{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:17:42Z","timestamp":1770059862106,"version":"3.49.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pyruvate increases myocardial performance in isolated myocardium and improves hemodynamics in patients with congestive heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the influence of pyruvate on detailed parameters of systolic and diastolic left ventricular (LV) function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>In patients with heart failure due to dilated cardiomyopathy (LVEF 30\u00b14%, n=9) pyruvate was infused intracoronarily. LV function was analysed before, during and after application of different pyruvate concentrations using a LV-micromanometer catheter. LV volumes were determined using cine ventriculography. Pyruvate increased maximum rate of LV isovolumic pressure rise (Peak +dP\/dt) from 802\u00b1106 to 1125\u00b1103 mmHg\/s (P&amp;lt;0.05). Left ventricular end-diastolic pressure declined in parallel from 17\u00b12 to 12\u00b12 mmHg (P&amp;lt;0.05) and heart rate decreased from 79\u00b14 to 72\u00b15 min\u22121 (P&amp;lt;0.05). Stroke volume index increased from 34\u00b14 to 43\u00b16 ml\/m2 (P&amp;lt;0.05), end-diastolic LV volume remained unchanged, thus left ventricular ejection fraction increased with pyruvate from 30\u00b14 to 39\u00b14% (P&amp;lt;0.05). Maximum rate of LV isovolumic pressure decline (Peak \u2212dP\/dt) was significantly increased with pyruvate (from 794\u00b194 to 980\u00b1108 mmHg\/s; P&amp;lt;0.05) and mean arterial pressure increased from 80\u00b15 to 88\u00b14 mmHg (P&amp;lt;0.05). Discontinuation of pyruvate resulted in immediate reversibility of its effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intracoronary pyruvate improves systolic and diastolic myocardial function and increases ejection fraction without increasing heart rate. Pyruvate thus exhibits the profile of a favourable inotropic agent, however, further investigation for the treatment of patients with acute heart failure is mandatory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ejheart.2003.10.001","type":"journal-article","created":{"date-parts":[[2004,2,21]],"date-time":"2004-02-21T05:23:03Z","timestamp":1077340983000},"page":"213-218","source":"Crossref","is-referenced-by-count":29,"title":["Improved Systolic and Diastolic Myocardial Function with Intracoronary Pyruvate in Patients with Congestive Heart Failure"],"prefix":"10.1093","volume":"6","author":[{"given":"Hans-Peter","family":"Hermann","sequence":"first","affiliation":[{"name":"Abteilung Kardiologie und Pneumologie, Georg-August-Universit\u00e4t G\u00f6ttingen , Robert-Koch-Str. 40, G\u00f6ttingen, D-37075 ,","place":["Germany"]}]},{"given":"Jordis","family":"Arp","sequence":"additional","affiliation":[{"name":"Abteilung Kardiologie und Pneumologie, Georg-August-Universit\u00e4t G\u00f6ttingen , Robert-Koch-Str. 40, G\u00f6ttingen, D-37075 ,","place":["Germany"]}]},{"given":"Burkert","family":"Pieske","sequence":"additional","affiliation":[{"name":"Abteilung Kardiologie und Pneumologie, Georg-August-Universit\u00e4t G\u00f6ttingen , Robert-Koch-Str. 40, G\u00f6ttingen, D-37075 ,","place":["Germany"]}]},{"given":"Harald","family":"K\u00f6gler","sequence":"additional","affiliation":[{"name":"Abteilung Kardiologie und Pneumologie, Georg-August-Universit\u00e4t G\u00f6ttingen , Robert-Koch-Str. 40, G\u00f6ttingen, D-37075 ,","place":["Germany"]}]},{"given":"Steffen","family":"Baron","sequence":"additional","affiliation":[{"name":"Abteilung Kardiologie und Pneumologie, Georg-August-Universit\u00e4t G\u00f6ttingen , Robert-Koch-Str. 40, G\u00f6ttingen, D-37075 ,","place":["Germany"]}]},{"given":"Paul M.L.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Abteilung Kardiologie und Pneumologie, 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