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We demonstrate that At5g02310 is a ubiquitin ligase and mediates degradation of proteins with amino\u2010terminal Arg residue. Unlike Ubr1, the <jats:italic>Arabidopsis<\/jats:italic> protein does not participate in degradation of proteins with amino\u2010terminal Phe or Leu. This modified target specificity coincides with characteristic differences in domain structure. In contrast to previous publications, our data indicate that At5g02310 is not identical to <jats:italic>CER3<\/jats:italic>, a gene involved in establishment of a protective surface wax layer. At5g02310 has therefore been re\u2010designated <jats:italic>PROTEOLYSIS 6<\/jats:italic> (<jats:italic>PRT6<\/jats:italic>), in accordance with its ubiquitin ligase function.<\/jats:p>","DOI":"10.1016\/j.febslet.2007.06.005","type":"journal-article","created":{"date-parts":[[2007,6,14]],"date-time":"2007-06-14T05:05:04Z","timestamp":1181797504000},"page":"3189-3196","source":"Crossref","is-referenced-by-count":113,"title":["<i>PRT6<\/i>\/At5g02310 encodes an <i>Arabidopsis<\/i> ubiquitin ligase of the N\u2010end rule pathway with arginine specificity and is not the <i>CER3<\/i> locus"],"prefix":"10.1002","volume":"581","author":[{"given":"Marcus","family":"Garz\u00f3n","sequence":"first","affiliation":[]},{"given":"Karolin","family":"Eifler","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Faust","sequence":"additional","affiliation":[]},{"given":"Hartmut","family":"Scheel","sequence":"additional","affiliation":[]},{"given":"Kay","family":"Hofmann","sequence":"additional","affiliation":[]},{"given":"Csaba","family":"Koncz","sequence":"additional","affiliation":[]},{"given":"Alexander","family":"Yephremov","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Bachmair","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2007,6,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.22.010605.093503"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.55.031903.141801"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aob\/mcl255"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127085"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2006.09.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1988"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.01.025"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3018930"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2000.101"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2007.02.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04027"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-18-1258"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.2002.01407.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07516.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.16.7120-7136.2005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.2.418"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.7904"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.103.029272"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.1996.10030459.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001220050959"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a110808"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7827(02)00045-0"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2006.03.001"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.004630"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:PLAN.0000009297.37235.4a"},{"key":"e_1_2_7_27_1","unstructured":"Yin X.-J. 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