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PAF stimulation rapidly induced cell elongation, accompanied by filopodia formation. The inhibition of Rho family proteins by the overexpression of Rho\u2010GDI attenuated the PAF\u2010mediated morphological changes. Both RhoA and Cdc42 were activated in response to PAF. Inhibition of RhoA or Cdc42 by dominant negative mutants abrogated morphological changes induced by PAF. Collectively, PAF regulates cytoarchitecture through Rho family proteins in macrophages.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.06.022","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T16:18:21Z","timestamp":1119975501000},"page":"4038-4042","source":"Crossref","is-referenced-by-count":11,"title":["Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP\u20101 macrophages"],"prefix":"10.1002","volume":"579","author":[{"given":"Chinuyo","family":"Sumita","sequence":"first","affiliation":[]},{"given":"Masako","family":"Yamane","sequence":"additional","affiliation":[]},{"given":"Takahisa","family":"Matsuda","sequence":"additional","affiliation":[]},{"given":"Makiko","family":"Maeda","sequence":"additional","affiliation":[]},{"given":"Tetsuro","family":"Nariai","sequence":"additional","affiliation":[]},{"given":"Yasushi","family":"Fujio","sequence":"additional","affiliation":[]},{"given":"Junichi","family":"Azuma","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,6,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00530-X"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01598"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.509"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.2.265"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)38167-5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1995.tb00894.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.20.2495"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2004.04.002"},{"key":"e_1_2_5_11_1","first-page":"1321","article-title":"Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins","volume":"5","author":"Fukumoto Y.","year":"1990","journal-title":"Oncogene"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.9.4826"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(08)60603-2"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.10.1829"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200212049"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.37.23633"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.3.578"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.110.6.707"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8924(96)10026-X"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.3.1121.415k04_1121_1130"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2005.06.022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2005.06.022","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2005.06.022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:45:02Z","timestamp":1694997902000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2005.06.022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,27]]},"references-count":19,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2005,7,18]]}},"alternative-id":["10.1016\/j.febslet.2005.06.022"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2005.06.022","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,27]]}}}