":"2024","journal-title":"Comput. Chem. Eng."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2022.120884","article-title":"Insights on sustainable separation of ternary azeotropic mixture tetrahydrofuran\/ethyl acetate\/water using hybrid vapor recompression assisted side-stream extractive distillation","volume":"290","author":"Yang","year":"2022","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0039","doi-asserted-by":"crossref","first-page":"21659","DOI":"10.1021\/acs.iecr.9b04294","article-title":"Design and optimization of sustainable pressure swing distillation for minimum-boiling azeotrope separation","volume":"58","author":"You","year":"2019","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0040","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.apenergy.2016.01.028","article-title":"Reducing process cost and CO2 emissions for extractive distillation by double-effect heat integration and mechanical heat pump","volume":"166","author":"You","year":"2016","journal-title":"Appl. Energy"},{"key":"10.1016\/j.compchemeng.2026.109708_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.psep.2025.107723","article-title":"Eco-intensified recovery of acetonitrile and ethanol from industrial wastewater via heat-integrated reactive pressure-swing distillation","volume":"202","author":"Zhai","year":"2025","journal-title":"Process Saf. Environ. Prot."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.ces.2025.122303","article-title":"Process design, multi-objective optimisation and energy-saving strategies of extractive distillation for separating ternary mixture containing two azeotropes","volume":"319","author":"Zhai","year":"2026","journal-title":"Chem. Eng. Sci."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2024.130622","article-title":"Novel sustainable design of pressure-swing distillation coupled with natural decanting and organic Rankine Cycle for separating n-propanol\/benzene\/water mixture","volume":"359","author":"Zhai","year":"2025","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2021.119712","article-title":"Intensified hybrid reactive-extractive distillation process for the separation of water-containing ternary mixtures","volume":"279","author":"Zhang","year":"2021","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2025.133752","article-title":"Process integration for separation of acetonitrile wastewater by reactive extractive distillation","volume":"375","author":"Zhao","year":"2025","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.compchemeng.2026.109708_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2024.129744","article-title":"Energy-efficient separation of a ternary azeotropic mixture via azeotropic reflux-induced sequences based on the intensified pressure-swing distillation","volume":"355","author":"Zhou","year":"2025","journal-title":"Sep. Purif. Technol."}],"container-title":["Computers & Chemical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098135426001614?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0098135426001614?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:21:43Z","timestamp":1783167703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0098135426001614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":46,"alternative-id":["S0098135426001614"],"URL":"https:\/\/doi.org\/10.1016\/j.compchemeng.2026.109708","relation":{},"ISSN":["0098-1354"],"issn-type":[{"value":"0098-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Process intensification of pressure-swing distillation and extractive distillation with reactive distillation for separating ethyl acetate\/ethanol\/water system","name":"articletitle","label":"Article Title"},{"value":"Computers & Chemical Engineering","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compchemeng.2026.109708","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109708"}}