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While ubiquitin ligases responsible for targeting misfolded secretory proteins to proteasomal degradation (ERAD) have been uncovered, no such E3 enzymes have been found for elimination of misfolded cytoplasmic proteins in yeast. Here we report on the discovery of Ubr1, the E3 ligase of the N\u2010end rule pathway, to be responsible for targeting misfolded cytosoplasmic protein to proteasomal degradation.<\/jats:p>","DOI":"10.1016\/j.febslet.2008.11.015","type":"journal-article","created":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T09:25:08Z","timestamp":1227864308000},"page":"4143-4146","source":"Crossref","is-referenced-by-count":144,"title":["Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1"],"prefix":"10.1002","volume":"582","author":[{"given":"Frederik","family":"Eisele","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter H.","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,11,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.14.9409541"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/scdb.1999.0321"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg227"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5446.1882"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1052"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2007.09.008"},{"key":"e_1_2_5_8_1","first-page":"123","volume-title":"Protein Degradation","author":"Sch&auml;fer A.","year":"2008"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.03.024"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E06-04-0338"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0805-736"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2001"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2004.10.007"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00560.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5282.1725"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2004.09.020"},{"key":"e_1_2_5_17_1","unstructured":"J. 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