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HGF significantly increased matrix metalloproteinase\u20109 production. This was inhibited by blocking phosphatidylinositide 3\u2010kinase (PI3K) and c\u2010Jun N\u2010terminal kinase (JNK), but not extracellular signal\u2010regulated kinase 1\/2 and p38 mitogen\u2010activated protein kinase signaling pathways. We also demonstrated that PI3K induced activation of JNK, with Akt as a potential point of this cross\u2010talk. These results provide new insights into the molecular mechanism responsible for NPC progression and metastasis.<\/jats:p>","DOI":"10.1016\/j.febslet.2008.09.004","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T08:45:17Z","timestamp":1221813917000},"page":"3415-3422","source":"Crossref","is-referenced-by-count":27,"title":["Hepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNK"],"prefix":"10.1002","volume":"582","author":[{"given":"Hong Yan","family":"Zhou","sequence":"first","affiliation":[]},{"given":"Kai Fung","family":"Wan","sequence":"additional","affiliation":[]},{"given":"Carman K.M.","family":"Ip","sequence":"additional","affiliation":[]},{"given":"Chris K.C.","family":"Wong","sequence":"additional","affiliation":[]},{"given":"Nai Ki","family":"Mak","sequence":"additional","affiliation":[]},{"given":"Kwok 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